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Journal Articles

Phase I Study of the T-Cell Receptor-like Antibody, Hu8F4 in Patients with Relapsed and Refractory Myeloid Malignancies

Blood (2023) 142 (Supplement 1): 1545.

https://doi.org/10.1182/blood-2023-189966

Published: 2023

Journal Articles

CD47 Blockade Enhances Phagocytic Activity of the TCR-Mimic Antibody Hu8F4 Against HLA-A2+ AML

Anna Sergeeva, Hong He, Lisa St. John, Ling Yu, Rong Cai, Kathryn Ruissard, Karen Clise-Dwyer, Rolando Vedia, Dan Li, Qing Ma, Celine Kerros, Mithil Chokshi, Vanshika Jhonsa, Gang Bao, Gheath Alatrash, Jeffrey J. Molldrem

Blood (2023) 142 (Supplement 1): 4176.

https://doi.org/10.1182/blood-2023-190099

Published: 2023

Journal Articles

Humanized T Cell Receptor-like Antibody Hu8F4 Reduces Leukemia By Fc-Mediated Mechanism

Blood (2022) 140 (Supplement 1): 9061–9062.

https://doi.org/10.1182/blood-2022-162593

Published: 2022

Journal Articles

LRP1-Deficient T Cells Protect Against Acute Graft Versus Host Disease in MHC-Mismatched Mice

Olga Sizova, Dan Li, Qing Ma, Lisa St John, Karen Clise-Dwyer, Abel Trujillo-Ocampo, Jeffrey J. Molldrem

Blood (2022) 140 (Supplement 1): 4483–4484.

https://doi.org/10.1182/blood-2022-167517

Published: 2022

Journal Articles

STAT3 Protects Hematopoietic Stem and Progenitor Cell Function in Non-Inflamed Conditions

Bhakti Patel, Yifan Zhou, Rachel L Babcock, Feiyang Ma, Yusra B Medik, Laura M Kahn, Josue E Pineda, Elizabeth Park, Karen Clise-Dwyer, Simona Colla, Stephanie S Watowich

Blood (2022) 140 (Supplement 1): 2864–2865.

https://doi.org/10.1182/blood-2022-170250

Published: 2022

Journal Articles

A Novel Approach to Reduce Toxicity and Preserve Efficacy of Chimeric Antigen Receptor T Cells for Adoptive Transfer

Rolando A. Vedia, Sijie Lu, Anne Philip, Anna Sergeeva, Lisa St John, Karen Clise-Dwyer, Jeffrey J. Molldrem

Blood (2022) 140 (Supplement 1): 10269–10270.

https://doi.org/10.1182/blood-2022-158603

Published: 2022

Journal Articles

Cord Derived 8F4CAR-iNKT Cells to Prevent Acute Myeloid Leukemia Relapse and Graft Vs. Host Disease after Allogeneic Stem Cell Transplantation

Maison Grefe, Abel Trujillo-Ocampo, Drew Boagni, Jelita Clinton, Hong He, Karen Clise-Dwyer, Hyunwoo Cho, Elizabeth J Shpall, Jeffrey J. Molldrem, Jin S. Im

Blood (2022) 140 (Supplement 1): 4517–4518.

https://doi.org/10.1182/blood-2022-167166

Published: 2022

Journal Articles

Pembrolizumab in Combination with Antigen-Specific Cytotoxic T Lymphocytes Enhances Killing of Acute Myeloid Leukemia

Amber Gibson, Mao Zhang, Pariya Sukhumalchandra, Anne V. Philips, Na Qiao, Alexander A. Perakis, Celine Kerros, Lisa St. John, Karen Clise-Dwyer, Sijie Lu, Qing Ma, Jeffrey J. Molldrem, Gheath Alatrash

Blood (2021) 138 (Supplement 1): 2775.

https://doi.org/10.1182/blood-2021-149318

Published: 2021

Journal Articles

Expansion of T Follicular Helper Cells in NLC Co-Cultures Reinforces the Concept of Co-Evolution of CLL and Supportive T Helper Cell Clones

Alicia Vaca, Nikolaos Ioannou, Mariela Sivina, Elisavet Vlachonikola, Karen Clise-Dwyer, Ekaterina Kim, Dan Li, Qing Ma, Alessandra Ferrajoli, Zeev E. Estrov, William G. Wierda, Piers E.M. Patten, Alan G. Ramsay, Jan A. Burger

Blood (2021) 138 (Supplement 1): 3716.

https://doi.org/10.1182/blood-2021-151351

Published: 2021

Journal Articles

Expansion of T Helper Cell Subsets in Chronic Lymphocytic Leukemia Cell Co-Cultures with Nurselike Cells

Alicia Vaca, PhD, Mariela Sivina, Karen Clise-Dwyer, PhD, Ekaterina Kim, MS, Michael J Keating, MBBS, Alessandra Ferrajoli, MD, William G. Wierda, MD PhD, Dan Li, PhD, Qing Ma, PhD, Jan A. Burger, MD PhD

Blood (2019) 134 (Supplement_1): 1746.

https://doi.org/10.1182/blood-2019-125827

Published: 2019

Journal Articles

Single-Cell RNA Sequencing Reveals Distinct Hematopoietic Stem Cell Hierarchies in MDS

Irene Ganan-Gomez, PhD, Hui Yang, PhDMD, Feiyang Ma, Bs, Matteo Pellegrini, PhD, Karen Clise-Dwyer, PhD, Guillermo Garcia-Manero, MD, Simona Colla, PhD

Blood (2019) 134 (Supplement_1): 771.

https://doi.org/10.1182/blood-2019-128798

Published: 2019

Journal Articles

Induced PD-1 Expression on Bone Marrow CD34+ Cells from MDS Patients Treated with 5-Azacitadine in Combination with Nivolumab and/or Ipilimumab

Hui Yang, PhDMD, Zhihong Fang, Karen Clise-Dwyer, PhD, Kathryn Ruisaard, Simona Colla, PhD, Irene Ganan-Gomez, PhD, Guillermo Montalban-Bravo, MD, Kelly Soltysiak, Naval G. Daver, MD, Elias J. Jabbour, MD, Hagop M. Kantarjian, MD, Guillermo Garcia-Manero, MD

Blood (2018) 132 (Supplement 1): 1807.

https://doi.org/10.1182/blood-2018-99-119278

Published: 2018

Journal Articles

Pembrolizumab Enhances the Anti-Leukemia Activity of Antigen Specific Cytotoxic T Lymphocytes

Mao Zhang, MPH, Pariya Sukhumalchandra, BS, Anne V. Philips, PhD, Na Qiao, PhD, Celine Kerros, PhD, Lisa St. John, PhD, Alexander A. Perakis, BS, Karen Clise-Dwyer, PhD, Elizabeth Mittendorf, MD PhD, Naval G. Daver, MD, Jeffrey J. Molldrem, MD, Qing Ma, PhD, Gheath Alatrash, DO, PhD

Blood (2018) 132 (Supplement 1): 4542.

https://doi.org/10.1182/blood-2018-99-114864

Published: 2018

Journal Articles

Telomere Damage Maintains Hematopoietic Stem Cells (HSCs) in an Activated Metabolic State, Which Compromises Their Self-Renewal Capability

Andrea Santoni, PhD, Elena Fiorini, MS, Fides D Lay, PhD BSc, Matteo Marchesini, PhD, Yamini Ogoti, Christopher Jackson, Ashley Rose, Karen Clise-Dwyer, PhD, Irene Ganan-Gomez, PhD, Guillermo Garcia-Manero, MD, Simona Colla, PhD

Blood (2018) 132 (Supplement 1): 174.

https://doi.org/10.1182/blood-2018-174

Published: 2018

Journal Articles

Cell-Type Specific Mechanisms of Hematopoietic Stem Cell (HSC) Expansion Underpin Progressive Disease in Myelodysplastic Syndromes (MDS) and Provide a Rationale for Targeted Therapies

Blood (2018) 132 (Supplement 1): 1798.

https://doi.org/10.1182/blood-2018-99-116881

Published: 2018

Journal Articles

Humanized Anti-PR1/HLA-A2 T Cell Receptor-like Monoclonal Antibody, h8F4, Has Multiple Effector Mechanisms

Anna Sergeeva, PhD, Hong He, MD, Kathryn Cox, Lisa St John, PhD, Mei Sang, Celine Kerros, PhD, Qiaochuan Li, PhD MD, Amanda Herrmann, Karen Clise-Dwyer, PhD, Qing Ma, PhD, Gregory Lizee, PhD, Gheath Alatrash, DO, PhD, Jeffrey J. Molldrem, MD

Blood (2016) 128 (22): 4061.

https://doi.org/10.1182/blood.V128.22.4061.4061

Published: 2016

Journal Articles

Hematopoietic Architecture of MDS before and after Progression Reveals Two Biologically Distinct Disease Subtypes

Irene Gañán-Gómez, PhD, Ana Alfonso, MD, Yamini Ogoti, MS, Hui Yang, MD PhD, Guillermo Montalban-Bravo, MD, Abraham C Yu, BS, Matteo Marchesini, PhD, Carlos E Bueso-Ramos, MD PhD, Koichi Takahashi, MD, Karen Clise-Dwyer, PhD, Guillermo Garcia-Manero, MD, Simona Colla, PhD

Blood (2016) 128 (22): 4310.

https://doi.org/10.1182/blood.V128.22.4310.4310

Published: 2016

Journal Articles

ILF2-YB1 Protein Interaction Modulates RNA Splicing to Induce Resistance to Chemotherapy in High Risk Multiple Myeloma

Matteo Marchesini, PhD, Yamini Ogoti, MS, Elena Fiorini, MS, Marianna D'anca, PhD, Paola Storti, PhD, Luigi Nezi, PhD, Mehmet K. Samur, PhD, Irene Gañán-Gómez, PhD, Mariateresa Fulciniti, PhD, Zachary S. Bohannan, MA, Karen Clise-Dwyer, PhD, Nicola Giuliani, MD PhD, Nikhil C Munshi, MD, Robert Z. Orlowski, PhD, MD, Guillermo Garcia-Manero, MD, Ronald A. DePinho, Simona Colla, PhD

Blood (2016) 128 (22): 359.

https://doi.org/10.1182/blood.V128.22.359.359

Published: 2016

Journal Articles

Tyrosine kinase inhibitors induce mesenchymal stem cell–mediated resistance in BCR-ABL + acute lymphoblastic leukemia

Blood (2015) 125 (19): 2968–2973.

https://doi.org/10.1182/blood-2014-05-576421

Published: 2015

Includes: Supplemental data

Journal Articles

Inhibition of T Cell Proliferation By Granulocyte Membrane-Associated Proteinase 3 Is Reversed By Blocking the Interaction of Calreticulin with LRP on T Cells

Tian-Hui Yang, PhD, Lisa S. St. John, PhD, Karen Clise-Dwyer, PhD, Kathryn Ruisaard, MS, Gheath Alatrash, DO, PhD, Jeffrey J. Molldrem, MD

Blood (2014) 124 (21): 4110.

https://doi.org/10.1182/blood.V124.21.4110.4110

Published: 2014

NARROW

Phase I Study of the T-Cell Receptor-like Antibody, Hu8F4 in Patients with Relapsed and Refractory Myeloid Malignancies

CD47 Blockade Enhances Phagocytic Activity of the TCR-Mimic Antibody Hu8F4 Against HLA-A2+ AML

Humanized T Cell Receptor-like Antibody Hu8F4 Reduces Leukemia By Fc-Mediated Mechanism

LRP1-Deficient T Cells Protect Against Acute Graft Versus Host Disease in MHC-Mismatched Mice

STAT3 Protects Hematopoietic Stem and Progenitor Cell Function in Non-Inflamed Conditions

A Novel Approach to Reduce Toxicity and Preserve Efficacy of Chimeric Antigen Receptor T Cells for Adoptive Transfer

Cord Derived 8F4CAR-iNKT Cells to Prevent Acute Myeloid Leukemia Relapse and Graft Vs. Host Disease after Allogeneic Stem Cell Transplantation

Pembrolizumab in Combination with Antigen-Specific Cytotoxic T Lymphocytes Enhances Killing of Acute Myeloid Leukemia

Expansion of T Follicular Helper Cells in NLC Co-Cultures Reinforces the Concept of Co-Evolution of CLL and Supportive T Helper Cell Clones

Expansion of T Helper Cell Subsets in Chronic Lymphocytic Leukemia Cell Co-Cultures with Nurselike Cells

Single-Cell RNA Sequencing Reveals Distinct Hematopoietic Stem Cell Hierarchies in MDS

Induced PD-1 Expression on Bone Marrow CD34+ Cells from MDS Patients Treated with 5-Azacitadine in Combination with Nivolumab and/or Ipilimumab

Pembrolizumab Enhances the Anti-Leukemia Activity of Antigen Specific Cytotoxic T Lymphocytes

Telomere Damage Maintains Hematopoietic Stem Cells (HSCs) in an Activated Metabolic State, Which Compromises Their Self-Renewal Capability

Cell-Type Specific Mechanisms of Hematopoietic Stem Cell (HSC) Expansion Underpin Progressive Disease in Myelodysplastic Syndromes (MDS) and Provide a Rationale for Targeted Therapies

Humanized Anti-PR1/HLA-A2 T Cell Receptor-like Monoclonal Antibody, h8F4, Has Multiple Effector Mechanisms

Hematopoietic Architecture of MDS before and after Progression Reveals Two Biologically Distinct Disease Subtypes

ILF2-YB1 Protein Interaction Modulates RNA Splicing to Induce Resistance to Chemotherapy in High Risk Multiple Myeloma

Tyrosine kinase inhibitors induce mesenchymal stem cell–mediated resistance in BCR-ABL + acute lymphoblastic leukemia

Inhibition of T Cell Proliferation By Granulocyte Membrane-Associated Proteinase 3 Is Reversed By Blocking the Interaction of Calreticulin with LRP on T Cells

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American Society of Hematology

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American Society of Hematology

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