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Journal Articles

Casein Kinase 1 Delta Is a Novel Regulator of mRNA Translation and Druggable Target in Aggressive Lymphomas

Ipsita Pal, PhD, Sohani Das Sharma, PhD, Andre M. Grilo, PhD, Prabhjot S. Mundi, MD, Luigi Scotto, PhD, Abdullah Mahmood Ali, PhD, Luke E Berchowitz, PhD, Siddhartha Mukherjee, MD PhD, Owen O'Connor, MD PhD, Marko Jovanovic, PhD, Changchun Deng, MD PhD

Blood (2019) 134 (Supplement_1): 2864.

https://doi.org/10.1182/blood-2019-129528

Published: 2019

Journal Articles

Regulation of eIF4E Guides a Unique Translational Program to Steer Erythroid Maturation

Craig M Forester, MD PhD, Gun Woo-Byeon, Juan Oses-Prieto, PhD, Al Burlingame, PhD, Maria Barna, PhD, Davide M Ruggero, PhD

Blood (2019) 134 (Supplement_1): 156.

https://doi.org/10.1182/blood-2019-129608

Published: 2019

Journal Articles

Targeting eIF4A Using MZ-735 Potently Induces Cell Death in Lymphoma Cells and Rapidly Represses mRNA Translation at the Global Level and in C-MYC and Other Oncogenes

Ipsita Pal, PhD, Yu Ri Kim, MD, Sohani Das Sharma, PhD, Prabhjot S. Mundi, MD, Andre M. Grilo, PhD, Luke E Berchowitz, PhD, Mingzhao Zhu, PhD, Hull G. Kenneth, PhD, Daniel Romo, PhD, Owen O'Connor, MD PhD, Marko Jovanovic, PhD, Changchun Deng, MD PhD

Blood (2019) 134 (Supplement_1): 4067.

https://doi.org/10.1182/blood-2019-131816

Published: 2019

Journal Articles

DNA Repair Genes' Expression Abnormalities in De Novo Acute Myelogenous Leukemia (AML): Implications for Targeted Treatment

Frieda Kontsioti, PhD, Eirini Maratou, PhD, Anthi Bouhla, MD, Vassiliki Mpakou, PhD, Konstantinos Gkodopoulos, MD, Georgia Stavroulaki, MD, Eirini Glezou, MD, Thomas Thomopoulos, MD, Efthimia Bazani, MD, Sotirios Papageorgiou, MD PhD, Argiris Symeonidis, MD PhD, George Dimitriadis, MD, Vassiliki Pappa, MD

Blood (2019) 134 (Supplement_1): 5176.

https://doi.org/10.1182/blood-2019-127501

Published: 2019

Journal Articles

Ywhae/14-3-3ε Expression Promotes Translation Initiation and Protein Synthesis in Multiple Myeloma Regulating Proteasome Load and Contributing to Proteasome Inhibitor Sensitivity/Resistance

Yan Xu, MD, Matthew Ho, PhD, Mehmet Kemal Samur, PhD, Kenneth Wen, Shuhui Deng, MD, Lanting Liu, MD, Tengteng Yu, MD PhD, Zuzana Chyra, PhD, Sanika Derebail, Kenneth C. Anderson, MD, Lugui Qiu, MD PhD, Mariateresa Fulciniti, PhD, Nikhil C. Munshi, MD

Blood (2019) 134 (Supplement_1): 5539.

https://doi.org/10.1182/blood-2019-130902

Published: 2019

Journal Articles

Targeting Oncogenic Polyamines in Refractory Pediatric Leukemias Using the Anti-Protozoan Drug Α-Difluoromethylornithine (DFMO) in Combination with GC7 and Aurothioglucose

Bradley Hofmann, MSc, Sunand Kannappan, Gupta Mehul, Chunfen Zhang, MD, Susan Chi, MD, Derek Hanson, MD, Ronald Anderson, MD FRCPC, Aru Narendran, MD PhD

Blood (2018) 132 (Supplement 1): 2725.

https://doi.org/10.1182/blood-2018-99-117229

Published: 2018

Journal Articles

Novel Conjugates of Butyrate and δ-Aminolevulinate Increase γ-Globin Gene Expression and Fetal Hemoglobin Synthesis in Erythroid Progenitors

Aluya R. Oseghale, BSc, Marjorie M. Johnson, BS, Xingguo Zhu, PhD, Abraham Nudelman, PhD, Ada Rephaeli, PhD, Betty S. Pace, MD

Blood (2017) 130 (Supplement 1): 3511.

https://doi.org/10.1182/blood.V130.Suppl_1.3511.3511

Published: 2017

Journal Articles

Salubrinal Mediated Fetal Hemoglobin Induction through the eIF2α-ATF4 Signaling Pathway

Nicole Hope Lopez, BS, Biaoru Li, MD PhD, Levi Makala, DVM, MBA, PhD, Betty S. Pace, MD

Blood (2017) 130 (Supplement 1): 2235.

https://doi.org/10.1182/blood.V130.Suppl_1.2235.2235

Published: 2017

Journal Articles

Attenuated Protein Synthesis Drives the Hematopoietic Defects in Shwachman-Diamond Syndrome

Pekka Jaako, PhD, Chi C Wong, PhD MD, David Adams, PhD, Alan J. Warren, PhD FRCP, FRCPath

Blood (2017) 130 (Supplement 1): 876.

https://doi.org/10.1182/blood.V130.Suppl_1.876.876

Published: 2017

Journal Articles

Ribosome Profiling Uncovers Selective mRNA Translation Associated with eIF2 Phosphorylation in Erythrocyte Progenitors

Paolini Nahuel, MSc, Moore Kat, MSc, di Summa Franca, BSc, Fokkema Ivo, MSc, Jansen Sjoert, MSc, 't Hoen Peter-Bram, PhD, Marieke Von Lindern, PhD

Blood (2016) 128 (22): 1197.

https://doi.org/10.1182/blood.V128.22.1197.1197

Published: 2016

Journal Articles

Prostaglandin E 2 Alters the Differentiation and Function of Antigen-Specific T Cells By Targeting the Metabolic Gene Regulatory Network Downstream of mTORC1

Christoph Herbel, PhD, Nikolaos Patsoukis, PhD, Jessica D Weaver, PhD, Vassiliki A. Boussiotis, MD PhD

Blood (2016) 128 (22): 552.

https://doi.org/10.1182/blood.V128.22.552.552

Published: 2016

Journal Articles

eFT508, a Potent and Selective Mitogen-Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 Inhibitor, Is Efficacious in Preclinical Models of Diffuse Large B-Cell Lymphoma (DLBCL)

Kevin R. Webster, PhD, Vikas K Goel, PhD, Ivy NJ Hung, PhD, Gregory S Parker, PhD, Jocelyn Staunton, BA, Melissa Neal, Jolene Molter, Gary G Chiang, PhD, Katti A. Jessen, PhD, Christopher J Wegerski, PhD, Samuel Sperry, PhD, Vera Huang, PhD, Joan Chen, PhD, Peggy A Thompson, PhD, James R Appleman, PhD, Stephen E Webber, PhD, Paul A Sprengeler, PhD, Siegfried H Reich, PhD

Blood (2015) 126 (23): 1554.

https://doi.org/10.1182/blood.V126.23.1554.1554

Published: 2015

Journal Articles

Interfering with Arginine Metabolism As a New Treatment Strategy for Multiple Myeloma

Bjoern Jacobi, MD, Lea Stroeher, MS, Nadine Leuchtner, Hakim Echchannaoui, PhD, Alexander Desuki, MD, Lara Kuerzer, Alice Habermeier, Edite Antunes, Eva Amann, John Bomalaski, MD, Closs Ellen, PhD Prof., Matthias Theobald, MD PhD, Markus Munder, MD

Blood (2015) 126 (23): 3005.

https://doi.org/10.1182/blood.V126.23.3005.3005

Published: 2015

Journal Articles

Special Delivery: The Role of Iron Chaperones in the Distribution of Iron in Developing Red Cells

Caroline C. Philpott, MD, Avery G Frey, PhD, Moon-Suhn Ryu, PhD, Daniel Palenchar, Justin Wildemann, Ajay A Vashisht, Ph. D., James Wohlschlegel, Ph. D., Kymberly Bullough, Ph. D.

Blood (2015) 126 (23): SCI-45.

https://doi.org/10.1182/blood.V126.23.SCI-45.SCI-45

Published: 2015

Journal Articles

Disruption of the mTOR-eIF4F Axis By Selectively Targeting PI3Kdelta and Proteasome Potently Inhibits Cap Dependent Translation of c-Myc in Aggressive Lymphomas

Changchun Deng, MD PhD, Mark Lipstein, Luigi Scotto, PhD, Yun Hao, Nicholas P. Tatonetti, PhD, Michael Mangone, PhD, Shirong Li, PhD, Suzanne Lentzsch, Ronald B. Realubit, PhD, Charles Karan, Jr., PhD, Owen A. O'Connor, MD PhD

Blood (2015) 126 (23): 593.

https://doi.org/10.1182/blood.V126.23.593.593

Published: 2015

Journal Articles

Inducible Silencing Of eIF4E Using a Tet-On System Results In Myeloma Growth In Vivo That Correlates With eIF4E Expression

Shirong Li, PHD, Jing Fu, Ph D, Jordan M. Schecter, MD, Caisheng Lu, PHD, Markus Y. Mapara, MD PhD, Suzanne Lentzsch, MD, PhD

Blood (2013) 122 (21): 3164.

https://doi.org/10.1182/blood.V122.21.3164.3164

Published: 2013

Journal Articles

Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism

Cynthia K. Hahn, Christopher H. Lowrey

Blood (2013) 122 (4): 477–485.

https://doi.org/10.1182/blood-2013-03-491043

Published: 2013

Includes: Supplemental data

Journal Articles

Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors

Jessica K. Altman, Amy Szilard, Bruce W. Konicek, Philip W. Iversen, Barbara Kroczynska, Heather Glaser, Antonella Sassano, Eliza Vakana, Jeremy R. Graff, Leonidas C. Platanias

Blood (2013) 121 (18): 3675–3681.

https://doi.org/10.1182/blood-2013-01-477216

Published: 2013

Journal Articles

Investigation of the Novel Anti-Leukemia Effects of the Marine Compound Pateamine A.

Andrea Dean, MD, Thien Nguyen, Nathan Cox, Matthew Cooper, Kristy L. Richards, PhD, MD, Thomas C. Shea, MD, Nathaniel Moorman, Ph.D, Lee Graves, Ph.D

Blood (2012) 120 (21): 2437.

https://doi.org/10.1182/blood.V120.21.2437.2437

Published: 2012

Journal Articles

Overexpression of Eukaryotic Initiation Factor 4E Induces Critical Transcription Factors Such As c-Myc in Multiple Myeloma Resulting in Enhanced Clonogenic Tumor Growth in Vitro and in Vivo .

Shirong Li, PhD, Jing Fu, Ph D, Jordan M. Schecter, MD, BS, Caisheng Lu, PhD, Markus Mapara, MD PhD, Suzanne Lentzsch, MD, PhD

Blood (2012) 120 (21): 2908.

https://doi.org/10.1182/blood.V120.21.2908.2908

Published: 2012

NARROW

Casein Kinase 1 Delta Is a Novel Regulator of mRNA Translation and Druggable Target in Aggressive Lymphomas

Regulation of eIF4E Guides a Unique Translational Program to Steer Erythroid Maturation

Targeting eIF4A Using MZ-735 Potently Induces Cell Death in Lymphoma Cells and Rapidly Represses mRNA Translation at the Global Level and in C-MYC and Other Oncogenes

DNA Repair Genes' Expression Abnormalities in De Novo Acute Myelogenous Leukemia (AML): Implications for Targeted Treatment

Ywhae/14-3-3ε Expression Promotes Translation Initiation and Protein Synthesis in Multiple Myeloma Regulating Proteasome Load and Contributing to Proteasome Inhibitor Sensitivity/Resistance

Targeting Oncogenic Polyamines in Refractory Pediatric Leukemias Using the Anti-Protozoan Drug Α-Difluoromethylornithine (DFMO) in Combination with GC7 and Aurothioglucose

Novel Conjugates of Butyrate and δ-Aminolevulinate Increase γ-Globin Gene Expression and Fetal Hemoglobin Synthesis in Erythroid Progenitors

Salubrinal Mediated Fetal Hemoglobin Induction through the eIF2α-ATF4 Signaling Pathway

Attenuated Protein Synthesis Drives the Hematopoietic Defects in Shwachman-Diamond Syndrome

Ribosome Profiling Uncovers Selective mRNA Translation Associated with eIF2 Phosphorylation in Erythrocyte Progenitors

Prostaglandin E 2 Alters the Differentiation and Function of Antigen-Specific T Cells By Targeting the Metabolic Gene Regulatory Network Downstream of mTORC1

eFT508, a Potent and Selective Mitogen-Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 Inhibitor, Is Efficacious in Preclinical Models of Diffuse Large B-Cell Lymphoma (DLBCL)

Interfering with Arginine Metabolism As a New Treatment Strategy for Multiple Myeloma

Special Delivery: The Role of Iron Chaperones in the Distribution of Iron in Developing Red Cells

Disruption of the mTOR-eIF4F Axis By Selectively Targeting PI3Kdelta and Proteasome Potently Inhibits Cap Dependent Translation of c-Myc in Aggressive Lymphomas

Inducible Silencing Of eIF4E Using a Tet-On System Results In Myeloma Growth In Vivo That Correlates With eIF4E Expression

Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism

Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors

Investigation of the Novel Anti-Leukemia Effects of the Marine Compound Pateamine A.

Overexpression of Eukaryotic Initiation Factor 4E Induces Critical Transcription Factors Such As c-Myc in Multiple Myeloma Resulting in Enhanced Clonogenic Tumor Growth in Vitro and in Vivo .

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American Society of Hematology

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American Society of Hematology

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