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Journal Articles

Break the lifeline of AML cells

Yoko Tabe, Marina Konopleva

Blood (2021) 137 (25): 3465–3467.

https://doi.org/10.1182/blood.2021011475

Published: 2021

Journal Articles

Lipidomic Profiling of Plasma Samples in Patients with Newly Diagnosed Multiple Myeloma; A Biomarker Study for Predicting the Response and Toxicities of Melphalan, Prednisolone and Bortezomib (MPB) Regimen : An Ancillary Study of the JCOG1105 (JCOG1105A1)

Masaki Ri, Shinsuke Iida, MD PhD, Dai Maruyama, MD PhD, Kosuke Saito, Yoshiro Saito, Satoshi Osaga, Masahiro Tohkin, Naoki Miyata, Kensei Tobinai, MD PhD, Noriko Fukuhara, MD PhD, Kana Miyazaki, MD PhD, Yosuke Minami, MD PhD, Norifumi Tsukamoto, MD PhD, Hideki Tsujimura, MD PhD, Makoto Yoshimitsu, MD PhD, Kenichi Miyamoto, Kunihiro Tsukasaki, MD PhD, Hirokazu Nagai, MD PhD

Blood (2019) 134 (Supplement_1): 3156.

https://doi.org/10.1182/blood-2019-122218

Published: 2019

Journal Articles

Identification of FASN-Dependent Onco-Metabolic Regulation of the Pentose Phosphate Pathway (PPP) and Nucleotide Metabolism in Non-Hodgkin Lymphoma (NHL)

Ravi Dashnamoorthy, PhD, Afshin Beheshti, PhD, Xiaoyang Su, PhD, Ying Chen, PhD, Maisarah Mokhtar, B.S, Gregory Dolnikowski, Frederick Lansigan, MD, William B Kinlaw, III, MD, Sandeep Dave, MD, Andrew M. Evens, DO, MSc

Blood (2019) 134 (Supplement_1): 1573.

https://doi.org/10.1182/blood-2019-126382

Published: 2019

Journal Articles

Chronic Lymphocytic Leukaemia Relies on Lipid Scavenging and Synthesis As an Energy Source

Lauren A Thurgood, PhD, Lara Escane, BMedSci, BSci (Hons), Christie A Bader, BSci (Hons), PhD, Karen M Lower, BSc (Hons), PhD GradCertEd (HighEd), Doug A Brooks, BSci, BSci (Hons), PhD, Bryone J. Kuss, PhD, BMBS, FRCPA, FRACP

Blood (2018) 132 (Supplement 1): 3117.

https://doi.org/10.1182/blood-2018-99-120241

Published: 2018

Journal Articles

Adaptation to Metabolic Stress By Mondoα in Common B-Cell Acute Lymphoblastic Leukemia

Alexandra Sipol, Andreas Petry, Erik Hameister, Agnes Görlach, Jürgen Ruland, Stefan Burdach, Poul Sorensen

Blood (2018) 132 (Supplement 1): 3888.

https://doi.org/10.1182/blood-2018-99-114014

Published: 2018

Journal Articles

Elucidating the Non-Catalytic Function of Fatty Acid Synthase and Its Autophagy-Dependent Degradation in Acute Myelocytic Leukemia Differentiation Therapy

Magali Humbert, PhD, Severin Mosimann, Vreni Rentsch, Mario P. Tschan, PhD

Blood (2018) 132 (Supplement 1): 2624.

https://doi.org/10.1182/blood-2018-99-112068

Published: 2018

Journal Articles

Myeloma-Associated Adipocytes Exhibit Reduced Adipogenic Gene Expression and Delipidation

Heather Fairfield, MS, Elizabeth J Harris, Carolyne Falank, PhD, Michaela Reagan, PhD

Blood (2017) 130 (Supplement 1): 1768.

https://doi.org/10.1182/blood.V130.Suppl_1.1768.1768

Published: 2017

Journal Articles

Reactive Oxygen Species and Metabolic Gene Expression Profiling Further Differentiate CXCR4/CD5 Fractions in Chronic Lymphocytic Leukemia

Eric Sturgill, BA, Xiao J. Yan, MDPhD, Florencia Palacios, PhD, Kanti Rai, MD, Jacqueline C. Barrientos, MD, Steven L. Allen, MD, Jonathan E. Kolitz, MD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 4287.

https://doi.org/10.1182/blood.V130.Suppl_1.4287.4287

Published: 2017

Journal Articles

Functional SCD1 Is Critical for Acute Lymphoblastic Leukaemia Maintenance in the Central Nervous System

Orianne Olivares, Antony Cousins, Elke Markert, Sergey Tumanov, Gillian Mackay, Jurre Kamphorst, Karen Keeshan, Pawel Herzyk, Eyal Gottlieb, Christina Halsey

Blood (2017) 130 (Supplement 1): 2608.

https://doi.org/10.1182/blood.V130.Suppl_1.2608.2608

Published: 2017

Journal Articles

Phosphoproteomic Profiling Reveals Metabolic Factors Facilitating Leukemia-Stroma Crosstalk in Acute Myeloid Leukemia

Liliana H Mochmann, PhD, Denise Treue, PhD, Michael Bockmayr, MD, Eva Kristin Von Der Heide, PhD, Patricia Silva, MS, Konstandina Isaakidis, Caroline Busch, MS, Hifza Siddiq, Martin Neumann, Lars Fransecky, MD, Frederick Klauschen, MD, Claudia D. Baldus, MD

Blood (2017) 130 (Supplement 1): 2695.

https://doi.org/10.1182/blood.V130.Suppl_1.2695.2695

Published: 2017

Journal Articles

Cyclin D1 Driven CDK4 Activity Is Responsible for Hypersensitivity to NOXA Inducing Combination Treatment in Mantle Cell Lymphoma (MCL) Cells

Simon Heine, MSc, Elisabeth Silkenstedt, MD, Michael A Dengler, PhD, Kleih Markus, MSc, German Ott, MD, Neus Giménez Carabaza, B.Pharm, Colomer Dolors, PhD, Heiko van der Kuip, PhD, Walter E. Aulitzky, MD

Blood (2017) 130 (Supplement 1): 2811.

https://doi.org/10.1182/blood.V130.Suppl_1.2811.2811

Published: 2017

Journal Articles

Prostaglandin E 2 Alters the Differentiation and Function of Antigen-Specific T Cells By Targeting the Metabolic Gene Regulatory Network Downstream of mTORC1

Christoph Herbel, PhD, Nikolaos Patsoukis, PhD, Jessica D Weaver, PhD, Vassiliki A. Boussiotis, MD PhD

Blood (2016) 128 (22): 552.

https://doi.org/10.1182/blood.V128.22.552.552

Published: 2016

Journal Articles

Genetic and Molecular Characterization of Ibrutinib-Resistant Mantle Cell Lymphoma: Designing Innovative Therapeutic Strategies

Hui Guo, MD PhD, Shengjian Huang, Yang Liu, PhD, Carrie J Li, Jack Wang, Victoria Zhang, Makhdum Ahmed, MD MPH, Laura T Lam, PhD, Hui Zhang, Krystle Nomie, PhD, Liang Zhang, MD PhD, Michael Wang, MD

Blood (2016) 128 (22): 1838.

https://doi.org/10.1182/blood.V128.22.1838.1838

Published: 2016

Journal Articles

Lipid Addiction of Diffuse Large B-Cell Lymphoma (DLBCL): Fatty Acid Synthase (FASN) and PI3K Dependent Cell Death Identifies a Novel Therapeutic Paradigm

Ravi Dashnamoorthy, PhD, Afshin Beheshti, PhD, Nassera Abermil, MS, PharmD, Frederick Lansigan, MD, William Kinlaw, MD, Ron Gartenhaus, MD, Graham Jones, PhD DSc, Lynn Hlatky, PhD, Andrew M. Evens, DO, MSc

Blood (2015) 126 (23): 1284.

https://doi.org/10.1182/blood.V126.23.1284.1284

Published: 2015

Journal Articles

Dual Targeting of NOXA/MCL-1 Synergistically Induces Cell Death in Mantle Cell Lymphoma (MCL) Cells

Elisabeth Höring, German Ott, MD, Christine Bayha, Kleih Markus, Matthias C. Voehringer, MD, Heiko van Der Kuip, Walter E. Aulitzky, MD

Blood (2015) 126 (23): 2757.

https://doi.org/10.1182/blood.V126.23.2757.2757

Published: 2015

Journal Articles

The mTOR Kinase Inhibitor AZD-2014 Effectively Reverses XPO1/CRM1 Antagonist KPT-185–induced Glycolysis / Gluconeogenesis, Enhancing Antitumor Effects in Mantle Cell Lymphoma

Yoko Tabe, MD PhD, Masako Harada, PhD, Yuka Miyamae, Hiromichi Matsushita, MD PhD, Kensuke Kojima, MD PhD, Tsutomu Fujimura, Saiko Kazuno, Takashi Ueno, Takashi Miida, MD PhD, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD

Blood (2014) 124 (21): 925.

https://doi.org/10.1182/blood.V124.21.925.925

Published: 2014

Journal Articles

The Lipid Addiction of Diffuse Large B-Cell Lymphoma (DLBCL) and Potential Treatment Strategies with Novel Fatty Acid Synthase (FASN) Small Molecule Inhibitors

Ravi Dashnamoorthy, PhD, Nassera Abermil, MS, PharmD, Afshin Behesti, PhD, Paige Kozlowski, BS, Frederick Lansigan, MD, William B Kinlaw, MD, Ronald Gartenhaus, MD, Graham Jones, PhD DSc, Lynn Hlatky, PhD, Andrew M. Evens, DO, MSc

Blood (2014) 124 (21): 4490.

https://doi.org/10.1182/blood.V124.21.4490.4490

Published: 2014

Journal Articles

FASN Is Critical for Maintenance of NUP98 Fusion-Induced Leukemias

Yutaka Shima, PhD, Issay Kitabayashi, PhD

Blood (2014) 124 (21): 2377.

https://doi.org/10.1182/blood.V124.21.2377.2377

Published: 2014

Journal Articles

Molecular Mechanisms Of Adipocyte-Leukemia Interactions Revealed By The Quantitative Proteomics Technology: Pro-Survival Function Of Adipocyte-Derived Free Fatty Acids On Acute Monoblastic Leukemia Mitochondrial Biogenesis

Yoko Tabe, MD, PhD, Linhua Jin, PhD, Saiko Kazuno, Tsutomu Fujimura, Hiromichi Matsushita, MD, PhD, Takashi Ueno, Takashi Miida, MD, PhD, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD

Blood (2013) 122 (21): 3881.

https://doi.org/10.1182/blood.V122.21.3881.3881

Published: 2013

Journal Articles

Molecular Mechanisms Of Inhibition Of Ribosomal Biogenesis and Translational Flux By The Selective Inhibitor Of Nuclear Export (SINE) XPO1/CRM1 Antagonist KPT-185 In Mantle Cell Lymphoma

Yoko Tabe, MD, PhD, Kensuke Kojima, MD, PhD, Linhua Jin, PhD, Hiroko Iwanami, Hiromichi Matsushita, MD, PhD, Saiko Kazuno, Tsutomu Fujimura, Takashi Ueno, Takashi Miida, MD, PhD, Michael Andreeff, MD, PhD

Blood (2013) 122 (21): 820.

https://doi.org/10.1182/blood.V122.21.820.820

Published: 2013

NARROW

Break the lifeline of AML cells

Lipidomic Profiling of Plasma Samples in Patients with Newly Diagnosed Multiple Myeloma; A Biomarker Study for Predicting the Response and Toxicities of Melphalan, Prednisolone and Bortezomib (MPB) Regimen : An Ancillary Study of the JCOG1105 (JCOG1105A1)

Identification of FASN-Dependent Onco-Metabolic Regulation of the Pentose Phosphate Pathway (PPP) and Nucleotide Metabolism in Non-Hodgkin Lymphoma (NHL)

Chronic Lymphocytic Leukaemia Relies on Lipid Scavenging and Synthesis As an Energy Source

Adaptation to Metabolic Stress By Mondoα in Common B-Cell Acute Lymphoblastic Leukemia

Elucidating the Non-Catalytic Function of Fatty Acid Synthase and Its Autophagy-Dependent Degradation in Acute Myelocytic Leukemia Differentiation Therapy

Myeloma-Associated Adipocytes Exhibit Reduced Adipogenic Gene Expression and Delipidation

Reactive Oxygen Species and Metabolic Gene Expression Profiling Further Differentiate CXCR4/CD5 Fractions in Chronic Lymphocytic Leukemia

Functional SCD1 Is Critical for Acute Lymphoblastic Leukaemia Maintenance in the Central Nervous System

Phosphoproteomic Profiling Reveals Metabolic Factors Facilitating Leukemia-Stroma Crosstalk in Acute Myeloid Leukemia

Cyclin D1 Driven CDK4 Activity Is Responsible for Hypersensitivity to NOXA Inducing Combination Treatment in Mantle Cell Lymphoma (MCL) Cells

Prostaglandin E 2 Alters the Differentiation and Function of Antigen-Specific T Cells By Targeting the Metabolic Gene Regulatory Network Downstream of mTORC1

Genetic and Molecular Characterization of Ibrutinib-Resistant Mantle Cell Lymphoma: Designing Innovative Therapeutic Strategies

Lipid Addiction of Diffuse Large B-Cell Lymphoma (DLBCL): Fatty Acid Synthase (FASN) and PI3K Dependent Cell Death Identifies a Novel Therapeutic Paradigm

Dual Targeting of NOXA/MCL-1 Synergistically Induces Cell Death in Mantle Cell Lymphoma (MCL) Cells

The mTOR Kinase Inhibitor AZD-2014 Effectively Reverses XPO1/CRM1 Antagonist KPT-185–induced Glycolysis / Gluconeogenesis, Enhancing Antitumor Effects in Mantle Cell Lymphoma

The Lipid Addiction of Diffuse Large B-Cell Lymphoma (DLBCL) and Potential Treatment Strategies with Novel Fatty Acid Synthase (FASN) Small Molecule Inhibitors

FASN Is Critical for Maintenance of NUP98 Fusion-Induced Leukemias

Molecular Mechanisms Of Adipocyte-Leukemia Interactions Revealed By The Quantitative Proteomics Technology: Pro-Survival Function Of Adipocyte-Derived Free Fatty Acids On Acute Monoblastic Leukemia Mitochondrial Biogenesis

Molecular Mechanisms Of Inhibition Of Ribosomal Biogenesis and Translational Flux By The Selective Inhibitor Of Nuclear Export (SINE) XPO1/CRM1 Antagonist KPT-185 In Mantle Cell Lymphoma

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American Society of Hematology

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American Society of Hematology

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