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Journal Articles

JAK inhibition for murine HLH requires complete blockade of IFN-γ signaling and is limited by toxicity of JAK2 inhibition

Brief Report
Vandana Chaturvedi, Nora Lakes, Minh Tran, Natalie Castillo, Michael B. Jordan
Journal: Blood
Blood (2021) 138 (12): 1034–1039.
https://doi.org/10.1182/blood.2020007930
Published: 2021
Journal Articles

T-cell activation profiles distinguish hemophagocytic lymphohistiocytosis and early sepsis

Vandana Chaturvedi, Rebecca A. Marsh, Adi Zoref-Lorenz, Erika Owsley, Vijaya Chaturvedi, Trung C. Nguyen, Jordana R. Goldman, Michael M. Henry, Jay N. Greenberg, Stephan Ladisch, Michelle L. Hermiston, Michael Jeng, Ahmed Naqvi, Carl E. Allen, Hector R. Wong, Michael B. Jordan
Journal: Blood
Blood (2021) 137 (17): 2337–2346.
https://doi.org/10.1182/blood.2020009499
Published: 2021
Includes: Supplemental data
Journal Articles

RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis

Artem Kalinichenko, Giovanna Perinetti Casoni, Loïc Dupré, Luca Trotta, Jakob Huemer, Donatella Galgano, Yolla German, Ben Haladik, Julia Pazmandi, Marini Thian, Özlem Yüce Petronczki, Samuel C. Chiang, Mervi Taskinen, Anne Hekkala, Saila Kauppila, Outi Lindgren, Terhi Tapiainen, Michael J. Kraakman, Kim Vettenranta, Alexis J. Lomakin, Janna Saarela, Mikko R. J. Seppänen, Yenan T. Bryceson, Kaan Boztug
Journal: Blood
Blood (2021) 137 (15): 2033–2045.
https://doi.org/10.1182/blood.2020008738
Published: 2021
Includes: Supplemental data
Journal Articles

JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation

Lauren K. Meyer, Katherine C. Verbist, Sabrin Albeituni, Brooks P. Scull, Rachel C. Bassett, Alexa N. Stroh, Heather Tillman, Carl E. Allen, Michelle L. Hermiston, Kim E. Nichols
Journal: Blood
Blood (2020) 136 (6): 657–668.
https://doi.org/10.1182/blood.2020006075
Published: 2020
Includes: Supplemental data
Journal Articles

EBV-triggered hemophagocytic lymphohistiocytosis in a boy with a history of non-Hodgkin lymphoma

Clinical Trials & Observations
Michael H. Albert, Fabian Hauck
Journal: Blood
Blood (2020) 136 (5): 644.
https://doi.org/10.1182/blood.2020006580
Published: 2020
Journal Articles

Hemophagocytic syndrome–associated intravascular large B-cell lymphoma

Kaleigh E. Lindholm, Mark D. Ewalt
Journal: Blood
Blood (2020) 135 (26): 2432.
https://doi.org/10.1182/blood.2020005434
Published: 2020
Journal Articles

Hemophagocytic lymphohistiocytosis in SARS-CoV-2 infection

Klaas Dewaele, Rowan Claeys
Journal: Blood
Blood (2020) 135 (25): 2323.
https://doi.org/10.1182/blood.2020006505
Published: 2020
Journal Articles

Pediatric hemophagocytic lymphohistiocytosis

Scott W. Canna, Rebecca A. Marsh
Journal: Blood
Blood (2020) 135 (16): 1332–1343.
https://doi.org/10.1182/blood.2019000936
Published: 2020
Journal Articles

HAVCR2 mutations are associated with severe hemophagocytic syndrome in subcutaneous panniculitis-like T-cell lymphoma

Gabrielle Sonigo, Maxime Battistella, Marie Beylot-Barry, Saskia Ingen-Housz-Oro, Nathalie Franck, Stéphane Barete, Serge Boulinguez, Olivier Dereure, Nathalie Bonnet, Gérard Socié, Pauline Brice, Olivia Boccara, Christine Bodemer, Henri Adamski, Michel D’Incan, Nicolas Ortonne, Sylvie Fraitag, Florence Brunet-Possenti, Stephane Dalle, Felipe Suarez, Ambroise Marçais, François Skowron, Dima Haidar, Eve Maubec, Gerome Bohelay, Liliane Laroche, Antoine Mahé, Elodie Birckel, Jean-David Bouaziz, Isabelle Brocheriou, Romain Dubois, Sarah Faiz, Jehane Fadlallah, Caroline Ram-Wolff, Agnes Carlotti, Guido Bens, Brigitte Balme, Beatrice Vergier, Sara Laurent-Roussel, Lydia Deschamps, Olivier Carpentier, Philippe Moguelet, Genevieve Herve, François Comoz, François Le Gall, Guy Leverger, Antoine Finon, Olivier Augereau, Claire Bléchet, Remy Kerdraon, Laurence Lamant, Emilie Tournier, Frédéric Franck, Valérie Costes-Martineau, Vanessa Szablewski, Sebastien Taix, Isabelle Beschet, Frédéric Guerin, Fernando E. Sepulveda, Martine Bagot, Genevieve de Saint Basile, David Michonneau, Adele de Masson
Journal: Blood
Blood (2020) 135 (13): 1058–1061.
https://doi.org/10.1182/blood.2019003811
Published: 2020
Includes: Supplemental data
Journal Articles

Nivolumab treatment of relapsed/refractory Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis in adults

Clinical Trials & Observations
Pengpeng Liu, Xiangyu Pan, Chong Chen, Ting Niu, Xiao Shuai, Jian Wang, Xuelan Chen, Jiazhuo Liu, Yong Guo, Liping Xie, Yu Wu, Yu Liu, Ting Liu
Journal: Blood
Blood (2020) 135 (11): 826–833.
https://doi.org/10.1182/blood.2019003886
Published: 2020
Includes: Supplemental data
Journal Articles

Hemophagocytic lymphohistiocytosis secondary to babesiosis

Josephine Kamtai Dermawan, Sudipto Mukherjee
Journal: Blood
Blood (2020) 135 (10): 779.
https://doi.org/10.1182/blood.2019004149
Published: 2020
Journal Articles

Prevalence and disease predisposition of p.A91V perforin in an aged population of European ancestry

Clinical Trials & Observations
Ilia Voskoboinik, Paul Lacaze, Helena Sung-In Jang, Thijs Flinsenberg, Suran L. Fernando, Ian Kerridge, Moeen Riaz, Robert Sebra, Kevin Thia, Taherah Noori, Eric E. Schadt, John J. McNeil, Joseph A. Trapani
Journal: Blood
Blood (2020) 135 (8): 582–584.
https://doi.org/10.1182/blood.2019003487
Published: 2020
Includes: Supplemental data
Journal Articles

Emapalumab for the treatment of relapsed/refractory hemophagocytic lymphohistiocytosis

Clinical Trials & Observations
Mounica Vallurupalli, Nancy Berliner
Journal: Blood
Blood (2019) 134 (21): 1783–1786.
https://doi.org/10.1182/blood.2019002289
Published: 2019
Journal Articles

Morbidity, Mortality, and Healthcare Utilization in a National Cohort of Pediatric Patients with Hemophagocytic Lymphohistiocytosis Who Received Hematopoietic Stem Cell Transplant

Archana Ramgopal, DO, Meghan McCormick, MD, Ram Kalpatthi, MD, Louis Rapkin, MD, James Zullo, Steven William Allen, MD BS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2183.
https://doi.org/10.1182/blood-2019-132084
Published: 2019
Journal Articles

Interferon Gamma, a Link between Hemophagocytic Lymphohistiocytosis and Dengue Fever Virus: A Literature Review of a Shared Inflammatory Pathway Resulting in Cytopenias and Potential Future Treatment Directions

Darla K Liles, MD, Heather Brody, MD MSc, Juan Alvarez Posada, MD, Karim Hebishi, MD, John Thiele, MDcal Student
Journal: Blood
Blood (2019) 134 (Supplement_1): 4869.
https://doi.org/10.1182/blood-2019-126124
Published: 2019
Journal Articles

Hematologic Immune-Related Adverse Events from Immune Checkpoint Inhibitors: A Systematic Review of Case-Reports and Case-Series

Karthik Gnanapandithan, MD MS, Prakash Kharel, MD, Alyssa Grimshaw, MSLIS, Smith Giri, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 3606.
https://doi.org/10.1182/blood-2019-132203
Published: 2019
Journal Articles

Radiation Therapy Can be an Effective Bridging Strategy Prior to Axicabtagene Ciloleucel Therapy for Relapsed/Refractory Large B-Cell Lymphoma

Chelsea C Pinnix, MD PhD, Jillian R Gunther, MD PhD, Bouthaina S. Dabaja, MD, Sherry Adkins, ANP, Misha Hawkins, Jason R. Westin, MD, Luis Fayad, MD, Sairah Ahmed, MD, Nathan H. Fowler, MD, Fredrick B. Hagemeister, MD, Swaminathan P. Iyer, MD, Maria Alma Rodriguez, MD, Hun Ju Lee, Raphael E Steiner, MD, Ranjit Nair, MBBS,MD, Paolo Strati, MD, Simrit Parmar, MBBS, Felipe Samaniego, MD, Michael Wang, MD, Sattva S Neelapu, MD, Loretta J. Nastoupil, MD MSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 1609.
https://doi.org/10.1182/blood-2019-131499
Published: 2019
Journal Articles

Preliminary Results from a Multicenter, Single-Arm, Phase 2 Study of CS1001, an Anti-Programmed Death-Ligand 1 (PD-L1) Human Monoclonal Antibody (mAb), in Patients (pts) with Relapsed or Refractory Extranodal Natural Killer/T Cell Lymphoma (rr-ENKTL)

Hui-qiang Huang, MD PhD, Rong Tao, MD PhD, Liqun Zou, Hong Cen, MD PhD, Ye Guo, MD PhD, Yunhong Huang, MD PhD, Wenbin Qian, MD PhD, Liling Zhang, MD PhD, Hui Zhou, MD PhD, Yu Yang, MD PhD, Haiyan Yang, Dan Zhu, Teng Fang, PhD, Hangjun Dai, Yueling Wang, Jianxin Yang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2833.
https://doi.org/10.1182/blood-2019-121865
Published: 2019
Journal Articles

Dramatic Resolution of HLH after Treatment with the JAK 1/2 Inhibitor, Ruxolitinib

Scott R. Goldsmith, MD, Sana Saif Ur Rehman, MD, Cara Lunn Shirai, PhD, Ravi Vij, MBBS, John F. DiPersio, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2325.
https://doi.org/10.1182/blood-2019-124176
Published: 2019
Journal Articles

Natural-Killer Cell Cytotoxicity Is a Diagnostic and Prognostic Marker in Adult Patients with Secondary Hemophagocytic Lymphohistiocytosis: Results from a Prospective Phase II Observational Study

Han Bi Lee, Jae-Ho Yoon, MD PhD, Gi June Min, MD, Sung-Soo Park, Silvia Park, Sung-Eun Lee, MD, Ki-Seong Eom, MD PhD, Yoo-Jin Kim, MD PhD, Seok Lee, MD PhD, Hee-Je Kim, MD PhD, Chang-Ki Min, MD PhD, Seok-Goo Cho, MD PhD, Jong Wook Lee, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2331.
https://doi.org/10.1182/blood-2019-129676
Published: 2019