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Journal Articles

Interim Results of a First in Man Study with the Fc-Optimized FLT3 Antibody Flysyn for Treatment of Acute Myeloid Leukemia with Minimal Residual Disease

Free
Sabine Kayser, MD, Jonas S. Heitmann, MD, Daniela Dörfel, MD, Felicitas Thol, MD, Michael Heuser, MD, Melanie Märklin, PhD, Carsten Müller-Tidow, MD, Martin Steiner, Ludger Grosse-Hovest, Gundram Jung, MD, Richard F. Schlenk, MD, Helmut R. Salih, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3928.
https://doi.org/10.1182/blood-2019-125327
Published: 2019
Journal Articles

A Phase I/II Study of AZD2811 Nanoparticles (NP) As Monotherapy or in Combination in Treatment-Naïve or Relapsed/Refractory AML/MDS Patients Not Eligible for Intensive Induction Therapy

Free
William B. Donnellan, MD, Ehab L. Atallah, MD, Adam S. Asch, MD, Manish R. Patel, MD, Jay Yang, MD, Alireza Eghtedar, MD, Gautam M. Borthakur, MD, Julie Charlton, PhD, Alexander MacDonald, MSc-PhD, Anna Korzeniowska, MD, Elizabeth Sainsbury, BSc, Donald K. Strickland, MD, Suzanne Jones, PharmD, Philip Overend, MSc, Carrie A. Adelman, PhD, Giulia Fabbri, MD PhD, Jon Travers, PhD, Simon Smith, PhD, J. Elizabeth Pease, PhD, Jan Cosaert, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3919.
https://doi.org/10.1182/blood-2019-130635
Published: 2019
Journal Articles

Frontline Treatment with Ibrutinib with Rituximab (IR) Combination Is Highly Effective in Elderly (≥65 years) Patients with Mantle Cell Lymphoma (MCL) - Results from a Phase II Trial

Free
Preetesh Jain, MBBS,MDDM,PhD, Hun Ju Lee, MD, Raphael Eric Steiner, MD, F. B. Hagemeister, MD, Felipe Samaniego, MD, Jason R. Westin, MD, Loretta J. Nastoupil, MD MSc, Sairah Ahmed, MD, Swaminathan P. Iyer, MD, Jorge Enrique Romaguera, MD, Shuangtao Zhao, PhD, Krystle Nomie, PhD, Chi Young Ok, MD, Rashmi Kanagal-Shamanna, MD, Onyeka Oriabure, Guofang Xu, MD, Liang Zhang, MD PhD, Changying Jiang, PhD, Dayoung Jung, Lucy Navsaria, MB BCh BAO, Wendy Chen, Omar Moghrabi, Tayyaba Nizam, Chloe Marie McClain, Maria Badillo, Selvi Thirumurthi, David Santos, Guilin Tang, MD, Keyur Patel, MD PhD, Sattva S Neelapu, MD, Linghua Wang, PhD, Nathan H. Fowler, MD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3988.
https://doi.org/10.1182/blood-2019-125800
Published: 2019
Journal Articles

Safety and Antithrombotic Efficacy of the Recombinant Protein C Activator AB002 (E-WE Thrombin) in End Stage Renal Disease Patients on Chronic Hemodialysis

Free
Norah G Verbout, PhD, Christina U Lorentz, PhD, Brandon D Markway, PhD, Joseph J Shatzel, MD, Erik I Tucker, PhD, Andras Gruber, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2433.
https://doi.org/10.1182/blood-2019-124999
Published: 2019
Journal Articles

Fast Onset of Action of Subcutaneously Administered Marzeptacog Alfa (Activated) Supports on-Demand Treatment in Hemophilia a Mice

Free
Frank Del Greco, MBA, Linda Neuman, MD, Howard Levy, PhD MBBChir, Jill Reckless, Tom Knudsen, PhD DVM, Grant E. Blouse, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2420.
https://doi.org/10.1182/blood-2019-128971
Published: 2019
Journal Articles

In Vitro and In Vivo Characterization of Marstacimab, an Anti-TFPI Antibody

Free
Chuenlei Parng, PhD, Macy Jin, PhD, Matthew Holsti, PhD, Susan Benard, Swapnil Rakhe, MS, Sunita R. Patel-Hett, PhD, Alison Joyce, Rob Webster, Debra D Pittman, MS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2391.
https://doi.org/10.1182/blood-2019-130327
Published: 2019
Journal Articles

Preliminary Results of a Phase 1 Dose Escalation Study of the First-in-Class Anti-CD74 Antibody Drug Conjugate (ADC), STRO-001, in Patients with Advanced B-Cell Malignancies

Free
Nirav N. Shah, MD, Amrita Y. Krishnan, MD, Nina D. Shah, MD, John M Burke, MD, Jason M. Melear, MD, Alexander I. Spira, PhD MD FACP, Leslie L. Popplewell, MD FRCPA, Charalambos B. Andreadis, MD, Saurabh Chhabra, MD, Jeff P. Sharman, MD, Jonathan L. Kaufman, MD, Jonathon B. Cohen, MDMS, Ruben Niesvizky, MD, Thomas G. Martin, III, MD, Clifford DiLea, RPh, Pharm.D., Jason Kuriakose, Shannon L. Matheny, PhD, John P. Leonard, MD, Arturo Molina, MDMS, FACP
Journal: Blood
Blood (2019) 134 (Supplement_1): 5329.
https://doi.org/10.1182/blood-2019-122754
Published: 2019
Journal Articles

Decitabine Can Improve the Efficacy of Second-Line Chemotherapy in Relapsed or Refractory Diffuse Llarge B Cell Lymphoma

Free
Xudong Zhang, Junxia Hu, Qingjiang Chen, Mingzhi Zhang, MD PhD, Ken H. Young
Journal: Blood
Blood (2019) 134 (Supplement_1): 5221.
https://doi.org/10.1182/blood-2019-128424
Published: 2019
Journal Articles

Phase 3, Multi-Center, International, Randomized, Double-Blind, Placebo Controlled Study of Oral Rigosertib + Injectable Azacitidine (AZA) Versus Injectable Azacitidine in Treatment-Naive Patients with Higher-Risk Myelodysplastic Syndrome (HR-MDS)

Free
Guillermo Garcia-Manero, MD, Shyamala C. Navada, MD, Pierre Fenaux, MD PhD, Patrick S. Zbyszewski, MBA, Afoluso Ronnee Adesanya, MD, Nozar Azarnia, PhD, Steven M. Fruchtman, MD, Lewis R. Silverman, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4268.
https://doi.org/10.1182/blood-2019-132149
Published: 2019
Journal Articles

Imerge: A Study to Evaluate Imetelstat (GRN163L) in Transfusion-Dependent Subjects with IPSS Low or Intermediate-1 Risk Myelodysplastic Syndromes (MDS) That Is Relapsed/Refractory to Erythropoiesis-Stimulating Agent (ESA) Treatment

Free
Uwe Platzbecker, David P. Steensma, MD, Koen Van Eygen, Azra Raza, Valeria Santini, MD, Ulrich Germing, MD, Patricia Font, María Díez-Campelo, MD PhD, Sylvain Thepot, MD, Edo Vellenga, Mrinal M Patnaik, MDMBBS, Jun Ho Jang, Laurie Sherman, Souria Dougherty, Faye Feller, MD, Libo Sun, Ying Wan, Fei Huang, Aleksandra Rizo, Pierre Fenaux, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4248.
https://doi.org/10.1182/blood-2019-127435
Published: 2019
Journal Articles

CD39 As a Master Regulator of Pulmonary Thrombosis in Sickle Cell Disease

Free
Tomasz Brzoska, PhD, Egemen Tutuncuoglu, MSc, Stevan P. Tofovic, Edwin K. Jackson, Mark T Gladwin, MD, Prithu Sundd, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2266.
https://doi.org/10.1182/blood-2019-130882
Published: 2019
Journal Articles

Severe Hypophosphatemia in Patients with Cancer Following IV Iron Treatment: Results from a Large Comparative Trial

Free
Ralph V. Boccia, MD, Naomi V Dahl, PharmD, William E Strauss, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2236.
https://doi.org/10.1182/blood-2019-126149
Published: 2019
Journal Articles

Arsenic Trioxide Synergistically Enhances the Antileukemia Activity of Bcl-2 Inhibitor ABT-199 in Acute Myeloid Leukemia

Free
Sha Liu, Lin Chen, MD, Xiaojiao Wang, Ruihua Mi, Qingsong Yin, Ruihua Fan, Xudong Wei, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2555.
https://doi.org/10.1182/blood-2019-129543
Published: 2019
Journal Articles

Intravital Imaging of Bright Cyan-Fluorescent AML Model Reveals Impact of CXCR4 Inhibitor on AML and Immune Cell Dynamics

Free
Tomasz Zal, PhD, Mateusz Rytelewski, PhD, Rodrigo Jacamo, PhD, Malgorzata Anna Zal, MSc, Meenakshi Shanmugasundaram, Michael Andreeff, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2674.
https://doi.org/10.1182/blood-2019-131945
Published: 2019
Journal Articles

A Phase Ib/II Study of the Histone Methyltransferase Inhibitor Pinometostat in Combination with Azacitidine in Patients with 11q23-Rearranged Acute Myeloid Leukemia

Free
Kamal Menghrajani, MD, Sheng F Cai, MD PhD, Sean M. Devlin, PhD, Scott A. Armstrong, MD PhD, Richard Piekarz, MD PhD MS, BA, Michelle Rudek, PharmD, PhD, Martin S. Tallman, MD, Eytan M. Stein, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2655.
https://doi.org/10.1182/blood-2019-121926
Published: 2019
Journal Articles

Response-Adapted Therapy with Infusional EPOCH Chemotherapy Plus Rituximab in HIV-Associated, B-Cell Non-Hodgkin's Lymphoma

Free
Juan Carlos Ramos, MD BS, Richard F. Ambinder, MD, Joseph Sparano, MD, Jeannette Y Lee, PhD, Lawrence D Kaplan, MD, William Wachsman, MD PhD, David M. Aboulafia, MD, Ariela Noy, MD, Lee Ratner, MD PhD, David H. Henry, MD, Amy Chadburn, MD, Ethel Cesarman, MD PhD, Ronald T. Mitsuyasu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2872.
https://doi.org/10.1182/blood-2019-123558
Published: 2019
Journal Articles

A Phase 1a/1b Trial of ST-001, a Fenretinide Phospholipid Suspension for 4-Hour Intravenous Infusion in Relapsed/Refractory T-Cell Non-Hodgkin's Lymphoma

Free
Ayad Al-Katib, MD, Timothy M. Kuzel, MD, Ralph Parchment, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4041.
https://doi.org/10.1182/blood-2019-127278
Published: 2019
Journal Articles

Phase 2 Study of E7777, a Diphtheria Toxin Fragment-Interleukin-2 Fusion Protein, in Japanese Patients with Relapsed or Refractory Peripheral and Cutaneous T-Cell Lymphoma

Free
Dai Maruyama, MD PhD, Kiyoshi Ando, Kazuhito Yamamoto, Eiji Kiyohara, MD, Yasuhito Terui, MD PhD, Noriko Fukuhara, MD PhD, Tomomitsu Miyagaki, MD PhD, Hidetsugu Kawai, MD, Yoshiki Tokura, MD PhD, Mamiko Sakata-Yanagimoto, MD PhD, Tadahiko Igarashi, MD PhD, Junya Kuroda, MD PhD, Jiro Fujita, MD PhD, Toshiki Uchida, MD PhD, Takayuki Ishikawa, MD PhD, Kentaro Yonekura, MD PhD, Koji Kato, MD PhD, Tadashi Nakanishi, Kenya Nakai, Risa Matsunaga, Kensei Tobinai, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4032.
https://doi.org/10.1182/blood-2019-121723
Published: 2019
Journal Articles

Alemtuzumab as First Line Treatment in Children with Familial Lymphohistiocytosis

Free
Despina Moshous, MD PhD, Coralie Briand, MD, Martin Castelle, MD, Laurent Dupic, MD, Guillaume Morelle, MD, Wadih Abou Chahla, MD, Vincent Barlogis, MD PhD, Yves Bertrand, MD, Bénédicte Bruno, MD, Eric Jeziorski, MD PhD, Catherine Paillard, MD PhD, Pierre Simon Rohrlich, MD PhD, Jean Louis Stephan, MD PhD, Caroline Thomas, MD, Stéphanie Chhun, PharmD, PhD, Isabelle Pellier, MD PhD, Aude Marie-Cardine, MD, Mathieu Fusaro, Genevieve de Saint Basile, MD PhD, Capucine Picard, MD PhD, Caroline Elie, MD PhD, Benedicte Neven, MD PhD, Stephane Blanche, MD, Alain Fischer, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 80.
https://doi.org/10.1182/blood-2019-124477
Published: 2019
Journal Articles

TJC4, a Differentiated Anti-CD47 Antibody with Novel Epitope and RBC Sparing Properties

Free
Zhen Meng, PhD, Zhengyi Wang, PhD, Bingshi Guo, PhD, Wei Cao, PhD, Huaqiong Shen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4063.
https://doi.org/10.1182/blood-2019-122793
Published: 2019