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Journal Articles

Mutant KRAS Enhances Stress Granules and Resistance to Proteasome Inhibition Via 15-d-PGJ2 in Multiple Myeloma

Ya-Wei Qiang, MD PhD, Shiqiao Ye, PhD BSc, MSc, Yu Chen, Joshua Epstein, DSc, Faith E. Davies, MD, Gareth Morgan, MD PhD, Brian A Walker, PhD, Frits van Rhee, MD PhD

Blood (2019) 134 (Supplement_1): 4383.

https://doi.org/10.1182/blood-2019-130493

Published: 2019

Journal Articles

Robust Hematopoietic Stem Cell Function and Minimal Myeloid Skewing with Aging in Un-Separated Murine Whole Bone Marrow: What Are We Losing with Hematopoietic Stem Cell Purification?

Mark S Dooner, Elaine Papa, Michael Del Tatto, Mandy Pereira, Sicheng Wen, MD PhD, Yan Cheng, PhD, Peter J. Quesenberry, MD, Laura R Goldberg, MD PhD

Blood (2019) 134 (Supplement_1): 3723.

https://doi.org/10.1182/blood-2019-124367

Published: 2019

Journal Articles

Therapeutic Stratification of PTEN-MYC Axis Appears to be Promising for Molecular Targeted Therapies in Refractory and Relapsed T-Cell Acute Lymphoblastic Leukemia

Heinz Ahlert, MSc, BSc, Sanil Bhatia, PhD, Marc Remke, MD, Melf Sönnichsen, M.Sc., Niklas Dienstbier, M.Sc., Ute Fischer, PhD, Julia Hauer, MD, Arndt Borkhardt, MD

Blood (2019) 134 (Supplement_1): 3883.

https://doi.org/10.1182/blood-2019-128136

Published: 2019

Journal Articles

Effect of Oral Iron Treatment in Tmprss6 Knock-out Mouse Model

Elisa Brilli, PhD, Michela Asperti, PhD, Annalisa Castagna, B.S., PhD, Claudio Cerchione, MD PhD, Domenico Girelli, MD, PhD, Maura Poli, PhD, Germano Tarantino

Blood (2019) 134 (Supplement_1): 2235.

https://doi.org/10.1182/blood-2019-122416

Published: 2019

Journal Articles

Anticancer Activity of a Highly Potent Small Molecule Tubulin Polymerization Inhibitor, AB8939

Martine Humbert, PhD, Armelle Goubard, PhD, Colin Mansfield, PhD, Olivier Hermine, MD PhD, Patrice Dubreuil, PhD, The AB8939 Study Group

Blood (2019) 134 (Supplement_1): 2075.

https://doi.org/10.1182/blood-2019-122540

Published: 2019

Journal Articles

Elucidation of the IMiDs-Resistant Mechanism and Development of the Overcoming Drugs Inducing CRBN Independent G2/M Cell Cycle Arrest in Myeloma Cells

Ryo Uozaki, Shuji Aida, Takasi Yamagughi, Tomofumi Yamamoto, BPharm, Sho Kashiwazaki, Hiroshi Yanagawa, Daiju Ichikawa, Maiko Matsushita, Yutaka Hattori

Blood (2018) 132 (Supplement 1): 4451.

https://doi.org/10.1182/blood-2018-99-115909

Published: 2018

Journal Articles

KMT2E-Mediated Epigenetic Reprogramming Promotes the Sensitivity to All-Trans Retinoic Acid and Increases the Granulocytic Differentiation in AML Cells

Luciana Yamamoto Almeida, PhD, Isabel Weinhäuser, MSc, Diego Antonio Pereira-Martins, MSc, Josiane Lilian Schiavinato, PhD, Patrícia Vianna Bonini Palma, BSc, Camila Bonaldo, Cleide Lucia Silva, MSc, Juliana Oliveira Poltronieri, MSc, Larissa Cândido, MSc, Antonio R. Lucena-Araujo, PhD, Eduardo Magalhães Rego, MD PhD

Blood (2018) 132 (Supplement 1): 3838.

https://doi.org/10.1182/blood-2018-99-118478

Published: 2018

Journal Articles

Inhibition of ATR Potentiates Acute Myeloid Leukemia Cells to the RNA Pol I Transcription Inhibitor CX-5461

Margaret Shatara, MD, Tingting Wang, Xinyu Li, Holly Edwards, BS, Jeffrey W. Taub, MD, Hai Lin, MD, Yubin Ge, PhD

Blood (2018) 132 (Supplement 1): 5224.

https://doi.org/10.1182/blood-2018-99-113937

Published: 2018

Journal Articles

High PARP-1 expression Predicts Poor Survival in Acute Myeloid Leukemia and PARP-1 Inhibitor and SAHA-Bendamustine Hybrid Inhibitor Combination Treatment Synergistically Enhances Anti-Tumor Effects

Xia Li, Chenying Li, Jingrui Jin, Jinghan Wang, Jie Jin, MD PhD

Blood (2018) 132 (Supplement 1): 5252.

https://doi.org/10.1182/blood-2018-99-114344

Published: 2018

Journal Articles

Highly Efficient Therapeutic Gene Editing of BCL11A enhancer in Human Hematopoietic Stem Cells from ß-Hemoglobinopathy Patients for Fetal Hemoglobin Induction

Blood (2018) 132 (Supplement 1): 3482.

https://doi.org/10.1182/blood-2018-99-119365

Published: 2018

Journal Articles

Mutant KRAS and Brafs Upregulate Stress Granules and Mediate Drug Resistance, Which Can be Modulated By Cox2 Inhibition in Multiple Myeloma

Ya-Wei Qiang, MD PhD, Shiqiao Ye, PhD BSc, MSc, Yu Chen, Joshua Epstein, DSc, Brian A Walker, PhD, Frits van Rhee, MD PhD, Gareth Morgan, MD, Faith E. Davies, MD

Blood (2018) 132 (Supplement 1): 3166.

https://doi.org/10.1182/blood-2018-99-117459

Published: 2018

Journal Articles

A Novel Phthalimide-Derivative, TC11, Induced G2/M Arrest and Apoptosis of High-Risk Myeloma Cells By Interacting with Nucleophosmin1 and α-Tubulin, but Not By Binding to Celeblon

Misa Nakamura, Daiju Ichikawa, PhD, Shuji Aida, Nahoko Hashimoto, Wakana Murota, Ryo Uozaki, Mikio Okayama, MD, Kota Fujimori, Yuko Yonemura, Noriko Tabata, PhD, Hiroshi Yanagawa, PhD, Maiko Matsushita, MD PhD, Yutaka Hattori, MD PhD

Blood (2017) 130 (Supplement 1): 5377.

https://doi.org/10.1182/blood.V130.Suppl_1.5377.5377

Published: 2017

Journal Articles

Sucrosomial Iron Absorption Involve M Cells Interaction

Elisa Brilli, PhD, Pawel Lipinski, Ramon Barnadas, Mercedes Camacho, Angela Fabiano, Giulio Giordano, Francesco Equitani, MD, Germano Tarantino

Blood (2017) 130 (Supplement 1): 2217.

https://doi.org/10.1182/blood.V130.Suppl_1.2217.2217

Published: 2017

Journal Articles

Adipocyte Induced Antagonism of ALL Growth Highlights a Novel Inhibitory Niche and Potential Therapeutic Opportunity

Nicholas Warrick, BSc, Farideh Miraki-Moud, PhD, A Aicher, Linda Ariza McNaughton, Pedro Casado-Izquierdo, Ai Nagano, PhD, Rebecca Carroll, Dominique Bonnet, PhD, John G. Gribben, MDDSc FMedSci, Bela Patel, MD

Blood (2017) 130 (Supplement 1): 371.

https://doi.org/10.1182/blood.V130.Suppl_1.371.371

Published: 2017

Journal Articles

Targeting Maternal Embryonic Leucine Zipper Kinase with OTSSP167 Displays Anti-Tumor Activities in Chronic Lymphocytic Leukemia through Down-Regulation of FoxM1

Ya Zhang, MD, Xiangxiang Zhou, MD, Ying Li, MD, Yangyang Xu, MD, Xin Wang, MD PhD

Blood (2017) 130 (Supplement 1): 801.

https://doi.org/10.1182/blood.V130.Suppl_1.801.801

Published: 2017

Journal Articles

Preclinical Evaluation of the First in Class BMI1 Inhibitor PTC-028 Confirms Potent Efficacy to Target BMI1-Addiction in Multiple Myeloma

Arnold Bolomsky, PhD, Roy Heusschen, PhD, Kathrin Stangelberger, MSc, Muller Joséphine, Marla Weetall, PhD, Art Branstrom, PhD, Niklas Zojer, MD, Jo Caers, MD, Heinz Ludwig, MD

Blood (2017) 130 (Supplement 1): 1804.

https://doi.org/10.1182/blood.V130.Suppl_1.1804.1804

Published: 2017

Journal Articles

CG '806, a Highly Potent First-in-Class Pan-FLT3/BTK Inhibitor, Targets Multiple Clusters of Kinases Operative in Diverse Subtypes of Acute Myeloid Leukemia

Hongying Zhang, MD, Andrea Local, PhD, Khalid Benbatoul, BS, Peter Folger, BS, Susan Sheng, PhD, Cheng-Yu Tsai, PhD, Stephen Howell, MD, William Rice, PhD

Blood (2017) 130 (Supplement 1): 5063.

https://doi.org/10.1182/blood.V130.Suppl_1.5063.5063

Published: 2017

Journal Articles

Development of a Novel Class of Microtubule Destabilizing Agents with Selectivity Against Diffuse Large B-Cell Lymphoma (DLBCL) with B-Cell Receptor (BCR) Activation

Benet Pera Gresely, PhD, Francisco de Asís Balaguer, BS, Mariano Gonzalo Cardenas, PhD, Maria Victoria Revuelta, PhD, Maria Nieves Calvo Vidal, PhD, Rossella Marullo, MD PhD, Nahuel Zamponi, PhD, Ildefonso Ismael Rodriguez Rivera, MD, Yong Ai, PhD, Joseph Fraser Glickman, MSPH, PhD, Isabel Barasoain, PhD, Fernando Díaz, PhD, Ari Melnick, MD, Fengtian Xue, PhD, Leandro Cerchietti, MD

Blood (2017) 130 (Supplement 1): 2546.

https://doi.org/10.1182/blood.V130.Suppl_1.2546.2546

Published: 2017

Journal Articles

LSD1 Inhibition Leads to Differentiation in Hoxa9/Meis1- but Not in MN1-Induced Acute Myeloid Leukemia

Jessica Barth, Anna-Maria Scheder, Sebastian Mohr, Johannes Schulz-Fincke, Martin Schmitt, PhD, Alexandra Walter, Milica Tosic, Eric Metzger, Gesine Bug, MD, Michael Lübbert, Manfred Jung, PhD, Hubert Serve, Roland Schüle, PhD, Tobias Berg, MD

Blood (2017) 130 (Supplement 1): 1246.

https://doi.org/10.1182/blood.V130.Suppl_1.1246.1246

Published: 2017

Journal Articles

Chemical Inhibition of the Macrophage Inhibitor Factor (MIF) Induces Cell Cycle Arrest and Apoptosis in Lymphoid and Myeloid Leukemia

Andrew Lewis, Chun Shik Park, PhD, Ye Shen, PhD, Nam Kyung Lee, B.S., H. Daniel Lacorazza, PhD

Blood (2017) 130 (Supplement 1): 1329.

https://doi.org/10.1182/blood.V130.Suppl_1.1329.1329

Published: 2017

NARROW

Mutant KRAS Enhances Stress Granules and Resistance to Proteasome Inhibition Via 15-d-PGJ2 in Multiple Myeloma

Robust Hematopoietic Stem Cell Function and Minimal Myeloid Skewing with Aging in Un-Separated Murine Whole Bone Marrow: What Are We Losing with Hematopoietic Stem Cell Purification?

Therapeutic Stratification of PTEN-MYC Axis Appears to be Promising for Molecular Targeted Therapies in Refractory and Relapsed T-Cell Acute Lymphoblastic Leukemia

Effect of Oral Iron Treatment in Tmprss6 Knock-out Mouse Model

Anticancer Activity of a Highly Potent Small Molecule Tubulin Polymerization Inhibitor, AB8939

Elucidation of the IMiDs-Resistant Mechanism and Development of the Overcoming Drugs Inducing CRBN Independent G2/M Cell Cycle Arrest in Myeloma Cells

KMT2E-Mediated Epigenetic Reprogramming Promotes the Sensitivity to All-Trans Retinoic Acid and Increases the Granulocytic Differentiation in AML Cells

Inhibition of ATR Potentiates Acute Myeloid Leukemia Cells to the RNA Pol I Transcription Inhibitor CX-5461

High PARP-1 expression Predicts Poor Survival in Acute Myeloid Leukemia and PARP-1 Inhibitor and SAHA-Bendamustine Hybrid Inhibitor Combination Treatment Synergistically Enhances Anti-Tumor Effects

Highly Efficient Therapeutic Gene Editing of BCL11A enhancer in Human Hematopoietic Stem Cells from ß-Hemoglobinopathy Patients for Fetal Hemoglobin Induction

Mutant KRAS and Brafs Upregulate Stress Granules and Mediate Drug Resistance, Which Can be Modulated By Cox2 Inhibition in Multiple Myeloma

A Novel Phthalimide-Derivative, TC11, Induced G2/M Arrest and Apoptosis of High-Risk Myeloma Cells By Interacting with Nucleophosmin1 and α-Tubulin, but Not By Binding to Celeblon

Sucrosomial Iron Absorption Involve M Cells Interaction

Adipocyte Induced Antagonism of ALL Growth Highlights a Novel Inhibitory Niche and Potential Therapeutic Opportunity

Targeting Maternal Embryonic Leucine Zipper Kinase with OTSSP167 Displays Anti-Tumor Activities in Chronic Lymphocytic Leukemia through Down-Regulation of FoxM1

Preclinical Evaluation of the First in Class BMI1 Inhibitor PTC-028 Confirms Potent Efficacy to Target BMI1-Addiction in Multiple Myeloma

CG '806, a Highly Potent First-in-Class Pan-FLT3/BTK Inhibitor, Targets Multiple Clusters of Kinases Operative in Diverse Subtypes of Acute Myeloid Leukemia

Development of a Novel Class of Microtubule Destabilizing Agents with Selectivity Against Diffuse Large B-Cell Lymphoma (DLBCL) with B-Cell Receptor (BCR) Activation

LSD1 Inhibition Leads to Differentiation in Hoxa9/Meis1- but Not in MN1-Induced Acute Myeloid Leukemia

Chemical Inhibition of the Macrophage Inhibitor Factor (MIF) Induces Cell Cycle Arrest and Apoptosis in Lymphoid and Myeloid Leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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