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Journal Articles

First in Human Study of SEL24/MEN1703, First in Class, Orally Available Dual PIM/FLT3 Kinase Inhibitor, in Patients with Acute Myeloid Leukemia

Scott R. Solomon, MD, Aziz Nazha, MD, Stephen A. Strickland, MD, Roland B. Walter, MD PhD MS, Ilaria Valimberti, Alessia Tagliavini, Paolo Mazzei, Caterina Fiesoli, Simona Scartoni, Daniela Bellarosa, Monica Binaschi, PhD, Pawel Chrom, MD PhD, Simone Baldini, MD, Krzysztof Brzózka, PhD, Angela Capriati, Andrea Pellacani, PhD MD, Farhad Ravandi, MD

Blood (2019) 134 (Supplement_1): 3920.

https://doi.org/10.1182/blood-2019-125878

Published: 2019

Journal Articles

Preliminary Results from an Ongoing Phase 1/2 Study of INCB053914, a Pan-Proviral Integration Sites for Moloney Virus (PIM) Kinase Inhibitor, in Patients with Advanced Hematologic Malignancies

Michael Byrne, MD, William Donnellan, Manish R Patel, MD, Amer M. Zeidan, MD, Mohamad Cherry, MDMS, Maria R. Baer, MD, Amir T. Fathi, MD MD BS, Jason Kaplan, MD, Feng Zhou, Fred Zheng, MD, April M. Barbour, Michael R. Savona, MD

Blood (2017) 130 (Supplement 1): 2585.

https://doi.org/10.1182/blood.V130.Suppl_1.2585.2585

Published: 2017

Journal Articles

A Descriptive Study of Viral RNA Sequences Identified from Single-Cell Analysis of Acute Myeloid Leukemia

Sharah Mae Capinpin, Chunkiat Lee, Ming Xuan Lin, Gabriel Yan, Dr, Kenneth Ban, Dr, Tin Wee Tan, Prof, Roger Foo, Assoc Prof, Wee Joo Chng, MB ChB, MRCP, PhD, Benedict Yan, Dr

Blood (2017) 130 (Supplement 1): 5091.

https://doi.org/10.1182/blood.V130.Suppl_1.5091.5091

Published: 2017

Journal Articles

High Titer Lentivector from a Stable Lenti-Producer Efficiently Corrects CD34+ Hematopoietic Stem Cells from Patients with p47phox-Deficient Chronic Granulomatous Disease

Uimook Choi, PhD, Narda Theobald, Throm E Robert, PhD, John Gray, PhD, David J. Rawlings, MD, Brian P. Sorrentino, MD, Harry Malech, Suk See De Ravin, MD

Blood (2015) 126 (23): 2036.

https://doi.org/10.1182/blood.V126.23.2036.2036

Published: 2015

Journal Articles

Activity of PIM Kinases in Chronic Lymphocytic Leukemia Modulates Tumor Cell Survival and Stromal Interactions through a Pleiotropic Mechanism Involving Modulation of CXCR4 - mTOR Pathway

Blood (2015) 126 (23): 1549.

https://doi.org/10.1182/blood.V126.23.1549.1549

Published: 2015

Journal Articles

The Biologic Relevance of PIM Kinases in the Context of Multiple Myeloma and Their Potential As Therapeutic Targets in Combination Drug Therapy

Janani Ramachandran, MA, Loredana Santo, MD, Homare Eda, MDPhD, Dharminder Chauhan, PhD, Ka Tat Siu, PhD, Miroslav Koulnis, PhD, Dennis Huszar, PhD, Kenneth C Anderson, MD, Noopur S. Raje, MD

Blood (2015) 126 (23): 2992.

https://doi.org/10.1182/blood.V126.23.2992.2992

Published: 2015

Journal Articles

Effect of the Pan-PIM Kinase Inhibitor, AZD1208, Alone and in Combination with Bortezomib in Multiple Myeloma

Loredana Santo, Janani Ramachandran, Diana D Cirstea, Homare Eda, Neeharika Nemani, Teru Hideshima, Chauhan Dharminder, Dennis Huszar, PhD, Kenneth C. Anderson, MD, Noopur Raje, MD

Blood (2014) 124 (21): 5726.

https://doi.org/10.1182/blood.V124.21.5726.5726

Published: 2014

Journal Articles

Systematic Comparison of the EF-1 Alpha Short (EFS) and Viral Promoters for Gene Modification of Human Primary Cells for Clinical Applications

Roy L. Kao, MD, Eric H. Gschweng, BS, Avigael Rebecca Lerman, Sarah M. Larson, MD, Andy Tu, Tulika Tyagi, MS, Shantha Senadheera, MS, Roger P. Hollis, PhD, Satiro N. De Oliveira, MD

Blood (2014) 124 (21): 3497.

https://doi.org/10.1182/blood.V124.21.3497.3497

Published: 2014

Journal Articles

Generation and Analysis of a Novel Mouse Model for Chronic Myelomonocytic Leukemia (CMML) with Acquired Expression of c-CBL Q367P

Yuichiro Nakata, Takeshi Ueda, MD PhD, Akiko Nagamachi, PhD, Linda Wolff, PhD, Ogawa Seishi, MD, Toshiya Inaba, MD, Hiroaki Honda, MD PhD

Blood (2014) 124 (21): 4602.

https://doi.org/10.1182/blood.V124.21.4602.4602

Published: 2014

Journal Articles

Analysis of Risk and Mechanism of Insertional Oncogenesis After Gene Transfer Into Hematopoietic Progenitors with Integrating Viral Vectors

Yasuhiro Ikawa, MD, PhD, Toru Uchiyama, MD, PhD, Guridevi Jayashree Jagadeesh, MS, Fabio Candotti, MD

Blood (2012) 120 (21): 2049.

https://doi.org/10.1182/blood.V120.21.2049.2049

Published: 2012

Journal Articles

The Pim Kinase Inhibitor SGI-1776 Chemosensitizes Multidrug Resistant Cells by Both Inhibiting Drug Transport by ABCB1 and ABCG2 and Decreasing ABCB1 and ABCG2 Surface Expression On Cells That Overexpress Pim-1.

Karthika Natarajan, PhD, Jasjeet Bhullar, PhD, Suneet Shukla, PhD, Mehmet Burcu, BS, Suresh V. Ambudkar, PhD, Maria R. Baer, M.D.

Blood (2012) 120 (21): 2462.

https://doi.org/10.1182/blood.V120.21.2462.2462

Published: 2012

Journal Articles

Comparison of Immortalization Potential of Gamma-Retroviral, Lentiviral and Foamy Virus Gene Transfer Vectors

Yasuhiro Ikawa, MD, PhD, Toru Uchiyama, MD, PhD, Guridevi Jayashree Jagadeesh, MS, Fabio Candotti, MD

Blood (2011) 118 (21): 3116.

https://doi.org/10.1182/blood.V118.21.3116.3116

Published: 2011

Journal Articles

STAT5 Has Tumor Suppressor-Like Activity in a Murine Model of Myc-Initiated Acute B-Lymphoblastic Leukemia/Lymphoma

Zhengqi Wang, Geqiang Li, Zizhen Kang, Silvia T Bunting, William Tse, Kevin D. Bunting, PhD

Blood (2011) 118 (21): 919.

https://doi.org/10.1182/blood.V118.21.919.919

Published: 2011

Journal Articles

Growth Factor Independent-1 (Gfi1) As a New Target for Human Leukemia Therapy

Cyrus Khandanpour, M.D., James D. Phelan, B.S., Riyan Chen, PhD., Shane Horman, PhD, Lothar Vassen, PhD, Marie-Claude Gaudreau, M.Sc., Joseph Krongold, BSc,, Jinfang Zhu, Ph.D., William E Paul, M.D., Judith Schütte, Berthold Goettgens, PhD., Ulrich Duehrsen, MD, H. Leighton Grimes, PhD, Tarik Moroy, Ph.D.

Blood (2011) 118 (21): 560.

https://doi.org/10.1182/blood.V118.21.560.560

Published: 2011

Journal Articles

Inhibition of the Serine/Threonine Kinase Pim-1 Has Anti-Proliferative Effects In Acute Myeloid Leukemia (AML) and Sensitizes Multidrug Resistant Cells to Chemotherapy

Karthika Natarajan, Ph.D., Mehmet Burcu, B.S., Maria R. Baer, M.D.

Blood (2010) 116 (21): 1832.

https://doi.org/10.1182/blood.V116.21.1832.1832

Published: 2010

Journal Articles

The PIM Kinase Inhibitor K00135 Sensitizes Primary Acute Lymphoblastic Leukaemia (ALL) Cells to DNA-Damaging Agents

David Da Costa, Victoria J Weston, PhD, Stefan Knapp, PhD, A. Malcolm R Taylor, PhD, Pamela R. Kearns, BSc, MBBCh, MRCP, PhD, Tatjana Stankovic, MD, PhD

Blood (2010) 116 (21): 3238.

https://doi.org/10.1182/blood.V116.21.3238.3238

Published: 2010

Journal Articles

Growth Factor Independent-1 (Gfi1) Is Critically Required for T-Cell Acute Lymphoblastic Leukemia (T-ALL) Tumor Initiation and Maintenance

James D. Phelan, B.S., Cyrus Khandanpour, M.D., Shane Horman, Ph.D., Marie-Claude Gaudreau, M.Sc., Jinfang Zhu, Ph.D., William E Paul, M.D., Ulrich Dührsen, Prof., H. Leighton Grimes, Ph.D., Tarik Moroy, Ph.D.

Blood (2010) 116 (21): 3156.

https://doi.org/10.1182/blood.V116.21.3156.3156

Published: 2010

Journal Articles

Growth Factor Independence 1 (Gfi1) Is Required for Initiation, Maintenance, Progression, and Transplantability of Lymphoma.

Cyrus Khandanpour, MD, Ehssan Sharif-Askari, PhD, Khashayar Afshar, Marie-Claude Gaudreau, Jinfang Zhu, Ph.D., William Paul, MD, Paul Jolicoeur, M.D., PhD, Ulrich Duhrsen, Tarik Moroy, PhD

Blood (2009) 114 (22): 447.

https://doi.org/10.1182/blood.V114.22.447.447

Published: 2009

Journal Articles

BMI1 , the Polycomb-Group Gene, Is Recurrently Targeted by Genomic Rearrangements in Progressive B-Cell Leukemia/Lymphoma.

Leila Rouhi, MD, Natalie Put, MD, Thomas Tousseyn, MD, PhD, Julio Finalet Ferreiro, Wim De Kelver, Hilde Demuynck, MD, Johan Verschuere, MD, Ivan Théate, MD, Carmen Vicente, Lucienne Michaux, MD, PhD, Chris De Wolf-Peeters, MD, PhD, Peter Vandenberghe, MD, PhD, Jan Cools, PhD, Iwona Wlodarska, PhD

Blood (2009) 114 (22): 1099.

https://doi.org/10.1182/blood.V114.22.1099.1099

Published: 2009

Journal Articles

Retroviral and Chemical Mutagenesis Identifies Pax5 as a Tumor Suppressor in B-Progenitor Acute Lymphoblastic Leukemia

Jinjun Dang, PhD, Charles G Mullighan, MBBS(Hons), MSc, MD, Letha A. Phillips, BS, Perdeep Mehta, PhD, James R. Downing, MD

Blood (2008) 112 (11): 1789.

https://doi.org/10.1182/blood.V112.11.1789.1789

Published: 2008

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First in Human Study of SEL24/MEN1703, First in Class, Orally Available Dual PIM/FLT3 Kinase Inhibitor, in Patients with Acute Myeloid Leukemia

Preliminary Results from an Ongoing Phase 1/2 Study of INCB053914, a Pan-Proviral Integration Sites for Moloney Virus (PIM) Kinase Inhibitor, in Patients with Advanced Hematologic Malignancies

A Descriptive Study of Viral RNA Sequences Identified from Single-Cell Analysis of Acute Myeloid Leukemia

High Titer Lentivector from a Stable Lenti-Producer Efficiently Corrects CD34+ Hematopoietic Stem Cells from Patients with p47phox-Deficient Chronic Granulomatous Disease

Activity of PIM Kinases in Chronic Lymphocytic Leukemia Modulates Tumor Cell Survival and Stromal Interactions through a Pleiotropic Mechanism Involving Modulation of CXCR4 - mTOR Pathway

The Biologic Relevance of PIM Kinases in the Context of Multiple Myeloma and Their Potential As Therapeutic Targets in Combination Drug Therapy

Effect of the Pan-PIM Kinase Inhibitor, AZD1208, Alone and in Combination with Bortezomib in Multiple Myeloma

Systematic Comparison of the EF-1 Alpha Short (EFS) and Viral Promoters for Gene Modification of Human Primary Cells for Clinical Applications

Generation and Analysis of a Novel Mouse Model for Chronic Myelomonocytic Leukemia (CMML) with Acquired Expression of c-CBL Q367P

Analysis of Risk and Mechanism of Insertional Oncogenesis After Gene Transfer Into Hematopoietic Progenitors with Integrating Viral Vectors

The Pim Kinase Inhibitor SGI-1776 Chemosensitizes Multidrug Resistant Cells by Both Inhibiting Drug Transport by ABCB1 and ABCG2 and Decreasing ABCB1 and ABCG2 Surface Expression On Cells That Overexpress Pim-1.

Comparison of Immortalization Potential of Gamma-Retroviral, Lentiviral and Foamy Virus Gene Transfer Vectors

STAT5 Has Tumor Suppressor-Like Activity in a Murine Model of Myc-Initiated Acute B-Lymphoblastic Leukemia/Lymphoma

Growth Factor Independent-1 (Gfi1) As a New Target for Human Leukemia Therapy

Inhibition of the Serine/Threonine Kinase Pim-1 Has Anti-Proliferative Effects In Acute Myeloid Leukemia (AML) and Sensitizes Multidrug Resistant Cells to Chemotherapy

The PIM Kinase Inhibitor K00135 Sensitizes Primary Acute Lymphoblastic Leukaemia (ALL) Cells to DNA-Damaging Agents

Growth Factor Independent-1 (Gfi1) Is Critically Required for T-Cell Acute Lymphoblastic Leukemia (T-ALL) Tumor Initiation and Maintenance

Growth Factor Independence 1 (Gfi1) Is Required for Initiation, Maintenance, Progression, and Transplantability of Lymphoma.

BMI1 , the Polycomb-Group Gene, Is Recurrently Targeted by Genomic Rearrangements in Progressive B-Cell Leukemia/Lymphoma.

Retroviral and Chemical Mutagenesis Identifies Pax5 as a Tumor Suppressor in B-Progenitor Acute Lymphoblastic Leukemia

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