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Journal Articles

Metabolomic Profiling Identifies Hypoxia-Induced Imbalanced Lands' Cycle Promotes Sickling and Disease Progression

Hongyu Wu, PhD, Mikhail Bogdanov, PhD, Yujin Zhang, MD, Kaiqi Sun, BS, Anren Song, PhD, Hong Liu, MD, Morayo G, Adebiyi, Danny C. Alexander, Michael V. Milburn, Modupe Idowu, MD, Harinder S. Juneja, MD, Yang Xia, MD PhD

Blood (2015) 126 (23): 2134.

https://doi.org/10.1182/blood.V126.23.2134.2134

Published: 2015

Journal Articles

Boudreau LH, Duchez A-C, Cloutier N, et al. Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A 2 to promote inflammation. Blood. 2014;124(14): 2173-2183 .

Blood (2015) 125 (5): 890.

https://doi.org/10.1182/blood-2014-12-615419

Published: 2015

Journal Articles

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A 2 to promote inflammation

Blood (2014) 124 (14): 2173–2183.

https://doi.org/10.1182/blood-2014-05-573543

Published: 2014

Includes: Multimedia, Supplemental data

Journal Articles

A Pilot Study of Tapered Oral Dexamethasone for the Acute Chest Syndrome of Sickle Cell Disease.

Charles T. Quinn, MD, MS, Marie J. Stuart, MD, Karen Kesler, PhD, Kenneth I. Ataga, MD, Winfred C. Wang, MD, Lori Styles, MD, Kim Smith-Whitley, MD, Ted Wun, MD, Suba Krishnan, MD, Frans A. Kuypers, PhD, Yamaja Setty, PhD, Nigel S. Key, MB, ChB, Seungshin Rhee, MS, George R. Buchanan, MD

Blood (2009) 114 (22): 1515.

https://doi.org/10.1182/blood.V114.22.1515.1515

Published: 2009

Journal Articles

Atorvastatin Reduces Collagen-Induced Platelet Function in Aspirin-Treated Patients with Acute Myocardial Infarction: Mechanisms Involved.

Maria Teresa Santos, PhD, Maria Paz Fuset, MD, Miguel Ruano, MD, Antonio Moscardo, PhD, Belen Cortina, PhD, Maria Angeles Dasi, MD, Juana Valles, PhD

Blood (2009) 114 (22): 3126.

https://doi.org/10.1182/blood.V114.22.3126.3126

Published: 2009

Journal Articles

Group IVA cytosolic phospholipase A 2 (cPLA 2 α) and integrin αIIbβ3 reinforce each other's functions during αIIbβ3 signaling in platelets

Nicolas Prévost, John V. Mitsios, Hisashi Kato, John E. Burke, Edward A. Dennis, Takao Shimizu, Sanford J. Shattil

Blood (2009) 113 (2): 447–457.

https://doi.org/10.1182/blood-2008-06-162032

Published: 2009

Includes: Supplemental data

Journal Articles

Genetic Disruption of □pdl and □pdlr Phospholipases in Mice Leads to Impaired Platelet Adhesion and Aggregation

DingYan Wang, Adili Reheman, Phil Connelly, Youdong Wang, Graham Maguire, Feng He, Armand Keating, Heyu Ni, Xiao-Yan Wen

Blood (2008) 112 (11): 412.

https://doi.org/10.1182/blood.V112.11.412.412

Published: 2008

Journal Articles

Hydroxyurea Treatment of Children with Sickle Cell Disease Inhibits RBC Membrane Degradation by Secretory Phospholipase a 2 .

James B Ball, MD, Samina Y Khan, BS, Nathan JD McLaughlin, BS, Rachelle Nuss, Laura Cole, RN, Christopher C. Silliman, MD, PhD

Blood (2008) 112 (11): 1427.

https://doi.org/10.1182/blood.V112.11.1427.1427

Published: 2008

Journal Articles

Phosphatidic Acid Enhances Procoagulant Activity and Thrombosis through Phosphatidylserine Exposure in Human Erythrocytes.

Ji-Yoon Noh, Kyung-Min Lim, Jin-Ho Chung

Blood (2008) 112 (11): 3846.

https://doi.org/10.1182/blood.V112.11.3846.3846

Published: 2008

Journal Articles

Platelet particle formation by anti–GPIIIa49-66 Ab, Ca 2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A 2 , 12-lipoxygenase, and NADPH oxidase

Michael A. Nardi, Yelena Gor, Steven J. Feinmark, Fang Xu, Simon Karpatkin

Blood (2007) 110 (6): 1989–1996.

https://doi.org/10.1182/blood-2006-10-054064

Published: 2007

Journal Articles

Dexamethasone (Dex) Inhibits Anti-GPIIIa49-66 Ab Induced Oxidative Fragmenation of Platelets: Inhibition of Platelet Phospholipase A 2 (PLA 2 ) and 12-Lipoxygenase (12-LO) MembraneTranslocation and Activity.

Michael A. Nardi, Steven J. Feinmark, Yelena Gor, Simon Karpatkin

Blood (2006) 108 (11): 1512.

https://doi.org/10.1182/blood.V108.11.1512.1512

Published: 2006

Journal Articles

Serum C-reactive protein parallels secretory phospholipase A 2 in sickle cell disease patients with vasoocclusive crisis or acute chest syndrome

Emilee M. Bargoma, Joyce K. Mitsuyoshi, Sandra K. Larkin, Lori A. Styles, Frans A. Kuypers, Samuel T. Test

Blood (2005) 105 (8): 3384–3385.

https://doi.org/10.1182/blood-2004-12-4676

Published: 2005

Journal Articles

Arachidonic Acid Rescues Defects on PMA-Elicited NADPH Oxidase Activity in Rac2-Deficient Neutrophils.

Chaekyun Kim, PhD, Mary C. Dinauer, MD, PhD

Blood (2004) 104 (11): 2386.

https://doi.org/10.1182/blood.V104.11.2386.2386

Published: 2004

Journal Articles

Inhibition of PAR4 Signaling in Ethanol-Attenuation of Platelet Function.

Shogo Kasuda, MD, Yoshihiko Sakurai, MD, PhD, Midori Shima, MD, PhD, Masahiro Takeyama, MD, Katsuhiko Hatake, MD, PhD, Akira Yoshioka, MD, PhD

Blood (2004) 104 (11): 3892.

https://doi.org/10.1182/blood.V104.11.3892.3892

Published: 2004

Journal Articles

Lipids That Prime Neutrophils Are Present upon Recognition of the Acute Chest Syndrome.

Christopher C. Silliman, MD/PhD, Nathan J.D. McLaughlin, BS, Marguerite R. Kelher, MS, Samina Khan, BS, Elisabeth K. Crawford, BSN, Kathryn Hassell, MD, Rachelle Nuss, MD

Blood (2004) 104 (11): 3572.

https://doi.org/10.1182/blood.V104.11.3572.3572

Published: 2004

Journal Articles

Cytosolic phospholipase A 2 type IVA is present in human red cells

Donald J. Macdonald, Rose M. Boyle, Alastair C. A. Glen, David F. Horrobin

Blood (2004) 103 (9): 3562–3564.

https://doi.org/10.1182/blood-2002-09-2698

Published: 2004

Journal Articles

Bcl-x L antagonism of BCR-coupled mitochondrial phospholipase A 2 signaling correlates with protection from apoptosis in WEHI-231 B cells

Elad Katz, Caroline Lord, Catriona A. Ford, Stephen B. Gauld, Natalie A. Carter, Margaret M. Harnett

Blood (2004) 103 (1): 168–176.

https://doi.org/10.1182/blood-2003-07-2473

Published: 2004

Journal Articles

Identification of an autoantigen on the surface of apoptotic human T cells as a new protein interacting with inflammatory group IIA phospholipase A 2

Eric Boilard, Sylvain G. Bourgoin, Chantale Bernatchez, Marc E. Surette

Blood (2003) 102 (8): 2901–2909.

https://doi.org/10.1182/blood-2002-12-3702

Published: 2003

Journal Articles

Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca ++ /NFAT

Valery N. Bochkov, Diana Mechtcheriakova, Marcus Lucerna, Joakim Huber, Roland Malli, Wolfgang F. Graier, Erhard Hofer, Bernd R. Binder, Norbert Leitinger

Blood (2002) 99 (1): 199–206.

https://doi.org/10.1182/blood.V99.1.199

Published: 2002

Journal Articles

Activation and priming of neutrophil nicotinamide adenine dinucleotide phosphate oxidase and phospholipase A 2 are dissociated by inhibitors of the kinases p42 ERK2 and p38 SAPK and by methyl arachidonyl fluorophosphonate, the dual inhibitor of cytosolic and calcium-independent phospholipase A 2

Elahe Mollapour, David C. Linch, Pamela J. Roberts

Blood (2001) 97 (8): 2469–2477.

https://doi.org/10.1182/blood.V97.8.2469

Published: 2001

NARROW

Metabolomic Profiling Identifies Hypoxia-Induced Imbalanced Lands' Cycle Promotes Sickling and Disease Progression

Boudreau LH, Duchez A-C, Cloutier N, et al. Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A 2 to promote inflammation. Blood. 2014;124(14): 2173-2183 .

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A 2 to promote inflammation

A Pilot Study of Tapered Oral Dexamethasone for the Acute Chest Syndrome of Sickle Cell Disease.

Atorvastatin Reduces Collagen-Induced Platelet Function in Aspirin-Treated Patients with Acute Myocardial Infarction: Mechanisms Involved.

Group IVA cytosolic phospholipase A 2 (cPLA 2 α) and integrin αIIbβ3 reinforce each other's functions during αIIbβ3 signaling in platelets

Genetic Disruption of □pdl and □pdlr Phospholipases in Mice Leads to Impaired Platelet Adhesion and Aggregation

Hydroxyurea Treatment of Children with Sickle Cell Disease Inhibits RBC Membrane Degradation by Secretory Phospholipase a 2 .

Phosphatidic Acid Enhances Procoagulant Activity and Thrombosis through Phosphatidylserine Exposure in Human Erythrocytes.

Platelet particle formation by anti–GPIIIa49-66 Ab, Ca 2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A 2 , 12-lipoxygenase, and NADPH oxidase

Dexamethasone (Dex) Inhibits Anti-GPIIIa49-66 Ab Induced Oxidative Fragmenation of Platelets: Inhibition of Platelet Phospholipase A 2 (PLA 2 ) and 12-Lipoxygenase (12-LO) MembraneTranslocation and Activity.

Serum C-reactive protein parallels secretory phospholipase A 2 in sickle cell disease patients with vasoocclusive crisis or acute chest syndrome

Arachidonic Acid Rescues Defects on PMA-Elicited NADPH Oxidase Activity in Rac2-Deficient Neutrophils.

Inhibition of PAR4 Signaling in Ethanol-Attenuation of Platelet Function.

Lipids That Prime Neutrophils Are Present upon Recognition of the Acute Chest Syndrome.

Cytosolic phospholipase A 2 type IVA is present in human red cells

Bcl-x L antagonism of BCR-coupled mitochondrial phospholipase A 2 signaling correlates with protection from apoptosis in WEHI-231 B cells

Identification of an autoantigen on the surface of apoptotic human T cells as a new protein interacting with inflammatory group IIA phospholipase A 2

Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca ++ /NFAT

Activation and priming of neutrophil nicotinamide adenine dinucleotide phosphate oxidase and phospholipase A 2 are dissociated by inhibitors of the kinases p42 ERK2 and p38 SAPK and by methyl arachidonyl fluorophosphonate, the dual inhibitor of cytosolic and calcium-independent phospholipase A 2

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American Society of Hematology

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