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Journal Articles

Non-Activating Integrin β3(R734C) Mutation Associated with Macrothrombocytopenia and Impaired Platelet Function

Keiichi Nakata, Keigo Akuta, Takaya Endo, Midori Koike, Hisashi Kato, Yoshiaki Tomiyama, Naoki Hosen, Hirokazu Kashiwagi

Blood (2023) 142 (Supplement 1): 2564.

https://doi.org/10.1182/blood-2023-178475

Published: 2023

Journal Articles

Proposal of New Diagnostic Criteria for Primary Immune Thrombocytopenia

Hirokazu Kashiwagi, Masataka Kuwana, Mitsuru Murata, Naoki Shimada, Toshiro Takafuta, Jun Yamanouchi, Hisashi Kato, Takaaki Hato, Yoshiaki Tomiyama

Blood (2023) 142 (Supplement 1): 1214.

https://doi.org/10.1182/blood-2023-179165

Published: 2023

Journal Articles

The Critical Role of Kindlin-3 in Intiation of Physiological Thrombus Formation ~ Analysis of Kindlin-3 Deficient Patient

Hisashi Kato, MD PhD, Shigenori Honda, MD, Hirokazu Kashiwagi, Nobuko Nishiura, Keigo Akuta, Koichi Kokame, Toshiyuki Miyata, Yoshiaki Tomiyama, MD

Blood (2019) 134 (Supplement_1): 1062.

https://doi.org/10.1182/blood-2019-129668

Published: 2019

Journal Articles

αIIb(R990W), a Gain-of Function Mutation of αIIbβ3, Knock-in Mice Show Moderately Impaired Thrombopoiesis

Keigo Akuta, Kazunobu Kiyomizu, MD, Hirokazu Kashiwagi, Shinji Kunishima, PhD, Fumiaki Banno, Koichi Kokame, Nobuko Nishiura, Hisashi Kato, MD PhD, Shigenori Honda, MD, Yuzuru Kanakura, MD PhD, Toshiyuki Miyata, Yoshiaki Tomiyama, MD

Blood (2018) 132 (Supplement 1): 3743.

https://doi.org/10.1182/blood-2018-99-115953

Published: 2018

Journal Articles

Platelet Integrin αIIbβ3 Activation Kinetics in Inherited Platelet Functional Disorders ∼ the Role of ADP Receptor P2Y12, Caldag-GEFI and Kindlin-3 αIIbβ3 Activation By inside-out Signaling

Hisashi Kato, MDPhD, Nobuko Nishiura, Keigo Akuta, Hirokazu Kashiwagi, Koichi Kokame, Toshiyuki Miyata, Yuzuru Kanakura, MD PhD, Yoshiaki Tomiyama, MD

Blood (2018) 132 (Supplement 1): 1136.

https://doi.org/10.1182/blood-2018-99-112852

Published: 2018

Journal Articles

Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation

Hisashi Kato, Yozo Nakazawa, Yumi Kurokawa, Hirokazu Kashiwagi, Yoichiro Morikawa, Daisuke Morita, Fumiaki Banno, Shigenori Honda, Yuzuru Kanakura, Yoshiaki Tomiyama

Blood (2016) 128 (23): 2729–2733.

https://doi.org/10.1182/blood-2016-03-704825

Published: 2016

Includes: Supplemental data

Journal Articles

The Association of PAR4 Polymorphism with Human Platelet Reactivity in Japanese

Yoichiro Morikawa, MD, Hisashi Kato, MD PhD, Keigo Akuta, MD, Hirokazu Kashiwagi, MD PhD, Shigenori Honda, MD PhD, Yuzuru Kanakura, MD PhD, Yoshiaki Tomiyama, MD PhD

Blood (2016) 128 (22): 4908.

https://doi.org/10.1182/blood.V128.22.4908.4908

Published: 2016

Journal Articles

Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptor

Zhongji Liao, Hisashi Kato, Manjula Pandey, Joseph M. Cantor, Ararat J. Ablooglu, Mark H. Ginsberg, Sanford J. Shattil

Blood (2015) 125 (12): 1995–2004.

https://doi.org/10.1182/blood-2014-09-603035

Published: 2015

Includes: Supplemental data

Journal Articles

αIIb(R990W), a Constitutive Activating Mutation of Integrin αIIbβ3, Knock-in Mice Show Macrothrombocytopenia with Impairment of Platelet Function

Kazunobu Kiyomizu, Hirokazu Kashiwagi, Shinji Kunishima, PhD, Fumiaki Banno, PhD, Hisashi Kato, Youichiro Morikawa, Seiji Tadokoro, Koichi Kokame, PhD, Shigenori Honda, MD PhD, Toshiyuki Miyata, PhD, Yuzuru Kanakura, Yoshiaki Tomiyama

Blood (2014) 124 (21): 4182.

https://doi.org/10.1182/blood.V124.21.4182.4182

Published: 2014

Journal Articles

Group IVA cytosolic phospholipase A 2 (cPLA 2 α) and integrin αIIbβ3 reinforce each other's functions during αIIbβ3 signaling in platelets

Nicolas Prévost, John V. Mitsios, Hisashi Kato, John E. Burke, Edward A. Dennis, Takao Shimizu, Sanford J. Shattil

Blood (2009) 113 (2): 447–457.

https://doi.org/10.1182/blood-2008-06-162032

Published: 2009

Includes: Supplemental data

Journal Articles

Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura

Fumiaki Banno, Koichi Kokame, Tomohiko Okuda, Shigenori Honda, Shigeki Miyata, Hisashi Kato, Yoshiaki Tomiyama, Toshiyuki Miyata

Blood (2006) 107 (8): 3161–3166.

https://doi.org/10.1182/blood-2005-07-2765

Published: 2006

Journal Articles

Critical Role of Endogenous ADP Via P2Y12 Receptor in Maintenance of α Iib β 3 Activation.

Tsuyoshi Kamae, MD, Masamichi Shiraga, MD, Hirokazu Kashiwagi, MD, Hisashi Kato, MD, Seiji Tadokoro, MD, Yoshiyuki Kurata, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD

Blood (2005) 106 (11): 1655.

https://doi.org/10.1182/blood.V106.11.1655.1655

Published: 2005

Journal Articles

Negative regulation of platelet function by a secreted cell repulsive protein, semaphorin 3A

Hirokazu Kashiwagi, Masamichi Shiraga, Hisashi Kato, Tsuyoshi Kamae, Naoko Yamamoto, Seiji Tadokoro, Yoshiyuki Kurata, Yoshiaki Tomiyama, Yuzuru Kanakura

Blood (2005) 106 (3): 913–921.

https://doi.org/10.1182/blood-2004-10-4092

Published: 2005

Journal Articles

Negative Regulation of Platelet Function by a Secreted Cell Repulsive Protein, Semaphorin 3A.

Hirokazu Kashiwagi, MD, Masamichi Shiraga, MD, Hisashi Kato, MD, Tsuyoshi Kamae, MD, Naoko Yamamoto, MD, Seiji Tadokoro, MD, Yoshiyuki Kurata, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD, PhD

Blood (2004) 104 (11): 1546.

https://doi.org/10.1182/blood.V104.11.1546.1546

Published: 2004

Journal Articles

Enhanced Platelet Aggregation and Thrombogenic Tendency in Adiponectin-Deficient Mice.

Hisashi Kato, Graduate Student, Hirokazu Kashiwagi, MD, Masamichi Shiraga, MD, Shigenori Honda, MD, Shigeki Miyata, MD, Junichiro Yamamoto, PhD, Yoshiyuki Kurata, MD, Tohru Funahashi, MD, Iichiro Shimomura, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD

Blood (2004) 104 (11): 800.

https://doi.org/10.1182/blood.V104.11.800.800

Published: 2004

Journal Articles

Impaired Platelet Function in a P2Y 12 -Deficient Patient Caused by a Mutation in the Translation Initiation Codon.

Masamichi Shiraga, MD, Shigeki Miyata, MD, Tsuyoshi Kamae, MD, Hisashi Kato, MD, Teruo Kiyoi, MD, Hirokazu Kashiwagi, MD, Shigenori Honda, MD, Yoshiyuki Kurata, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD

Blood (2004) 104 (11): 742.

https://doi.org/10.1182/blood.V104.11.742.742

Published: 2004

Journal Articles

A naturally occurring Tyr143Hisα IIb mutation abolishes α IIb β 3 function for soluble ligands but retains its ability for mediating cell adhesion and clot retraction: comparison with other mutations causing ligand-binding defects

Teruo Kiyoi, Yoshiaki Tomiyama, Shigenori Honda, Seiji Tadokoro, Morio Arai, Hirokazu Kashiwagi, Satoru Kosugi, Hisashi Kato, Yoshiyuki Kurata, Yuji Matsuzawa

Blood (2003) 101 (9): 3485–3491.

https://doi.org/10.1182/blood-2002-07-2144

Published: 2003

Journal Articles

Platelet-associated anti–GPIIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura recognizing epitopes close to the ligand-binding site of glycoprotein (GP) IIb

Satoru Kosugi, Yoshiaki Tomiyama, Shigenori Honda, Hisashi Kato, Teruo Kiyoi, Hirokazu Kashiwagi, Yoshiyuki Kurata, Yuji Matsuzawa

Blood (2001) 98 (6): 1819–1827.

https://doi.org/10.1182/blood.V98.6.1819

Published: 2001

NARROW

Non-Activating Integrin β3(R734C) Mutation Associated with Macrothrombocytopenia and Impaired Platelet Function

Proposal of New Diagnostic Criteria for Primary Immune Thrombocytopenia

The Critical Role of Kindlin-3 in Intiation of Physiological Thrombus Formation ~ Analysis of Kindlin-3 Deficient Patient

αIIb(R990W), a Gain-of Function Mutation of αIIbβ3, Knock-in Mice Show Moderately Impaired Thrombopoiesis

Platelet Integrin αIIbβ3 Activation Kinetics in Inherited Platelet Functional Disorders ∼ the Role of ADP Receptor P2Y12, Caldag-GEFI and Kindlin-3 αIIbβ3 Activation By inside-out Signaling

Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation

The Association of PAR4 Polymorphism with Human Platelet Reactivity in Japanese

Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptor

αIIb(R990W), a Constitutive Activating Mutation of Integrin αIIbβ3, Knock-in Mice Show Macrothrombocytopenia with Impairment of Platelet Function

Group IVA cytosolic phospholipase A 2 (cPLA 2 α) and integrin αIIbβ3 reinforce each other's functions during αIIbβ3 signaling in platelets

Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura

Critical Role of Endogenous ADP Via P2Y12 Receptor in Maintenance of α Iib β 3 Activation.

Negative regulation of platelet function by a secreted cell repulsive protein, semaphorin 3A

Negative Regulation of Platelet Function by a Secreted Cell Repulsive Protein, Semaphorin 3A.

Enhanced Platelet Aggregation and Thrombogenic Tendency in Adiponectin-Deficient Mice.

Impaired Platelet Function in a P2Y 12 -Deficient Patient Caused by a Mutation in the Translation Initiation Codon.

A naturally occurring Tyr143Hisα IIb mutation abolishes α IIb β 3 function for soluble ligands but retains its ability for mediating cell adhesion and clot retraction: comparison with other mutations causing ligand-binding defects

Platelet-associated anti–GPIIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura recognizing epitopes close to the ligand-binding site of glycoprotein (GP) IIb

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American Society of Hematology

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American Society of Hematology

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