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Journal Articles

A Phase 2 Open-Label, Sequential-Cohort, Dose-Escalation Study of AMG 531 in Japanese Patients with Chronic Immune Thrombocytopenic Purpura (ITP).

Yukari Shirasugi, Kiyoshi Ando, Satoshi Hashino, Toshiro Nagasawa, Yoshiyuki Kurata, Yuji Kishimoto, Koji Iwato, Yusuke Sonehara, Masayuki Ohkura, Tomoko Ohtsu, Janet L. Nichol

Blood (2007) 110 (11): 1308.

https://doi.org/10.1182/blood.V110.11.1308.1308

Published: 2007

Journal Articles

P2Y 12 -Independent Transient Activation and P2Y 12 -Dependent Prolonged Activation of Platelet Integrin α IIb β 3 .

Masamichi Shiraga, MD, Tsuyoshi Kamae, MD, Masao Akiyama, MD, Seiji Tadokoro, MD, Hirokazu Kashiwagi, MD, Kenji Oritani, MD, Yoshiyuki Kurata, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD

Blood (2006) 108 (11): 1509.

https://doi.org/10.1182/blood.V108.11.1509.1509

Published: 2006

Journal Articles

Critical Role of Endogenous ADP Via P2Y12 Receptor in Maintenance of α Iib β 3 Activation.

Tsuyoshi Kamae, MD, Masamichi Shiraga, MD, Hirokazu Kashiwagi, MD, Hisashi Kato, MD, Seiji Tadokoro, MD, Yoshiyuki Kurata, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD

Blood (2005) 106 (11): 1655.

https://doi.org/10.1182/blood.V106.11.1655.1655

Published: 2005

Journal Articles

Negative regulation of platelet function by a secreted cell repulsive protein, semaphorin 3A

Hirokazu Kashiwagi, Masamichi Shiraga, Hisashi Kato, Tsuyoshi Kamae, Naoko Yamamoto, Seiji Tadokoro, Yoshiyuki Kurata, Yoshiaki Tomiyama, Yuzuru Kanakura

Blood (2005) 106 (3): 913–921.

https://doi.org/10.1182/blood-2004-10-4092

Published: 2005

Journal Articles

Initial Laboratory Findings Useful for Predicting the Diagnosis of Chronic ITP: Results of a Multicenter Prospective Study.

Masataka Kuwana, MD, Yoshiyuki Kurata, MD, Kingo Fujimura, MD, Koji Fujisawa, MD, Hideo Wada, MD, Toshiro Nagasawa, MD, Shosaku Nomura, MD, Tetsuhito Kojima, MD, Hideo Yagi, MD, Yasuo Ikeda, MD

Blood (2004) 104 (11): 2061.

https://doi.org/10.1182/blood.V104.11.2061.2061

Published: 2004

Journal Articles

Clinical Features and Effects of Eradication on Helicobacter Pylori Positive 207 ITP Cases in Japan.

Kingo Fujimura, MD, Masataka Kuwana, MD, Yoshiyuki Kurata, MD, Masahiro Imamura, MD, Hiroshi Harada, MD, Hisashi Sakamaki, MD, Masanao Teramura, MD, Kyuhei Koda, MD, Shosaku Nomura, MD, Sayaka Sugihara, MD, Takeshi Shimomura, MD, Tetsuro Takahiro Fujimoto, MD, Kazuma Oyashiki, MD, Yasuo Ikeda, MD

Blood (2004) 104 (11): 2071.

https://doi.org/10.1182/blood.V104.11.2071.2071

Published: 2004

Journal Articles

Negative Regulation of Platelet Function by a Secreted Cell Repulsive Protein, Semaphorin 3A.

Hirokazu Kashiwagi, MD, Masamichi Shiraga, MD, Hisashi Kato, MD, Tsuyoshi Kamae, MD, Naoko Yamamoto, MD, Seiji Tadokoro, MD, Yoshiyuki Kurata, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD, PhD

Blood (2004) 104 (11): 1546.

https://doi.org/10.1182/blood.V104.11.1546.1546

Published: 2004

Journal Articles

Enhanced Platelet Aggregation and Thrombogenic Tendency in Adiponectin-Deficient Mice.

Hisashi Kato, Graduate Student, Hirokazu Kashiwagi, MD, Masamichi Shiraga, MD, Shigenori Honda, MD, Shigeki Miyata, MD, Junichiro Yamamoto, PhD, Yoshiyuki Kurata, MD, Tohru Funahashi, MD, Iichiro Shimomura, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD

Blood (2004) 104 (11): 800.

https://doi.org/10.1182/blood.V104.11.800.800

Published: 2004

Journal Articles

Impaired Platelet Function in a P2Y 12 -Deficient Patient Caused by a Mutation in the Translation Initiation Codon.

Masamichi Shiraga, MD, Shigeki Miyata, MD, Tsuyoshi Kamae, MD, Hisashi Kato, MD, Teruo Kiyoi, MD, Hirokazu Kashiwagi, MD, Shigenori Honda, MD, Yoshiyuki Kurata, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD

Blood (2004) 104 (11): 742.

https://doi.org/10.1182/blood.V104.11.742.742

Published: 2004

Journal Articles

Effect of a single injection of humanized anti-CD154 monoclonal antibody on the platelet-specific autoimmune response in patients with immune thrombocytopenic purpura

Masataka Kuwana, Shosaku Nomura, Kingo Fujimura, Toshiro Nagasawa, Yoshitomo Muto, Yoshiyuki Kurata, Shigeru Tanaka, Yasuo Ikeda

Blood (2004) 103 (4): 1229–1236.

https://doi.org/10.1182/blood-2003-06-2167

Published: 2004

Journal Articles

A naturally occurring Tyr143Hisα IIb mutation abolishes α IIb β 3 function for soluble ligands but retains its ability for mediating cell adhesion and clot retraction: comparison with other mutations causing ligand-binding defects

Teruo Kiyoi, Yoshiaki Tomiyama, Shigenori Honda, Seiji Tadokoro, Morio Arai, Hirokazu Kashiwagi, Satoru Kosugi, Hisashi Kato, Yoshiyuki Kurata, Yuji Matsuzawa

Blood (2003) 101 (9): 3485–3491.

https://doi.org/10.1182/blood-2002-07-2144

Published: 2003

Journal Articles

Missense mutations in the β 3 subunit have a different impact on the expression and function between α IIb β 3 and α v β 3

Seiji Tadokoro, Yoshiaki Tomiyama, Shigenori Honda, Hirokazu Kashiwagi, Satoru Kosugi, Masamichi Shiraga, Teruo Kiyoi, Yoshiyuki Kurata, Yuji Matsuzawa

Blood (2002) 99 (3): 931–938.

https://doi.org/10.1182/blood.V99.3.931

Published: 2002

Journal Articles

Platelet-associated anti–GPIIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura recognizing epitopes close to the ligand-binding site of glycoprotein (GP) IIb

Satoru Kosugi, Yoshiaki Tomiyama, Shigenori Honda, Hisashi Kato, Teruo Kiyoi, Hirokazu Kashiwagi, Yoshiyuki Kurata, Yuji Matsuzawa

Blood (2001) 98 (6): 1819–1827.

https://doi.org/10.1182/blood.V98.6.1819

Published: 2001

Journal Articles

Ligand binding to integrin α v β 3 requires tyrosine 178 in the α v subunit

Shigenori Honda, Yoshiaki Tomiyama, Nisar Pampori, Hirokazu Kashiwagi, Teruo Kiyoi, Satoru Kosugi, Seiji Tadokoro, Yoshiyuki Kurata, Sanford J. Shattil, Yuji Matsuzawa

Blood (2001) 97 (1): 175–182.

https://doi.org/10.1182/blood.V97.1.175

Published: 2001

Journal Articles

A Mutation in the Extracellular Cysteine-Rich Repeat Region of the β 3 Subunit Activates Integrins  IIb β 3 and  V β 3

Hirokazu Kashiwagi, Yoshiaki Tomiyama, Seiji Tadokoro, Shigenori Honda, Masamichi Shiraga, Hajime Mizutani, Makoto Handa, Yoshiyuki Kurata, Yuji Matsuzawa, Sanford J. Shattil

Blood (1999) 93 (8): 2559–2568.

https://doi.org/10.1182/blood.V93.8.2559

Published: 1999

Journal Articles

Association Between Ligand-Induced Conformational Changes of Integrin  IIb β 3 and  IIb β 3 -Mediated Intracellular Ca 2+ Signaling

Shigenori Honda, Yoshiaki Tomiyama, Toshiaki Aoki, Masamichi Shiraga, Yoshiyuki Kurata, Jiro Seki, Yuji Matsuzawa

Blood (1998) 92 (10): 3675–3683.

https://doi.org/10.1182/blood.V92.10.3675

Published: 1998

Journal Articles

Involvement of Na + /Ca 2+ Exchanger in Inside-Out Signaling Through the Platelet Integrin  IIb β 3

Masamichi Shiraga, Yoshiaki Tomiyama, Shigenori Honda, Hidenori Suzuki, Satoru Kosugi, Seiji Tadokoro, Yuzuru Kanakura, Kenjiro Tanoue, Yoshiyuki Kurata, Yuji Matsuzawa

Blood (1998) 92 (10): 3710–3720.

https://doi.org/10.1182/blood.V92.10.3710

Published: 1998

Journal Articles

A Gln747→Pro Substitution in the  IIb Subunit Is Responsible for a Moderate  IIb β 3 Deficiency in Glanzmann Thrombasthenia

Seiji Tadokoro, Yoshiaki Tomiyama, Shigenori Honda, Morio Arai, Naomasa Yamamoto, Masamichi Shiraga, Satoru Kosugi, Yuzuru Kanakura, Yoshiyuki Kurata, Yuji Matsuzawa

Blood (1998) 92 (8): 2750–2758.

https://doi.org/10.1182/blood.V92.8.2750

Published: 1998

Journal Articles

Markedly Reduced Expression of Platelet c-mpl Receptor in Essential Thrombocythemia

Yoko Horikawa, Itaru Matsumura, Koji Hashimoto, Masamichi Shiraga, Satoru Kosugi, Seiji Tadokoro, Takashi Kato, Hiroshi Miyazaki, Yoshiaki Tomiyama, Yoshiyuki Kurata, Yuji Matsuzawa, Yuzuru Kanakura

Blood (1997) 90 (10): 4031–4038.

https://doi.org/10.1182/blood.V90.10.4031

Published: 1997

NARROW

A Phase 2 Open-Label, Sequential-Cohort, Dose-Escalation Study of AMG 531 in Japanese Patients with Chronic Immune Thrombocytopenic Purpura (ITP).

P2Y 12 -Independent Transient Activation and P2Y 12 -Dependent Prolonged Activation of Platelet Integrin α IIb β 3 .

Critical Role of Endogenous ADP Via P2Y12 Receptor in Maintenance of α Iib β 3 Activation.

Negative regulation of platelet function by a secreted cell repulsive protein, semaphorin 3A

Initial Laboratory Findings Useful for Predicting the Diagnosis of Chronic ITP: Results of a Multicenter Prospective Study.

Clinical Features and Effects of Eradication on Helicobacter Pylori Positive 207 ITP Cases in Japan.

Negative Regulation of Platelet Function by a Secreted Cell Repulsive Protein, Semaphorin 3A.

Enhanced Platelet Aggregation and Thrombogenic Tendency in Adiponectin-Deficient Mice.

Impaired Platelet Function in a P2Y 12 -Deficient Patient Caused by a Mutation in the Translation Initiation Codon.

Effect of a single injection of humanized anti-CD154 monoclonal antibody on the platelet-specific autoimmune response in patients with immune thrombocytopenic purpura

A naturally occurring Tyr143Hisα IIb mutation abolishes α IIb β 3 function for soluble ligands but retains its ability for mediating cell adhesion and clot retraction: comparison with other mutations causing ligand-binding defects

Missense mutations in the β 3 subunit have a different impact on the expression and function between α IIb β 3 and α v β 3

Platelet-associated anti–GPIIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura recognizing epitopes close to the ligand-binding site of glycoprotein (GP) IIb

Ligand binding to integrin α v β 3 requires tyrosine 178 in the α v subunit

A Mutation in the Extracellular Cysteine-Rich Repeat Region of the β 3 Subunit Activates Integrins  IIb β 3 and  V β 3

Association Between Ligand-Induced Conformational Changes of Integrin  IIb β 3 and  IIb β 3 -Mediated Intracellular Ca 2+ Signaling

Involvement of Na + /Ca 2+ Exchanger in Inside-Out Signaling Through the Platelet Integrin  IIb β 3

A Gln747→Pro Substitution in the  IIb Subunit Is Responsible for a Moderate  IIb β 3 Deficiency in Glanzmann Thrombasthenia

Markedly Reduced Expression of Platelet c-mpl Receptor in Essential Thrombocythemia

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