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Journal Articles

Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP

James B. Bussel, David J. Kuter, Vinod Pullarkat, Roger M. Lyons, Matthew Guo, Janet L. Nichol

Blood (2009) 113 (10): 2161–2171.

https://doi.org/10.1182/blood-2008-04-150078

Published: 2009

Includes: Supplemental data

Journal Articles

Evaluation of AMG 531 Efficacy in Nonsplenectomized Patients with Chronic Immune Thrombocytopenic Purpura (ITP) in a Randomized Placebo-Controlled Phase 3 Study.

David J. Kuter, James B. Bussel, Francis M. Senecal, Louis M. Aledort, Craig M. Kessler, Miguel A. Sanz, Howard A. Liebman, Frank T. Slovick, Reggie Kelly, Matthew Guo, Janet L. Nichol

Blood (2007) 110 (11): 565.

https://doi.org/10.1182/blood.V110.11.565.565

Published: 2007

Journal Articles

Reduction in Immunoglobulin (IVIG or Anti D) Use in Patients with Chronic Immune Thrombocytopenic Purpura (ITP) Receiving AMG 531: Results from Two Phase 3 Randomized Placebo-Controlled Trials.

Vinod Pullarkat, Terry B. Gernsheimer, J. Th. M. de Wolf, Troy H. Guthrie, Jr., Adrian Newland, Jeffrey S. Wasser, Solomon I. Hamburg, Sue Gao, Ron Stewart, Janet L. Nichol

Blood (2007) 110 (11): 1304.

https://doi.org/10.1182/blood.V110.11.1304.1304

Published: 2007

Journal Articles

A Phase 2 Open-Label, Sequential-Cohort, Dose-Escalation Study of AMG 531 in Japanese Patients with Chronic Immune Thrombocytopenic Purpura (ITP).

Yukari Shirasugi, Kiyoshi Ando, Satoshi Hashino, Toshiro Nagasawa, Yoshiyuki Kurata, Yuji Kishimoto, Koji Iwato, Yusuke Sonehara, Masayuki Ohkura, Tomoko Ohtsu, Janet L. Nichol

Blood (2007) 110 (11): 1308.

https://doi.org/10.1182/blood.V110.11.1308.1308

Published: 2007

Journal Articles

Health-Related Quality of Life (HRQoL) in Patients (Pts) with Chronic Immune Thrombocytopenic Purpura (ITP): Results from Two Placebo-Controlled Phase 3 Studies of AMG 531.

James N. George, Roger Lyons, Francis J. Cuevas, Ronald S. Go, David H. Henry, Robert L. Redner, Lawrence Rice, Martin R. Schipperus, Susan D. Mathias, Sue Gao, Matthew Guo, Janet L. Nichol

Blood (2007) 110 (11): 1314.

https://doi.org/10.1182/blood.V110.11.1314.1314

Published: 2007

Journal Articles

Health-Related Quality of Life (HRQoL) in Patients with Chronic Immune Thrombocytopenic Purpura (ITP): Interim Results from an Open-Label Study of AMG 531.

Michael D. Tarantino, David H. Henry, Ronald S. Go, Francois Lefrere, Alan E. Lichtin, Howard R. Terebelo, Jean-Francois Viallard, Susan D. Mathias, Robert Deeter, Kun Nie, Janet L. Nichol

Blood (2007) 110 (11): 1324.

https://doi.org/10.1182/blood.V110.11.1324.1324

Published: 2007

Journal Articles

Development and Initial Validation of the Immune Thrombocytopenic Purpura Patient Assessment Questionnaire (ITP-PAQ), a Disease-Specific Health-Related Quality of Life (HRQoL) Questionnaire.

Susan D. Mathias, MPH, James B. Bussel, MD, James N. George, MD, Robert McMillan, MD, Gary J. Okano, RPh, PhD, Janet L. Nichol, MS

Blood (2006) 108 (11): 1078.

https://doi.org/10.1182/blood.V108.11.1078.1078

Published: 2006

Journal Articles

Analysis of Health-Related Quality of Life in Patients Receiving AMG 531 Using the Disease-Specific Immune Thrombocytopenic Purpura Patient Assessment Questionnaire.

James N. George, James B. Bussel, Robert McMillan, Matthew Guo, Gary J. Okano, Janet L. Nichol

Blood (2006) 108 (11): 3292.

https://doi.org/10.1182/blood.V108.11.3292.3292

Published: 2006

Journal Articles

Long-Term Dosing of AMG 531 Is Effective and Well Tolerated in Thrombocytopenic Patients with Immune Thrombocytopenic Purpura.

James B. Bussel, David J. Kuter, James N. George, Louis M. Aledort, Alan E. Lichtin, Roger M. Lyons, Jorge Nieva, Jeffrey S. Wasser, Emanuelle Bourgeois, Mies Kappers-Klunne, Francois LeFrere, Martin R. Schipperus, Reggie Kelly, Jenny Christal, Chien-Feng Chen, Janet L. Nichol

Blood (2005) 106 (11): 220.

https://doi.org/10.1182/blood.V106.11.220.220

Published: 2005

Journal Articles

A Novel Thrombopoiesis-Stimulating Agent, AMG 531: Pharmacokinetics and Pharmacodynamics in FcRn Knock-Out and Wild Type Mice.

Yu-Nien Sun, PhD, Rosalin Arends, PhD, Anthony Smithson, Ann Watson, BS, Janet L. Nichol, MS

Blood (2005) 106 (11): 3575.

https://doi.org/10.1182/blood.V106.11.3575.3575

Published: 2005

Journal Articles

Safety Profile of AMG 531 in Healthy Volunteers and in Thrombocytopenic Patients with Immune Thromobocytopenic Purpura.

Daniel E. Stepan, MD, Elaine Sergis-Deavenport, RN, MS, CPNP, Reggie Kelly, BS, Jenny Christal, PhD, Chien-Feng Chen, PhD, Janet L. Nichol, MS

Blood (2005) 106 (11): 1240.

https://doi.org/10.1182/blood.V106.11.1240.1240

Published: 2005

Journal Articles

A Phase 2 Placebo Controlled Study Evaluating the Platelet Response and Safety of Weekly Dosing with a Novel Thrombopoietic Protein (AMG531) in Thrombocytopenic Adult Patients (pts) with Immune Thrombocytopenic Purpura (ITP).

David Kuter, MD, DPhil, James B. Bussel, MD, Louis M. Aledort, MD, James George, MD, Roger M. Lyons, MD, George T. Conklin, MD, Alan E. Lichtin, MD, Jorge Nieva, MD, Reggie Kelly, BA, Chien-Feng Chen, PhD, Janet L. Nichol, MS

Blood (2004) 104 (11): 511.

https://doi.org/10.1182/blood.V104.11.511.511

Published: 2004

Journal Articles

An Open-Label, Unit Dose-Finding Study Evaluating the Safety and Platelet Response of a Novel Thrombopoietic Protein (AMG531) in Thrombocytopenic Adult Patients (Pts) with Immune Thrombocytopenic Purpura (ITP).

Adrian Newland, MD, Marie T. Caulier, MD, Martin R. Schipperus, MD, Maria Kappers-Klunne, MD, Bruno R. Varet, Karen Watkins, BA, Chien-Feng Chen, PhD, Janet L. Nichol, MS

Blood (2004) 104 (11): 2058.

https://doi.org/10.1182/blood.V104.11.2058.2058

Published: 2004

Journal Articles

Ex Vivo Cultured Megakaryocytes Express Functional Glycoprotein IIb-IIIa Receptors and Are Capable of Adenovirus-Mediated Transgene Expression

Nauder Faraday, Jeffrey J. Rade, David C. Johns, Gopal Khetawat, Stephen J. Noga, John F. DiPersio, Ying Jin, Janet L. Nichol, Jeff S. Haug, Paul F. Bray

Blood (1999) 94 (12): 4084–4092.

https://doi.org/10.1182/blood.V94.12.4084

Published: 1999

Journal Articles

Ineffective Platelet Production in Thrombocytopenic Human Immunodeficiency Virus–Infected Patients

James L. Cole, Ulla M. Marzec, Clifford J. Gunthel, Simon Karpatkin, Lydia Worford, I. Birgitta Sundell, Jeffrey L. Lennox, Janet L. Nichol, Laurence A. Harker

Blood (1998) 91 (9): 3239–3246.

https://doi.org/10.1182/blood.V91.9.3239

Published: 1998

Journal Articles

Chronic Thrombocytopenia Is Induced in Dogs by Development of Cross-Reacting Antibodies to the MpL Ligand

David C. Dale, Janet L. Nichol, Douglas A. Rich, Dawn M. Best, Sherrill J. Slichter, William Sheridan, Pam Hunt

Blood (1997) 90 (9): 3456–3461.

https://doi.org/10.1182/blood.V90.9.3456

Published: 1997

Journal Articles

Prevention of Thrombocytopenia and Neutropenia in a Nonhuman Primate Model of Marrow Suppressive Chemotherapy by Combining Pegylated Recombinant Human Megakaryocyte Growth and Development Factor and Recombinant Human Granulocyte Colony-Stimulating Factor

Laurence A. Harker, Ulla M. Marzec, Andrew B. Kelly, Ellen Cheung, Aaron Tomer, Janet L. Nichol, Stephen R. Hanson, Richard B. Stead

Blood (1997) 89 (1): 155–165.

https://doi.org/10.1182/blood.V89.1.155

Published: 1997

NARROW

Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP

Evaluation of AMG 531 Efficacy in Nonsplenectomized Patients with Chronic Immune Thrombocytopenic Purpura (ITP) in a Randomized Placebo-Controlled Phase 3 Study.

Reduction in Immunoglobulin (IVIG or Anti D) Use in Patients with Chronic Immune Thrombocytopenic Purpura (ITP) Receiving AMG 531: Results from Two Phase 3 Randomized Placebo-Controlled Trials.

A Phase 2 Open-Label, Sequential-Cohort, Dose-Escalation Study of AMG 531 in Japanese Patients with Chronic Immune Thrombocytopenic Purpura (ITP).

Health-Related Quality of Life (HRQoL) in Patients (Pts) with Chronic Immune Thrombocytopenic Purpura (ITP): Results from Two Placebo-Controlled Phase 3 Studies of AMG 531.

Health-Related Quality of Life (HRQoL) in Patients with Chronic Immune Thrombocytopenic Purpura (ITP): Interim Results from an Open-Label Study of AMG 531.

Development and Initial Validation of the Immune Thrombocytopenic Purpura Patient Assessment Questionnaire (ITP-PAQ), a Disease-Specific Health-Related Quality of Life (HRQoL) Questionnaire.

Analysis of Health-Related Quality of Life in Patients Receiving AMG 531 Using the Disease-Specific Immune Thrombocytopenic Purpura Patient Assessment Questionnaire.

Long-Term Dosing of AMG 531 Is Effective and Well Tolerated in Thrombocytopenic Patients with Immune Thrombocytopenic Purpura.

A Novel Thrombopoiesis-Stimulating Agent, AMG 531: Pharmacokinetics and Pharmacodynamics in FcRn Knock-Out and Wild Type Mice.

Safety Profile of AMG 531 in Healthy Volunteers and in Thrombocytopenic Patients with Immune Thromobocytopenic Purpura.

A Phase 2 Placebo Controlled Study Evaluating the Platelet Response and Safety of Weekly Dosing with a Novel Thrombopoietic Protein (AMG531) in Thrombocytopenic Adult Patients (pts) with Immune Thrombocytopenic Purpura (ITP).

An Open-Label, Unit Dose-Finding Study Evaluating the Safety and Platelet Response of a Novel Thrombopoietic Protein (AMG531) in Thrombocytopenic Adult Patients (Pts) with Immune Thrombocytopenic Purpura (ITP).

Ex Vivo Cultured Megakaryocytes Express Functional Glycoprotein IIb-IIIa Receptors and Are Capable of Adenovirus-Mediated Transgene Expression

Ineffective Platelet Production in Thrombocytopenic Human Immunodeficiency Virus–Infected Patients

Chronic Thrombocytopenia Is Induced in Dogs by Development of Cross-Reacting Antibodies to the MpL Ligand

Prevention of Thrombocytopenia and Neutropenia in a Nonhuman Primate Model of Marrow Suppressive Chemotherapy by Combining Pegylated Recombinant Human Megakaryocyte Growth and Development Factor and Recombinant Human Granulocyte Colony-Stimulating Factor

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American Society of Hematology

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American Society of Hematology

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