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Journal Articles

Combination of Phosphodiesterase 4 (PDE4) Inhibitor Roflumilast and R-CHOP As First-Line Therapy for High-Risk Diffuse Large B Cell Lymphoma Patients

Adolfo E Diaz, MD, Matthew James Butler, MD, Anand Karnad, MD, Ricardo Aguiar, MD PhD

Blood (2019) 134 (Supplement_1): 1592.

https://doi.org/10.1182/blood-2019-124382

Published: 2019

Journal Articles

Cyclic-AMP Is an Actionable Novel Regulator of PD-L1 Expression in Untransformed Lymphocytes and Diffuse Large B Cell Lymphomas

Binu Sasi, PhD, Zhijun Qiu, PhD, Shoulei Jiang, PhD, An-Ping Lin, MD, Ricardo Aguiar, MD PhD

Blood (2019) 134 (Supplement_1): 3962.

https://doi.org/10.1182/blood-2019-123155

Published: 2019

Journal Articles

Nitric Oxide Promotes Human Hematopoietic Stem Cell Homing and Engraftment Via cGMP-Pkg Signaling

Xinxin Huang, PhD, Bin Guo, PhD, Maegan L. Capitano, PhD, Hal E. Broxmeyer, PhD

Blood (2018) 132 (Supplement 1): 807.

https://doi.org/10.1182/blood-2018-99-112993

Published: 2018

Journal Articles

Soluble Guanylate Cyclase Modulators Effect Fetal Hemoglobin Levels through a Non-cGMP-Protein Kinase G Signaling Pathway

Bin Sun, PhD, Valerie Miller, MS, Karin P Potoka, MD, Yukio Nakamura, MD PhD, Mark T Gladwin, MD, Grant C. Bullock, MD PhD

Blood (2018) 132 (Supplement 1): 1060.

https://doi.org/10.1182/blood-2018-99-120306

Published: 2018

Journal Articles

Trauma Leads to a Rise in Intracellular cAMP and Adenylate Cyclase Activity in Rats

Daniel N Darlington, PhD, Bunyan Teng, PhD, Xiaowu Wu, MD MSc, Andrew P Cap, MD PhD

Blood (2018) 132 (Supplement 1): 1155.

https://doi.org/10.1182/blood-2018-99-114805

Published: 2018

Journal Articles

Intravascular Hemolysis Leads to Priapism Phenotype: Experimental Evidence

Fabio H Silva, Beatriz Pereira Bossarino, Fabiano B Calmasini, PhD, Eduardo Costa Alexandre, PhD, Fernando F. Costa, MD, PhD

Blood (2018) 132 (Supplement 1): 1076.

https://doi.org/10.1182/blood-2018-99-115513

Published: 2018

Journal Articles

Selective Pharmacologic Inhibition of Paroxysmal Nocturnal Hemoglobinuria Clones

Amy C Graham, BS, MS, Alexey Efanov, PhD, Bartlomiej P. Przychodzen, Cassandra M. Hirsch, Vera Adema, PhD, Valeria Visconte, PhD, Jaroslaw P. Maciejewski

Blood (2018) 132 (Supplement 1): 1303.

https://doi.org/10.1182/blood-2018-99-114973

Published: 2018

Journal Articles

Akt-Mediated Platelet Apoptosis and Its Therapeutic Implications in Immune Thrombocytopenia

Rong Yan, Dr., Mengxing Chen, Kesheng Dai, MD PhD

Blood (2018) 132 (Supplement 1): 2448.

https://doi.org/10.1182/blood-2018-99-114952

Published: 2018

Journal Articles

Coenzyme Q10 Attenuates Platelet Integrin αIIbβ3 Outside-in Signaling through Targeting cAMP/PKA Pathway and Inhibits Atherosclerosis

Yan Yang, MD PhD, Xiaohong Ruby Xu, MD PhD, Heyu Ni, MD MSc, PhD, Liping Ma, MD, Wenhua Ling, Fuli Ya

Blood (2018) 132 (Supplement 1): 2423.

https://doi.org/10.1182/blood-2018-99-120196

Published: 2018

Journal Articles

Small Molecule Regulated Cytokine Expression Enables Potent and Durable Responses to Engineered T-Cell Therapy

Vipin Suri, PhD MBA, Jennifer L Gori, PhD

Blood (2018) 132 (Supplement 1): 2045.

https://doi.org/10.1182/blood-2018-99-111922

Published: 2018

Journal Articles

Adenosine Regulation of cAMP through Phosphodiesterases

Bunyan Teng, PhD, Daniel N Darlington, PhD, Andrew P Cap, MD PhD

Blood (2018) 132 (Supplement 1): 2424.

https://doi.org/10.1182/blood-2018-99-114929

Published: 2018

Journal Articles

Combined Treatment with Hydroxyurea and a Phosphodiesterase 9 (PDE9) Inhibitor Decreases Hepatic Damage in an Animal Model of Sickle Cell Anemia

Juliete A.F. Silva, PhD, Hanan Chweih, BSc, Erica M.F. Gotardo, PhD, Wilson A. Ferreira, Jr., PhD, Carla F. Franco-Penteado, B.Sc. PhD, Camila B. Almeida, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2017) 130 (Supplement 1): 3514.

https://doi.org/10.1182/blood.V130.Suppl_1.3514.3514

Published: 2017

Journal Articles

Safety and Tolerability of PF-04447943 across a Clinical Trial Program Including 277 Patients

Robert J Charnigo, MS, Beesan Tan, PhD, Denis Rybin, PhD, Debra D Pittman, MS, Krupa M. Sivamurthy, MBBS, MD, David Beidler, PhD, Nicholas Clarke, PhD

Blood (2017) 130 (Supplement 1): 3558.

https://doi.org/10.1182/blood.V130.Suppl_1.3558.3558

Published: 2017

Journal Articles

A Phase 1b, Randomized, Double-Blind, Placebo-Controlled Study of PF-04447943 in Patients with Stable Sickle Cell Disease: Changes in Exploratory Biomarkers

Robert J Charnigo, MS, Jo Howard, MBBCh, David Beidler, PhD, Denis Rybin, PhD, Beesan Tan, PhD, Alan D Michelson, MD, Andrew L Frelinger, III, PhD, Nicholas Clarke, PhD

Blood (2017) 130 (Supplement 1): 974.

https://doi.org/10.1182/blood.V130.Suppl_1.974.974

Published: 2017

Journal Articles

Overexpression of Phospholipase C Beta 2 Is Associated with Favorable Prognosis in Normal Karyotype Acute Myeloid Leukemia

Jun Hyung Lee, MD MS, Hyun-Jung Choi, MD PhD, Soo-Hyun Kim, MD PhD, Jong-Hee Shin, MD PhD, Soon-Pal Suh, MD PhD, Myung-Geun Shin, MD PhD

Blood (2017) 130 (Supplement 1): 2677.

https://doi.org/10.1182/blood.V130.Suppl_1.2677.2677

Published: 2017

Journal Articles

The Pharmacological Blockade of Phosphodiesterase IV Potentiates the Anti-Tumor Effects of Arsenic Trioxide (ATO) in Acute Myelogenous Leukemia Cells through Multiple Signaling Pathways

Laura Mazzera, PhD, Manuela Abeltino, PhD, Antonio Bonati, MD, Paolo Lunghi, PhD

Blood (2017) 130 (Supplement 1): 2520.

https://doi.org/10.1182/blood.V130.Suppl_1.2520.2520

Published: 2017

Journal Articles

The Clinical-Stage sGC Stimulator IW-1701 Prevents Increase of Plasma Biomarkers of Intravascular Inflammation and Suppresses Leukocyte-Endothelial Interactions in Tnfα-Treated Mice

Boris Tchernychev, Susanne Feil, Peter Germano, William Warren, Elisabeth Lonie, Robert Feil, Todd G Milne, John Hadcock, Yueh-Tyng Chien, Mark G Currie, Regina Margaret Graul

Blood (2017) 130 (Supplement 1): 447.

https://doi.org/10.1182/blood.V130.Suppl_1.447.447

Published: 2017

Journal Articles

Phosphodiesterase 4 inhibitors have wide-ranging activity in B-cell malignancies

Jeffrey D. Cooney, Ricardo C. T. Aguiar

Blood (2016) 128 (25): 2886–2890.

https://doi.org/10.1182/blood-2016-09-737676

Published: 2016

Journal Articles

A Novel, Highly Potent and Selective PDE9 Inhibitor for the Treatment of Sickle Cell Disease

James G McArthur, PhD, Thiago Maciel, PhD, Chunsheng Chen, PhD, Aurelie Fricot, Dione Kobayashi, PhD, Julia Nguyen, BS, Phong Nguyen, Anna Parachova, PhD, Fuad Abdulla, Gregory M. Vercellotti, MD, Niels Svenstrup, PhD, John D Belcher, PhD

Blood (2016) 128 (22): 268.

https://doi.org/10.1182/blood.V128.22.268.268

Published: 2016

Journal Articles

Liposomal Delivery of a Phosphodiesterase 5 Inhibitor Enhances Prostacyclin-Mediated Adenosine Triphosphate Release from Human Red Blood Cells

Elizabeth Bowles, Randy Sprague, MD, Nuran Ercal, MD PhD

Blood (2016) 128 (22): 4803.

https://doi.org/10.1182/blood.V128.22.4803.4803

Published: 2016

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Combination of Phosphodiesterase 4 (PDE4) Inhibitor Roflumilast and R-CHOP As First-Line Therapy for High-Risk Diffuse Large B Cell Lymphoma Patients

Cyclic-AMP Is an Actionable Novel Regulator of PD-L1 Expression in Untransformed Lymphocytes and Diffuse Large B Cell Lymphomas

Nitric Oxide Promotes Human Hematopoietic Stem Cell Homing and Engraftment Via cGMP-Pkg Signaling

Soluble Guanylate Cyclase Modulators Effect Fetal Hemoglobin Levels through a Non-cGMP-Protein Kinase G Signaling Pathway

Trauma Leads to a Rise in Intracellular cAMP and Adenylate Cyclase Activity in Rats

Intravascular Hemolysis Leads to Priapism Phenotype: Experimental Evidence

Selective Pharmacologic Inhibition of Paroxysmal Nocturnal Hemoglobinuria Clones

Akt-Mediated Platelet Apoptosis and Its Therapeutic Implications in Immune Thrombocytopenia

Coenzyme Q10 Attenuates Platelet Integrin αIIbβ3 Outside-in Signaling through Targeting cAMP/PKA Pathway and Inhibits Atherosclerosis

Small Molecule Regulated Cytokine Expression Enables Potent and Durable Responses to Engineered T-Cell Therapy

Adenosine Regulation of cAMP through Phosphodiesterases

Combined Treatment with Hydroxyurea and a Phosphodiesterase 9 (PDE9) Inhibitor Decreases Hepatic Damage in an Animal Model of Sickle Cell Anemia

Safety and Tolerability of PF-04447943 across a Clinical Trial Program Including 277 Patients

A Phase 1b, Randomized, Double-Blind, Placebo-Controlled Study of PF-04447943 in Patients with Stable Sickle Cell Disease: Changes in Exploratory Biomarkers

Overexpression of Phospholipase C Beta 2 Is Associated with Favorable Prognosis in Normal Karyotype Acute Myeloid Leukemia

The Pharmacological Blockade of Phosphodiesterase IV Potentiates the Anti-Tumor Effects of Arsenic Trioxide (ATO) in Acute Myelogenous Leukemia Cells through Multiple Signaling Pathways

The Clinical-Stage sGC Stimulator IW-1701 Prevents Increase of Plasma Biomarkers of Intravascular Inflammation and Suppresses Leukocyte-Endothelial Interactions in Tnfα-Treated Mice

Phosphodiesterase 4 inhibitors have wide-ranging activity in B-cell malignancies

A Novel, Highly Potent and Selective PDE9 Inhibitor for the Treatment of Sickle Cell Disease

Liposomal Delivery of a Phosphodiesterase 5 Inhibitor Enhances Prostacyclin-Mediated Adenosine Triphosphate Release from Human Red Blood Cells

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