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Journal Articles

PIG-a Gene Expression Deficiency Association with Reduced DNA Damage Checkpoint Response and Activation

Jeffrey J Pu, MD PhD, Shasha Lu, MD PhD, Matthew Nemesure, Emmanuel Kwame Teye, PhD, Emily Schleicher, George-Lucian Moldovan, PhD, Robert A. Brodsky, MD, Fangyuan Chen, MD PhD

Blood (2018) 132 (Supplement 1): 3875.

https://doi.org/10.1182/blood-2018-99-119177

Published: 2018

Journal Articles

Paroxysmal Nocturnal Hemoglobinuria Results from Initial Clonal PIG-a Mosaicism

Michael J. Clemente, Bartlomiej Przychodzen, Cassandra M. Hirsch, BS, Bhumika J. Patel, MD, Taha Bat, Yasunobu Nagata, MD PhD, Marcin W. Wlodarski, MD PhD, Hideki Makishima, MD PhD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 1179.

https://doi.org/10.1182/blood.V130.Suppl_1.1179.1179

Published: 2017

Journal Articles

Elucidation of Autoinflammatory Mechanism in Pigt-PNH

Makiko Osato, MS, Yoshiko Murakami, MD PhD, Shogo Murata, MD PhD, Jun-Ichi Nishimura, MD PhD, Yasutaka Ueda, MD PhD, Taroh Kinoshita, PhD, Yuzuru Kanakura, MD PhD

Blood (2017) 130 (Supplement 1): 2201.

https://doi.org/10.1182/blood.V130.Suppl_1.2201.2201

Published: 2017

Journal Articles

Clonal Events of Aplastic Anemia Related to the Evolution to Myelodysplastic Syndrome

Eiju Negoro, MD, PhD, Michael Clemente, M.S., Naoko Hosono, MD,PhD, Aziz Nazha, MD, Wenyi Shen, MD, Yasunobu Nagata, MD, PhD, Cassandra M. Hirsch, BSc, Bartlomiej P Przychodzen, MSc, Reda Z. Mahfouz, MD, PhD, Teodora Kuzmanovic, BSc, Hideki Makishima, MD PhD FACP., Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski, MD, PhD, FACP

Blood (2016) 128 (22): 4290.

https://doi.org/10.1182/blood.V128.22.4290.4290

Published: 2016

Journal Articles

Progress Towards Creation of a Rhesus Macaque Animal Model for PNH Disease Via Crispr/Cas9 Technology to Knock out the PIG-a Gene

Marcus A.F. Corat, PhD, Jean-Yves Metais, PhD, Cynthia E. Dunbar, MD

Blood (2014) 124 (21): 4389.

https://doi.org/10.1182/blood.V124.21.4389.4389

Published: 2014

Journal Articles

Inherited GPI-Anchor Deficiencies Caused By The Hypomorphic Mutations In PIG A gene: Comparison To Paroxysmal Nocturnal Hemogrobinuria

Yoshiko Murakami, MD, PhD, Mitsuhiro Kato, Hirotomo Saitsu, Kenjiro Kikuchi, Shuei Watanabe, Mizue Iai, Ryuki Matsuura, Rumiko Takayama, Chihiro Ohba, Shin-ichiro Hamano, Hitoshi Osaka, Kiyoshi Hayasaka, Naomichi Matsumoto, Taroh Kinoshita, PhD

Blood (2013) 122 (21): 3701.

https://doi.org/10.1182/blood.V122.21.3701.3701

Published: 2013

Journal Articles

Leukemic Blasts With The PNH Phenotype: Correlation With Cytogenetics In ALL

David J Araten, MD, Mignon L. Loh, MD, Meenakshi Devidas, PhD, Andrew J. Carroll, PhD, Nyla A. Heerema, PhD, Stephen P. Hunger, MD, Chris Amro, Leah Zamechek

Blood (2013) 122 (21): 2628.

https://doi.org/10.1182/blood.V122.21.2628.2628

Published: 2013

Journal Articles

The Presence Of Leukemogenic Mutational Events In Paroxysmal Nocturnal Hemoglobinuria Suggests That Clonal Architecture Of Bone Marrow Failure Is Similar To Myelodysplastic Syndrome

Wenyi Shen, MD, Bartlomiej P. Przychodzen, PhD, Michael J. Clemente, Brittney Dienes, Tetsuichi Yoshisato, Masashi Sanada, MD, PhD, Kenichi Yoshida, MD, Seishi Ogawa, MD, PhD, Jaroslaw P. Maciejewski, MD, PhD, Hideki Makishima, MD, PhD

Blood (2013) 122 (21): 804.

https://doi.org/10.1182/blood.V122.21.804.804

Published: 2013

Journal Articles

Autoreactive T Cells From Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Specifically Recognize Glycosyl- Phosphatidyl-Inositol (GPI)

Lucia Gargiulo, PhD, Michela Sica, PhD, Maria Papaioannou, MD, PhD, Giulia Talini, PhD, Aristeidis Chaidos, MD, PhD, Barbara Richichi, PhD, Andrei V Nikolaev, PhD, Cristina Nativi, PhD, Mark Layton, MD, Josu de la Fuente, MRCP, MRCPCH, FRCPath, Irene Roberts, Lucio Luzzatto, MD, FRCP, FRCPath, Rosario Notaro, MD, Anastasios Karadimitris, MD, PhD

Blood (2012) 120 (21): 647.

https://doi.org/10.1182/blood.V120.21.647.647

Published: 2012

Journal Articles

Identification of Ex Vivo Myeloma Cells with the PNH Phenotype

David J Araten, MD, Ken Csehak, Leah Zamechek, Jeesun Park, B.A., Cynthia Liu, MD, PhD, Sherif Ibrahim, MD, PhD, Amitabha Mazumder, M.D.

Blood (2012) 120 (21): 3994.

https://doi.org/10.1182/blood.V120.21.3994.3994

Published: 2012

Journal Articles

A Role for TET2 Mutations in Paroxysmal Nocturnal Hemoglobinuria (PNH)

David J Araten, MD, Ashish Bains, MD, Camille Lobry, PhD, Iannis Aifantis, PhD, Sherif Ibrahim, MD, PhD

Blood (2012) 120 (21): 1262.

https://doi.org/10.1182/blood.V120.21.1262.1262

Published: 2012

Journal Articles

Generation of GPI Anchor Deficient Blood Cells From Human iPSCs.

Xuan Yuan, MD, Zhaohui Ye, PhD, Cyndi F. Liu, Jizhong Zou, PhD, Linzhao Cheng, PhD, Robert A. Brodsky, MD

Blood (2012) 120 (21): 2358.

https://doi.org/10.1182/blood.V120.21.2358.2358

Published: 2012

Journal Articles

Karyotypic and Genetic Abnormalities Associated with Clonal Evolution in Paroxysmal Nocturnal Hemoglobinuria.

Hideki Makishima, MD, PhD, Kenichi Yoshida, MD, Michael J. Clemente, Masashi Sanada, MD, Yasunobu Nagata, MD, Manuel G. Afable, II, MD, Andres Jerez, MD, Kenichi Chiba, BA, Yuichi Shiraishi, PhD, Satoru Miyano, PhD, Seishi Ogawa, MD, PhD, Jaroslaw P. Maciejewski, MD, PhD

Blood (2012) 120 (21): 2371.

https://doi.org/10.1182/blood.V120.21.2371.2371

Published: 2012

Journal Articles

The Somatic Mutation of PIG-A Gene and the Expressions of EGR-1 and WT1 Genes in Bone Marrow Cells of the Patients with Paroxysmal Nocturnal Hemoglobinuria

Rong Fu, MD, Liyan Li, MD, Zonghong Shao, MD, Jun Wang, MD, Lijuan Li, MD, Hui Liu, MD

Blood (2011) 118 (21): 4379.

https://doi.org/10.1182/blood.V118.21.4379.4379

Published: 2011

Journal Articles

Quantitative Analysis of the Effects of MYC Overexpression on the Mutation Rate in Human Cells Using the PIG-A Gene

David J Araten, MD, Ken Csehak, Daniel Anscher, Leah Zamechek

Blood (2011) 118 (21): 4406.

https://doi.org/10.1182/blood.V118.21.4406.4406

Published: 2011

Journal Articles

Reduction of Tregs with Expansion of Th1 Cells and Lack of IFN-γ Secretion by GPI Negative T-Cells In PNH

Shahram Kordasti, MD, PhD, Modupe Elebute, MBBS, MD, MRCP, FRCPath, Pilar Perez Abellan, Austin G Kulasekararaj, Janet Hayden, Azim Mohamedali, PHD, Ghulam J. Mufti, DM, FRCP, FRCPath

Blood (2010) 116 (21): 2240.

https://doi.org/10.1182/blood.V116.21.2240.2240

Published: 2010

Journal Articles

A High Frequency of Blasts with the PNH Phenotype in Patients with ALL.

David Araten, MD, Katie J Sanders, Dan Anscher, Leah Zamechek, Stephen P Hunger, MD, Sherif Ibrahim, MD, PhD

Blood (2009) 114 (22): 1575.

https://doi.org/10.1182/blood.V114.22.1575.1575

Published: 2009

Journal Articles

Reduced Hematopoietic Stem Cell Function in a Mouse Model with Conditional Pig-a Gene Deletion.

Valeria Visconte, PhD, Regis Peffault de Latour, MD PhD, Rodrigo T. Calado, MD PhD, Marie Desierto, Jichun Chen, PhD, Neal S Young, MD

Blood (2009) 114 (22): 2428.

https://doi.org/10.1182/blood.V114.22.2428.2428

Published: 2009

Journal Articles

Spontaneously Arising Red Cells with a McLeod-Like Phenotype in Normal Donors

David J. Araten, MD, Katie J Sanders, Jeffrey Pu, Soohee Lee

Blood (2008) 112 (11): 2883.

https://doi.org/10.1182/blood.V112.11.2883.2883

Published: 2008

Journal Articles

Clonally-Restricted T-Lymphocytes in PigA Mutant Mice.

Valeria Visconte, PhD, Nalini Raghavachari, PhD, Keyvan Keyvanfar, Delong Liu, PhD, Marie Desierto, Jichun Chen, PhD, Neal S. Young, MD

Blood (2008) 112 (11): 2040.

https://doi.org/10.1182/blood.V112.11.2040.2040

Published: 2008

NARROW

PIG-a Gene Expression Deficiency Association with Reduced DNA Damage Checkpoint Response and Activation

Paroxysmal Nocturnal Hemoglobinuria Results from Initial Clonal PIG-a Mosaicism

Elucidation of Autoinflammatory Mechanism in Pigt-PNH

Clonal Events of Aplastic Anemia Related to the Evolution to Myelodysplastic Syndrome

Progress Towards Creation of a Rhesus Macaque Animal Model for PNH Disease Via Crispr/Cas9 Technology to Knock out the PIG-a Gene

Inherited GPI-Anchor Deficiencies Caused By The Hypomorphic Mutations In PIG A gene: Comparison To Paroxysmal Nocturnal Hemogrobinuria

Leukemic Blasts With The PNH Phenotype: Correlation With Cytogenetics In ALL

The Presence Of Leukemogenic Mutational Events In Paroxysmal Nocturnal Hemoglobinuria Suggests That Clonal Architecture Of Bone Marrow Failure Is Similar To Myelodysplastic Syndrome

Autoreactive T Cells From Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Specifically Recognize Glycosyl- Phosphatidyl-Inositol (GPI)

Identification of Ex Vivo Myeloma Cells with the PNH Phenotype

A Role for TET2 Mutations in Paroxysmal Nocturnal Hemoglobinuria (PNH)

Generation of GPI Anchor Deficient Blood Cells From Human iPSCs.

Karyotypic and Genetic Abnormalities Associated with Clonal Evolution in Paroxysmal Nocturnal Hemoglobinuria.

The Somatic Mutation of PIG-A Gene and the Expressions of EGR-1 and WT1 Genes in Bone Marrow Cells of the Patients with Paroxysmal Nocturnal Hemoglobinuria

Quantitative Analysis of the Effects of MYC Overexpression on the Mutation Rate in Human Cells Using the PIG-A Gene

Reduction of Tregs with Expansion of Th1 Cells and Lack of IFN-γ Secretion by GPI Negative T-Cells In PNH

A High Frequency of Blasts with the PNH Phenotype in Patients with ALL.

Reduced Hematopoietic Stem Cell Function in a Mouse Model with Conditional Pig-a Gene Deletion.

Spontaneously Arising Red Cells with a McLeod-Like Phenotype in Normal Donors

Clonally-Restricted T-Lymphocytes in PigA Mutant Mice.

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American Society of Hematology

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American Society of Hematology

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