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Journal Articles

CML: new tools to answer old questions

George Giotopoulos, Brian J. P. Huntly
Journal: Blood
Blood (2020) 135 (26): 2327–2328.
https://doi.org/10.1182/blood.2020005599
Published: 2020
Journal Articles

An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia

Tun Kiat Ko, Asif Javed, Kian Leong Lee, Thushangi N. Pathiraja, Xingliang Liu, Simeen Malik, Sheila Xinxuan Soh, Xiu Ting Heng, Naoto Takahashi, Joanna H. J. Tan, Ravi Bhatia, Alexis J. Khng, Wee-Joo Chng, Yee Yen Sia, David A. Fruman, King Pan Ng, Zhu En Chan, Kim Jiajing Xie, Qiangze Hoi, Cheryl Xueli Chan, Audrey S. M. Teo, Oscar Velazquez Camacho, Wee Yang Meah, Chiea Chuen Khor, Chin Thing J. Ong, Wei Jia W. Soon, Patrick Tan, Pauline C. Ng, Charles Chuah, Axel M. Hillmer, S. Tiong Ong
Journal: Blood
Blood (2020) 135 (26): 2337–2353.
https://doi.org/10.1182/blood.2020004834
Published: 2020
Includes: Supplemental data
Journal Articles

Impact of U2AF1 Mutations on Clinical Characteristics and RNA Splicing in Myelodysplastic Syndromes (MDS)

Bing Li, MD, Jinqin Liu, Tiejun Qin, Zefeng Xu, MD, Gang Huang, PhD, Zhijian Xiao, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2979.
https://doi.org/10.1182/blood-2019-126346
Published: 2019
Journal Articles

Variant Pcgf-PRC1 Regulates Susceptibility of PRC2 Mediated H3K27me3 to Safeguard B Cell Fate of Hematopoietic Stem/Progenitor Cells

Junichiro Takano, MD, Yaeko Nakajima-Takagi, PhD, Shinsuke Ito, PhD, Haruhiko Koseki, MD PhD, Atsushi Iwama, MD PhD, Tomokatsu Ikawa, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3717.
https://doi.org/10.1182/blood-2019-129518
Published: 2019
Journal Articles

Synthetic Lethality-Based Approach Identified EED and BRD4 As Critical Survival Factorsin Acte Myeloid Leukemia with Monosomy 7

Kensuke Matsuda, MD, Yuki Kagoya, MD PhD, Sho Yamazaki, MD PhD, Masashi Miyauchi, MD PhD, Mineo Kurokawa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1233.
https://doi.org/10.1182/blood-2019-123595
Published: 2019
Journal Articles

Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome

Shiro Tara, Yusuke Isshiki, Yaeko Nakajima-Takagi, Motohiko Oshima, Kazumasa Aoyama, Tomoyuki Tanaka, Daisuke Shinoda, Shuhei Koide, Atsunori Saraya, Satoru Miyagi, Ichiro Manabe, Hirotaka Matsui, Haruhiko Koseki, Vivian J. Bardwell, Atsushi Iwama
Journal: Blood
Blood (2018) 132 (23): 2470–2483.
https://doi.org/10.1182/blood-2018-01-827964
Published: 2018
Includes: Supplemental data
Journal Articles

LUC7L2 Is a Novel RNA-Splicing Regulatory Factor Mutated in Myelodysplastic Syndromes

Courtney Hershberger, BS, James Hiznay, Rosemary Dietrich, Xiaorong Gu, PhD, Cassandra M. Hirsch, Amy Graham, BS, MS, Bartlomiej P. Przychodzen, Valeria Visconte, PhD, Vera Adema, PhD, Yvonne Parker, Hetty E. Carraway, MD MBA, Tomas Radivoyevitch, PhD, Mikkael A. Sekeres, MD MS, Yogenthiran Saunthararajah, MD, Jaroslaw P. Maciejewski, Richard A Padgett
Journal: Blood
Blood (2018) 132 (Supplement 1): 3073.
https://doi.org/10.1182/blood-2018-99-112838
Published: 2018
Journal Articles

BCOR Regulates Cell Fate Transition, Myeloid Differentiation and Leukaemogenesis

Lev M Kats, PhD, Madison J Kelly, Gareth Gregory, MBBS, PhD FRACP, FRCPA, Ricky W Johnstone, PhD, Stephin J Vervoort, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3907.
https://doi.org/10.1182/blood-2018-99-117893
Published: 2018
Journal Articles

Dual Effects of BCOR-PRC1.1 Dependent Gene Regulation Mediate Cooperation of BCOR and TET2 Mutations in Myeloid Transformation

Eva Johanna Schaefer, MD, Iman Fares, PhD, Clifford Meyer, PhD, Paloma Cejas, PhD, Annie Apffel, BA, Monica Schenone, PhD, Henry W Long, PhD, R. Coleman Lindsley, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 651.
https://doi.org/10.1182/blood-2018-99-119519
Published: 2018
Journal Articles

Bcor Mutations Cooperate with Tet2 Deficiency to Promote RAS Transformation of Mouse Hematopoietic Progenitors

Iman Fares, PhD, Rahul S. Vedula, MD, Shabbir M. Vahanvaty, Christopher S Waters, Marlise R. Luskin, MD, Priti Kumari, M.S., Marie McConkey, PhD, Anne Charles, BS, Kevin Copson, MA, Gregory A. Abel, MDMPH, Richard M. Stone, MD, Benjamin L. Ebert, MDPhD, R. Coleman Lindsley, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 888.
https://doi.org/10.1182/blood-2018-99-120096
Published: 2018
Journal Articles

Role of KDM2B and Non-Canonical PRC1.1 As a Tumor Suppressor in T-ALL

Yusuke Isshiki, MD, Yaeko Nakajima-Takagi, PhD, Motohiko Oshima, PhD, Kazumasa Aoyama, PhD, Atsunori Saraya, Emiko Sakaida, MD PhD, Chiaki Nakaseko, MD PhD, Koutaro Yokote, MD PhD, Haruhiko Koseki, PhD, Atsushi Iwama, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2597.
https://doi.org/10.1182/blood-2018-99-117831
Published: 2018
Journal Articles

Direct Binding of BCOR, but Not CBX8, to MLL-AF9 Is Essential for MLL-AF9 Leukemia Via Regulation of the EYA1/SIX1 Gene Network

John H. Bushweller, PhD, Charles Schmidt, Nicholas Achille, Aravinda Kuntimaddi, Adam Boulton, Benjamin Leach, Shubin Zhang, Nancy J. Zeleznik-Le, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1316.
https://doi.org/10.1182/blood-2018-99-111388
Published: 2018
Journal Articles

Insufficiency of Non-Canonical PRC1 Complex Cooperates with an Activating JAK2 Mutation in the Pathogenesis of Myelofibrosis

Daisuke Shinoda, MD, Yaeko Nakajima-Takagi, PhD, Motohiko Oshima, PhD, Atsunori Saraya, Hironori Harada, MD PhD, Haruhiko Koseki, PhD, Kazuya Shimoda, MD PhD, Goro Sashida, MD PhD, Atsushi Iwama, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 100.
https://doi.org/10.1182/blood-2018-99-117741
Published: 2018
Journal Articles

Bmi-1 Regulates Ex Vivo Self-Renewal of Human Erythroblasts

Jayme L. Olsen, MS, Judith Aeschlimann, Connie M. Westhoff, PhD, James Palis, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 844.
https://doi.org/10.1182/blood-2018-99-118421
Published: 2018
Journal Articles

Genetic or Pharmacological Inhibition of the Polycomb Group Protein BMI1 Impairs Leukemic Transformation Mediated By the CALM-AF10 Fusion Oncoprotein

Karina O. Barbosa, BSc, Anwesha Ghosh, PhD, Anagha Deshpande, PhD, Sayantanee Dutta, PhD, Scott A. Armstrong, MD PhD, Stefan K. Bohlander, MD, Aniruddha J. Deshpande, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 762.
https://doi.org/10.1182/blood-2018-99-115552
Published: 2018
Journal Articles

Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells

Haruko Shima, Emi Takamatsu-Ichihara, Mika Shino, Kazutsune Yamagata, Takuo Katsumoto, Yukiko Aikawa, Shuhei Fujita, Haruhiko Koseki, Issay Kitabayashi
Journal: Blood
Blood (2018) 131 (16): 1833–1845.
https://doi.org/10.1182/blood-2017-05-787226
Published: 2018
Includes: Supplemental data
Journal Articles

Modeling ASXL1 Mutation Revealed Myelodysplasia Caused By Derepression of p16Ink4a through Aberrant PRC1-Mediated Histone Modification

Masahiro Uni, MD PhD, Yosuke Masamoto, MD PhD, Tomohiko Sato, MD PhD, Shunya Arai, MD PhD, Eiji Hara, PhD, Mineo Kurokawa, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 118.
https://doi.org/10.1182/blood.V130.Suppl_1.118.118
Published: 2017
Journal Articles

Novel Stem Cell-Targeted Therapy for Multiple Myeloma Based on Dual Inhibition of EZH1/2

Makoto Nakagawa, MD, Shuhei Fujita, MD BS, Daisuke Honma, PhD, Kazushi Araki, D.V.M., PhD, Tatsuya Inoue, Ayako Kato, Koichiro Inaki, PhD, Chisa Wada, Ono Yoshimasa, Yasuharu Nakashima, MDPhD, Issay Kitabayashi, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 590.
https://doi.org/10.1182/blood.V130.Suppl_1.590.590
Published: 2017
Journal Articles

EZH1/2, SWI/SNF, and MLL2 Dependent Heterochromatin Formation and Abnormal Transcriptome in Hematological Malignancies

Makoto Yamagishi, PhD, Dai Fujikawa, PhD, Makoto Hori, Daisuke Honma, PhD, Nobuaki Adachi, PhD, Seiichiro Kobayashi, MD, PhD, Masako Iwanaga, MD PhD MPH, Atae Utsunomiya, MD, Seiji Okada, MD, PhD, Kunihiro Tsukasaki, MD PhD, Kensei Tobinai, MD PhD, Kazushi Araki, D.V.M., PhD, Toshiki Watanabe, MD, PhD, Kaoru Uchimaru, MD, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1200.
https://doi.org/10.1182/blood.V130.Suppl_1.1200.1200
Published: 2017
Journal Articles

CBFβ-SMMHC Inhibition Disrupts Enhancer Chromatin Dynamics and Represses MYC Transcriptional Program in Inv(16) Leukemia

John Anto Pulikkan, PhD, Mahesh Hegde, Houda Belaghzal, Anuradha Illendula, Jun Yu, Hafiz Ahmed, Kelsey O'Hagen, Jianhong Ou, Carsten Müller-Tidow, Scot A. Wolfe, Julie Zhu, Job Dekker, John H. Bushweller, Lucio H. Castilla
Journal: Blood
Blood (2017) 130 (Supplement 1): 784.
https://doi.org/10.1182/blood.V130.Suppl_1.784.784
Published: 2017