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Journal Articles

Identification of Small Molecule Kinase Inhibitors That Potently and Reversibly Block Chimeric Antigen Receptor T Cell Proliferation and Cytotoxicity

Parmeshwar Amatya, PhD, Matthew L. Cooper, PhD, Alun J Carter, PhD BSc, John F. DiPersio, MD PhD

Blood (2019) 134 (Supplement_1): 2068.

https://doi.org/10.1182/blood-2019-126165

Published: 2019

Journal Articles

Identification of a New Targeted Therapy for T-Cell Acute Lymphoblastic Leukemia and Studies on Its Mechanism of Action

Kinjal Shah, MS, Julhash U. Kazi, PhD

Blood (2019) 134 (Supplement_1): 2752.

https://doi.org/10.1182/blood-2019-129823

Published: 2019

Journal Articles

Phospho-Proteomic Profiling of T-Cell Acute Lymphoblastic Leukemia Identifies Specific Kinase Activation Signatures That Can Predict Response to Targeted Therapy

Valentina Cordo', MSc, Rico Hagelaar, Sander Piersma, Thang V Pham, Connie Jimenez, PhD, Jules P.P. Meijerink, PhD

Blood (2019) 134 (Supplement_1): 4649.

https://doi.org/10.1182/blood-2019-122898

Published: 2019

Journal Articles

A CK1δ/CK1ε Regulated Metabolic Circuit Is a Therapeutic Vulnerability for Multiple Myeloma

Karen L Burger, PhD, Mark B. Meads, PhD, Anders Berglund, Paula S. Oliveira, Allison Distler, Praneeth Reddy Sudalagunta, PhD, Timothy Jacobson, Jamie Teer, PhD, Eric A. Welsh, PhD, Hongyue Dai, PhD, John M. Koomen, PhD, Alugubelli Raghunandan Reddy, Gabriel De Avila, Alexandre Tungesvik, MD, William Roush, PhD, Ariosto Siqueira Silva, PhD, Kenneth H. Shain, MD PhD, John Cleveland, PhD

Blood (2019) 134 (Supplement_1): 5537.

https://doi.org/10.1182/blood-2019-130830

Published: 2019

Journal Articles

Polycomb Group Proteins Recruit TET1 to Remove Aberrant DNA Methylation in Murine Embryonic Stem Cells

Yong Lei, PhD, Margaret A. Goodell, PhD

Blood (2018) 132 (Supplement 1): 2571.

https://doi.org/10.1182/blood-2018-99-116841

Published: 2018

Journal Articles

Identification of Target Pathways of Acquired IMiD and Proteasome Inhibitor Resistance in Multiple Myeloma

Mark B. Meads, PhD, Paula Oliveira, Bin Fang, Praneeth Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Tuan Nguyen, Allison Distler, Salah-Eddin Komrokji, Aunshka Collins, Hongyue Dai, PhD, John M. Koomen, Ariosto Siqueira Silva, PhD, Kenneth H Shain, MD PhD

Blood (2017) 130 (Supplement 1): 4411.

https://doi.org/10.1182/blood.V130.Suppl_1.4411.4411

Published: 2017

Journal Articles

Targeting the Transcriptional Addiction of Leukemia Stem Cells By a New Class of Protein Kinase Inhibitors

Yinon Ben-Neriah, MD PhD, Avanthika Venkatachalam, MSc, Avner Fink, PhD, Eric Hung, MSc, Joseph Vacca, PhD, Frank Mercurio, PhD, Moshe Oren, PhD, Eli Pikarsky, MDPhD, Irit Snir-Alkalay, PhD, Waleed Minzel, MSc

Blood (2017) 130 (Supplement 1): 812.

https://doi.org/10.1182/blood.V130.Suppl_1.812.812

Published: 2017

Journal Articles

A CK1δ/CK1ε-to-β-Catenin Circuit Is a Therapeutic Vulnerability for Primary and Drug Resistant Multiple Myeloma

Karen L Burger, PhD, Mark B. Meads, PhD, Ariosto Siqueira Silva, PhD, Paula Oliveira, Tuan Nguyen, Allison Distler, Maria Coelho Siqueira Silva, Timothy Jacobson, Jamie Teer, PhD, Hongyue Dai, PhD, William Roush, PhD, John Cleveland, PhD, Kenneth H Shain, MD PhD

Blood (2017) 130 (Supplement 1): 591.

https://doi.org/10.1182/blood.V130.Suppl_1.591.591

Published: 2017

Journal Articles

Comparison of the Profile of the AML Drug Midostaurin (Rydapt®) As a Kinase Inhibitor with Those of Its Predominant Primary Human Metabolites

Paul W Manley, Giorgio Caravatti, Pascal Furet, Johannes Roesel, Phi Tran, Trixie Wagner

Blood (2017) 130 (Supplement 1): 1383.

https://doi.org/10.1182/blood.V130.Suppl_1.1383.1383

Published: 2017

Journal Articles

Enhancing Functional Platelet Release In Vivo from in Vitro-Grown Megakaryocytes Using the Protein Kinase Inhibitor SU6656

Danuta Jadwiga Jarocha, PhD, Karen K Vo, BS, Randolph B Lyde, Jr., BS, Vincent M Hayes, BS, Mortimer Poncz

Blood (2016) 128 (22): 1029.

https://doi.org/10.1182/blood.V128.22.1029.1029

Published: 2016

Journal Articles

Identification of Target Pathways Induced By the Multiple Myeloma Tumor Microenvironment Using Activity-Based Protein Profiling and Ex Vivo Protein Kinase Inhibitor Screening

Mark B Meads, PhD, Paula Oliveira, BS, Allison Distler, B.S., Maria Silva, M.Sc, Karen Burger, PhD, Bin Fang, PhD, Aunshka Collins, BS, John L. Cleveland, PhD, John M. Koomen, PhD, Ariosto Silva, PhD, Dmitri Rebatchouk, PhD, Kenneth H. Shain, MD PhD, William R. Roush, PhD

Blood (2016) 128 (22): 3288.

https://doi.org/10.1182/blood.V128.22.3288.3288

Published: 2016

Journal Articles

Protein Kinase C-ß Dependent IL-8 Release Promotes Acute Myeloid Leukemia Blast Cell Survival in Co-Cultures with Bone Marrow Stromal Cells

Amina M Abdul-Aziz, MSc., Manar S Shafat, MSc, Matthew J Lawes, MD, Kristian M Bowles, MB BS, PhD, Stuart A Rushworth, PhDBSc

Blood (2015) 126 (23): 3064.

https://doi.org/10.1182/blood.V126.23.3064.3064

Published: 2015

Journal Articles

A Multidisciplinary Model Predicts Clinical Response in Relapsed Multiple Myeloma

Kenneth H. Shain, MD PhD, Ariosto Silva, PhD, Mark B Meads, PhD, Allison Distler, B.S., Timothy Jacobson, B.S., Robert Gatenby, MD, PhD, Rachid Baz, Maria Silva, M.Sc, Dmitri Rebatchouk, PhD, Chris Cubitt, PhD

Blood (2015) 126 (23): 501.

https://doi.org/10.1182/blood.V126.23.501.501

Published: 2015

Journal Articles

CD97 Expression in Acute Myeloid Leukemia Is Associated with FLT3-ITD Mutation Status

Manja Wobus, PhD, Martin Bornhäuser, MD, Claudia Ortlepp, PhD, Angela Jacobi, PhD, Gerhard Ehninger, MD, Christian Thiede, MD, Uta Oelschlägel, PhD

Blood (2014) 124 (21): 1001.

https://doi.org/10.1182/blood.V124.21.1001.1001

Published: 2014

Journal Articles

Growth Inhibitory Function Of a Novel T-LAK Cell-Originated Protein Kinase Inhibitor On FLT3-ITD Positive Acute Myeloid Leukemia (AML) Cells

Houda Alachkar, PharmD, PhD, Jae-Hyun Park, PhD, Makoto Nakakido, PhD, Alex Wood, Gordana Raca, MD, PhD, Yo Matsuo, Wendy Stock, MD, Yusuke Nakamura, MD, PhD

Blood (2013) 122 (21): 1459.

https://doi.org/10.1182/blood.V122.21.1459.1459

Published: 2013

Journal Articles

STAT5 and NF-κB Induced Oncogenic Mir-155 Directly Targets PU.1 in FLT3-ITD Associated AML

Dennis Gerloff, Rebekka Grundler, Daniela Braeuer-Hartmann, Christiane Katzerke, Jens-Uwe Hartmann, Carsten Mueller-Tidow, MD, Justus Duyster, MD, Daniel G. Tenen, MD, Dietger Niederwieser, Gerhard Behre, MD

Blood (2012) 120 (21): 3515.

https://doi.org/10.1182/blood.V120.21.3515.3515

Published: 2012

Journal Articles

FLT3-ITD Signaling Induces Oncogenic Mir-155 by NF-κB and STAT5 Pathways In Acute Myeloid Leukemia Thereby Targeting Transcription Factor PU.1,

Dennis Gerloff, Daniela Braeuer-Hartmann, Christiane Katzerke, Jens-Uwe Hartmann, Carsten Mueller-Tidow, MD, Daniel G. Tenen, Dietger Niederwieser, MD, Gerhard Behre, MD

Blood (2011) 118 (21): 3469.

https://doi.org/10.1182/blood.V118.21.3469.3469

Published: 2011

Journal Articles

Cyclic-AMP Responsive Element Binding Protein 1 (CREB) As a New Potential Druggable Target in Pediatric Acute Lymphoblastic Leukemia

Naomi E van der Sligte, Arja ter Elst, PhD, Kim R Kampen, Frank JG Scherpen, Hendrik Mulder, Sander H Diks, PhD, Frank N. van Leeuwen, PhD, Evelina S. De Bont, MD, PhD

Blood (2011) 118 (21): 1368.

https://doi.org/10.1182/blood.V118.21.1368.1368

Published: 2011

Journal Articles

Shiga toxin (Stx)1B and Stx2B induce von Willebrand factor secretion from human umbilical vein endothelial cells through different signaling pathways

Fang Liu, Jing Huang, J. Evan Sadler

Blood (2011) 118 (12): 3392–3398.

https://doi.org/10.1182/blood-2011-06-363648

Published: 2011

Journal Articles

Protein Kinase Inhibitor Dasatinib Potently Suppresses Immunostimulatory Activity of Human Plasmacytoid Dendritic Cells

Haruyuki Fujita, MD, Toshio Kitawaki, MD, PhD, Takashi Uchiyama, MD, PhD, Akifumi Takaori-Kondo, MD, PhD, Norimitsu Kadowaki, MD, PhD

Blood (2010) 116 (21): 3896.

https://doi.org/10.1182/blood.V116.21.3896.3896

Published: 2010

NARROW

Identification of Small Molecule Kinase Inhibitors That Potently and Reversibly Block Chimeric Antigen Receptor T Cell Proliferation and Cytotoxicity

Identification of a New Targeted Therapy for T-Cell Acute Lymphoblastic Leukemia and Studies on Its Mechanism of Action

Phospho-Proteomic Profiling of T-Cell Acute Lymphoblastic Leukemia Identifies Specific Kinase Activation Signatures That Can Predict Response to Targeted Therapy

A CK1δ/CK1ε Regulated Metabolic Circuit Is a Therapeutic Vulnerability for Multiple Myeloma

Polycomb Group Proteins Recruit TET1 to Remove Aberrant DNA Methylation in Murine Embryonic Stem Cells

Identification of Target Pathways of Acquired IMiD and Proteasome Inhibitor Resistance in Multiple Myeloma

Targeting the Transcriptional Addiction of Leukemia Stem Cells By a New Class of Protein Kinase Inhibitors

A CK1δ/CK1ε-to-β-Catenin Circuit Is a Therapeutic Vulnerability for Primary and Drug Resistant Multiple Myeloma

Comparison of the Profile of the AML Drug Midostaurin (Rydapt®) As a Kinase Inhibitor with Those of Its Predominant Primary Human Metabolites

Enhancing Functional Platelet Release In Vivo from in Vitro-Grown Megakaryocytes Using the Protein Kinase Inhibitor SU6656

Identification of Target Pathways Induced By the Multiple Myeloma Tumor Microenvironment Using Activity-Based Protein Profiling and Ex Vivo Protein Kinase Inhibitor Screening

Protein Kinase C-ß Dependent IL-8 Release Promotes Acute Myeloid Leukemia Blast Cell Survival in Co-Cultures with Bone Marrow Stromal Cells

A Multidisciplinary Model Predicts Clinical Response in Relapsed Multiple Myeloma

CD97 Expression in Acute Myeloid Leukemia Is Associated with FLT3-ITD Mutation Status

Growth Inhibitory Function Of a Novel T-LAK Cell-Originated Protein Kinase Inhibitor On FLT3-ITD Positive Acute Myeloid Leukemia (AML) Cells

STAT5 and NF-κB Induced Oncogenic Mir-155 Directly Targets PU.1 in FLT3-ITD Associated AML

FLT3-ITD Signaling Induces Oncogenic Mir-155 by NF-κB and STAT5 Pathways In Acute Myeloid Leukemia Thereby Targeting Transcription Factor PU.1,

Cyclic-AMP Responsive Element Binding Protein 1 (CREB) As a New Potential Druggable Target in Pediatric Acute Lymphoblastic Leukemia

Shiga toxin (Stx)1B and Stx2B induce von Willebrand factor secretion from human umbilical vein endothelial cells through different signaling pathways

Protein Kinase Inhibitor Dasatinib Potently Suppresses Immunostimulatory Activity of Human Plasmacytoid Dendritic Cells

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American Society of Hematology

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ASH Publications

American Society of Hematology

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