1-20 of 45
protein-arginine n-methyltransferase
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

PRMT5 Inhibition Modulates E2F1 Methylation and Gene Regulatory Networks Leading to Therapeutic Efficacy in JAK2VF Mutant MPN

Friederike Pastore, MD, Neha Bhagwat, PhDBS, Aishwarya Krishnan, Alessandro Pastore, Bing Li, MD, Robert L Bowman, PhD, Wenbin Xiao, MD PhD, Aaron D Viny, MDMS, Abdul Karzai, Anouar Zouak, Young C Park, Keith Cordner, Stephanie Braunstein, Alexander Grego, Jaanvi Mehta, Benjamin H Durham, MD, Richard P. Koche, PhD, Jesper Maag, Peggy Scherle, PhD, Kris Vaddi, PhD, Ross L. Levine, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 473.
https://doi.org/10.1182/blood-2019-127122
Published: 2019
Journal Articles

Protein Arginine Methyltransferase 1 (PRMT1) Dampens Self-Renewal and Promotes Differentiation of Hematopoietic Stem Cells in Mouse Models

Hairui Su, PhD, Szu-Mam Liu, PhD, Chiao-Wang Sun, PhD, Mark T. Bedford, PhD, Xinyang Zhao, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2460.
https://doi.org/10.1182/blood-2019-127226
Published: 2019
Journal Articles

PRMT5 Inhibition Drives Therapeutic Vulnerability to BCL-2 Inhibition with Venetoclax and Provides Rationale for Combination Therapy in Mantle Cell Lymphoma

Fiona Brown, BS, Yang Zhang, PhD, Claire Hinterschied, Alexander Prouty, BS, Shelby Sloan, BS, JoBeth Helmig-Mason, Msc, Ji Hyun Chung, PhD, Kris Vaddi, PhD, Selina Chen-Kiang, PhD, Maurizio Di Liberto, PhD, Lapo Alinari, MD PhD, Peggy Scherle, PhD, Rosa Lapalombella, PhD, Jihye Paik, PhD, Robert A Baiocchi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 302.
https://doi.org/10.1182/blood-2019-130797
Published: 2019
Journal Articles

Genetically Defined Metabolic Targets Overcome Ibrutinib Resistance in Mantle Cell Lymphoma

Liang Zhang, MD PhD, Hui Guo, PhD, Hui Zhang, Yixin Yao, PhD, Yang Liu, MD, Shaojun Zhang, PhD, Lixin Rui, PhD, Linghua Wang, PhD, Krystle Nomie, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 395.
https://doi.org/10.1182/blood-2019-125934
Published: 2019
Journal Articles

Protein Arginine Methyltransferase 1 Is Required for Maintenance of Normal Adult Hematopoiesis

Lei Zhu, MD, Xin He, PhD, Haojie Dong, PhD, Jie Sun, PhD, Hanying Wang, PhD, Yinghui Zhu, PhD, Feiteng Huang, Jingying Zou, Xiaoying Zhao, MD, Ling Li, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3708.
https://doi.org/10.1182/blood-2019-126050
Published: 2019
Journal Articles

Targeting PRMT5 to Circumvent Acquired Ibrutinib Resistance in Mantle Cell Lymphoma

Shelby Sloan, BS, Fiona Brown, BS, JI Hyun Chung, PhD, Alexander Prouty, BS, Esther Wheeler, BS, Bonnie K Harrington, DVM, PhD, Eric Brooks, BS, Ayse S Yilmaz, MS, Hatice G Ozer, PhD, John C. Byrd, MD, Selina Chen-Kiang, PhD, Maurizio Di Liberto, PhD, Rosa Lapalombella, PhD, Kris Vaddi, PhD, Peggy Scherle, PhD, Youssef Youssef, MD, Robert A Baiocchi, MD PhD, Lapo Alinari, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4065.
https://doi.org/10.1182/blood-2019-128998
Published: 2019
Journal Articles

C-Myc-Driven and PRMT5-Dependent Regulation of Multiple Myeloma Cell Proliferation through TNRC6B Gene

Peipei Xu, Guo Dan, Bing Chen, PhD, Quan Zhao, Rong-Fu Zhou, Prof., Jian Ouyang
Journal: Blood
Blood (2019) 134 (Supplement_1): 5520.
https://doi.org/10.1182/blood-2019-125027
Published: 2019
Journal Articles

PRMT5 Is a Key Epigenetic Regulator That Promotes Transcriptional Activation in Mantle Cell Lymphoma By Regulating the Lysine Methyltransferase SETD7 and MLL1 Activity

JI Hyun Chung, PhD, Shelby Sloan, BS, Peggy Scherle, PhD, Kris Vaddi, PhD, Said Sif, PhD, Rosa Lapalombella, PhD, Robert A Baiocchi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2777.
https://doi.org/10.1182/blood-2019-131020
Published: 2019
Journal Articles

A Phase I/II Study to Investigate the Safety and Clinical Activity of the Protein Arginine Methyltransferase 5 Inhibitor GSK3326595 in Subjects with Myelodysplastic Syndrome and Acute Myeloid Leukemia

Justin M. Watts, MD, Terrence J Bradley, MD, Amber Thomassen, Andrew M. Brunner, MD, Mark D. Minden, MD PhD, Nikolaos Papadantonakis, MDPhDMSc, Sameem Abedin, MD, Amanda J Baines, Olena Barbash, PhD, Shelby Gorman, Brandon E Kremer, MD PhD, Gautam M. Borthakur, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2656.
https://doi.org/10.1182/blood-2019-130337
Published: 2019
Journal Articles

CARM1 Inhibition: Evaluation of Response and Efficacy in Acute Myeloid Leukemia

Adnan K Mookhtiar, BS, Sarah Greenblatt, PhD, Na Man, PhD, Daniel Karl, PhD, Vasileios Stathias, PhD, Stephan Schurer, PhD, Stephen D. Nimer, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2719.
https://doi.org/10.1182/blood-2018-99-114981
Published: 2018
Journal Articles

DNMT3A expression Analysis in AML

Yubin Xing, MD, Franziska Behrenbeck, Mirgul Bayanova, MD, Igor Blau, MD PhD, Lars Bullinger, MD, Olga Blau, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5276.
https://doi.org/10.1182/blood-2018-99-113626
Published: 2018
Journal Articles

Inhibition of DOT1L and PRMT5 Promotes Anti-Tumor Activity in a Human MLL Leukemia Model Induced By CRISPR/Cas9

Kathy-Ann Secker, MSc, Hildegard Keppeler, Silke Duerr-Stoerzer, Hannes Schmid, MSc, Dominik Schneidawind, MD, Thomas Hentrich, PhD, Julia Schulze-Hentrich, PhD, Barbara Mankel, Falko Fend, MD, Lothar Kanz, Corina Schneidawind, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5147.
https://doi.org/10.1182/blood-2018-99-115975
Published: 2018
Journal Articles

Exploring PRMT5 As a Potential Therapeutic Target in Canine Lymphomas

Kyle Renaldo, DVM, MS, Shelby Sloan, BS, JiHyun Chung, PhD, Lindsay Courtney, BS, Konstantin Shilo, MD, William Kisseberth, DVM, PhD, Robert A Baiocchi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4182.
https://doi.org/10.1182/blood-2018-99-119115
Published: 2018
Journal Articles

PRMT5 Is Upregulated in Activated T Cells and Is a Novel Therapeutic Target for Acute Gvhd

Parvathi Ranganathan, PhD, Katiri Snyder, Nina Zizter, Hannah K. Choe, MD, Robert A Baiocchi, MD PhD, Kris Vaddi, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2034.
https://doi.org/10.1182/blood-2018-99-114835
Published: 2018
Journal Articles

PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival

Xiaoqing Lu, Tharu M. Fernando, Chen Lossos, Nevin Yusufova, Fan Liu, Lorena Fontán, Matthew Durant, Huimin Geng, Jacob Melnick, Yuan Luo, Francisco Vega, Vincent Moy, Giorgio Inghirami, Stephen Nimer, Ari M. Melnick, Izidore S. Lossos
Journal: Blood
Blood (2018) 132 (19): 2026–2039.
https://doi.org/10.1182/blood-2018-02-831438
Published: 2018
Includes: Supplemental data
Journal Articles

Targeting PRMT1 As a Novel Curative Therapy for Acute Myeloid Leukemia

Hairui Su, BS, PhD, Shuiling Jin, PhD, Yudao Shen, Matthew A. Kutny, MD, Jian Jin, PhD, Minkui Luo, Xinyang Zhao, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2650.
https://doi.org/10.1182/blood.V130.Suppl_1.2650.2650
Published: 2017
Journal Articles

PRMT5 Initiates an Epigenetic Program That Promotes Progression of Chronic Lymphocytic Leukemia

Zachary A Hing, BS, Jordan N. Skinner, B.S., Larry P. Beaver, Tzung-Huei Lai, PhD, Casey B. Cempre, B.S., Bonnie K. Harrington, DVM, Deepa Sampath, PhD, Amy M. Lehman, PhD, Lianbo Yu, PhD, Lapo Alinari, MD PhD, John C. Byrd, MD, Robert A Baiocchi, MD PhD, Rosa Lapalombella, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2487.
https://doi.org/10.1182/blood.V130.Suppl_1.2487.2487
Published: 2017
Journal Articles

Genetic Ablation or Pharmacological Inhibition of PRMT5 Affects Maintenance of Genomic Integrity in Hematopoietic Stem Cells

Darren Qiancheng Tan, BS, Desmond Wai Loon Chin, PhD, Ying Li, Ayako Nakamura-Ishizu, MD PhD, Henry Yang, PhD, Toshio Suda, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 711.
https://doi.org/10.1182/blood.V130.Suppl_1.711.711
Published: 2017
Journal Articles

Arginine Methylation Mediated By PRMT5 Has Significant Biological and Clinical Impact in Multiple Myeloma

Annamaria Gulla, MD, Teru Hideshima, MD PhD, Giada Bianchi, MD, Mariateresa Fulciniti, PhD, Mehmet K. Samur, PhD, Yu-Tzu Tai, PhD, Jun Qi, PhD, Takeshi Harada, MD PhD, Eugenio Morelli, MD, Nicola Amodio, PhD, Ruben D. Carrasco, MD PhD, Pierosandro Tagliaferri, MD, Nikhil C. Munshi, MD, Pierfrancesco Tassone, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2016) 128 (22): 1140.
https://doi.org/10.1182/blood.V128.22.1140.1140
Published: 2016
Journal Articles

Protein Arginine Methyltransferase 5 Regulates WNT/β-Catenin Target Gene Expression in at Multiple Levels

Jihyun Chung, PhD, Vrajesh Karkhanis, PhD, Sif Said, PhD, Robert A Baiocchi, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4106.
https://doi.org/10.1182/blood.V128.22.4106.4106
Published: 2016