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Journal Articles

Pralatrexate-Resistant Cell Lines Show Intact Internalization Via RFC1 but Collateral Sensitivity to Nucleoside Analogs

Kana Oiwa, MD, Naoko Hosono, MD, Rie Nishi, PhD, Takanori Ueda, MD PhD, Luigi Scott, PhD, Owen A. O'Connor, MD, PhD, Takahiro Yamauchi, MD PhD

Blood (2018) 132 (Supplement 1): 3961.

https://doi.org/10.1182/blood-2018-99-110147

Published: 2018

Journal Articles

Expression Signature of Myeloma Residual Cells Is Characterized By Genes Associated with Proliferation, Epigenetic Modification, and Stem Cell Maintenance

Michael A Bauer, PhD, Matthew Henry, M.S., Purvi Patel, Yan Wang, Joshua Epstein, DSc, Faith E. Davies, MD, Carolina D. Schinke, MD, Maurizio Zangari, MD, Sharmilan Thanendrarajan, MD, Frits van Rhee, MD PhD, Gareth Morgan, MD, Brian A Walker, PhD, Sarah K Johnson, PhD

Blood (2018) 132 (Supplement 1): 4465.

https://doi.org/10.1182/blood-2018-99-119131

Published: 2018

Journal Articles

Homozygosity for the 2R Tandem Repeat Polymorphism in the Thymidylate Synthase (TS) Promoter Is Associated with Increased Risk for Bony Morbidity Among Children Treated for Acute Lymphoblastic Leukemia on DFCI Protocol 05-001

Peter D. Cole, MD, Traci M. Blonquist, MS, Veena Vijayanathan, PhD, Donna S. Neuberg, Sc.D., Lynda M. Vrooman, MD, Stephen E. Sallan, MD, Lewis B. Silverman, MD, Yaron Finkelstein, MD

Blood (2015) 126 (23): 251.

https://doi.org/10.1182/blood.V126.23.251.251

Published: 2015

Journal Articles

Polymorphisms in Genes Related to Oxidative Stress Are Associated with Inferior Cognitive Function after Therapy for Childhood ALL

Peter Cole, MD, Donna S. Neuberg, ScD, Lewis B. Silverman, MD, Kristen E. Stevenson, MS, Veena Vijayanathan, PhD, Yaron Finkelstein, MD, Stephen E. Sallan, Deborah Waber, PhD

Blood (2014) 124 (21): 856.

https://doi.org/10.1182/blood.V124.21.856.856

Published: 2014

Journal Articles

Genetic Polymorphisms In Candidate Genes Predict Increased Toxicity With Methotrexate Therapy In Children With Acute Lymphoblastic Leukemia In Lebanon

Nathalie K Zgheib, MD, Maya Akra-Ismail, Carol Aridi, MD, Rami Mahfouz, MD, MPH, Raya Saab, MD, Miguel R. Abboud, MD, MHA, Hassan Solh, MD, Samar A. Muwakkit, MD

Blood (2013) 122 (21): 4926.

https://doi.org/10.1182/blood.V122.21.4926.4926

Published: 2013

Journal Articles

The Poison Oligonucleotide F10 Is Efficiently Taken Up By, and Highly Effective Against, Acute Lymphoblastic Leukemia While Sparing Normal Hematopoietic Cells

Timothy Pardee, MD, PhD, Jamie Jennings-Gee, PhD, Kristin Stadelman, MS, David L. Caudell, DVM, PhD, William Gmeiner, PhD

Blood (2013) 122 (21): 2674.

https://doi.org/10.1182/blood.V122.21.2674.2674

Published: 2013

Journal Articles

Lineage- and Developmental Stage-Specific Patterns Of Auf-1 Isoform Expression Contribute To The Regulation Of Erythroid-Specific mRNAs

Sebastiaan Van Zalen, PhD, Grace R Jeschke, Elizabeth Hexner, MD, J. Eric Russell, MD

Blood (2013) 122 (21): 10.

https://doi.org/10.1182/blood.V122.21.10.10

Published: 2013

Journal Articles

Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemia

Susanne Radtke, Oliver Zolk, Bertold Renner, Marios Paulides, Martin Zimmermann, Anja Möricke, Martin Stanulla, Martin Schrappe, Thorsten Langer

Blood (2013) 121 (26): 5145–5153.

https://doi.org/10.1182/blood-2013-01-480335

Published: 2013

Includes: Supplemental data

Journal Articles

Characterization of the Two Populations of NK-Like CD56 + T Cells and KIR + T Cells in Human

Wing Keung Chan, PhD, Piya Rujkijyanont, MD, Geoffrey A. Neale, PhD, Jie Yang, PhD, Rafijul Bari, PhD, Neha Das Gupta, MS, Martha Holladay, BSc, Barbara Rooney, MS, Susanne Wendt, MD, Wing Leung, MD, PhD

Blood (2012) 120 (21): 3292.

https://doi.org/10.1182/blood.V120.21.3292.3292

Published: 2012

Journal Articles

Thymidylate Synthase Inhibition with the Novel Fluoropyrimidine FdUMP[10] Is Highly Effective Against Acute Lymphoblastic Leukemia

Timothy Pardee, MD, PhD, Jamie Jennings-Gee, PhD, Peter Alexander, BA, William Gmeiner, PhD

Blood (2012) 120 (21): 1505.

https://doi.org/10.1182/blood.V120.21.1505.1505

Published: 2012

Journal Articles

Impact of Single Nucleotide Polymorphisms in Genes Involved in DNA Repair and Drug Metabolism On Survival After Autologous Stem Cell Transplantation in Patients with Multiple Myeloma.

Carlos Fernández de Larrea, Alfons Navarro, PhD, Natalia Tovar, Fabiola Pedrosa, Tania Díaz, PhD, María Teresa Cibeira, Laura Magnano, Laura Rosiñol, MD, Montserrat Rovira, María Rozman, Mariano Monzó, MD, PhD, Joan Blade, MD

Blood (2012) 120 (21): 2934.

https://doi.org/10.1182/blood.V120.21.2934.2934

Published: 2012

Journal Articles

Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity

Timothy S. Pardee, Evan Gomes, Jamie Jennings-Gee, David Caudell, William H. Gmeiner

Blood (2012) 119 (15): 3561–3570.

https://doi.org/10.1182/blood-2011-06-362442

Published: 2012

Includes: Supplemental data

Journal Articles

Host Pharmacogenetic Factors Significantly Contribute to Refinement of Prognosis in Children with Acute Lymphoblastic Leukemia (ALL): Result From the Malaysia-Singapore (Ma-Spore) ALL 2003 Study

Yi Lu, Ph.D., Shirley Kow Yin Kham, B.Sc., Arrifin Hany, M.D., Ah Moy Tan, M.D., Thuan Chong Quah, M.D., Allen Eng Juh Yeoh, M.D.

Blood (2011) 118 (21): 567.

https://doi.org/10.1182/blood.V118.21.567.567

Published: 2011

Journal Articles

Unique Dual Targeting of Thymidylate Synthase and Topoisomerase1 by FdUMP[10] Results in High Efficacy Against AML and Low Toxicity

Timothy Pardee, MD, PhD, Evan Gomes, PhD, Jamie Jennings-Gee, PhD, David L. Caudell, DVM, PhD, William Gmeiner, PhD

Blood (2011) 118 (21): 2584.

https://doi.org/10.1182/blood.V118.21.2584.2584

Published: 2011

Journal Articles

The Novel Fluoropyrimidine FdUMP[10] Is Highly Active Against Acute Myeloid Leukemia

Timothy Pardee, MD, PhD, Evan Gomes, PhD, Jamie Jennings-Gee, PhD, David L. Caudell, DVM, PhD, William Gmeiner, PhD

Blood (2010) 116 (21): 3302.

https://doi.org/10.1182/blood.V116.21.3302.3302

Published: 2010

Journal Articles

Effect of Genetic Polymorphisms Related to Folate and Homocysteine Metabolism In the Etiology of Recurrent Miscarriages

Elvira Maria Guerra-Shinohara, PhD, Kelma Cordeiro da Silva Giusti, Nathalia Sierra Monteiro, Robson José Lazaro, Fernanda Midori Seino, Carolina Tosin Bueno, Mário Henrique Burlacchini Carvalho, MD, PhD, Antônio Amorim Filho, MD, Carlos Chiattone, MD, PhD, Marcelo Zugaib, MD, PhD

Blood (2010) 116 (21): 5136.

https://doi.org/10.1182/blood.V116.21.5136.5136

Published: 2010

Journal Articles

Thymidylate Synthase (TS) Expression In Diffuse Large B-Cell Lymphoma (DLBCL): Identification of a Potential Therapeutic Target

Emilian Racila, Sergei I Syrbu, MD, Michel Nasr, MD, Malik E. Juweid, MD

Blood (2010) 116 (21): 5107.

https://doi.org/10.1182/blood.V116.21.5107.5107

Published: 2010

Journal Articles

Vorinostat Reverses Relapse-Specific Drug Resistance Gene Expression Signatures In Childhood Acute Lymphoblastic Leukemia (ALL).

Teena Bhatla, MD, Jinhua Wang, PhD, Debra J. Morrison, PhD, Wafik T. Zaky, MD, Elizabeth A. Raetz, MD, William L. Carroll, MD

Blood (2010) 116 (21): 3630.

https://doi.org/10.1182/blood.V116.21.3630.3630

Published: 2010

Journal Articles

Up-Regulation of Genes Involved in Folate Metabolism Characterize Late but Not Early Relapse in Childhood Acute Lymphoblastic Leukemia.

Laura Hogan, MD, Deepa Bhojwani, MD, Jinhua Wang, PhD, Debra Morrison, PhD, Jun J Yang, PhD, Yutong Zhang, Jiri Zavadil, PhD, Gregory Condos, Stephen P Hunger, MD, Cheryl L. Willman, MD, Mary V. Relling, PharmD, Elizabeth Raetz, MD, William L. Carroll, MD

Blood (2009) 114 (22): 1733.

https://doi.org/10.1182/blood.V114.22.1733.1733

Published: 2009

Journal Articles

Integrated Molecular and Pharmacogenetic Profiles in Prediction of Early Response to Therapy in Children with Acute Lymphoblastic Leukemia (ALL): A Report From Malaysia-Singapore ALL Study Group.

Yi Lu, Ph.D., Shirley Kow Yin Kham, B.Sc., Hany Ariffin, M.D., Ah Moy Tan, M.D., Hai Peng Lin, M.D., Thuan Chong Quah, M.D., Allen Eng Juh Yeoh, M.D.

Blood (2009) 114 (22): 2624.

https://doi.org/10.1182/blood.V114.22.2624.2624

Published: 2009

NARROW

Pralatrexate-Resistant Cell Lines Show Intact Internalization Via RFC1 but Collateral Sensitivity to Nucleoside Analogs

Expression Signature of Myeloma Residual Cells Is Characterized By Genes Associated with Proliferation, Epigenetic Modification, and Stem Cell Maintenance

Homozygosity for the 2R Tandem Repeat Polymorphism in the Thymidylate Synthase (TS) Promoter Is Associated with Increased Risk for Bony Morbidity Among Children Treated for Acute Lymphoblastic Leukemia on DFCI Protocol 05-001

Polymorphisms in Genes Related to Oxidative Stress Are Associated with Inferior Cognitive Function after Therapy for Childhood ALL

Genetic Polymorphisms In Candidate Genes Predict Increased Toxicity With Methotrexate Therapy In Children With Acute Lymphoblastic Leukemia In Lebanon

The Poison Oligonucleotide F10 Is Efficiently Taken Up By, and Highly Effective Against, Acute Lymphoblastic Leukemia While Sparing Normal Hematopoietic Cells

Lineage- and Developmental Stage-Specific Patterns Of Auf-1 Isoform Expression Contribute To The Regulation Of Erythroid-Specific mRNAs

Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemia

Characterization of the Two Populations of NK-Like CD56 + T Cells and KIR + T Cells in Human

Thymidylate Synthase Inhibition with the Novel Fluoropyrimidine FdUMP[10] Is Highly Effective Against Acute Lymphoblastic Leukemia

Impact of Single Nucleotide Polymorphisms in Genes Involved in DNA Repair and Drug Metabolism On Survival After Autologous Stem Cell Transplantation in Patients with Multiple Myeloma.

Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity

Host Pharmacogenetic Factors Significantly Contribute to Refinement of Prognosis in Children with Acute Lymphoblastic Leukemia (ALL): Result From the Malaysia-Singapore (Ma-Spore) ALL 2003 Study

Unique Dual Targeting of Thymidylate Synthase and Topoisomerase1 by FdUMP[10] Results in High Efficacy Against AML and Low Toxicity

The Novel Fluoropyrimidine FdUMP[10] Is Highly Active Against Acute Myeloid Leukemia

Effect of Genetic Polymorphisms Related to Folate and Homocysteine Metabolism In the Etiology of Recurrent Miscarriages

Thymidylate Synthase (TS) Expression In Diffuse Large B-Cell Lymphoma (DLBCL): Identification of a Potential Therapeutic Target

Vorinostat Reverses Relapse-Specific Drug Resistance Gene Expression Signatures In Childhood Acute Lymphoblastic Leukemia (ALL).

Up-Regulation of Genes Involved in Folate Metabolism Characterize Late but Not Early Relapse in Childhood Acute Lymphoblastic Leukemia.

Integrated Molecular and Pharmacogenetic Profiles in Prediction of Early Response to Therapy in Children with Acute Lymphoblastic Leukemia (ALL): A Report From Malaysia-Singapore ALL Study Group.

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American Society of Hematology

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American Society of Hematology

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