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Journal Articles

Loss of a 7q gene, CUX1 , disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms

Molly K. Imgruet, Julian Lutze, Ningfei An, Bonnie Hu, Saira Khan, Jeffrey Kurkewich, Tanner C. Martinez, Donald Wolfgeher, Sandeep K. Gurbuxani, Stephen J. Kron, Megan E. McNerney

Blood (2021) 138 (9): 790–805.

https://doi.org/10.1182/blood.2020009195

Published: 2021

Includes: Supplemental data

Journal Articles

Enhanced homology-directed repair for highly efficient gene editing in hematopoietic stem/progenitor cells

Blood (2021) 137 (19): 2598–2608.

https://doi.org/10.1182/blood.2020008503

Published: 2021

Includes: Supplemental data

Journal Articles

Accumulation of DNA Damage and Alteration of the DNA Damage Response in Chronic Myeloid Leukemia

Henning D. Popp, Vanessa Kohl, MSc, Johanna Flach, PhD, Susanne Brendel, MTA, Helga Kleiner, MTA, Wolfgang Seifarth, PhD, Christel Weiss, PhD, Susanne Saussele, MD, Wolf-Karsten Hofmann, MD PhD, Alice Fabarius, PhD

Blood (2019) 134 (Supplement_1): 5364.

https://doi.org/10.1182/blood-2019-122698

Published: 2019

Journal Articles

STAG2 Loss Gives Rise to Therapeutically Targetable DNA Damage Repair Defects and Altered Replication Fork Dynamics in Acute Myeloid Leukaemia

Harmony Estelle Black, BSc, Satpal Jhujh, Grant S Stewart, BSc, PhD, Kienan I Savage, PhD, Ken I Mills, PhD FRCPath, BSc

Blood (2019) 134 (Supplement_1): 1255.

https://doi.org/10.1182/blood-2019-129828

Published: 2019

Journal Articles

Targeting DNA Damage and Repair in Acute Myeloid Leukemia Carrying Internal Tandem Duplication of Fms-like Tyrosine Kinase 3 (FLT3-ITD) - a Mechanistic Study

Ka Lam Nelson Ng, PhD, Claire Lynn, Thomas Wing Yan Leung, Eric Chi Wai So, PhD, Anskar Yu Hung Leung, MD PhD

Blood (2019) 134 (Supplement_1): 1261.

https://doi.org/10.1182/blood-2019-129472

Published: 2019

Journal Articles

Impact of U2AF1 Mutations on Clinical Characteristics and RNA Splicing in Myelodysplastic Syndromes (MDS)

Bing Li, MD, Jinqin Liu, Tiejun Qin, Zefeng Xu, MD, Gang Huang, PhD, Zhijian Xiao, MD

Blood (2019) 134 (Supplement_1): 2979.

https://doi.org/10.1182/blood-2019-126346

Published: 2019

Journal Articles

Accumulation of Endogenous DNA Damage Sustain Malignant Progression and Increase Therapy Resistance in Multiple Myeloma

Maria Gkotzamanidou, MD PhD, Evangelos Terpos, MD PhD, Nikhil C. Munshi, MD, Vassilis L. Souliotis, PhD, Meletios A. Dimopoulos, MD

Blood (2019) 134 (Supplement_1): 1788.

https://doi.org/10.1182/blood-2019-123502

Published: 2019

Journal Articles

LMO2 Facilitates Synthetic Lethality after PARP Inhibition (PARPi) in Diffuse Large B-Cell Lymphoma (DLBCL)

Ramiro E Verdun, PhD, Salma Parvin, PhD, Ariel Ramirez Labrada, PhD, Gabriel Emmanuel Santiago, Cortizas M Elena, Sharabi Eden, Aumann Shlomzion, MD, Zhang Yu, PhD, Isidro Sanchez-Garcia, PhD, Francisco Vega, MD PhD, Jennifer Rose Chapman-Fredricks, MD, Izidore S. Lossos, MD

Blood (2018) 132 (Supplement 1): 674.

https://doi.org/10.1182/blood-2018-99-110825

Published: 2018

Journal Articles

Cells with DNMT3A Mutations Are More Sensitive to Cytarabine-Induced DNA Damage

Kartika Venugopal, MS, Jianping Li, MD, Daniil E Shabashvili, PhD, Luisa M Posada, Yang Feng, MS, Daphne Dupere-Richer, PhD, Aditya Bele, PhD, Jonathan D. Licht, MD, Olga A Guryanova, MD PhD

Blood (2018) 132 (Supplement 1): 2643.

https://doi.org/10.1182/blood-2018-99-118708

Published: 2018

Journal Articles

BCL6 Enables RAS-Driven Pre-B Cell Transformation in Acute Lymphoblastic Leukemia

Lai N Chan, Christian Hurtz, PhD, Rebecca Caesar, Seyedmehdi Shojaee, PhD, Gang Xiao, PhD, Huimin Geng, PhD, Mignon L. Loh, MD, B. Hilda Ye, PhD, Steven Kornblau, MD, Markus Muschen, MD

Blood (2017) 130 (Supplement 1): 1211.

https://doi.org/10.1182/blood.V130.Suppl_1.1211.1211

Published: 2017

Journal Articles

AURKA Regulates the Mechanism of ATR Mediated DNA Damage Response about Drug Resistance in Multiple Myeloma

Zhang Shuaishuai, MD, Yu Qin, An Gang, MD, Mu Hao, PhD, Yan Xu, MD, Shuhui Deng, Tengteng Yu, Wen Zhou, Lugui Qiu, MD

Blood (2017) 130 (Supplement 1): 5354.

https://doi.org/10.1182/blood.V130.Suppl_1.5354.5354

Published: 2017

Journal Articles

Midostaurin Shows Efficacy in Refractory Multiple Myeloma with TP53 Mutation and Elevated Expression of NTRK1, NTRK3 and AURKA

Muntasir M Majumder, MSc, BPharm, David Tamborero, PhD, Pekka Anttila, Raija Helena Silvennoinen, MD, Samuli Eldfors, MSc, Juha Lievonen, Ashwini Kumar, MRes, Alun Parsons, Minna Suvela, MSC, Esa Jantunen, Kimmo Porkka, MD PhD, Caroline A Heckman, PhD

Blood (2017) 130 (Supplement 1): 4412.

https://doi.org/10.1182/blood.V130.Suppl_1.4412.4412

Published: 2017

Journal Articles

TAK-243 Is a Selective UBA1 Inhibitor That Displays Preclinical Activity in Acute Myeloid Leukemia (AML)

Samir H. Barghout, BSPharm, MSc, Parasvi Patel, BSc (Hons), Xiaoming Wang, G. Wei Xu, Simon Kavanagh, Marcela Gronda, MSc, Rose Hurren, BSc, Danny V. Jeyaraju, PhD, Neil MacLean, Marc Hyer, PhD, Allison Berger, PhD, Tary Traore, Michael Sintchak, Michael Milhollen, Mark D. Minden, MD PhD, Razq Hakem, PhD, Aaron D. Schimmer, MDPhD

Blood (2017) 130 (Supplement 1): 814.

https://doi.org/10.1182/blood.V130.Suppl_1.814.814

Published: 2017

Journal Articles

Proteomic Profiling Identifies c-KIT and 53BP1 As Resistance Factors of AML Relapse Post Allogeneic Stem Cell Transplantation with G-CSF/Plerixafor/Busulfan-Fludarabine Conditioning

Zhihong Zeng, MD, Hongbo Lu, MD, Rui-Yu Wang, MD, Wenbin Lu, PhD, Julianne Chen, Christopher B Benton, MD, Keith Baggerly, PhD, Elizabeth J Shpall, MD, Richard E Champlin, MD, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD

Blood (2017) 130 (Supplement 1): 2528.

https://doi.org/10.1182/blood.V130.Suppl_1.2528.2528

Published: 2017

Journal Articles

Increase of DNA Damage and Alteration of the DNA Damage Response in Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia

Henning D. Popp, MD, Susanne Brendel, MTA, Sabrina Ruppenthal, PhD, Helga Kleiner, MTA, Sven Schneider, MD, Torsten Schulze, MD, Christel Weiss, PhD, Frederik Wenz, MD, Wolf-Karsten Hofmann, MD, Alice Fabarius

Blood (2017) 130 (Supplement 1): 4300.

https://doi.org/10.1182/blood.V130.Suppl_1.4300.4300

Published: 2017

Journal Articles

The Genomic and Transcriptomic Landscape of Systemic Mastocytosis

Blood (2016) 128 (22): 3136.

https://doi.org/10.1182/blood.V128.22.3136.3136

Published: 2016

Journal Articles

γH2AX Foci Increase Across the Spectrum from Myelodysplastic Syndromes to Acute Myeloid Leukemias and Co-Localize with 53BP1 in Specific Patterns in the Context of an Impaired DNA Damage Response

Henning D Popp, MD, Susanne Brendel, Nicole Naumann, Thomas Henzler, MD, Wolf-Karsten Hofmann, MD, Alice Fabarius, PhD

Blood (2016) 128 (22): 5226.

https://doi.org/10.1182/blood.V128.22.5226.5226

Published: 2016

Journal Articles

SET8 Is a Potential Therapeutic Target in MM

Herviou Laurie, Fanny Izard, Elke De Bruyne, PhD, Eva Desmedt, Anqi Ma, PhD, Jian Jin, PhD, Karin Vanderkerken, PhD, Eric Julien, Jerome Moreaux, PhD

Blood (2016) 128 (22): 4435.

https://doi.org/10.1182/blood.V128.22.4435.4435

Published: 2016

Journal Articles

Novel Role of LMO2 in DNA Repair Control in Diffuse Large B Cell Lymphoma

Salma Parvin, Ariel Ramirez Labrada, PhD, Gabriel E. Santiago, Elena M. Cortizas, Elena Cubedo Gil, PhD, Ramiro E Verdun, PhD, Izidore S Lossos, MD

Blood (2016) 128 (22): 776.

https://doi.org/10.1182/blood.V128.22.776.776

Published: 2016

Journal Articles

Pml Nuclear Body Disruption Cooperates in APL Pathogenesis, Impacting DNA Damage Repair Pathways

Edwige Voisset, PhD, Eva Moravcsik, Eva W Stratford, Amie Jaye, Christopher J Palgrave, Robert K Hills, DPhil, Paolo Salomoni, Scott C. Kogan, MD, Ellen Solomon, David Grimwade, PhD FRCPath

Blood (2016) 128 (22): 742.

https://doi.org/10.1182/blood.V128.22.742.742

Published: 2016

NARROW

Loss of a 7q gene, CUX1 , disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms

Enhanced homology-directed repair for highly efficient gene editing in hematopoietic stem/progenitor cells

Accumulation of DNA Damage and Alteration of the DNA Damage Response in Chronic Myeloid Leukemia

STAG2 Loss Gives Rise to Therapeutically Targetable DNA Damage Repair Defects and Altered Replication Fork Dynamics in Acute Myeloid Leukaemia

Targeting DNA Damage and Repair in Acute Myeloid Leukemia Carrying Internal Tandem Duplication of Fms-like Tyrosine Kinase 3 (FLT3-ITD) - a Mechanistic Study

Impact of U2AF1 Mutations on Clinical Characteristics and RNA Splicing in Myelodysplastic Syndromes (MDS)

Accumulation of Endogenous DNA Damage Sustain Malignant Progression and Increase Therapy Resistance in Multiple Myeloma

LMO2 Facilitates Synthetic Lethality after PARP Inhibition (PARPi) in Diffuse Large B-Cell Lymphoma (DLBCL)

Cells with DNMT3A Mutations Are More Sensitive to Cytarabine-Induced DNA Damage

BCL6 Enables RAS-Driven Pre-B Cell Transformation in Acute Lymphoblastic Leukemia

AURKA Regulates the Mechanism of ATR Mediated DNA Damage Response about Drug Resistance in Multiple Myeloma

Midostaurin Shows Efficacy in Refractory Multiple Myeloma with TP53 Mutation and Elevated Expression of NTRK1, NTRK3 and AURKA

TAK-243 Is a Selective UBA1 Inhibitor That Displays Preclinical Activity in Acute Myeloid Leukemia (AML)

Proteomic Profiling Identifies c-KIT and 53BP1 As Resistance Factors of AML Relapse Post Allogeneic Stem Cell Transplantation with G-CSF/Plerixafor/Busulfan-Fludarabine Conditioning

Increase of DNA Damage and Alteration of the DNA Damage Response in Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia

The Genomic and Transcriptomic Landscape of Systemic Mastocytosis

γH2AX Foci Increase Across the Spectrum from Myelodysplastic Syndromes to Acute Myeloid Leukemias and Co-Localize with 53BP1 in Specific Patterns in the Context of an Impaired DNA Damage Response

SET8 Is a Potential Therapeutic Target in MM

Novel Role of LMO2 in DNA Repair Control in Diffuse Large B Cell Lymphoma

Pml Nuclear Body Disruption Cooperates in APL Pathogenesis, Impacting DNA Damage Repair Pathways

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American Society of Hematology

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