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Issue Archive

Volume 9, Issue 24
December 23 2025
Blood Advances Cover Image for Volume 9, Issue 24

Table of Contents

EDITORIAL

Celebrating a year of ASH Scholar awardees
Catherine M. Bollard,Andrew S. Weyrich
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INSIDE BLOOD ADVANCES

Emicizumab in infants: not just cost-effective but mandatory
Guy Young
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Abatacept today, TMA away: protecting the endothelium
Alexander Ngwube,Allistair Abraham
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A new sUSPect in T-ALL risk stratification
Stephanie J. Si Lim,David T. Teachey
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Sickle cell disease and thalassemia go to the PROm
Clinical Trials & Observations
Miguel R. Abboud,Biree Andemariam
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ADVANCES VIEWPOINT

Challenges and opportunities for improvement in the practical management of adults with acute lymphoblastic leukemia
Ryan D. Cassaday
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Challenges and limitations of mobilization and stem cell collection for gene therapy of sickle cell disease
Yvette C. Tanhehco,Suzanne Thibodeaux,Patricia A. Shi,Stella T. Chou,Shannon A. Kelly,Grace Fortes Monis,Carly Newton,Kamille West-Mitchell,Yan Zheng,Christine Fernandez,Christina Anderson,Kimberly Ching,Victoria Coleman-Cowger,Adrienne Shapiro,John P Manis
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DRUG ADVANCES

Antibody-DNA nanostructure conjugates integrate doxorubicin and rituximab to enhance therapeutic efficacy for DLBCL
Zuguang Xia,Jiazhen Cao,Yingzhu Li,Jianing Wu,Jun Ren,Weiqi Sheng,Chengxun Li,Shengjie Li
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TESTING ADVANCES

Clinical applications of mass spectrometry in multiple myeloma
Clinical Trials & Observations
Benjamin A. Derman,Andrew J. Yee
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REVIEW ARTICLES

Fifteen years of use of functional imaging in multiple myeloma: where we started and where we are going
Elena Zamagni,Marco Talarico
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Predictive markers for the efficacy of CAR T-cell therapy: the interplay between CAR T-cell fitness and systemic immunity
Kwai Han Yoo,Szymon Szymura,Zhenyuan Dong,Anmol Kandel,Soung-chul Cha,Larry W. Kwak
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Applying principles of vaccine development to oncomicrobial vaccines
Cody A. Despins,Nicholas J. P. Viegas,Robert A. Holt
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SYSTEMATIC REVIEW

Luspatercept for patients with lower-risk myelodysplastic syndromes/neoplasms: a systematic review and meta-analysis
Clinical Trials & Observations
Abdulrahman Alhajahjeh,Naira Link Woite,Benjamin Rolles,Jessica M. Stempel,Alain Mina,Lourdes Mendez,Tariq Kewan,Nikolai A. Podoltsev,Maximilian Stahl,Alyssa A. Grimshaw,Amer M. Zeidan,Jan Philipp Bewersdorf
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CLINICAL TRIALS AND OBSERVATIONS

Brentuximab vedotin addition to gemcitabine in relapsed or refractory peripheral T-cell lymphoma: a LYSA phase 2 study
Clinical Trials & Observations
Olivier Tournilhac,Kamal Bouabdallah,Solène Lecolant,Maya Hacini,Kamel Laribi,Sébastien Bailly,Thibaut Belmondo,Marie Maerevoet,Loic Ysebaert,Stéphanie Guidez,Steven Le Gouill,Christophe Bonnet,Marc André,Jehan Dupuis,Catherine Thieblemont,Emmanuel Bachy,Nicolas Daguindau,Franck Morschhauser,Sabine Tricot,Charline Moulin,Anne Banos,Roch Houot,Adrien Chauchet,Emmanuel Gyan,Guillaume Cartron,Hassan Farhat,Vincent Camus,Bernard Drenou,Hacene Zerazhi,David Sibon,Emmanuelle Nicolas-Virelizier,Caroline Delette,Sylvia Snauwaert,Sarah Bailly,Richard Delarue,Sylvain Carras,Albane Ledoux-Pilon,Marie-Cécile Parrens,Samuel Griolet,Philippe Gaulard,Marie-Hélène Delfau-Larue,Laurence de Leval,Gandhi Laurent Damaj
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Supplemental data
Safety and efficacy of combining midostaurin and gemtuzumab ozogamicin with induction chemotherapy in FLT3-mutated AML
Clinical Trials & Observations
Nigel Russell,Jad Othman,Oliver Cumming,Abin Thomas,Aditya Tedjaseputra,Nicola Potter,Jelena Jovanovic,Amanda Gilkes,Leona Batten,Joanna Canham,Emily Hinson,Manohursingh Runglall,Phoebe Aucken,Panos Kottaridis,Jamie Cavenagh,Claire Arnold,Sylvie Freeman,Mike Dennis,Steven Knapper,Richard Dillon
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Supplemental data
Improvements in health-related quality of life in patients with severe sickle cell disease after exagamglogene autotemcel
Clinical Trials & Observations
Akshay Sharma,Franco Locatelli,Monica Bhatia,Lyndsay Molinari,Markus Y. Mapara,Robert I. Liem,Laurence Dedeken,Donna Wall,Michael J. Eckrich,Kevin H. M. Kuo,Wally Smith,Suzan Imren,Puja Kohli,Nanxin Li,Tina Liu,Jaime Rubin,William Hobbs,Stephan A. Grupp,Haydar Frangoul,on behalf of the CLIMB SCD-121 and CLIMB-131 Study Groups
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Sickle cell disease and thalassemia go to the PROm
Clinical Trials & Observations
Miguel R. Abboud,Biree Andemariam
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Improvements in health-related quality of life in patients with transfusion-dependent β-thalassemia after exagamglogene autotemcel
Clinical Trials & Observations
Josu de la Fuente,Haydar Frangoul,Peter Lang,Donna Wall,Roland Meisel,Selim Corbacioglu,Amanda M. Li,Ami J. Shah,Ben Carpenter,Janet L. Kwiatkowski,Markus Y. Mapara,Robert I. Liem,Joachim Rupprecht,Kevin H.M. Kuo,Hayley Merkeley,Mattia Algeri,Wally Smith,Puja Kohli,Nanxin Li,Jaime Rubin,Siyu Zhang,William Hobbs,Franco Locatelli,on behalf of the CLIMB THAL-111 and CLIMB-131 Study Groups
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Sickle cell disease and thalassemia go to the PROm
Clinical Trials & Observations
Miguel R. Abboud,Biree Andemariam
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Outcomes after transition from ibrutinib to zanubrutinib in patients with Waldenström macroglobulinemia from the ASPEN study
Clinical Trials & Observations
Ramón García-Sanz,Roger G. Owen,Wojciech Jurczak,Meletios A. Dimopoulos,Helen McCarthy,Gavin Cull,Stephen S. Opat,Jorge J. Castillo,Marie José Kersten,Björn E. Wahlin,Sebastian Grosicki,Radha Prathikanti,Tian Tian,Heather Allewelt,Aileen Cleary Cohen,Constantine S. Tam
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GENE THERAPY

In situ gene editing of hematopoietic stem cells via AAV-delivered CRISPR guide RNAs
Alborz Karimzadeh,Rebekah Kim,Vivian Garcia,Michael Florea,Bryan L. Peacker,Shio Kobayashi,Drake Watkins,Kathleen Messemer,Jing Zeng,Daniel E. Bauer,Thomas Serwold,Amy J. Wagers
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IMMUNOBIOLOGY AND IMMUNOTHERAPY

Patient-reported outcomes in patients with hematologic malignancies treated with CAR T-cell therapy in Europe
Elise R. A. Pennings,Anne M. Spanjaart,Frederick W. Thielen,Simone Oerlemans,Anna Fleischer,Carmen Sanges,Maria Gomes Da Silva,Yolanda Cabrerizo,Pacôme Lecot,Lutgart Roux-Opstaele,Caroline Dreuillet,Eglys Gonzalez-Marcano,Olga Millán,Ulrich Jaeger,Julio Delgado,Maik Luu,Barbara Huber,Margot Lorrain,Mariana Pina,Andreas Kremer,Natacha Bolaños,Solène Clavreul,Samantha Nier,Roberto D. K. Liu,Birgit I. Lissenberg-Witte,Sébastien Anguille,Marie Robin,Emma C. Morris,Anna Sureda,Marie Préau,Myriam Pannard,Geertruida H. De Bock,Scott S. Wagers,Hélène Negre,Delphine Maucort-Boulch,Michael Hudecek,Carin A. Uyl-de Groot,Marie José Kersten
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Supplemental data

LYMPHOID NEOPLASIA

SOX11 modulates BCR signaling through the PAX5/CD19 axis for therapeutic targeting in BTK-resistant mantle cell lymphoma
Rudra Prasad Dutta,Heng-Huan Lee,Violetta V. Leshchenko,Ravi Prakash Shukla,Fangfang Yan,Yang Liu,H. Ümit Kaniskan,Xing Qiu,Jian Jin,Lapo Alinari,Michael Wang,Samir Parekh
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Supplemental data
Monoclonal gammopathy defines distinct clinical subsets in chronic lymphocytic leukemia across therapeutic eras
Yuting Yan,Bolin Yuan,Tonglu Qiu,Guoqiang Liu,Weihao Chen,Tingyu Wang,Ying Yu,Wenjie Xiong,Gang An,Dehui Zou,Jianyong Li,Liang Wang,Shuhua Yi
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Supplemental data
Polatuzumab vedotin in CNS lymphoma: proof-of-concept study for blood-brain barrier penetration
Lei Gao,Avyakta Kallam,Geoffrey Shouse,John H. Baird,Stacy Pak,Yue Qin,Joo Y. Song,Guido Marcucci,Lucy Y. Ghoda,Claire Guillen,Suk-Joon Hyung,Ola M. Saad,Helen Davis,Randall Dere,Connie L. Batlevi,Joshua Meinert,Lihua E. Budde,Alexey V. Danilov,Alex F. Herrera,Larry W. Kwak,Stephen J. Forman,James K. Godfrey
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Development and validation of a gene expression signature to predict early events in patients with follicular lymphoma
Colleen A. Ramsower,George Wright,Hongli Li,James R. Cerhan,Matthew J. Maurer,Raphael Mwangi,Allison C. Rosenthal,Anne J. Novak,Brian K. Link,Thomas E. Witzig,Thomas M. Habermann,Robert Kridel,Michael L. LeBlanc,Mazyar Shadman,Sonali M. Smith,Jonathan W. Friedberg,David W. Scott,Christian Steidl,Louis M. Staudt,Lisa M. Rimsza
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Supplemental data
Outcomes of CAR T-cell therapy in high-grade B-cell lymphomas compared to DLBCL: a weighted comparison analysis
Anna Dodero,Giusy Ceparano,Beatrice Casadei,Piera Angelillo,Stefania Bramanti,Maria Chiara Tisi,Silva Ljevar,Federico Stella,Annalisa Chiappella,Barbara Botto,Ilaria Cutini,Giada Zanirato,Patrizia Chiusolo,Anna Maria Barbui,Mirko Farina,Alice Di Rocco,Giovanni Grillo,Jacopo Olivieri,Mauro Krampera,Marco Ladetto,Anna Guidetti,Pier Luigi Zinzani,Cristiana Carniti,Paolo Corradini
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MYELOID NEOPLASIA

Androgen receptor signaling as a new target for intervention in acute myeloid leukemia
Fenghua Qian,Deborpita Sarkar,Brooke E. Arner,Vanessa M. Peduzzi,Yuting Bai,Baiye Ruan,Bei Jia,Hong Zheng,Robert F. Paulson,K. Sandeep Prabhu
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Supplemental data
Combining drugs that bypass p53 to treat TP53-mutated leukemias
Sudipta Biswas,Zeinab Albadry M. Zahran,Xiaorong Gu,Lisa Cardone,Remuna Marti,Nour Mouannes,Maximilian Stich,Akriti Jain,Kateryna Fedorov,Benjamin Tomlinson,Mendel Goldfinger,Amit Verma,Yogen Saunthararajah
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Critical role of niche S100A8 for acute myeloid leukemia progression and hematopoiesis regeneration
Xiaoyan Liu,Jinxian Wu,Xinqi Li,Ruiyang Pan,Li Liu,Tingting Huang,Linlu Ma,Guopeng Chen,Qian Wang,Nan Zhang,Xiqin Tong,Yuxin Tan,Hongqiang Jiang,Yuxing Liang,Min Shen,Ruihang Li,Wanyue Yin,Xian Zhang,Fuling Zhou
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RED CELLS, IRON, AND ERYTHROPOIESIS

A novel isoform of tensin-1 promotes actin filament assembly for efficient erythroblast enucleation
Arit Ghosh,Megan Coffin,Dimitri M. Diaz,Sarah Barndt,Vincent P. Schulz,Patrick G. Gallagher,Su Hao Lo,Velia M. Fowler
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THROMBOSIS AND HEMOSTASIS

Emicizumab for preventing intracranial hemorrhage in infants with severe hemophilia A: a cost-effectiveness analysis
Samira Glaeser-Khan,Satoko Ito,Manraj Sra,Rhys Richmond,Robert D. Bona,Harlan M. Krumholz,Stacy E. Croteau,Adam Cuker,George Goshua
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Emicizumab in infants: not just cost-effective but mandatory
Guy Young
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TRANSPLANTATION

Outcomes with third-party virus-specific T cells after the use of single-antigen cell lines to predict HLA restriction
Clinical Trials & Observations
Jeremy D. Rubinstein,Giang Pham,Anusha Sridharan,Ruby Khoury,YunZu M. Wang,Zahra Hudda,Jamie Wilhelm,Daniel A. Lichtenstein,Daria Heyenbruch,Jose A. Cancelas,Stella M. Davies,Carolyn Lutzko,Michael S. Grimley
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Allogeneic hematopoietic stem cell transplantation in patients with germ line DDX41 mutated myeloid malignancies
Michael Loschi,Marie-Charlotte Villy,Jacques-Emmanuel Galimard,Marie-Mathilde Auboiroux,Nathalie Gachard,Alexandre Perani,Matthieu Duchmann,Laetitia Largeaud,Stéphanie Nguyen,Flore Sicre de Fontbrune,Marie Robin,Ibrahim Yakoub-Agha,Etienne Daguindau,Sylvain Chantepie,Amandine Charbonnier,Delphine Lebon,Sébastien Maury,Hélène Labussiere-Wallet,Anne Huynh,Edouard Forcade,Cristina Castilla-Llorente,Thomas Cluzeau,Lionel Adès,Maud D’aveni,Raynier Devillier,Natacha Maillard,Sami Benachour,Hervé Dombret,Christian Récher,Arnaud Pigneux,Emmanuelle Clappier,Eric Delabesse,Nicolas Duployez,Pascal Turlure,Régis Peffault de Latour,Marie Sébert
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Abatacept improves posttransplant survival and reduces endothelial injury syndromes in β-thalassemia major
Pooja Khandelwal,Azada Ibrahimova,Adam Lane,Michael Grimley,Stella M. Davies,Sonata Jodele
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Abatacept today, TMA away: protecting the endothelium
Alexander Ngwube,Allistair Abraham
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Soluble urokinase plasminogen activator receptor and acute kidney injury in hematopoietic cell transplantation
Bhavna Bhasin-Chhabra,Tao Wang,John E. Levine,Shalini Shenoy,Miguel-Angel Perales,Asad Bashey,Hershel Raff,Wael Saber
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RESEARCH LETTERS

Progressive NK-cell dysfunction and ILC imbalance favor immune evasion in multiple myeloma
Maria Teresa Bilotta,Antonio Giovanni Solimando,Vanessa Desantis,Lucia Di Marzo,Andrea Sabatini,Sergio Forcelloni,Alessandro Andriano,Arcangelo Morizio,Antonella Argentiero,Roberto Ria,Linda Quatrini,Lorenzo Moretta,Paola Vacca,Nicola Tumino
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Supplemental data
Dual anti-CD19/22 and anti-BCMA CAR T-cell therapy in a patient with multiple myeloma and secondary B-ALL
Malte Roerden,Luca Hensen,Britta Besemer,Friederike Schwartz,Kristina Reuss,Alisha Weiss-Haug,Lennart Harland,Franziska Ginsberg,Christoph Faul,Wolfgang Bethge,Claudia Lengerke
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USP7 alterations are associated with a poor survival in pediatric T-cell acute lymphoblastic leukemia
Unai Illarregi,Angela Gutierrez-Camino,Ricardo Lopez-Almaraz,Javier Arzuaga-Mendez,Manuel Ramirez-Orellana,Emily Ashcraft,Daniel Sinnett,Itziar Astigarraga,Idoia Martin-Guerrero,Elixabet Lopez-Lopez
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A new sUSPect in T-ALL risk stratification
Stephanie J. Si Lim,David T. Teachey
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A patient-derived CABIN1 mutation recapitulates features of idiopathic multicentric Castleman disease in a mouse model
Dorottya Laczko,Patricia Tsao,Ruth-Anne Pai,Joseph Zinski,Michael V. Gonzalez,Melanie D. Mumau,Tobias Raabe,Hiromi Muramatsu,Norbert Pardi,Taku Kambayashi,David C. Fajgenbaum
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LETTER TO THE EDITOR

Time to redefine HHV-8 MCD and KICS criteria?
Romain Stammler,Yannick Dieudonné,Anthony Vanjak,Eric Oksenhendler,Lionel Galicier,David Boutboul
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ERRATA

Bond DA, Switchenko JM, Villa D, et al. Early relapse identifies MCL patients with inferior survival after intensive or less intensive frontline therapy. Blood Adv. 2021;5(23):5179-5189.
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Greenbaum U, Strati P, Saliba RM, et al. CRP and ferritin in addition to the EASIX score predict CAR-T–related toxicity. Blood Adv. 2021;5(14):2799-2806.
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  • Cover Image

    Cover Image

    issue cover

    Androgen receptor (AR) signaling drives acute myeloid leukemia (AML) progression through both ligand-dependent and -independent mechanisms in MLL-AF9 and patient-derived xenograft models. In males, elevated dihydrotestosterone (DHT) promotes disease despite low AR expression in leukemia-initiating cells, while females compensate for low DHT with high AR expression. Therapeutic interventions with finasteride (blocking DHT) and ARN509 (inhibiting AR activity) reduce disease burden. High AR expression activates upstream signaling events involving RTK/GAB2, PI3K/AKT/mTOR, and SRC/HIF-1α pathways in close collaboration with the elevated expression of ephrin receptor EPHA7 leading to AML cell survival. AR antagonism or inhibition disrupts this interplay, underscoring their critical role in AML therapy. Image generated using Biorender.com. See the article by Qian et al.

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