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Marina Konopleva
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Journal Articles

Dual-targeting CD33/CD123 NANOBODY T-cell engager with potent anti-AML activity and good safety profile

Zhihong Zeng, Annelies Roobrouck, Geert Deschamps, Helene Bonnevaux, Stephane Guerif, Veronique De Brabandere, Céline Amara, Eline Dejonckheere, Angela Virone-Oddos, Marielle Chiron, Marina Konopleva, Melissa Dullaers
Journal: Blood Advances
Blood Adv (2024) 8 (9): 2059–2073.
https://doi.org/10.1182/bloodadvances.2023011858
Published: 2024
Includes: Supplemental data
Journal Articles

A phase 1/2 study of mini-hyper-CVD plus venetoclax in patients with relapsed/refractory acute lymphoblastic leukemia

Clinical Trials & Observations
Nicholas J. Short, Elias Jabbour, Nitin Jain, Jayastu Senapati, Lewis Nasr, Fadi G. Haddad, Zhenhua Li, Yu-Chih Hsiao, Jun J. Yang, Naveen Pemmaraju, Maro Ohanian, William G. Wierda, Guillermo Montalban-Bravo, Gautam Borthakur, Lina Han, Lianchun Xiao, Xuelin Huang, Regina Abramova, Min Zhao, Rebecca Garris, Marina Konopleva, Farhad Ravandi, Hagop Kantarjian
Journal: Blood Advances
Blood Adv (2024) 8 (4): 909–915.
https://doi.org/10.1182/bloodadvances.2023012231
Published: 2024
Includes: Supplemental data
Journal Articles

Phase 1b trial of tagraxofusp in combination with azacitidine with or without venetoclax in acute myeloid leukemia

Clinical Trials & Observations
Andrew A. Lane, Jacqueline S. Garcia, Evangeline G. Raulston, Jada L. Garzon, Ilene Galinsky, Emilie W. Baxter, Rebecca Leonard, Daniel J. DeAngelo, Marlise R. Luskin, Christopher R. Reilly, Maximilian Stahl, Richard M. Stone, Rahul S. Vedula, Martha M. Wadleigh, Eric S. Winer, Tariq Mughal, Christopher Brooks, Ira V. Gupta, Kristen E. Stevenson, Donna S. Neuberg, Siyang Ren, Julia Keating, Marina Konopleva, Anthony Stein, Naveen Pemmaraju
Journal: Blood Advances
Blood Adv (2024) 8 (3): 591–602.
https://doi.org/10.1182/bloodadvances.2023011721
Published: 2024
Includes: Supplemental data
Journal Articles

Cigarette smoke exposure accelerates AML progression in FLT3-ITD models

Clinical Trials & Observations
Mary Figueroa, Huaxian Ma, Mansour Alfayez, Daniel Enrique Morales-Mantilla, Fei Wang, Yue Lu, Marcos R. Estecio, Katherine Y. King, Eugenie Kleinerman, Seyed Javad Moghaddam, Naval Daver, Michael Andreeff, Marina Konopleva, Courtney DiNardo, Joya Chandra
Journal: Blood Advances
Blood Adv (2023) 7 (21): 6624–6629.
https://doi.org/10.1182/bloodadvances.2023010111
Published: 2023
Includes: Supplemental data
Journal Articles

Impact of type of induction therapy on outcomes in older adults with AML after allogeneic stem cell transplantation

Clinical Trials & Observations
Nicholas J. Short, Faustine Ong, Farhad Ravandi, Graciela Nogueras-Gonzalez, Tapan M. Kadia, Naval Daver, Courtney D. DiNardo, Marina Konopleva, Gautam Borthakur, Betul Oran, Gheath Al-Atrash, Rohtesh Mehta, Elias J. Jabbour, Musa Yilmaz, Ghayas C Issa, Abhishek Maiti, Richard E Champlin, Hagop Kantarjian, Elizabeth J Shpall, Uday Popat
Journal: Blood Advances
Blood Adv (2023) 7 (14): 3573–3581.
https://doi.org/10.1182/bloodadvances.2022009632
Published: 2023
Includes: Supplemental data
Journal Articles

Undetectable measurable residual disease is associated with improved outcomes in AML irrespective of treatment intensity

Alexandre Bazinet, Tapan Kadia, Nicholas J. Short, Gautam Borthakur, Sa A. Wang, Wei Wang, Sanam Loghavi, Jeffrey Jorgensen, Keyur Patel, Courtney DiNardo, Naval Daver, Yesid Alvarado, Fadi G. Haddad, Sherry Pierce, Graciela Nogueras Gonzalez, Abhishek Maiti, Koji Sasaki, Musa Yilmaz, Philip Thompson, William Wierda, Guillermo Garcia-Manero, Michael Andreeff, Elias Jabbour, Marina Konopleva, Xuelin Huang, Hagop Kantarjian, Farhad Ravandi
Journal: Blood Advances
Blood Adv (2023) 7 (13): 3284–3296.
https://doi.org/10.1182/bloodadvances.2022009391
Published: 2023
Includes: Supplemental data
Journal Articles

BH3 profiling identifies BCL-2 dependence in adult patients with early T-cell progenitor acute lymphoblastic leukemia

Elyse A. Olesinski, Karanpreet S. Bhatia, Aarthi N. Mahesh, Shazwina Rosli, Jameelah S. Mohamed, Wei Y. Jen, Nitin Jain, Jacqueline S. Garcia, Gee C. Wong, Melissa Ooi, Anthony Letai, Marina Konopleva, Shruti Bhatt
Journal: Blood Advances
Blood Adv (2023) 7 (12): 2917–2923.
https://doi.org/10.1182/bloodadvances.2022007728
Published: 2023
Includes: Supplemental data
Journal Articles

TET2 truncating mutations predict a worse outcome in blastic plasmacytoid dendritic cell neoplasm

Hannah Beird, C. Cameron Yin, Joseph D. Khoury, Sherry Pierce, Hussein A. Abbas, Li Zhao, Anna Skwarska, Muzaffar Qazilbash, Marina Konopleva, P. Andrew Futreal, Naveen Pemmaraju
Journal: Blood Advances
Blood Adv (2023) 7 (10): 2000–2003.
https://doi.org/10.1182/bloodadvances.2022007879
Published: 2023
Includes: Supplemental data
Journal Articles

A phase 2 study of nivolumab combined with ibrutinib in patients with diffuse large B-cell Richter transformation of CLL

Clinical Trials & Observations
Nitin Jain, Jayastu Senapati, Beenu Thakral, Alessandra Ferrajoli, Philip Thompson, Jan Burger, Sreyashi Basu, Tapan Kadia, Naval Daver, Gautam Borthakur, Marina Konopleva, Naveen Pemmaraju, Erin Parry, Catherine J. Wu, Joseph Khoury, Carlos Bueso-Ramos, Naveen Garg, Xuemei Wang, Wanda Lopez, Ana Ayala, Susan O’Brien, Hagop Kantarjian, Michael Keating, James Allison, Padmanee Sharma, William Wierda
Journal: Blood Advances
Blood Adv (2023) 7 (10): 1958–1966.
https://doi.org/10.1182/bloodadvances.2022008790
Published: 2023
Includes: Supplemental data
Journal Articles

Clinical outcomes associated with NPM1 mutations in patients with relapsed or refractory AML

Ghayas C. Issa, Aram Bidikian, Sangeetha Venugopal, Marina Konopleva, Courtney D. DiNardo, Tapan M. Kadia, Gautam Borthakur, Elias Jabbour, Naveen Pemmaraju, Musa Yilmaz, Nicholas J. Short, Abhishek Maiti, Koji Sasaki, Lucia Masarova, Sherry Pierce, Koichi Takahashi, Guilin Tang, Sanam Loghavi, Keyur Patel, Michael Andreeff, Kapil Bhalla, Guillermo Garcia-Manero, Farhad Ravandi, Hagop Kantarjian, Naval Daver
Journal: Blood Advances
Blood Adv (2023) 7 (6): 933–942.
https://doi.org/10.1182/bloodadvances.2022008316
Published: 2023
Includes: Supplemental data
Journal Articles

Validation of the ALFA-1200 model in older patients with AML treated with intensive chemotherapy

Clinical Trials & Observations
Hussein A. Abbas, Hanxiao Sun, Sherry Pierce, Rashmi Kanagal-Shamanna, Ziyi Li, Musa Yilmaz, Gautam Borthakur, Adam J. DiPippo, Elias Jabbour, Marina Konopleva, Nicholas J. Short, Courtney DiNardo, Naval Daver, Farhad Ravandi, Tapan M. Kadia
Journal: Blood Advances
Blood Adv (2023) 7 (5): 828–831.
https://doi.org/10.1182/bloodadvances.2022007172
Published: 2023
Includes: Supplemental data
Journal Articles

Validation of ALFA 1200 score in patients with AML >60 years treated with double nucleoside–based low-intensity therapy

Sangeetha Venugopal, Gautam Borthakur, Naval Daver, Courtney D. DiNardo, Naveen Pemmaraju, Nicholas J. Short, Hussein A. Abbas, Guillermo Garcia-Manero, Marina Konopleva, Farhad Ravandi, Tapan M. Kadia
Journal: Blood Advances
Blood Adv (2022) 6 (19): 5546–5549.
https://doi.org/10.1182/bloodadvances.2021006689
Published: 2022
Journal Articles

High-sensitivity next-generation sequencing MRD assessment in ALL identifies patients at very low risk of relapse

Nicholas J. Short, Hagop Kantarjian, Farhad Ravandi, Marina Konopleva, Nitin Jain, Rashmi Kanagal-Shamanna, Keyur P. Patel, Walid Macaron, Tapan M. Kadia, Sa Wang, Jeffrey L. Jorgensen, Joseph D. Khoury, Musa Yilmaz, Partow Kebriaei, Koichi Takahashi, Guillermo Garcia-Manero, Naval Daver, Sean M. Post, Xuelin Huang, Steven M. Kornblau, Sara Pelletier, Wilmer Flores, Jairo Matthews, Rebecca Garris, Elias Jabbour
Journal: Blood Advances
Blood Adv (2022) 6 (13): 4006–4014.
https://doi.org/10.1182/bloodadvances.2022007378
Published: 2022
Includes: Supplemental data
Journal Articles

Characteristics and outcomes of patients with blastic plasmacytoid dendritic cell neoplasm treated with frontline HCVAD

Naveen Pemmaraju, Nathaniel R. Wilson, Guillermo Garcia-Manero, Koji Sasaki, Joseph D. Khoury, Nitin Jain, Gautam Borthakur, Farhad Ravandi, Naval Daver, Tapan Kadia, Courtney DiNardo, Elias Jabbour, Sherry Pierce, Muzaffar Qazilbash, Marina Konopleva, Hagop Kantarjian
Journal: Blood Advances
Blood Adv (2022) 6 (10): 3027–3035.
https://doi.org/10.1182/bloodadvances.2021006645
Published: 2022
Includes: Supplemental data
Journal Articles

Single-cell polyfunctional proteomics of CD4 cells from patients with AML predicts responses to anti–PD-1–based therapy

Hussein A. Abbas, Zoe Alaniz, Sean Mackay, Matthew Cyr, Jing Zhou, Ghayas C. Issa, Mansour Alfayez, Jairo Matthews, Steven M. Kornblau, Elias Jabbour, Guillermo Garcia-Manero, Marina Konopleva, Michael Andreeff, Naval Daver
Journal: Blood Advances
Blood Adv (2021) 5 (22): 4569–4574.
https://doi.org/10.1182/bloodadvances.2021004583
Published: 2021
Includes: Supplemental data
Journal Articles

Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition

Kaori Saito, Qi Zhang, Haeun Yang, Kotoko Yamatani, Tomohiko Ai, Vivian Ruvolo, Natalia Baran, Tianyu Cai, Helen Ma, Rodrigo Jacamo, Vinitha Kuruvilla, Junichi Imoto, Sonoko Kinjo, Kazuho Ikeo, Kaori Moriya, Koya Suzuki, Takashi Miida, Yong-Mi Kim, Christopher P. Vellano, Michael Andreeff, Joseph R. Marszalek, Yoko Tabe, Marina Konopleva
Journal: Blood Advances
Blood Adv (2021) 5 (20): 4233–4255.
https://doi.org/10.1182/bloodadvances.2020003661
Published: 2021
Includes: Supplemental data
Journal Articles

Single-center experience with venetoclax combinations in patients with newly diagnosed and relapsed AML evolving from MPNs

Clinical Trials & Observations
Lucia Masarova, Courtney D. DiNardo, Prithviraj Bose, Naveen Pemmaraju, Naval G. Daver, Tapan M. Kadia, Helen T. Chifotides, Lingsha Zhou, Gautam Borthakur, Zeev Estrov, Marina Konopleva, Srdan Verstovsek
Journal: Blood Advances
Blood Adv (2021) 5 (8): 2156–2164.
https://doi.org/10.1182/bloodadvances.2020003934
Published: 2021
Includes: Supplemental data
Journal Articles

Prognostic impact of complete remission with MRD negativity in patients with relapsed or refractory AML

Clinical Trials & Observations
Nicholas J. Short, Hind Rafei, Naval Daver, Hyunsoo Hwang, Jing Ning, Jeffrey L. Jorgensen, Tapan M. Kadia, Courtney D. DiNardo, Sa A. Wang, Elias Jabbour, Uday Popat, Betul Oran, Jorge Cortes, Marina Konopleva, Musa Yilmaz, Ghayas C. Issa, Hagop Kantarjian, Farhad Ravandi
Journal: Blood Advances
Blood Adv (2020) 4 (24): 6117–6126.
https://doi.org/10.1182/bloodadvances.2020002811
Published: 2020
Includes: Supplemental data
Journal Articles

Prognostic and therapeutic impacts of mutant TP53 variant allelic frequency in newly diagnosed acute myeloid leukemia

Clinical Trials & Observations
Nicholas J. Short, Guillermo Montalban-Bravo, Hyunsoo Hwang, Jing Ning, Miguel J. Franquiz, Rashmi Kanagal-Shamanna, Keyur P. Patel, Courtney D. DiNardo, Farhad Ravandi, Guillermo Garcia-Manero, Koichi Takahashi, Marina Konopleva, Naval Daver, Ghayas C. Issa, Michael Andreeff, Hagop Kantarjian, Tapan M. Kadia
Journal: Blood Advances
Blood Adv (2020) 4 (22): 5681–5689.
https://doi.org/10.1182/bloodadvances.2020003120
Published: 2020
Includes: Supplemental data
Journal Articles

Outcome of patients with IDH1/2- mutated post–myeloproliferative neoplasm AML in the era of IDH inhibitors

Clinical Trials & Observations
Helen T. Chifotides, Lucia Masarova, Mansour Alfayez, Naval Daver, Yesid Alvarado, Elias Jabbour, Marina Konopleva, Hagop M. Kantarjian, Keyur P. Patel, Courtney D. DiNardo, Srdan Verstovsek
Journal: Blood Advances
Blood Adv (2020) 4 (21): 5336–5342.
https://doi.org/10.1182/bloodadvances.2020001528
Published: 2020