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Journal Articles

Plasma cell–derived mtDAMPs activate the macrophage STING pathway, promoting myeloma progression

Aisha Jibril, Charlotte Hellmich, Edyta E. Wojtowicz, Katherine Hampton, Rebecca Maynard, Ravindu De Silva, Dominic J. Fowler-Shorten, Jayna J. Mistry, Jamie A. Moore, Kristian M. Bowles, Stuart A. Rushworth

Blood (2023) 141 (25): 3065–3077.

https://doi.org/10.1182/blood.2022018711

Published: 2023

Includes: Supplemental data

Journal Articles

Malignant Plasma Cell Derived Mitochondrial Damps Activate Macrophages Via Sting Signalling to Promote Myeloma Development

Aisha Jibril, Charlotte Hellmich, Jamie A Moore, Jayna J Mistry, Rebecca S Maynard, Katherine Hampton, Kristian M Bowles, Stuart A Rushworth

Blood (2022) 140 (Supplement 1): 856.

https://doi.org/10.1182/blood-2022-158523

Published: 2022

Journal Articles

LC3-Associated Phagocytosis Is Impaired in Bone Marrow Macrophages during Ageing Leading to Defective Processing of Apoptotic Cells and Suppression of Sting Activation

Katherine Hampton, Charlotte Hellmich, Rebecca S Maynard, Jamie A Moore, Aisha Jibril, Kristian M Bowles, Stuart A Rushworth

Blood (2022) 140 (Supplement 1): 5759.

https://doi.org/10.1182/blood-2022-169240

Published: 2022

Journal Articles

Mitochondrial Membrane Potential Defines the HSC Population with Serial Repopulating Potential in Young but Not Aged Animals

Charlotte Hellmich, Edyta Wojtowicz, Rebecca S Maynard, Katherine Hampton, Jayna J Mistry, Jamie A Moore, Aisha Jibril, Charlotte L Utting, Iain Macauley, Kristian M Bowles, Stuart A Rushworth

Blood (2022) 140 (Supplement 1): 8580–8581.

https://doi.org/10.1182/blood-2022-158264

Published: 2022

Journal Articles

LC3-Associated Phagocytosis in Bone Marrow Macrophages Suppresses AML Progression through Mitochondrial DAMP Induced Sting Activation

Jamie A Moore, Jayna J Mistry, Charlotte Hellmich, Rebecca H Horton, Edyta Wojtowicz, Aisha Jibril, Tom Wileman, Matthew Jefferson, Naiara Beraza, Kristian M Bowles, Stuart A Rushworth

Blood (2021) 138 (Supplement 1): 3441.

https://doi.org/10.1182/blood-2021-152778

Published: 2021

Journal Articles

Multiple Myeloma Derived Mitochondrial Damps Induce Inflammation in the Bone Marrow Adipose Tissue Which Promotes Tumour Development

Aisha Jibril, Charlotte Hellmich, Jamie A Moore, Jayna J Mistry, Stuart A Rushworth, Kristian M Bowles, Victoria Willimott

Blood (2021) 138 (Supplement 1): 2654.

https://doi.org/10.1182/blood-2021-149191

Published: 2021

Journal Articles

BCL-Xl Driven Accumulation of Dysfunctional Mitochondria in Aged Stromal Cells Impairs the Haematopoietic Stem Cell Response to Stress

Charlotte Hellmich, Jayna J Mistry, Aisha Jibril, Jamie A Moore, Benjamin B Johnson, James G W Smith, Edyta Wojtowicz, Naiara Beraza, Kristian M Bowles, Stuart A Rushworth

Blood (2021) 138 (Supplement 1): 1097.

https://doi.org/10.1182/blood-2021-148405

Published: 2021

Journal Articles

Mitochondrial Function Is Impaired in a Subset of Aged Haematopoietic Stem Cells in Response to Infection

Charlotte Hellmich, MBBChir, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Aisha Jibril, BSc, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2020) 136 (Supplement 1): 27–28.

https://doi.org/10.1182/blood-2020-140311

Published: 2020

Journal Articles

Myeloma Derived Mitochondrial Damage Associated Molecular Patterns Promote Pro-Tumoral Expansion By Inducing a Pro-Inflammatory Signature in the Bone Marrow Microenvironment

Aisha Jibril, BSc, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Victoria Willimott, MB BS, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2020) 136 (Supplement 1): 1.

https://doi.org/10.1182/blood-2020-139811

Published: 2020

Journal Articles

Investigating the Dual Targeting of BCL-2 and CD38 in Models of Acute Myeloid Leukemia

Jayna J Mistry, BSc, Charlotte Hellmich, Amelia Lambert, Jamie A Moore, BSc, MSc, Aisha Jibril, BSc, Angela Collins, MBBS, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2020) 136 (Supplement 1): 10.

https://doi.org/10.1182/blood-2020-139527

Published: 2020

Journal Articles

Genomic Ancestry in B Cell Lymphoid Malignancies

Jay A Moore, Andrew M. Evens, DO,MMSc, Justin Newberg, PhD, Eric A. Severson, MD, PhD, MMSc, Jennifer Mills, PhD MSW, MPH, Jordan Carter, MD, Rahul Matnani, MD, Jo-Anne Vergilio, MD, Sally E Trabucco, PhD, Shridar Ganesan, MD, PhD

Blood (2020) 136 (Supplement 1): 5–6.

https://doi.org/10.1182/blood-2020-137533

Published: 2020

Journal Articles

Enhanced Free Fatty Acid Uptake Via CD36 Promotes a Metabolic Switch to B-Oxidation within Hematopoietic Stem Cells in Response to Acute Infection

Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, Aisha Jibril, BSc, Iain Macauley, PhD BSc, Mar Moreno-Gonzalez, Federica Di Palma, PhD, Naiara Beraza, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2020) 136 (Supplement 1): 39–40.

https://doi.org/10.1182/blood-2020-139454

Published: 2020

Journal Articles

Superoxide Drives PI3 Kinase Mediated Mitochondria Transfer from the Bone Marrow Microenvironment to Hematopoietic Stem Cells in Response to Salmonella Typhimurium

Jayna J Mistry, BSc, Christopher R Marlein, PhD, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Iain Macauley, PhD BSc, Naiara Beraza, PhD, Yu Sun, BSc, MSc, PhD, Adam Morfakis, BSc, Angela Patterson, PhD, Rebecca H Horton, Devina Divekar, Christopher J Morris, PhD, Anna Haestier, Bsc, PgD MBBS, MRCOG, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2019) 134 (Supplement_1): 2490.

https://doi.org/10.1182/blood-2019-128241

Published: 2019

Journal Articles

Myeloma Derived Extracellular Vesicles Containing Endoplasmic Reticulum Remodel the Bone Marrow Microenvironment Towards a Pro-Tumoral Senescent Phenotype

Yu Sun, BSc, MSc, PhD, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Christopher R Marlein, PhD, Anna Haestier, Cesar A. Gomez, MD PhD FRCPath, Christopher J Morris, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2019) 134 (Supplement_1): 689.

https://doi.org/10.1182/blood-2019-128268

Published: 2019

Journal Articles

Free Fatty Acid Uptake By Hematopoietic Stem and Progenitor Cells Drives Immune Cell Expansion in Response to Salmonella Typhimurium infection

Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Christopher R Marlein, PhD, Naiara Beraza, PhD, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2019) 134 (Supplement_1): 1197.

https://doi.org/10.1182/blood-2019-128237

Published: 2019

Journal Articles

Daratumumab Inhibits AML Metabolic Capacity and Tumor Growth through Inhibition of CD38 Mediated Mitochondrial Transfer from Bone Marrow Stromal Cells to Blasts in the Leukemic Microenvironment

Jayna J Mistry, BSc, Charlotte Hellmich, MBBChir, Jamie A Moore, BSc, MSc, Christopher R Marlein, PhD, Genevra Pillinger, MB BS, Angela Collins, MBBS, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2019) 134 (Supplement_1): 1385.

https://doi.org/10.1182/blood-2019-128592

Published: 2019

Journal Articles

Acute Myeloid Leukemia Export Mitochondria in Extracellular Vesicles Which Induces Pro-Tumoral Changes in Bone Marrow Macrophages

Jamie A Moore, BSc, MSc, Jayna J Mistry, BSc, Rebecca H Horton, Charlotte Hellmich, MBBChir, Adam Pattinson, MSc, BSc, Adam Morfakis, BSc, Yu Sun, BSc, MSc, PhD, Matthew Lawes, MD, Christopher J Morris, PhD, Anna Haestier, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2019) 134 (Supplement_1): 1427.

https://doi.org/10.1182/blood-2019-128447

Published: 2019

Journal Articles

Prediction and Characterization of Diffuse Large B-Cell Lymphoma (DLBCL) Cell of Origin (COO) Subtypes Using Genomic Features from Targeted Next-Generation Sequencing

Sally E Trabucco, BS, Ethan S Sokol, Jay A Moore, Sophia Maund, Garrett M Frampton, Vincent A Miller, Jeffrey Venstrom, Lee A Albacker, PhD, Laurie H Sehn, MDMPH, Mikkel Z Oestergaard, Christopher R Bolen

Blood (2018) 132 (Supplement 1): 1561.

https://doi.org/10.1182/blood-2018-99-116677

Published: 2018

Journal Articles

In Vitro Hematopoietic Reprogramming and Generation of Hematopoietic Stem Cells

Kateri A. Moore, DVM

Blood (2017) 130 (Supplement 1): SCI-44.

https://doi.org/10.1182/blood.V130.Suppl_1.SCI-44.SCI-44

Published: 2017

Journal Articles

Targeting CD123 in acute myeloid leukemia using a T-cell–directed dual-affinity retargeting platform

Muneera Al-Hussaini, Michael P. Rettig, Julie K. Ritchey, Darja Karpova, Geoffrey L. Uy, Linda G. Eissenberg, Feng Gao, William C. Eades, Ezio Bonvini, Gurunadh R. Chichili, Paul A. Moore, Syd Johnson, Lynne Collins, John F. DiPersio

Blood (2016) 127 (1): 122–131.

https://doi.org/10.1182/blood-2014-05-575704

Published: 2016

Includes: Supplemental data

NARROW

Plasma cell–derived mtDAMPs activate the macrophage STING pathway, promoting myeloma progression

Malignant Plasma Cell Derived Mitochondrial Damps Activate Macrophages Via Sting Signalling to Promote Myeloma Development

LC3-Associated Phagocytosis Is Impaired in Bone Marrow Macrophages during Ageing Leading to Defective Processing of Apoptotic Cells and Suppression of Sting Activation

Mitochondrial Membrane Potential Defines the HSC Population with Serial Repopulating Potential in Young but Not Aged Animals

LC3-Associated Phagocytosis in Bone Marrow Macrophages Suppresses AML Progression through Mitochondrial DAMP Induced Sting Activation

Multiple Myeloma Derived Mitochondrial Damps Induce Inflammation in the Bone Marrow Adipose Tissue Which Promotes Tumour Development

BCL-Xl Driven Accumulation of Dysfunctional Mitochondria in Aged Stromal Cells Impairs the Haematopoietic Stem Cell Response to Stress

Mitochondrial Function Is Impaired in a Subset of Aged Haematopoietic Stem Cells in Response to Infection

Myeloma Derived Mitochondrial Damage Associated Molecular Patterns Promote Pro-Tumoral Expansion By Inducing a Pro-Inflammatory Signature in the Bone Marrow Microenvironment

Investigating the Dual Targeting of BCL-2 and CD38 in Models of Acute Myeloid Leukemia

Genomic Ancestry in B Cell Lymphoid Malignancies

Enhanced Free Fatty Acid Uptake Via CD36 Promotes a Metabolic Switch to B-Oxidation within Hematopoietic Stem Cells in Response to Acute Infection

Superoxide Drives PI3 Kinase Mediated Mitochondria Transfer from the Bone Marrow Microenvironment to Hematopoietic Stem Cells in Response to Salmonella Typhimurium

Myeloma Derived Extracellular Vesicles Containing Endoplasmic Reticulum Remodel the Bone Marrow Microenvironment Towards a Pro-Tumoral Senescent Phenotype

Free Fatty Acid Uptake By Hematopoietic Stem and Progenitor Cells Drives Immune Cell Expansion in Response to Salmonella Typhimurium infection

Daratumumab Inhibits AML Metabolic Capacity and Tumor Growth through Inhibition of CD38 Mediated Mitochondrial Transfer from Bone Marrow Stromal Cells to Blasts in the Leukemic Microenvironment

Acute Myeloid Leukemia Export Mitochondria in Extracellular Vesicles Which Induces Pro-Tumoral Changes in Bone Marrow Macrophages

Prediction and Characterization of Diffuse Large B-Cell Lymphoma (DLBCL) Cell of Origin (COO) Subtypes Using Genomic Features from Targeted Next-Generation Sequencing

In Vitro Hematopoietic Reprogramming and Generation of Hematopoietic Stem Cells

Targeting CD123 in acute myeloid leukemia using a T-cell–directed dual-affinity retargeting platform

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American Society of Hematology

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American Society of Hematology

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