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Alan Chant
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Journal Articles

Double hit ultra-high risk myeloma treated with isatuximab, bortezomib, lenalidomide, dexamethasone and cyclophosphamide (Isa-VRDc) induction and isa-VRD consolidation: Initial results of the UK myeloma research alliance (UKMRA)  RADAR trial in newly diagnosed transplant eligible patients

Free
Karthik Ramasamy, Kara-Louise Royle, Robert Cicero, Ruth de Tute, Matthew Jenner, Ceri Bygrave, Rakesh Popat, Dipal Mehta, Laura Chiecchio, Berrin Balik, Mohammad Kazeroun, Guy Pratt, Catherine Olivier, Lorna Barnard, Sharon Jackson, Charlotte Kennaway, Gordon Cook, Alan Chant, David Meads, Bryony Dawkins, Michael Chapman, Graham Jackson, Andrew Chantry, Martin Kaiser, Jonathan Sive, Sarah Gooding, Eileen Boyle, Christopher Parrish, Dean Smith, Y L Tracey Chan, Roger Owen, David Cairns, Kwee Yong
Journal: Blood
Blood (2025) 146 (Supplement 1): 98.
https://doi.org/10.1182/blood-2025-98
Published: 2025
Journal Articles

Is IMWG frailty-score-adjusted dosing the right approach to improve toxicity and outcomes in FRAIL patients? Results from the UK-MRA FiTNEss trial in newly diagnosed myeloma patients ineligible for ASCT.

Free
Charlotte Pawlyn, Kara-Louise Royle, Ethan Senior, Dax Everritt, Jenny Bird, Stella Bowcock, Bryony Dawkins, Mark Drayson, Sharon Gillson, Catherine Olivier, Matthew Jenner, John Jones, Martin Kaiser, Bhuvan Kishore, David Meads, Neil Rabin, Roger Owen, Ruth de Tute, Christopher Parrish, Alan Chant, David Cairns, Graham Jackson, Gordon Cook
Journal: Blood
Blood (2025) 146 (Supplement 1): 369.
https://doi.org/10.1182/blood-2025-369
Published: 2025
Journal Articles

Long-read RNA sequencing of first multiple myeloma patient cohort reveals landscape of variant expression in newly diagnosed patients from the UKMRA RADAR trial

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Bethan Hudson-Lund, Anandagopal Srinivasan, Eleanor Calcutt, Neelam Mehta, Ines Fethi, Emma Lyon, Jessica Kimber, Alice Lefever, Conor Garrod-Ketchley, Annabel Laidler, Elise Rees, Amatta Mirandari, Daniel Hughes, Louise Ainley, Jongwon Yoon, Lydia Lee, Maximilian Goodman, Megan Hawksley, Angela Brown, Mohammad Kazeroun, Naser Ansari-Pour, Matthew Jenner, Laura Chiecchio, Martin Kaiser, Michael Chapman, Angela Hamblin, Lorna Barnard, Kara-Louise Royle, Robert Cicero, Catherine Olivier, Sharon Jackson, Charlotte Kennaway, Gordon Cook, Guy Pratt, Alan Chant, Jonathan Sive, Christopher Parrish, Udo Oppermann, Karthik Ramasamy, Kwee Yong, Eileen Boyle, Sarah Gooding, Adam Cribbs
Journal: Blood
Blood (2025) 146 (Supplement 1): 2141.
https://doi.org/10.1182/blood-2025-2141
Published: 2025
Journal Articles

IMWG Frailty Score-Adjusted Therapy Delivery Reduces the Early Mortality Risk in Newly Diagnosed Tne Multiple Myeloma: Results of the UK Myeloma Research Alliance (UK-MRA) Myeloma XIV Fitness Trial

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Gordon Cook, Charlotte Pawlyn, Kara-Louise Royle, Ethan R Senior, Dax Everritt, Jenny Bird, Stella Bowcock, Bryony Dawkins, Mark Drayson, Sharon Gillson, Catherine Olivier, Matthew W. Jenner, John Jones, Martin F Kaiser, Bhuvan Kishore, David Meads, Neil Rabin, Roger G Owen, Ruth M de Tute, Christopher Parrish, Alan Chant, David A. Cairns, Graham Jackson
Journal: Blood
Blood (2024) 144 (Supplement 1): 673.
https://doi.org/10.1182/blood-2024-209653
Published: 2024
Journal Articles

Cost-Effectiveness of Frailty-Adjusted Therapy in Transplant Non-Eligible Patients with Newly Diagnosed Multiple Myeloma - an Economic Evaluation of the Fitness Trial

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Bryony Dawkins, Georgios Gkountouras, David Meads, Charlotte Pawlyn, Kara-Louise Royle, Ethan R Senior, Dax Everritt, Jenny Bird, Stella Bowcock, Mark Drayson, Sharon Gillson, Catherine Olivier, Matthew W. Jenner, John R Jones, Martin F Kaiser, Bhuvan Kishore, Neil Rabin, Roger G Owen, Ruth M de Tute, Christopher Parrish, David A. Cairns, Alan Chant, Graham Jackson, Gordon Cook
Journal: Blood
Blood (2024) 144 (Supplement 1): 385.
https://doi.org/10.1182/blood-2024-209720
Published: 2024
Journal Articles

Dynamic Frailty Assessment in Transplant Non-Eligible Newly Diagnosed Myeloma Patients: Initial Data from UK Myeloma Research Alliance (UK-MRA) Myeloma XIV (FiTNEss): A Frailty-Adjusted Therapy Study

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Gordon Cook, Charlotte Pawlyn, Kara-Louise Royle, Ethan R Senior, Dax Everritt, Jenny Bird, Stella J. Bowcock, Bryony Dawkins, Mark Drayson, Sharon Gillson, Catherine Olivier, Alan Chant, Matthew W. Jenner, John Robert Jones, Martin F. Kaiser, Bhuvan Kishore, David Meads, Neil Rabin, Roger Owen, Ruth M de Tute, Christopher Parrish, David Allan Cairns, Graham Jackson
Journal: Blood
Blood (2023) 142 (Supplement 1): 4748.
https://doi.org/10.1182/blood-2023-188672
Published: 2023
Journal Articles

Health-Related Quality of Life (HRQoL) in Patients with Genetic Standard and High-Risk Disease at Trial Entry: A Cross-Sectional Analysis of RADAR (UK-MRA Myeloma XV)

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Catherine SY Lecat, Alan Chant, Orla McCourt, David Meads, Robert Cicero, Kara-Louise Royle, Ceri Bygrave, Andrew Chantry, Michael A. Chapman, Gordon Cook, Bryony Dawkins, Mark Drayson, Graham Jackson, Matthew W. Jenner, Martin F. Kaiser, Dipal Mehta, Roger Owen, Rakesh Popat, Christopher Parrish, Guy Pratt, Jonathan Sive, Dean Smith, Ruth M de Tute, Lorna Barnard, Sharon Jackson, Doina Levinte, Catherine Olivier, Karthik Ramasamy, Kwee Yong, David Allan Cairns
Journal: Blood
Blood (2023) 142 (Supplement 1): 4710.
https://doi.org/10.1182/blood-2023-187453
Published: 2023
Journal Articles

High Success Rates Utilizing Local Standard of Care Cytogenetic Testing for Risk Stratified Frontline Therapy for Newly Diagnosed Multiple Myeloma: Experience from the Ukmra RADAR Study

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Dipal Mehta, Laura Chiecchio, Martin F. Kaiser, Sarah Gooding, Kara-Louise Royle, Doina Levinte, Catherine Olivier, David Allan Cairns, Lorna Barnard, Sharon Jackson, Robert Cicero, Gordon Cook, Michael A. Chapman, Alan Chant, David Meads, Bryony Dawkins, Guy Pratt, Rakesh Popat, Graham Jackson, Ceri Bygrave, Andrew Chantry, Jonathan Sive, Christopher Parrish, Dean Smith, Mark Drayson, Roger Owen, Ruth M de Tute, Karthik Ramasamy, Kwee Yong, Matthew W. Jenner
Journal: Blood
Blood (2023) 142 (Supplement 1): 6715.
https://doi.org/10.1182/blood-2023-188697
Published: 2023
Journal Articles

Health-Related Quality of Life (HRQoL) in Fit, Unfit and Frail Patients Enrolled in Fitness (UK-MRA Myeloma XIV): A Cross Sectional Study

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Orla McCourt, David Allan Cairns, Sally Moore, Christopher Parrish, Charlotte Pawlyn, Frances Seymour, Ethan R Senior, Kara-Louise Royle, Jennifer Bird, Stella J. Bowcock, Alan Chant, Mark Drayson, Hayley Gardner, Matthew W. Jenner, John R Jones, Martin F. Kaiser, Bhuvan Kishore, Roger Owen, Neil Rabin, Ruth M de Tute, Bryony Dawkins, David Meads, Sharon Gillson, Sharon Jackson, Catherine Olivier, Graham Jackson, Gordon Cook
Journal: Blood
Blood (2023) 142 (Supplement 1): 3368.
https://doi.org/10.1182/blood-2023-187202
Published: 2023
Journal Articles

RADAR Trial: MRD Response Adapted Trial for Newly Diagnosed Transplant Eligible Myeloma Patients

Free
Karthik Ramasamy, David Allan Cairns, Kara-Louise Royle, Robert Cicero, Catherine Olivier, Lorna Barnard, Sharon Jackson, Doina Levinte, Gordon Cook, Alan Chant, David Meads, Bryony Dawkins, Michael A. Chapman, Guy Pratt, Rakesh Popat, Graham Jackson, Ceri Bygrave, Andrew Chantry, Martin F. Kaiser, Jonathan Sive, Christopher Parrish, Dean Smith, Matthew W. Jenner, Mark Drayson, Roger Owen, Ruth M de Tute, Dipal Mehta, Kwee Yong
Journal: Blood
Blood (2023) 142 (Supplement 1): 3390.
https://doi.org/10.1182/blood-2023-188844
Published: 2023