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Dean Smith
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Journal Articles

Can a patient questionnaire (VRAT) reduce the need for ocular examinations with less frequent belantamab mafodotin combined with bortezomib and dexamethasone? the ukmra prommise d trial

Free
Rakesh Popat, Robert Cicero, Andrew Hall, Alexandra Welsh, Charlotte Pawlyn, Ceri Bygrave, Dean Smith, Simona Degli Esposti, Daniel Larkin, Gordon Cook, Matthew Jenner, Martin Kaiser, Lydia Lee, Rashmi Chandrashekar, Michael Nathan, Heena Patel, Sadie Roberts, Sarah Brown, Christopher Parrish
Journal: Blood
Blood (2025) 146 (Supplement 1): 4065.
https://doi.org/10.1182/blood-2025-4065
Published: 2025
Journal Articles

Elranatamab for relapsed/refractory multiple myeloma – multi-centre real-world outcomes from the United Kingdom

Free
Oliver Tomkins, Hannah Giles, Guy Pratt, Bhuvan Kishore, Frances Seymour, Kanta Devi, Charles Agbuduwe, Fatema Alnashaba, Thomas Creasey, Eleanor Ziegler, Pablo Tenorio Feixas, Katharine Bailey, Dean Smith, Ellen Gokkel, Karthik Ramasamy, Ceri Bygrave, Grant Mehrjou, Matthew Jenner, Annisa Butt, Andrew King, Dunnya De-Silva, Fenella Willis, Shelina Sachedina, Clemens Ziller, Jindriska Lindsay, Kenna Robertson, Hugues de Lavallade, Sajitha Sachchithanantham, Neeraj Kohli, Majid Kazmi, Matthew Streetly, Dana Warcel
Journal: Blood
Blood (2025) 146 (Supplement 1): 4045.
https://doi.org/10.1182/blood-2025-4045
Published: 2025
Journal Articles

Cancer-selective targeting of the NF-κB pathway via GADD45β/MKK7 inhibition: Results from the phase I trial of the first-in-class inhibitor, DTP3, in patients with relapsed or refractory multiple myeloma

Free
Aristeidis Chaidos, Dimitrios Potolidis, Jessica Cornice, Holger Auner, Gary Acton, Ceri Bygrave, Gordon Cook, Rakesh Popat, Andrew Davies, Christopher Parrish, Maria Atta, Kim Linton, Dean Smith, Christopher Fox, Iain McNeish, Elizabeth Hadley, Elena Ferrer Martinez Del Peral, Mario Pellegatti, Nigel Adams, Albert Chau, Precious Nnebedum, Daria Capece, Daniela Verzella, Daniel D'Andrea, Jan Rekowski, Christina Yap, Laura Tornatore, Guido Franzoso
Journal: Blood
Blood (2025) 146 (Supplement 1): 5825.
https://doi.org/10.1182/blood-2025-5825
Published: 2025
Journal Articles

Double hit ultra-high risk myeloma treated with isatuximab, bortezomib, lenalidomide, dexamethasone and cyclophosphamide (Isa-VRDc) induction and isa-VRD consolidation: Initial results of the UK myeloma research alliance (UKMRA)  RADAR trial in newly diagnosed transplant eligible patients

Free
Karthik Ramasamy, Kara-Louise Royle, Robert Cicero, Ruth de Tute, Matthew Jenner, Ceri Bygrave, Rakesh Popat, Dipal Mehta, Laura Chiecchio, Berrin Balik, Mohammad Kazeroun, Guy Pratt, Catherine Olivier, Lorna Barnard, Sharon Jackson, Charlotte Kennaway, Gordon Cook, Alan Chant, David Meads, Bryony Dawkins, Michael Chapman, Graham Jackson, Andrew Chantry, Martin Kaiser, Jonathan Sive, Sarah Gooding, Eileen Boyle, Christopher Parrish, Dean Smith, Y L Tracey Chan, Roger Owen, David Cairns, Kwee Yong
Journal: Blood
Blood (2025) 146 (Supplement 1): 98.
https://doi.org/10.1182/blood-2025-98
Published: 2025
Journal Articles

Efficacy and safety of daratumumab in intermediate/high-risk smoldering multiple myeloma: final analysis of CENTAURUS

Available to Purchase
Clinical Trials & Observations
Ola Landgren, Ajai Chari, Yael C. Cohen, Andrew Spencer, Peter M. Voorhees, Irwindeep Sandhu, Matthew W. Jenner, Dean Smith, Michele Cavo, Niels W. C. J. van de Donk, Meral Beksac, Philippe Moreau, Hartmut Goldschmidt, Diego Vieyra, Linlin Sha, Liang Li, Els Rousseau, Robyn Dennis, Robin Carson, Craig C. Hofmeister
Journal: Blood
Blood (2025) 145 (15): 1658–1669.
https://doi.org/10.1182/blood.2024025897
Published: 2025
Includes: Supplemental data
Journal Articles

Targeting Cks1b in Multiple Myeloma Using Fluoxetine

Free
Alice Worker, Dean Smith, Martin Grundy, Joanne Lindsey-Hill, Tanatswa Makore, Mark J Bishton, Claire Seedhouse
Journal: Blood
Blood (2024) 144 (Supplement 1): 6811.
https://doi.org/10.1182/blood-2024-194791
Published: 2024
Journal Articles

Risk Assignment Using the Myeloma Genome Project Panel: A Comparison to Standard of Care Genetic Testing within the UK-MRA RADAR Trial

Free
Sarah Gooding, Kara-Louise Royle, Mohammad Kazeroun, Robert Cicero, Laura Chiecchio, Dipal Mehta, Emma J Lyon, Bethan Hudson-Lund, Jasmin Rahman, Khrystal McBean, Martin F Kaiser, Catherine Olivier, Doina Levinte, Charlotte Kennaway, Dean Smith, Jonathan Sive, Ceri Bygrave, Guy Pratt, Michael A. Chapman, Graham Jackson, Rakesh Popat, Christopher Parrish, Gordon Cook, Angela Hamblin, Naser Ansari-Pour, David A. Cairns, Anjan Thakurta, Karthik Ramasamy, Eileen M Boyle, Kwee Yong, Matthew W. Jenner
Journal: Blood
Blood (2024) 144 (Supplement 1): 3333.
https://doi.org/10.1182/blood-2024-209772
Published: 2024
Journal Articles

Daratumumab, Bortezomib and Dexamethasone for Previously Treated Myeloma - Comparing Real-World Outcomes in England to the Castor Phase III Clinical Trial

Free
Sarah Lawton, Mark J Bishton, Peter Clark, Katherine Thackray, Dean Smith
Journal: Blood
Blood (2024) 144 (Supplement 1): 3778.
https://doi.org/10.1182/blood-2024-207341
Published: 2024
Journal Articles

Belantamab Mafodotin Plus Cyclophosphamide and Dexamethasone for Patients with Relapsed or Refractory Multiple Myeloma: Interim Results from the UK Myeloma Research Alliance Prommise Clinical Trial

Free
Rakesh Popat, Charlotte Pawlyn, Robert Cicero, Andrew Hall, Ceri Bygrave, Dean Smith, Simona Degli Esposti, Daniel Frank Larkin, Gordon Cook, Matthew W. Jenner, Martin F Kaiser, Lydia Sarah Hui Lee, Amrutha Sridhar, Marzia Rahman, Hanna Renshaw, Jennifer Ryan, Victoria Ware, Thea Chandler, Laura Clayton, Sadie Roberts, Sarah R Brown, Christopher Parrish
Journal: Blood
Blood (2024) 144 (Supplement 1): 1984.
https://doi.org/10.1182/blood-2024-204055
Published: 2024
Journal Articles

High Success Rates Utilizing Local Standard of Care Cytogenetic Testing for Risk Stratified Frontline Therapy for Newly Diagnosed Multiple Myeloma: Experience from the Ukmra RADAR Study

Free
Dipal Mehta, Laura Chiecchio, Martin F. Kaiser, Sarah Gooding, Kara-Louise Royle, Doina Levinte, Catherine Olivier, David Allan Cairns, Lorna Barnard, Sharon Jackson, Robert Cicero, Gordon Cook, Michael A. Chapman, Alan Chant, David Meads, Bryony Dawkins, Guy Pratt, Rakesh Popat, Graham Jackson, Ceri Bygrave, Andrew Chantry, Jonathan Sive, Christopher Parrish, Dean Smith, Mark Drayson, Roger Owen, Ruth M de Tute, Karthik Ramasamy, Kwee Yong, Matthew W. Jenner
Journal: Blood
Blood (2023) 142 (Supplement 1): 6715.
https://doi.org/10.1182/blood-2023-188697
Published: 2023
Journal Articles

Efficacy and Safety of Daratumumab (DARA) Monotherapy in Patients with Intermediate-Risk or High-Risk Smoldering Multiple Myeloma (SMM): Final Analysis of the Phase 2 Centaurus Study

Free
Ola Landgren, Ajai Chari, Yael C. Cohen, Andrew Spencer, Peter M. Voorhees, Irwindeep Sandhu, Matthew W. Jenner, Dean Smith, Michele Cavo, Niels WCJ van de Donk, Meral Beksac, Philippe Moreau, Hartmut Goldschmidt, Linlin Sha, Liang Li, Els Rousseau, Robyn Dennis, Robin Carson, Craig C. Hofmeister
Journal: Blood
Blood (2023) 142 (Supplement 1): 210.
https://doi.org/10.1182/blood-2023-181765
Published: 2023
Journal Articles

RADAR Trial: MRD Response Adapted Trial for Newly Diagnosed Transplant Eligible Myeloma Patients

Free
Karthik Ramasamy, David Allan Cairns, Kara-Louise Royle, Robert Cicero, Catherine Olivier, Lorna Barnard, Sharon Jackson, Doina Levinte, Gordon Cook, Alan Chant, David Meads, Bryony Dawkins, Michael A. Chapman, Guy Pratt, Rakesh Popat, Graham Jackson, Ceri Bygrave, Andrew Chantry, Martin F. Kaiser, Jonathan Sive, Christopher Parrish, Dean Smith, Matthew W. Jenner, Mark Drayson, Roger Owen, Ruth M de Tute, Dipal Mehta, Kwee Yong
Journal: Blood
Blood (2023) 142 (Supplement 1): 3390.
https://doi.org/10.1182/blood-2023-188844
Published: 2023
Journal Articles

Health-Related Quality of Life (HRQoL) in Patients with Genetic Standard and High-Risk Disease at Trial Entry: A Cross-Sectional Analysis of RADAR (UK-MRA Myeloma XV)

Free
Catherine SY Lecat, Alan Chant, Orla McCourt, David Meads, Robert Cicero, Kara-Louise Royle, Ceri Bygrave, Andrew Chantry, Michael A. Chapman, Gordon Cook, Bryony Dawkins, Mark Drayson, Graham Jackson, Matthew W. Jenner, Martin F. Kaiser, Dipal Mehta, Roger Owen, Rakesh Popat, Christopher Parrish, Guy Pratt, Jonathan Sive, Dean Smith, Ruth M de Tute, Lorna Barnard, Sharon Jackson, Doina Levinte, Catherine Olivier, Karthik Ramasamy, Kwee Yong, David Allan Cairns
Journal: Blood
Blood (2023) 142 (Supplement 1): 4710.
https://doi.org/10.1182/blood-2023-187453
Published: 2023
Journal Articles

Risk-Adapted Therapy Directed According to Response (RADAR, UK-MRA Myeloma XV) - Comparing MRD-Guided Treatment Escalation and De-Escalation Strategies in Patients with Newly Diagnosed Myeloma Suitable for Stem Cell Transplantation

Free
Kwee Yong, Kara-Louise Royle, Karthik Ramasamy, Christopher Parrish, Anna Hockaday, Samir Asher, Mark T Drayson, Ruth M. de Tute, Matthew W Jenner, Martin F. Kaiser, Guy Pratt, Jonathan Sive, Ceri Bygrave, Gordon Cook, Rakesh Popat, Dean Smith, Catherine Olivier, Lorna Barnard, Doina Levinte, Bryony Dawkins, Michael A Chapman, Andrew D Chantry, Graham Jackson, Sergio A Quezada, Roger G Owen, David Cairns
Journal: Blood
Blood (2022) 140 (Supplement 1): 1844–1846.
https://doi.org/10.1182/blood-2022-168842
Published: 2022
Journal Articles

Prevalence of TP53 Mutations in Del(17p) Myeloma: Spectrum of Mutations and Effect on Survival

Free
Melody Chin, BSc, MSc, Jonathan Sive, MBBS, Christopher Allen, BSc, Claire Roddie, MD PhD, Selina J Chavda, MBBS BSc MRCP, Dean Smith, MBBS, Rakesh Popat, Ali Rismani, MBBS, Shirley D'Sa, Neil Rabin, Rosemary E. Gale, PhD BSc, Kwee L Yong
Journal: Blood
Blood (2016) 128 (22): 4455.
https://doi.org/10.1182/blood.V128.22.4455.4455
Published: 2016
Journal Articles

Cell Cycle Responses of Cyclin D1 and D2-Bearing Multiple Myeloma Tumours to DNA Damage Caused By Ionising Radiation

Free
Dean Smith, MBBS, Kwee L Yong, MBChB, PhD, David Mann, PhD
Journal: Blood
Blood (2014) 124 (21): 2011.
https://doi.org/10.1182/blood.V124.21.2011.2011
Published: 2014
Journal Articles

Synergistic Induction of Cell Death By Combined Inhibition of PIM and AKT Kinases in Cytogenetically Defined Standard and High-Risk Multiple Myeloma

Free
Koremu Meja, Dean Smith, MBBS, Laura Percy, Dennis Huszar, PhD, Barry R Davies, Kwee L Yong, MBChB, PhD, Asim Khwaja
Journal: Blood
Blood (2014) 124 (21): 4723.
https://doi.org/10.1182/blood.V124.21.4723.4723
Published: 2014
Journal Articles

Global Methylation Analysis of Cyclin D1vs D2 Dysregulated Primary Myeloma Samples

Free
Jonathan I Sive, MBChB, Andrew Feber, PhD, Dean Smith, MBBS, John Quinn, MB, PhD, Stephan Beck, PhD, Kwee L Yong, MBChB, PhD
Journal: Blood
Blood (2014) 124 (21): 3389.
https://doi.org/10.1182/blood.V124.21.3389.3389
Published: 2014
Journal Articles

Cohort Analysis of FISH Testing of CD138+ Cells in Relapsed Multiple Myeloma: Implications for Prognosis and Choice of Therapy

Free
Dean Smith, MBBS, Clemency Stephenson, Anna Lach, Steve Chatters, Helena Kempski, Kwee L Yong, MBChB, PhD
Journal: Blood
Blood (2014) 124 (21): 3399.
https://doi.org/10.1182/blood.V124.21.3399.3399
Published: 2014