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Alberto Orfao, MD
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Journal Articles

Discordances between Immunofixation (IFx) and Minimal Residual Disease (MRD) Assessment with Next-Generation Flow (NGF) and Sequencing (NGS) in Patients (Pts) with Multiple Myeloma (MM): Clinical and Pathogenic Significance

Free
Sara Rodríguez, PhD, Ibai Goicoechea, PhD, Katerina Gemenetzi, Cirino Botta, MDPhD, Andreas Agathangelidis, PhD, Noemi Puig, MD PhD, María Teresa Cedena, MD, Alejandro Medina, MD, Rafael Valdés-Mas, Juan José Garcés, José J Pérez, Leire Burgos, María José Calasanz, PhD, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Sarvide Sarai, Felipe Prosper, MD, Jose Angel Martinez-Climent, MD PhD, Alberto Orfao, MD PhD, Ramón García-Sanz, MD PhD, Ana Jiménez Ubieto, MDPhD, Joaquin Martinez Lopez, Juan Jose Lahuerta, MD PhD, Laura Rosinol, MD PhD, Joan Bladé, MD PhD, María-Victoria Mateos, MD PhD, Anastasia Chatzidimitriou, Jesus F. San-Miguel, MD PhD, Bruno Paiva, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-136258
Published: 2020
Journal Articles

Impact of Measurable Residual Disease (MRD) By Multiparameter Flow Cytometry (MFC): A Real-World Study in 1,076 Patients with Acute Myeloid Leukemia (AML)

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Bruno Paiva, PhD, María Belén Vidriales, Maria Desamparados Sampere Talens, Fabian Tarin, Enrique Colado, Celina Benavente, María Teresa Cedena, MD, Joaquin Sanchez, MD, Teresa Caballero-Velázquez, MD PhD, Lourdes Cordon, David Martínez-Cuadron, MD, Teresa Bernal del Castillo, MD PhD, Carmen Botella, Sofia Grille, MDPhD, Josefina Serrano, MD, Carlos Rodriguez, Jesús Lorenzo Algarra, Juan Manuel Alonso Dominguez, MD PhD MSc, Maria Luz Amigo, MD, Manuel BARRIOS García, MDPhD, Raimundo García-Boyero, MD, Mercedes Colorado, MD, Jaime Perez De Oteyza, MDPhD, Manuel Perez Encinas, MD, Lissette Del Pilar Costilla, MD, Maria Jose Sayas, Olga Pérez-López, Marcos González, Jose A. Perez-Simon, MD PhD, Joaquin Martinez-Lopez, MD PhD, Claudia Lucia Sossa, Alberto Orfao, MD PhD, Jesús F. San-Miguel, Miguel Sanz, MD PhD, Pau Montesinos, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–15.
https://doi.org/10.1182/blood-2020-134349
Published: 2020
Journal Articles

Outcome of Adults with Relapsed T-Cell Acute Lymphoblastic Leukemia (T-ALL) Included in Minimal Residual Disease (MRD)-Oriented Trials

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Josep-Maria Ribera, Eduardo Cerello Chapchap, MD, Mireia Morgades, M.Prob.S, Eulàlia Genescà, PhD, Cristina Gil, Irene García-Cadenas, Pere Barba, MD PhD, José González-Campos, MD, Anna Torrent, Teresa Bernal del Castillo, MD PhD, Maria Paz Queipo De Llano, MD, María-Luz Amigo, MD, Mar Tormo, MD, Rosa Coll, MD, Ferran Vall-Llovera, MD, Jordi Ribera, PhD, Maria Jose Sanchez, MD, Beatriz Soria, MD, Antonia Cladera, María Teresa Artola, MD, Antoni Garcia-Guiñon, MD, Alberto Giménez Conca, MD, Lourdes Amador Barciela, MD, Juana Ciudad, PhD, Alberto Orfao, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–7.
https://doi.org/10.1182/blood-2020-137383
Published: 2020
Journal Articles

Single-Cell Characterization of the Multiple Myeloma (MM) Immune Microenvironment Identifies CD27-Negative T Cells As Potential Source of Tumor-Reactive Lymphocytes

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Cirino Botta, MD, Cristina Pérez Ruiz, Ibai Goicoechea, PhD, Noemi Puig, MD PhD, María Teresa Cedena, Lourdes Cordon, Aintzane Zabaleta, PhD, Leire Burgos, Catarina Maia, Sara Rodríguez, PhD, Idoia Rodriguez, Sarai Sarvide, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Erika Lorenzo-Vivas, PhD, Laura Rosinol Dachs, Albert Oriol, MD, María Jesús Blanchard, Rafael Rios, MD PhD, Anna Sureda, MD PhD, Rafael Martínez, Jesús Martín, Joan Bargay, MD PhD, Javier De La Rubia, Marco Rossi, MD, Pierosandro Tagliaferri, MD, Pierfrancesco Tassone, MD, Massimo Gentile, Juana Merino, Felipe Prosper, MD PhD, Alberto Orfao, MD PhD, Maria-Victoria Mateos, Juan-José Lahuerta, MD PhD, Joan Bladé, MD PhD, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 506.
https://doi.org/10.1182/blood-2019-123974
Published: 2019
Journal Articles

Altered Immunophenotypes on Leukemic and/or Monocytic Cells from Acute Myeloid Leukemia Highly Predict for Nucleophosmin Gene Mutation

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Sergio Matarraz, Pilar Leoz, Xavier Calvo, MD PhD, Luis García Alonso, Rosa Ayala Bueno, José Ignacio Sánchez-Gallego, PhD, Neus Villamor, Enrique Colado, MD PhD, María Belén Vidriales, María Isabel Prieto Conde, Maria Carmen Chillon, Ramón García-Sanz, MD PhD, Vincent H.J. Van Der Velden, PhD, Félix López Cadenas, MD, María Díez-Campelo, MD PhD, Leonor Arenillas, MD PhD, Sara Alonso, MD, Ariana Fonseca, Covadonga Quirós Caso, Laura Magnano, José Antonio Garcia Vela, MD, Carlos Fernandez, Daniela Damasceno, Andrea Mayado, Susana Barrena, PhD, Alberto Orfao, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2687.
https://doi.org/10.1182/blood-2019-131733
Published: 2019
Journal Articles

Circulating Tumor Cells (CTCs) for Comprehensive and Multiregional Non-Invasive Genetic Characterization of Multiple Myeloma (MM)

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Juan José Garcés, Gabriel Bretones, Leire Burgos, Rafael Valdes-Mas, Diego Alignani, PhD, Diana Álvarez Puente, Ibai Goicoechea, PhD, Miguel García Álvarez, Sonia Garate, Idoia Rodriguez, Maria Jose Calasanz, PhD BSc, Paula Rodriguez, MD, Rafael Rios, MD PhD, Joaquin Martinez-Lopez, MD PhD, Pamela Millacoy, Luis Palomera, MD PhD, Rafael Del Orbe, MD PhD, Albert Pérez, MD, Xabier Agirre, PhD, Juan Flores-Montero, Luzalba Sanoja-Flores, Alberto Orfao, MD PhD, Halima El Omri, Felipe Prosper, MD PhD, Carlos Lopez-Otin, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3064.
https://doi.org/10.1182/blood-2019-126527
Published: 2019
Journal Articles

Post-Remission Treatment with Chemotherapy or Allogeneic Hematopoietic Stem Cell Transplantation (alloHSCT) in Adult Patients with High-Risk (HR) Philadelphia Chromosome-Negative (Ph-neg) Acute Lymphoblastic Leukemia (ALL) According to Their Minimal Residual Disease (MRD). Final Results of the Pethema ALL-HR-11 Trial

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Josep-Maria Ribera, MD PhD, Mireia Morgades, M.Prob.S, Juana Ciudad, PhD, Pau Montesinos, MD PhD, Pere Barba, MD PhD, Irene García-Cadenas, María José Moreno, MD, Susana Vives, MD, Jordi Esteve, Cristina Gil, Silvia Monsalvo, MD, María Teresa Artola, MD, Jordi Ribera, PhD, Eulàlia Genescà, PhD, Mar Tormo, MD PhD, Marta Cervera, MD, Daniel Martínez-Carballeira, MD, Andrés Novo, MD, José González-Campos, MD, Beatriz Soria, MD, Arancha Bermúdez, MD, Aurelio López Martínez, MD, Santiago Mercadal, MD, Rosa Fernández-Martín, MD, Rosa Coll, MD, Josefina Serrano, Maria Luz Amigo, MD, Pilar Martínez-Sánchez, Juan-Miguel Bergua, MD, Alfons Serrano-Maestro, MD, Alberto Giménez Conca, MD, Susana Barrena, PhD, Isabel Granada, PhD, Evarist Feliu, MD PhD, Alberto Orfao, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 826.
https://doi.org/10.1182/blood-2019-123613
Published: 2019
Journal Articles

The Pathogenesis of Multiple Myeloma (MM) Is Preceded By Mutated Lymphopoiesis and B Cell Oligoclonality That Persist in Patients with Negative Minimal Residual Disease (MRD)

Free
Sara Rodríguez, PhD, Noemi Puig, MD PhD, Katerina Gemenetzi, Ibai Goicoechea, PhD, Cirino Botta, MD, Andreas Agathangelidis, PhD, Rafael Valdés-Mas, Juan José Garcés, María Teresa Cedena, José J Pérez, Leire Burgos, Maria Jose Calasanz, PhD BSc, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Erika Lorenzo-Vivas, PhD, Irene Aires, Idoia Rodriguez, Sarvide Sarai, Felipe Prosper, MD PhD, Jose Angel Martinez-Climent, MD PhD, Alberto Orfao, MD PhD, Ramón García-Sanz, MD PhD, Joaquin Martinez-Lopez, MD PhD, Juan-José Lahuerta, MD PhD, Laura Rosinol Dachs, Joan Bladé, MD, Maria-Victoria Mateos, Anastasia Hadzidimitriou, PhD, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 509.
https://doi.org/10.1182/blood-2019-128049
Published: 2019
Journal Articles

Impact of Treatment on B-Cell Regeneration By Next Generation Flow Cytometry in Patients with Multiple Myeloma

Free
Robéria Pontes, MSc, Juan Flores-Montero, Luzalba Sanoja-Flores, Noemi Puig, MD PhD, Roberto José Pessoa Magalhães, MD, Alba Corral Mateos, Anna Beatriz Salgado, Angelo Maiolino, MD, Maria-Victoria Mateos, MD PhD, Bruno Paiva, MD PhD, Elaine Sobral da Costa, PhD, Jacques JM van Dongen, Alberto Orfao, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4491.
https://doi.org/10.1182/blood-2018-99-117162
Published: 2018
Journal Articles

Prognostic Value of the Hevylite Chain in MGUS Patients in a Population Study

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Aránzazu García Mateo, PhD, Maria-Victoria Mateos, MD PhD, Alberto Orfao, MD PhD, Teresa Contreras Sanfeliciano, Luzalba del Carmen Contreras Sanfeliciano, Mª Del Rosario Caro Narros, Noemi Puig, MD PhD, José Antonio Queizan, Carmen Olivier
Journal: Blood
Blood (2018) 132 (Supplement 1): 4506.
https://doi.org/10.1182/blood-2018-99-110329
Published: 2018
Journal Articles

Multidimensional Immunophenotyping Identifies Hallmarks of Systemic Light-Chain Amyloidosis (AL) and Maps the Disease in the Crossroad between MGUS and Multiple Myeloma (MM)

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Noemi Puig, MD PhD, Bruno Paiva, MD PhD, Marta Lasa, Leire Burgos, José J Pérez, Juana Merino, Cristina Moreno, Maria-Belen Vidriales, MD, Dolores Gómez, María Teresa Cedena, Enrique M. Ocio, MD, Ramon Lecumberri, MD PhD, Alfonso García de Coca, MD PhD, Jorge Labrador, MD, Esther González Garcia, MD, Luis Palomera, MD PhD, Mercedes Gironella, MD, Valentin Cabañas, MD, Maria Casanova, MD, Albert Oriol, MD, Isabel Krsnik, MD PhD, Albert Pérez, MD, Javier De La Rubia, MD, José Enrique de la Puerta, Felipe De Arriba, PhD, Felipe Prosper, MD PhD, Joaquin Martinez Lopez, MD PhD, Quentin Lecrevisse, Javier Verde, Maria-Victoria Mateos, MD PhD, Juan Jose Lahuerta, MD PhD, Alberto Orfao, MD PhD, Jesús F San-Miguel, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3170.
https://doi.org/10.1182/blood-2018-99-119281
Published: 2018
Journal Articles

Clinical Significance and Transcriptional Profiling of Persistent Minimal Residual Disease (MRD) in Multiple Myeloma (MM) Patients with Standard-Risk (SR) and High-Risk (HR) Cytogenetics

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Ibai Goicoechea, PhD, Noemi Puig, MD PhD, María Teresa Cedena, Lourdes Cordon, Maria-Belen Vidriales, MD, Leire Burgos, Juan Flores-Montero, Norma C. Gutierrez, MD PhD, Maria Jose Calasanz, BSc, PhD, Maria Luisa Martin-Ramos, David Lara-Astiaso, PhD, Amaia Vilas-Zornoza, PhD, Diego Alignani, PhD, Idoia Rodriguez, Sarai Sarvide, Ramon Garcia-Sanz, MD PhD, Joaquin Martinez-Lopez, MD PhD, Albert Oriol, MD, Rafael Rios, MD PhD, Jesús Martín, Rafael Martínez, Josep Sarra, Miguel T Hernández, MD PhD, Javier De La Rubia, MD, Isabel Krsnik, Jose Maria Moraleda, Luis Palomera, MD PhD, Joan Bargay, MD PhD, Alberto Orfao, MD PhD, Laura Rosiñol, Maria-Victoria Mateos, MD PhD, Juan Jose Lahuerta, MD PhD, Joan Bladé, MD PhD, Jesus F San-Miguel, MD PhD, Bruno Paiva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 112.
https://doi.org/10.1182/blood-2018-99-113312
Published: 2018
Journal Articles

Characteristics and Outcome of Early T Cell Precursor ALL (ETP-ALL) Patients Treated with High-Risk Spanish Pethema Protocols

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Eulalia Genesca, PhD, Mireia Morgades, M.Prob.S, Pau Montesinos, MD PhD, Pere Barba, MD, Cristina Gil, MD PhD, Ramon Guàrdia, MD, Maria Jose Moreno, MD, Daniel Martínez-Carballeira, MD, Irene García-Cadenas, Susana Vives, MD, Jordi Ribera, José González-Campos, MD, Marina Diaz-Beyá, MD, Santiago Mercadal, MD, Maria Teresa Artola, MD, Antonia Cladera, MD, Mar Tormo, MD PhD, Arancha Bermudez, MD, Ferran Vall-Llovera, MD, Pilar Martinez, MD, María-Luz Amigo, MD, Juan-Miguel Bergua, MD, María Calbacho, MD, Jesús-María Hernández-Rivas, MD PhD, Silvia Monsalvo, Andrés Novo, MD, Marta Cervera, MD, Antonio Garcia-Guiñon, MD, Jordi Junca, MD, Juana Ciudad, PhD, Alberto Orfao, MD PhD, Josep-Maria Ribera, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1553.
https://doi.org/10.1182/blood-2018-99-114559
Published: 2018
Journal Articles

Impact of Next-Generation Flow (NGF) Minimal Residual Disease (MRD) Monitoring in Multiple Myeloma (MM): Results from the Pethema/GEM2012 Trial

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Bruno Paiva, PhD, Noemi Puig, MD PhD, Maria Teresa Cedena, Lourdes Cordon, Maria-Belen Vidriales, Leire Burgos, Juan Flores-Montero, Lucía Lopez-Anglada, Norma Gutierrez, MD PhD, Maria Jose Calasanz, BSc, PhD, Maria Luisa Martin-Ramos, Ramon Garcia-Sanz, MD PhD, Joaquin Martinez-Lopez, MD PhD, Albert Oriol, MD, M Jesús Blanchard, Rafael Rios, Jesús Martín, Rafael Martínez, Josep Sarra, Miguel T Hernández, Javier de la Rubia, Isabel Krsnik, Jose M Moraleda, Luis Palomera, Juan Bargay, Alberto Orfao, MD PhD, Laura Rosinol, MD PhD, Maria-Victoria Mateos, MD, Juan-José Lahuerta, Joan Bladé, MD PhD, Jesus F. San Miguel, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 905.
https://doi.org/10.1182/blood.V130.Suppl_1.905.905
Published: 2017
Journal Articles

Low-Count Monoclonal B-Cell Lymphocytosis Persists after 7 Years of Follow-up and Confers a Higher Risk of Death

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Alberto Orfao, MD PhD, Ignacio Criado, MSc, BSc, Arancha Rodríguez-Caballero, PhD, M. Laura Gutiérrez, PhD, Carlos Eduardo Pedreira, PhD, Miguel Alcoceba, PhD, Wendy Grey Nieto, PhD, Cristina Teodosio, PhD, Paloma Barcena, BSc, Alfonso Romero, MD, Paulino Fernández-Navarro, MD PhD, Marcos González, MD, Julia Almeida
Journal: Blood
Blood (2017) 130 (Supplement 1): 4299.
https://doi.org/10.1182/blood.V130.Suppl_1.4299.4299
Published: 2017
Journal Articles

New Alternatives for the Evaluation of Minimal Residual Disease (MRD) Detection By Next Generation Sequencing in Multiple Myeloma

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Alejandro Medina, BSc, Cristina Jiménez, PhD, Noemi Puig, MD PhD, Beatriz Sanchez-Vega, Juan Flores-Montero, Marcos González, MD, Maria Jose Calasanz, BSc, PhD, Rosa M. Ayala, MD PhD, Maria E Sarasquete, PhD, Bruno Paiva, PhD, Maria Teresa Cedena, Marta Fernández-Mercado, Inmaculada Rapado, Laura Rosinol, MD PhD, Enrique M. Ocio, MDPhD, Albert Oriol, MD, Miguel Alcoceba, PhD, Miguel T Hernández, Rafael Martinez Martinez, Maria-Victoria Mateos, MD, Juan-José Lahuerta, Joan Bladé, MD PhD, Alberto Orfao, MD PhD, Jesus F. San Miguel, MD, Joaquin Martínez-López, Ramón García-Sanz, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1783.
https://doi.org/10.1182/blood.V130.Suppl_1.1783.1783
Published: 2017
Journal Articles

Results of the Full Pediatric, Minimal Residual Disease (MRD)-Oriented Trial LAL-RI/2008 for Adolescents and Young Adults (AYA) with Standard Risk (SR), Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia (ALL)

Free
Josep-Maria Ribera, MD, Mireia Morgades, M.Prob.S, Pau Montesinos, MD PhD, Daniel Martínez-Carballeira, MD, Cristina Gil, MD, Pere Barba, MD, Mar Tormo, MD PhD, Raimundo García-Boyero, MD, Ramon Guàrdia, MD, María Pedreño, MD, Santiago Mercadal, MD, Andrés Novo, MD, Jesús-María Hernández-Rivas, MD PhD, Juan Bergua, MD, José González-Campos, MD, María-Luz Amigo, MD, Marta Cervera, MD, Pilar Martínez-Sánchez, MD, Rodrigo Martino, MD PhD, María Calbacho, MD, Antoni Garcia-Guiñon, MD, Susana Vives, MD, Evarist Feliu, MD PhD, Alberto Orfao, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1273.
https://doi.org/10.1182/blood.V130.Suppl_1.1273.1273
Published: 2017
Journal Articles

Comparison of Efficacy and Safety of Two Types of E.coli Asparaginase (Native or Pegylated) for Treatment of Adult Patients with High-Risk (HR), Philadelphia (Ph) Chromosome-Negative ALL Included in the Prospective MRD-Oriented Protocol ALL-HR-11 from the Spanish Pethema Group

Free
Josep-Maria Ribera, MD PhD, Mireia Morgades, MProbS, Pau Montesinos, MD PhD, Irene García-Cadenas, MD, Pere Barba, MD PhD, Beatriz Soria, MD, Arancha Bermúdez, MªJosé Moreno, MD, José González-Campos, MD, Susana Vives, MD, Cristina Gil, MD, Eugenia Abella, MD PhD, Ramon Guàrdia, MD PhD, Teresa Bernal, MD PhD, Pilar Martínez-Sánchez, MD, MªLuz Amigo, MD, Santiago Mercadal, MD, Alfons Serrano, MD, Aurelio López-Martínez, MD, Ferran Vall-llovera, MD, MªJosé Sánchez-Sánchez, MD, MªJesús Peñarrubia, MD PhD, María Calbacho, MD, Jose-Angel Méndez, MD, Juan Bergua, MD, Antònia Cladera, MD, Mar Tormo, MD, Daniel García-Belmonte, MD, Juana Ciudad, MD PhD, Evarist Feliu, MD PhD, Alberto Orfao, MD PhD
Journal: Blood
Blood (2016) 128 (22): 180.
https://doi.org/10.1182/blood.V128.22.180.180
Published: 2016
Journal Articles

Euroflow-Based Immunophenotypic Characterization of CD34+ Cell Compartment in Juvenile Myelomonocytic Leukemia (JMML): A New Tool for Differential Diagnosis

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Giuseppe Gaipa, PhD, Cristina Bugarin, Sergio Matarraz, Chiara Buracchi, PhD, Lukasz Sedek, MDPhD, Vincent H.J. van der Velden, PhD, Tomasz Szczepanski, Prof MD PhD, Alita van der Sluijs, Elaine Sobral da Costa, Michaela Novakova, Ester Mejstrikova, MD PhD, Carmen Aanei, Jacques JM van Dongen, Andrea Biondi, MD, Alberto Orfao, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3127.
https://doi.org/10.1182/blood.V128.22.3127.3127
Published: 2016
Journal Articles

Non-Invasive Genetic Profiling Is Highly Applicable in Multiple Myeloma (MM) through Characterization of Circulating Tumor Cells (CTCs)

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Leire Burgos, Diego Alignani, Juan-Jose Garces, Lourdes Ortiz, Tomas Jelinek, MD, Victor Segura, PhD, Luzalba Sanoja, Maria-Jose Calasanz, Xabier Agirre, PhD, Felipe Prosper, MD, Paula Rodriguez-Otero, MD PhD, Rafael Rios, Joaquin Martinez-Lopez, Luis Palomera, MD PhD, Maria Teresa Zudaire, Rafael Del Orbe, MD, Jacques J.M. van Dongen, MD PhD, Alberto Orfao, MD PhD, Bruno Paiva, PhD, Jesus San Miguel, MD PhD
Journal: Blood
Blood (2016) 128 (22): 801.
https://doi.org/10.1182/blood.V128.22.801.801
Published: 2016