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Changying Jiang, PhD
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Journal Articles

Oncogenic MALT1 Promotes Cell Survival and Mediates Ibrutinib Resistance and Ibrutinib-Venetoclax Resistance in Mantle Cell Lymphoma

Vivian Changying Jiang, PhD, Junwei Lian, PhD, Shengjian Huang, PhD, Shaojun Zhang, PhD, Yang Liu, PhD, Linghua Wang, MDPhDMS, Michael Wang, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18.
https://doi.org/10.1182/blood-2020-140871
Published: 2020
Journal Articles

Targeting Glutamine Metabolism Overcomes Resistance to Targeted Therapies in Refractory Mantle Cell Lymphoma

Lingzhi Li, Changying Jiang, PhD, Lucy Jayne Navsaria, Yang Liu, PhD, Angela Leeming, Michael Wang, MD, Yixin Yao, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–26.
https://doi.org/10.1182/blood-2020-140736
Published: 2020
Journal Articles

Targeting Transcription Checkpoint Using a Novel CDK9 Inhibitor in Mantle Cell Lymphoma

Junwei Lian, PhD, Yu Xue, PhD, Alexa A Jordan, BS, Joseph McIntosh, BS, Yang Liu, PhD, Michael Wang, MD, Jia Zhou, PhD, Vivian Changying Jiang, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-140865
Published: 2020
Journal Articles

Interrogation of Dysregulated Pathways Enables Precision Medicine in Mantle Cell Lymphoma

Yang Liu, PhD, Shuangtao Zhao, PhD, Changying Changying Jiang, PhD, Yixin Yao, PhD, Joseph McIntosh, BS, Alexa A Jordan, BS, Yijing Li, MS, Yuxuan Che, Preetesh Jain, MBBS,MDDM,PhD, Linghua Wang, PhD, Michael Wang, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33.
https://doi.org/10.1182/blood-2020-140794
Published: 2020
Journal Articles

Abemaciclib-Based Combinational Therapies to Overcome Therapeutic Resistance in Mantle Cell Lymphoma

Yuxuan Che, Yang Liu, PhD, Lingzhi Li, Holly Hill, Joseph McIntosh, BS, Alexa A Jordan, BS, Dayoung Jung, Yixin Yao, PhD, Vivian Changying Jiang, PhD, Michael Wang, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-140856
Published: 2020
Journal Articles

Targeting ROR1 Using the Antibody Drug Conjugate Vls-101 in Aggressive Mantle Cell Lymphoma

Vivian Changying Jiang, PhD, Yang Liu, PhD, Joseph McIntosh, BS, Alexa A Jordan, BS, Angela Leeming, Zhihong Chen, Katti A. Jessen, PhD, Brian J. Lannutti, PhD, Michael Wang, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33.
https://doi.org/10.1182/blood-2020-137660
Published: 2020
Journal Articles

Targeting Antibody Checkpoint Fcgriib Using Monoclonal Antibody BI-1206 to Overcome Therapeutic Resistance in Mantle Cell Lymphoma

Alexa A Jordan, BS, Joseph McIntosh, BS, Yang Liu, PhD, Angela Leeming, William Lee, Ingrid Karlsson, PhD, Linda Mårtensson, PhD, Mathilda Kovacek, Ingrid Teige, PhD, Björn Frendéus, PhD, Michael Wang, MD, Changying Changying Jiang, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 35.
https://doi.org/10.1182/blood-2020-140849
Published: 2020
Journal Articles

Overcoming CAR T Resistance with Non-Covalent BTK Inhibitor Loxo-305 in Mantle Cell Lymphoma

Yang Liu, PhD, Vivian Changying Jiang, PhD, Joseph McIntosh, BS, Alexa A Jordan, BS, Yijing Li, MS, Michael Wang, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10.
https://doi.org/10.1182/blood-2020-137645
Published: 2020
Journal Articles

Single Cell Transcriptomic Evolution and Resistance Mechanisms of BTK and BCL-2 Inhibition in Mantle Cell Lymphoma

Vivian Changying Jiang, PhD, Shaojun Zhang, PhD, Junwei Lian, PhD, Yuanxin Wang, Rongjia Zhang, Yang Liu, PhD, Joseph McIntosh, BS, Guangchun Han, Ruiping Wang, PhD, David Santos, Maria Badillo, MSN, RN, OCN, CCRP, Angela Leeming, Zhihong Chen, Kimberly Hartig, John Bigcal, Hun Lee, MD, Raphael Eric Steiner, MD, Jorge Enrique Romaguera, MD, Preetesh Jain, MBBS,MDDM,PhD, Krystle Nomie, PhD, Andy Futreal, Linghua Wang, MDPhDMS, Michael Wang, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-140882
Published: 2020
Journal Articles

Xeno-MCL: Genomic, Transcriptomic and Pathologic Landscape Associated with Disease Progression, Clonal Evolution and Tissue Tropism in Patient-Derived Xenografts of Mantle Cell Lymphoma

Vivian Changying Jiang, PhD, Shaojun Zhang, PhD, Shuangtao Zhao, PhD, Yang Liu, PhD, Joseph McIntosh, BS, Linghua Wang, MDPhDMS, Michael Wang, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 20.
https://doi.org/10.1182/blood-2020-140878
Published: 2020
Journal Articles

AZD4320 Is a Novel and Potent BCL-2/X L Dual Inhibitor in Targeting Aggressive Mantle Cell Lymphoma

Yijing Li, MS, Yang Liu, PhD, Joseph McIntosh, BS, Alexa A Jordan, BS, Angela Leeming, Courtney L Andersen, PhD, Justin Cidado, PhD, Vivian Changying Jiang, PhD, Michael Wang, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44.
https://doi.org/10.1182/blood-2020-140775
Published: 2020
Journal Articles

Analysis of Factors Predictive of Risk of Transformation and Time to Transformation in Patients (pts) with Mantle Cell Lymphoma - Cohort Study of 369 Patients

Preetesh Jain, MBBS,MDDM,PhD, Rashmi Kanagal-Shamanna, MD, Chi Young Ok, MD, Gonzalez-Pagan Omarya, Lucy Navsaria, MB BCh BAO, Graciela M. Nogueras González, MPH, Shaojun Zhang, PhD, Guangchun Han, Ahmad Ghorab, Prajwal Boddu, MD, F. B. Hagemeister, MD, Hun Ju Lee, MD, Krystle Nomie, PhD, Changying Jiang, PhD, Luis Fayad, MD, Jason R. Westin, MD, Loretta J. Nastoupil, MD MSc, Sairah Ahmed, MD, Swaminathan P. Iyer, MD, Richard E. Champlin, MD, Sattva S Neelapu, MD, Jorge Enrique Romaguera, MD, Nathan H. Fowler, MD, Guilin Tang, MD, Shaoying Li, MD, Keyur Patel, MD PhD, Selvi Thirumurthi, Pan Tinsu, Guofang Xu, MD, Linghua Wang, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1526.
https://doi.org/10.1182/blood-2019-125936
Published: 2019
Journal Articles

The Development of a Precision Medicine Platform to Overcome Ibrutinib Resistance in Mantle Cell Lymphoma

Yang Liu, MD, Shuangtao Zhao, PhD, Changying Jiang, PhD, Yixin Yao, PhD, Kelley Paige Murfin, MSPH, Hadley Grundman, Liang Zhang, MD PhD, Krystle Nomie, PhD, Linghua Wang, PhD, Michael Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1487.
https://doi.org/10.1182/blood-2019-131079
Published: 2019
Journal Articles

Non-Bcl2 Mutations Are Predominant in Patients (pts) with Venetoclax Resistant Mantle Cell Lymphoma (MCL) - Response and Clinical Outcomes in Ultra-Refractory MCL

Preetesh Jain, MBBS,MDDM,PhD, Shuangtao Zhao, PhD, Rashmi Kanagal-Shamanna, MD, Lucy Navsaria, MB BCh BAO, Holly Hill, Ankita Misra, Krystle Nomie, PhD, Changying Jiang, PhD, Yixin Yao, PhD, Liang Zhang, MD PhD, Loretta J. Nastoupil, MD MSc, F. B. Hagemeister, MD, Jason R. Westin, MD, Ranjit Nair, MD, Raphael Eric Steiner, MD, Onyeka Oriabure, Wendy Chen, Guilin Tang, MD, C. Cameron Yin, MD PhD, Keyur Patel, MD PhD, Jorge Enrique Romaguera, MD, Nathan H. Fowler, MD, Linghua Wang, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2815.
https://doi.org/10.1182/blood-2019-126175
Published: 2019
Journal Articles

BI-1206, a Monoclonal Antibody Against Fcγriib, Showed Superior Anti-Tumor Activity in an Ibrutinib-Venetoclax Dual Resistant PDX Model in Mantle Cell Lymphoma

Changying Jiang, PhD, Yang Liu, MD, Joseph Mitchell McIntosh, Angela Leeming, Rongjia Zhang, William Lee, Krystle Nomie, PhD, Ingrid Karlsson, PhD, Linda Mårtensson, PhD, Mathilda Kovacek, Ingrid Teige, PhD, Björn Frendéus, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2863.
https://doi.org/10.1182/blood-2019-126957
Published: 2019
Journal Articles

Targeting PI3K and PLK1 to Overcome Ibrutinib-Venetoclax Resistance in Mantle Cell Lymphoma

Changying Jiang, PhD, Rongjia Zhang, Shaojun Zhang, PhD, William Lee, Shengjian Huang, PhD, Yang Liu, MD, Angela Leeming, Joseph Mitchell McIntosh, Preetesh Jain, MBBS,MDDM,PhD, Krystle Nomie, PhD, Linghua Wang, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4062.
https://doi.org/10.1182/blood-2019-128299
Published: 2019
Journal Articles

Frontline Treatment with Ibrutinib Plus Rituximab (IR) Followed By Short Course R-Hypercvad/MTX Is Extremely Potent and Safe in Patients (age ≤ 65 years) with Mantle Cell Lymphoma (MCL) - Results of Phase-II Window-1 Clinical Trial

Michael L. Wang, MD, Preetesh Jain, MBBS,MDDM,PhD, Hun Ju Lee, MD, F. B. Hagemeister, MD, Felipe Samaniego, MD, Jason R. Westin, MD, Loretta J. Nastoupil, MD MSc, Wendy Chen, Krystle Nomie, PhD, Shaojun Zhang, PhD, Omar Moghrabi, Shuangtao Zhao, PhD, Rashmi Kanagal-Shamanna, MD, Chi Young Ok, MD, Onyeka Oriabure, Graciela M. Nogueras González, MPH, Dayoung Jung, Lucy Navsaria, MB BCh BAO, Ann Uy, Archie Pedersen, Liang Zhang, MD PhD, Changying Jiang, PhD, Feng Lei, MS, Yixin Yao, PhD, Guofang Xu, MD, Nicolaus Wagner-Bartak, MD, Selvi Thirumurthi, David Santos, Guilin Tang, MD, Keyur Patel, MD PhD, C. Cameron Yin, MD PhD, Michelle Avellaneda, Maria Badillo, Luis Fayad, MD, Sattva S Neelapu, MD, Nathan H. Fowler, MD, Jorge Enrique Romaguera, MD, Linghua Wang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3987.
https://doi.org/10.1182/blood-2019-126044
Published: 2019
Journal Articles

Frontline Treatment with Ibrutinib with Rituximab (IR) Combination Is Highly Effective in Elderly (≥65 years) Patients with Mantle Cell Lymphoma (MCL) - Results from a Phase II Trial

Preetesh Jain, MBBS,MDDM,PhD, Hun Ju Lee, MD, Raphael Eric Steiner, MD, F. B. Hagemeister, MD, Felipe Samaniego, MD, Jason R. Westin, MD, Loretta J. Nastoupil, MD MSc, Sairah Ahmed, MD, Swaminathan P. Iyer, MD, Jorge Enrique Romaguera, MD, Shuangtao Zhao, PhD, Krystle Nomie, PhD, Chi Young Ok, MD, Rashmi Kanagal-Shamanna, MD, Onyeka Oriabure, Guofang Xu, MD, Liang Zhang, MD PhD, Changying Jiang, PhD, Dayoung Jung, Lucy Navsaria, MB BCh BAO, Wendy Chen, Omar Moghrabi, Tayyaba Nizam, Chloe Marie McClain, Maria Badillo, Selvi Thirumurthi, David Santos, Guilin Tang, MD, Keyur Patel, MD PhD, Sattva S Neelapu, MD, Linghua Wang, PhD, Nathan H. Fowler, MD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3988.
https://doi.org/10.1182/blood-2019-125800
Published: 2019
Journal Articles

Transcriptomic Heterogeneity and Clonal Evolution Associated with Therapeutic Resistance in Mantle Cell Lymphoma Revealed By Single Cell RNA-Seq

Changying Jiang, PhD, Shaojun Zhang, PhD, Yuanxin Wang, Rongjia Zhang, Yang Liu, MD, Joseph Mitchell McIntosh, Guangchun Han, PhD, Ruiping Wang, PhD, David Santos, Maria Badillo, Angela Leeming, Zhihong Chen, Kimberly Hartig, John Bigcal, Hun Ju Lee, Raphael E Steiner, MD, Jorge Enrique Romaguera, MD, Preetesh Jain, MBBS, MDDM, PhD, Krystle Nomie, PhD, Andy Futreal, PhD, Linghua Wang, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5217.
https://doi.org/10.1182/blood-2019-129134
Published: 2019
Journal Articles

Pdox Models Empower Preclinical Drug Evaluation and Mechanistic Studies Via Faithful Recapitulation of the Pathology, Complex Heterogeneity, Genetic-Transcriptomic Landscape, and Therapeutic Response of Mantle Cell Lymphoma

Changying Jiang, PhD, Shaojun Zhang, PhD, Shengjian Huang, PhD, Yang Liu, MD, Rongjia Zhang, Angela Leeming, Joseph Mitchell McIntosh, William Lee, Krystle Nomie, PhD, Linghua Wang, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3974.
https://doi.org/10.1182/blood-2019-128810
Published: 2019