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Yuxuan Che
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Journal Articles

Predicting CAR-T Response in Mantle Cell Lymphoma Using Deep Neural Network Models on Single-Cell RNA Sequencing Data

Fangfang Yan, Vivian Changying Jiang, Yang Liu, Yijing Li, Yuxuan Che, Preetesh Jain, Lukas Simon, Michael Wang
Journal: Blood
Blood (2023) 142 (Supplement 1): 4377.
https://doi.org/10.1182/blood-2023-187544
Published: 2023
Journal Articles

Modulating Immunometabolism to Reinvigorate T-Cell Effector Function and Antitumor Immunity in the Mantle Cell Lymphoma Microenvironment

Yixin Yao, Yang Liu, Yuxuan Che, Yijing Li, Heng-Huan Lee, Michael L. Wang, Joseph McIntosh
Journal: Blood
Blood (2022) 140 (Supplement 1): 6446–6447.
https://doi.org/10.1182/blood-2022-169543
Published: 2022
Journal Articles

HSP27 Promotes Mantle Cell Lymphoma Growth and Mediates Resistance to Venetoclax

Yuxuan Che, Wei Wang, Yang Liu, Heng-Huan Lee, Yijing Li, Zhihong Chen, Joseph McIntosh, Changying Jiang, Yixin Yao, Michael Wang
Journal: Blood
Blood (2022) 140 (Supplement 1): 6405–6406.
https://doi.org/10.1182/blood-2022-167611
Published: 2022
Journal Articles

Targeting the HSP90-MYC-CDK9 Axis to Overcome Dual Resistance to BTK Inhibition and CAR-T Therapy in Mantle Cell Lymphoma

Vivian Changying Jiang, Fangfang Yan, Alexa A Jordan, Yuxuan Che, Yang Liu, Qingsong Cai, Yijing Li, Joseph McIntosh, Zhihong Chen, Jovanny Vargas, Yixin Yao, Heng-Huan Lee, Jingling Jin, Wei Wang, Lei Nie, Zhongming Zhao, Lukas M Simon, Michael L. Wang
Journal: Blood
Blood (2022) 140 (Supplement 1): 3512–3513.
https://doi.org/10.1182/blood-2022-163696
Published: 2022
Journal Articles

Establishment of a Patient-Derived Organoid Culture Platform for Mantle Cell Lymphoma Drug Sensitivity and CAR T Cell Anti-Tumor Activity Assay

Lei Nie, Yang Liu, Changying Jiang, Yuxuan Che, Jingling Jin, Qingsong Cai, Wei Wang, Yijing Li, Alexa A Jordan, Joseph McIntosh, Jovanny Vargas, Yixin Yao, Heng-Huan Lee, Michael L. Wang
Journal: Blood
Blood (2022) 140 (Supplement 1): 9219–9220.
https://doi.org/10.1182/blood-2022-169622
Published: 2022
Journal Articles

Establishment of Patient-Derived Organoid Culture Platform of Mantle Cell Lymphoma

Lei Nie, Yang Liu, Yuxuan Che, Yijing Li, Wei Wang, Jingling Jin, Qingsong Cai, Jovanny Vargas, Joseph McIntosh, Alexa A Jordan, Vivian Changying Jiang, Yixin Yao, Michael Wang
Journal: Blood
Blood (2021) 138 (Supplement 1): 3508.
https://doi.org/10.1182/blood-2021-152994
Published: 2021
Journal Articles

Immune-Depleted Tumor Microenvironment Signature Is Associated with BTK Inhibitor Resistance in Mantle Cell Lymphoma

Preetesh Jain, Krystle Nomie, Vitaly Segodin, Evgeniy Egorov, Yixin Yao, Lucy Navsaria, Holly Hill, Nikita Kotlov, Rashmi Kanagal-Shamanna, Chi Young Ok, Francisco Vega, Shaoying Li, Yuxuan Che, Yijing Li, Viktor Svekolkin, Alexander Bagaev, Felix Frenkel, Ravshan Attaulakhanov, Nathan H. Fowler, Christopher R. Flowers, Michael Wang
Journal: Blood
Blood (2021) 138 (Supplement 1): 1321.
https://doi.org/10.1182/blood-2021-151416
Published: 2021
Journal Articles

Single Cell Transcriptomic Profiling of Patient-Derived Xenografts of Mantle Cell Lymphoma Reveals a Special Tumor Cell Population: Seed Cells for Disease Dissemination and Progression

Vivian Changying Jiang, Qingsong Cai, Dapeng Hao, Yang Liu, Yijing Li, Yuxuan Che, Joseph McIntosh, Alexa A Jordan, Zhihong Chen, Angela Leeming, Lei Nie, Linghua Wang, Michael Wang
Journal: Blood
Blood (2021) 138 (Supplement 1): 1319.
https://doi.org/10.1182/blood-2021-149280
Published: 2021
Journal Articles

Bispecific CD19-CD20 and CD19-CD22 CAR-T Cells with Glycogen Synthase Kinase (GSK)-3β Inhibitor TWS119 Treatment Have Superior Therapeutic Effects on Mantle Cell Lymphoma

Jingling Jin, Yijing Li, Yang Liu, Alexa A Jordan, Joseph McIntosh, Jovanny Vargas, Yuxuan Che, Yixin Yao, Michael Wang
Journal: Blood
Blood (2021) 138 (Supplement 1): 1698.
https://doi.org/10.1182/blood-2021-150000
Published: 2021
Journal Articles

Combination Therapy of Bcl-2/X L dual Inhibitor AZD0466 with Acalabrutinib to Overcome Therapeutic Resistance in Aggressive R/R Mantle Cell Lymphoma

Yijing Li, Yang Liu, Yuxuan Che, Joseph McIntosh, Alexa A Jordan, Angela Leeming, Courtney L Andersen, Justin Cidado, Jingling Jin, Vivian Changying Jiang, Michael Wang
Journal: Blood
Blood (2021) 138 (Supplement 1): 1867.
https://doi.org/10.1182/blood-2021-151609
Published: 2021
Journal Articles

Pirtobrutinib Overcomes Ibrutinib and Venetoclax Resistance in Mantle Cell Lymphoma

Yang Liu, Changying Jiang, Fangfang Yan, Joseph McIntosh, Alexa A Jordan, Yijing Li, Yuxuan Che, Qingsong Cai, Wei Wang, Lei Nie, Michael Wang
Journal: Blood
Blood (2021) 138 (Supplement 1): 1182.
https://doi.org/10.1182/blood-2021-151401
Published: 2021
Journal Articles

Dual Targeting Bcl-2 By Venetoclax and Mcl-1 By AZD5991 to Overcome Therapeutic Resistance in Aggressive R/R Mantle Cell Lymphoma

Yijing Li, Yang Liu, Yuxuan Che, Alexa A Jordan, Joseph McIntosh, Angela Leeming, Courtney L Andersen, Justin Cidado, Jingling Jin, Vivian Changying Jiang, Michael Wang
Journal: Blood
Blood (2021) 138 (Supplement 1): 1181.
https://doi.org/10.1182/blood-2021-151062
Published: 2021
Journal Articles

Abemaciclib in Combination with Copanlisib to Overcome Therapeutic Resistance in Mantle Cell Lymphoma

Yuxuan Che, Yang Liu, Yijing Li, Joseph McIntosh, Alexa A Jordan, Zhihong Chen, Fangfang Yan, Wei Wang, Jingling Jin, Changying Jiang, Yixin Yao, Michael Wang
Journal: Blood
Blood (2021) 138 (Supplement 1): 2253.
https://doi.org/10.1182/blood-2021-150942
Published: 2021
Journal Articles

Interrogation of Dysregulated Pathways Enables Precision Medicine in Mantle Cell Lymphoma

Yang Liu, PhD, Shuangtao Zhao, PhD, Changying Changying Jiang, PhD, Yixin Yao, PhD, Joseph McIntosh, BS, Alexa A Jordan, BS, Yijing Li, MS, Yuxuan Che, Preetesh Jain, MBBS,MDDM,PhD, Linghua Wang, PhD, Michael Wang, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33.
https://doi.org/10.1182/blood-2020-140794
Published: 2020
Journal Articles

Complex Karyotype Is a Significant Predictor for Worst Outcomes in Patients with Mantle Cell Lymphoma (MCL) Treated with BTK Inhibitors - Comprehensive Analysis of 396 Patients

Preetesh Jain, MBBS,MDDM,PhD, Guilin Tang, MD, C. Cameron Yin, MD PhD, Chi Young Ok, MD, Lucy Navsaria, MB BCh BAO, Maria Badillo, MSN, RN, OCN, CCRP, Wendy Chen, Yijing Li, MS, Yuxuan Che, Yang Liu, PhD, Onyeka Oriabure, Graciela M. Nogueras González, MPH, Jason Westin, MD, Loretta J. Nastoupil, MD, Sairah Ahmed, MD, Ranjit Nair, Selvi Thirumurthi, Shaoying Li, MD, Rashmi Kanagal-Shamanna, MD, Francisco Vega, MDPhD, Christopher Flowers, MDMS, Michael Wang, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32–33.
https://doi.org/10.1182/blood-2020-137473
Published: 2020
Journal Articles

Abemaciclib-Based Combinational Therapies to Overcome Therapeutic Resistance in Mantle Cell Lymphoma

Yuxuan Che, Yang Liu, PhD, Lingzhi Li, Holly Hill, Joseph McIntosh, BS, Alexa A Jordan, BS, Dayoung Jung, Yixin Yao, PhD, Vivian Changying Jiang, PhD, Michael Wang, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-140856
Published: 2020
Journal Articles

Targeting the Synthetic Lethality Interaction of MTAP and PRMT5 to Overcome Drug Resistance and Enhance Anti-Cancer Immunity in Mantle Cell Lymphoma

Yixin Yao, PhD, Lingzhi Li, Yuxuan Che, Joseph McIntosh, BS, Holly Hill, Yang Liu, PhD, Michael Wang, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 15.
https://doi.org/10.1182/blood-2020-138553
Published: 2020
Journal Articles

MCL Cells in Tumor Microenvironment Impair T-Cell Metabolic Fitness and Effector Function

Yixin Yao, PhD, Yuxuan Che, Yang Liu, PhD, Lingzhi Li, Alexa A Jordan, BS, Preetesh Jain, MBBS,MDDM,PhD, Michael Wang, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16.
https://doi.org/10.1182/blood-2020-139611
Published: 2020
Journal Articles

Ibrutinib Plus Rituximab (IR) Followed By Short Course R-Hypercvad/MTX in Patients (age ≤ 65 years) with Previously Untreated Mantle Cell Lymphoma - Phase-II Window-1 Clinical Trial

Michael Wang, MD, Preetesh Jain, MBBS,MDDM,PhD, Yixin Yao, PhD, Yang Liu, PhD, Shuangtao Zhao, PhD, Holly Hill, Omar Moghrabi, Hun Ju Lee, MD, Felipe Samaniego, MD, Jason Westin, MD, Loretta J. Nastoupil, MD, Rashmi Kanagal-Shamanna, MD, Chi Young Ok, MD, Wendy Chen, Onyeka Oriabure, Yuxuan Che, Yijing Li, MS, Lei Feng, MS, Graciela M. Nogueras González, MPH, Guofang Xu, MD, Nicolaus Wagner-Bartak, MD, Selvi Thirumurthi, David Santos, Guilin Tang, MD, Francisco Vega, MDPhD, C. Cameron Yin, MD PhD, Michelle Avellaneda, Maria Badillo, MSN, RN, OCN, CCRP, Christopher Flowers, MDMS, Linghua Wang, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 35–36.
https://doi.org/10.1182/blood-2020-137259
Published: 2020
Journal Articles

Outcomes of Acalabrutinib Failures in Relapsed Mantle Cell Lymphoma

Preetesh Jain, MBBS,MDDM,PhD, Shaojun Zhang, PhD, Rashmi Kanagal-Shamanna, MD, Lucy Navsaria, MB BCh BAO, Chi Young Ok, MD, Guilin Tang, MD, C. Cameron Yin, MD PhD, Maria Badillo, MSN, RN, OCN, CCRP, Wendy Chen, Onyeka Oriabure, Hun Ju Lee, MD, Jason Westin, MD, Loretta J. Nastoupil, MD, Omar Moghrabi, Yuxuan Che, Felipe Samaniego, MD, Sairah Ahmed, MD, Ranjit Nair, Shaoying Li, MD, Francisco Vega, MDPhD, Christopher Flowers, MDMS, Linghua Wang, PhD, Michael Wang, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 9–10.
https://doi.org/10.1182/blood-2020-137440
Published: 2020