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Journal Articles

Ibrutinib Off-Target Inhibition Inhibits Antibody-Dependent Cellular Phagocytosis but Not Efferocytosis of CLL Cells

Charles C. Chu, PhD, Jonathan J. Pinney, PhD, Sara K. Blick-Nitko, MS, Andrea M. Baran, MS, Derick R. Peterson, PhD, Hannah E. Whitehead, Raquel Izumi, PhD, Veerendra Munugalavadla, PhD, Paul M. Barr, MD, Karl R. VanDerMeid, BS, Michael Rusty Elliott, PhD, Clive S. Zent, MD

Blood (2020) 136 (Supplement 1): 45.

https://doi.org/10.1182/blood-2020-139483

Published: 2020

Journal Articles

Anti-CD20 Therapy Reliance on Antibody-Dependent Cellular Phagocytosis Affects Combination Drug Choice

Charles C. Chu, PhD, Jonathan J. Pinney, MS, Karl R. VanDerMeid, BS, Raquel Izumi, PhD, Veerendra Munugalavadla, PhD, Paul M. Barr, MD, Michael Rusty Elliott, PhD, Clive S Zent, MD

Blood (2019) 134 (Supplement_1): 682.

https://doi.org/10.1182/blood-2019-124901

Published: 2019

Journal Articles

CLL Stereotyped Subset #4 Igs Acquire Binding to Viable B Lymphocyte Surfaces By Somatic Mutations, Isotype Class Switching, and with the Prerequisite of IG Self-Association

Yun Liu, MS, Rosa Catera, PhD, Chao Gao, PhD, Xiao J. Yan, MDPhD, Steven L. Allen, MD, Jonathan E. Kolitz, MD, Kanti Rai, MD, Charles C Chu, PhD, Ten Feizi, MD, Kostas Stamatopoulos, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 58.

https://doi.org/10.1182/blood.V130.Suppl_1.58.58

Published: 2017

Journal Articles

TLR-9 and IL-15-Driven Clonal Expansion of B-CLL Cells

Patricia K. A. Mongini, PhD, Rashmi Gupta, PhD, Charles C. Chu, PhD, Joanna Stein, MPH, Tatjana Stankovic, MDPhD, Jacqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2014) 124 (21): 1937.

https://doi.org/10.1182/blood.V124.21.1937.1937

Published: 2014

Journal Articles

IGHV-D-J Ultra-Deep Sequencing Reveals APOBEC and AID Targeted Mutations during Clonal Evolution of CLL in a Xenograft Mouse Model

Charles C. Chu, PhD, Piers E.M. Patten, BSc, MRCP, MRCPath, PhD, Thomas MacCarthy, PhD, Chaohui Yuan, MS, Xiao-Jie Yan, MD PhD, Jacqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2014) 124 (21): 300.

https://doi.org/10.1182/blood.V124.21.300.300

Published: 2014

Journal Articles

Clinical Impact of Stereotyped Antigen Receptors in Chronic Lymphocytic Leukemia

Panagiotis Baliakas, Anastasia Hadzidimitriou, Lesley-Ann Sutton, Evangelia Minga, Andreas Agathangelidis, Athina Tsanousa, Lydia Scarfo, Zadie Davis, Joy Yan, Tait D. Shanafelt, MD, Karla Plevova, M.S., PhD, Yorick Sandberg, Fie Juhl Vojdeman, Myriam Boudjoghra, Tatiana Tzenou, Maria Chatzouli, Charles C. Chu, PhD, Silvio Veronese, Anne Catherine Gardiner, Larry Mansouri, Karin E Smedby, MD PhD, Lone Pedersen, Denis Moreno, Kirsten van Lom, Veronique Giudicelli, Hana Francova, Florence Nguyen-Khac, MDPhD, Panagiotis Panagiotidis, Gunnar Juliusson, Lefteris Angelis, Achilles Anagnostopoulos, Marie-Paule Lefranc, Monica Facco, Livio Trentin, Mark Catherwood, Marco Montillo, MD, Christian H Geisler, Anton W Langerak, Sarka Pospisilova, Nicholas Chiorazzi, MD, David Oscier, Diane F. Jelinek, Nikos Darzentas, Chrysoula Belessi, Frederic Davi, MD PhD, Richard Rosenquist, Paolo Ghia, MD PhD, Kostas Stamatopoulos, on behalf of ERIC, the European Research Initiative on CLL

Blood (2014) 124 (21): 3280.

https://doi.org/10.1182/blood.V124.21.3280.3280

Published: 2014

Journal Articles

Evaluation of IGHV Ultra-Deep Sequences for Activation-Induced Deaminase Characteristics in CLL Cells after T Cell Stimulation

Charles C. Chu, PhD, Piers E.M. Patten, MD, PhD, Thomas MacCarthy, PhD, Xiao-Jie Yan, MD PhD, Jacqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2013) 122 (21): 2583.

https://doi.org/10.1182/blood.V122.21.2583.2583

Published: 2013

Journal Articles

CLL Cells Can Diversify, Switch, and Differentiate in Response to Autologous T Cell Stimuli Present in a Murine Adoptive Transfer Model

Piers E.M. Patten, MBBCh, PhD, Shih-Shih Chen, Ph.D., Davide Bagnara, Ph.D., Rita Simone, PhD, Sonia Marsilio, PhD, Xiao-Jie Yan, MD PhD, Jacqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kanti R. Rai, MD, Thomas MacCarthy, PhD, Charles C. Chu, PhD, Nicholas Chiorazzi, MD

Blood (2012) 120 (21): 315.

https://doi.org/10.1182/blood.V120.21.315.315

Published: 2012

Journal Articles

CLL Cell Viability Promoted by Myosin Heavy Chain IIA Exposed Apoptotic Cells is BTK-dependent

Charles C. Chu, PhD, Lu Zhang, MS, Xiaoxuan Cui, MD PhD, Amanda R. Magli, BSE, Xiao-Jie Yan, MD PhD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Jacqueline C. Barrientos, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2012) 120 (21): 1767.

https://doi.org/10.1182/blood.V120.21.1767.1767

Published: 2012

Journal Articles

Ultra-Deep Sequencing of De Novo IGHV Mutations in Activated CLL Cells: Evidence for Activation-Induced Deaminase Function.

Piers E.M. Patten, MBBCh, PhD, Thomas MacCarthy, PhD, Xiao-Jie Yan, MD PhD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Jacqueline C. Barrientos, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD, Charles C. Chu, PhD

Blood (2012) 120 (21): 2545.

https://doi.org/10.1182/blood.V120.21.2545.2545

Published: 2012

Journal Articles

Single Cell Network Profiling (SCNP) Identifies Altered Signaling Between Patient Risk Groups in B-Cell Chronic Lymphocytic Leukemia (B-CLL).

Jason Ptacek, PhD, Erik Evensen, Ph.D., Greg Friedland, James Cordeiro, Jodi R. Ware, PharmD, Charles C. Chu, PhD, Rajendra N Damle, PhD, Lu Zhang, MS, Nicholas Chiorazzi, MD, Alessandra Cesano, M.D., Ph.D., Rachael E. Hawtin, Ph.D.

Blood (2012) 120 (21): 2876.

https://doi.org/10.1182/blood.V120.21.2876.2876

Published: 2012

Journal Articles

Promiscuous Antigen Reactivity May Underlie Clinical Aggressiveness and Increased Risk for Richter's Syndrome in Chronic Lymphocytic Leukemia with Stereotyped IGHV4-39/IGKV1(D)-39 B Cell Receptors

Maria Gounari, Stavroula Ntoufa, Charles C. Chu, PhD, Athanasios Tsaftaris, Nicholas Chiorazzi, MD, Kostas Stamatopoulos, Paolo Ghia

Blood (2012) 120 (21): 561.

https://doi.org/10.1182/blood.V120.21.561.561

Published: 2012

Journal Articles

Some CLL Cells Bind Myosin-Exposed Apoptotic Cells. Exposure of Cytoplasmic Myosin Results From Transfer of Caspase-3 Dependent Cleavage Products to the Outer Cell Membrane

Xiaoxuan Cui, MD, PhD, Lu Zhang, MS, Amanda R Magli, BSE, Rosa Catera, PhD, Jonathan E Kolitz, MD, Steven L. Allen, MD, Kanti R Rai, MD, Nicholas Chiorazzi, MD, Charles C Chu, PhD

Blood (2010) 116 (21): 3900.

https://doi.org/10.1182/blood.V116.21.3900.3900

Published: 2010

Journal Articles

Chronic Lymphocytic Leukemia B Cells Variably Express Functional Activation-Induced Cytosine Deaminase Protein

Piers EM Patten, BSc, MBBCh, PhD, Charles C Chu, PhD, Rajendra N Damle, PhD, Steven L. Allen, MD, Jonathan E Kolitz, MD, Kanti R Rai, MD, Patricia K Mongini, PhD, Nicholas Chiorazzi, MD

Blood (2010) 116 (21): 378.

https://doi.org/10.1182/blood.V116.21.378.378

Published: 2010

Journal Articles

The Composition of the B Cell Receptor Repertoire In 7428 Cases of Chronic Lymphocytic Leukemia: One Third Stereotyped, Two Thirds Heterogeneous - What Does This Mean?

Blood (2010) 116 (21): 43.

https://doi.org/10.1182/blood.V116.21.43.43

Published: 2010

Journal Articles

Somatic Hypermutation In Stereotyped Subset 4 BCRs/mAbs of CLL Patients, Expressing IGHV4-34 gene, Edit Anti-DNA Reactivity

Rosa Catera, Ph.D., Amanda R Magli, BSE, Jonathan E Kolitz, MD, Steven L. Allen, MD, Kanti R Rai, MD, Charles C Chu, PhD, Kostas Stamatopoulos, MD, Nicholas Chiorazzi, MD

Blood (2010) 116 (21): 2444.

https://doi.org/10.1182/blood.V116.21.2444.2444

Published: 2010

Journal Articles

Detection of Activation-Induced Cytidine Deaminase RNA In CLL Cells Correlates with Shorter Patient Survival and High Numbers of CD38 + Cells

Charles C Chu, PhD, Piers EM Patten, BSc, MBBCh, PhD, Emilia Albesiano, PhD, Linda P Johnson, BS, William J Kennedy, RN, MS, Lu Zhang, MS, Amanda R Magli, BSE, Rajendra N Damle, PhD, Xiao-Jie Yan, MD, PhD, Shabirul Haque, PhD, Patricia K Mongini, PhD, Jonathan E Kolitz, MD, Steven L Allen, MD, Kanti R Rai, MD, Nicholas Chiorazzi, MD

Blood (2010) 116 (21): 2415.

https://doi.org/10.1182/blood.V116.21.2415.2415

Published: 2010

Journal Articles

Frequently Occurring B-CLL Antibodies Recognize Apoptotic Cells That Expose Non-Muscle Myosin Heavy Chain IIA

Charles C Chu, PhD, Rosa Catera, PhD, Sebastien Didier, MS, Lu Zhang, MA, Briana Agagnina, Steven L Allen, MD, Kanti R Rai, MD, Nicholas Chiorazzi, MD

Blood (2008) 112 (11): 3123.

https://doi.org/10.1182/blood.V112.11.3123.3123

Published: 2008

Journal Articles

Chronic Lymphocytic Leukemia Cells Recognize Conserved Epitopes Associated with Apoptosis and Catabolic Chemical Modifications

Rosa Catera, Gregg J. Silverman, Katerina Hatzi, Till Seiler, Sebastien Didier, Lu Zhang, MA, Maxime Hervé, Eric Meffre, David Graham Oscier, MD, Helen Vlassara, Yifang Chen, Steven L. Allen, Kanti R. Rai, MD, Charles C. Chu, PhD, Nicholas Chiorazzi, MD

Blood (2008) 112 (11): 3150.

https://doi.org/10.1182/blood.V112.11.3150.3150

Published: 2008

Journal Articles

Activation of Nucleic Acid-Sensing Toll-Like Receptors Induces Proliferation, Cytokine Production, Immunogenic Phenotype, and Plasma Cell Differentiation of CLL Cells and Immunoglobulin Production.

Santanu Paul, PhD, Charles C. Chu, PhD, Brian A. McCarthy, PhD, Erin Boyle, BS, Bettie M. Steinberg, PhD, Matthew Kaufman, MD, Jonathan Kolitz, MD, Steven L. Allen, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2007) 110 (11): 1137.

https://doi.org/10.1182/blood.V110.11.1137.1137

Published: 2007

NARROW

Ibrutinib Off-Target Inhibition Inhibits Antibody-Dependent Cellular Phagocytosis but Not Efferocytosis of CLL Cells

Anti-CD20 Therapy Reliance on Antibody-Dependent Cellular Phagocytosis Affects Combination Drug Choice

CLL Stereotyped Subset #4 Igs Acquire Binding to Viable B Lymphocyte Surfaces By Somatic Mutations, Isotype Class Switching, and with the Prerequisite of IG Self-Association

TLR-9 and IL-15-Driven Clonal Expansion of B-CLL Cells

IGHV-D-J Ultra-Deep Sequencing Reveals APOBEC and AID Targeted Mutations during Clonal Evolution of CLL in a Xenograft Mouse Model

Clinical Impact of Stereotyped Antigen Receptors in Chronic Lymphocytic Leukemia

Evaluation of IGHV Ultra-Deep Sequences for Activation-Induced Deaminase Characteristics in CLL Cells after T Cell Stimulation

CLL Cells Can Diversify, Switch, and Differentiate in Response to Autologous T Cell Stimuli Present in a Murine Adoptive Transfer Model

CLL Cell Viability Promoted by Myosin Heavy Chain IIA Exposed Apoptotic Cells is BTK-dependent

Ultra-Deep Sequencing of De Novo IGHV Mutations in Activated CLL Cells: Evidence for Activation-Induced Deaminase Function.

Single Cell Network Profiling (SCNP) Identifies Altered Signaling Between Patient Risk Groups in B-Cell Chronic Lymphocytic Leukemia (B-CLL).

Promiscuous Antigen Reactivity May Underlie Clinical Aggressiveness and Increased Risk for Richter's Syndrome in Chronic Lymphocytic Leukemia with Stereotyped IGHV4-39/IGKV1(D)-39 B Cell Receptors

Some CLL Cells Bind Myosin-Exposed Apoptotic Cells. Exposure of Cytoplasmic Myosin Results From Transfer of Caspase-3 Dependent Cleavage Products to the Outer Cell Membrane

Chronic Lymphocytic Leukemia B Cells Variably Express Functional Activation-Induced Cytosine Deaminase Protein

The Composition of the B Cell Receptor Repertoire In 7428 Cases of Chronic Lymphocytic Leukemia: One Third Stereotyped, Two Thirds Heterogeneous - What Does This Mean?

Somatic Hypermutation In Stereotyped Subset 4 BCRs/mAbs of CLL Patients, Expressing IGHV4-34 gene, Edit Anti-DNA Reactivity

Detection of Activation-Induced Cytidine Deaminase RNA In CLL Cells Correlates with Shorter Patient Survival and High Numbers of CD38 + Cells

Frequently Occurring B-CLL Antibodies Recognize Apoptotic Cells That Expose Non-Muscle Myosin Heavy Chain IIA

Chronic Lymphocytic Leukemia Cells Recognize Conserved Epitopes Associated with Apoptosis and Catabolic Chemical Modifications

Activation of Nucleic Acid-Sensing Toll-Like Receptors Induces Proliferation, Cytokine Production, Immunogenic Phenotype, and Plasma Cell Differentiation of CLL Cells and Immunoglobulin Production.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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