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SPPL3-glycosylation axis governs CD22 CAR T-cell susceptibility in B-ALL independent of antigen recognition

Jaehyun Suh, Ukhyun Jo, Craig Thomas, Nirali Shah, Jack Shern, Christopher Chien, Naomi Taylor

Blood (2025) 146 (Supplement 1): 2347.

https://doi.org/10.1182/blood-2025-2347

Published: 2025

Journal Articles

From bench to IND: Validation of TSLPR CAR T-cells reveal discrepancies in detection modalities and inform dose selection for a Phase 1 clinical trial in relapsed/refractory CRLF2-rearranged B-ALL patients.

Christopher Chien, Marie Pouzolles, Angela Su, Hannah Song, Brynn Duncan, Dina Schneider, Rimas Orentas, Haneen Shalabi, Sarah Tasian, Terry Fry, Steven Highfill, Nirali Shah, Naomi Taylor

Blood (2025) 146 (Supplement 1): 4101.

https://doi.org/10.1182/blood-2025-4101

Published: 2025

Journal Articles

CD19/22 CAR T-cells in children and young adults with B-ALL: Final Phase 1 trial results

Sara Silbert, Flavia Gava, Bonnie Yates, Alexander Rankin, Lauren Little, Toni Foley, Alexandra Dreyzin, Christopher Chien, Naomi Taylor, Terry Fry, Constance Yuan, Hao-Wei Wang, David Stroncek, Steven Highfill, Haneen Shalabi, Nirali Shah

Blood (2025) 146 (Supplement 1): 814.

https://doi.org/10.1182/blood-2025-814

Published: 2025

Journal Articles

Single-cell metabolic profiling of post-infusion CD22 and CD19/CD22 CAR T-cells reveals a shift toward amino acid–driven oxphos informing SLC-armored CAR design

Blood (2025) 146 (Supplement 1): 502.

https://doi.org/10.1182/blood-2025-502

Published: 2025

Journal Articles

A Vaccination Regimen Incorporating the Synergistic Combination of CpG-Containing Oligodeoxynucleotides and IL-2 Can Elicit CD8+ T Cell Responses That Effect Anti-Tumor Immunity from T Cell Repertoires Undergoing Reconstitution by Homeostatic Peripheral Expansion after BMT.

James Kochenderfer, Christopher Chien, Jessica Simpson, Ronald Gress

Blood (2005) 106 (11): 61.

https://doi.org/10.1182/blood.V106.11.61.61

Published: 2005

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SPPL3-glycosylation axis governs CD22 CAR T-cell susceptibility in B-ALL independent of antigen recognition

From bench to IND: Validation of TSLPR CAR T-cells reveal discrepancies in detection modalities and inform dose selection for a Phase 1 clinical trial in relapsed/refractory CRLF2-rearranged B-ALL patients.

CD19/22 CAR T-cells in children and young adults with B-ALL: Final Phase 1 trial results

Single-cell metabolic profiling of post-infusion CD22 and CD19/CD22 CAR T-cells reveals a shift toward amino acid–driven oxphos informing SLC-armored CAR design

A Vaccination Regimen Incorporating the Synergistic Combination of CpG-Containing Oligodeoxynucleotides and IL-2 Can Elicit CD8+ T Cell Responses That Effect Anti-Tumor Immunity from T Cell Repertoires Undergoing Reconstitution by Homeostatic Peripheral Expansion after BMT.

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ASH Publications

American Society of Hematology

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SPPL3-glycosylation axis governs CD22 CAR T-cell susceptibility in B-ALL independent of antigen recognition

From bench to IND: Validation of TSLPR CAR T-cells reveal discrepancies in detection modalities and inform dose selection for a Phase 1 clinical trial in relapsed/refractory CRLF2-rearranged B-ALL patients.

CD19/22 CAR T-cells in children and young adults with B-ALL: Final Phase 1 trial results

Single-cell metabolic profiling of post-infusion CD22 and CD19/CD22 CAR T-cells reveals a shift toward amino acid–driven oxphos informing SLC-armored CAR design

A Vaccination Regimen Incorporating the Synergistic Combination of CpG-Containing Oligodeoxynucleotides and IL-2 Can Elicit CD8+ T Cell Responses That Effect Anti-Tumor Immunity from T Cell Repertoires Undergoing Reconstitution by Homeostatic Peripheral Expansion after BMT.

Email alerts

ASH Publications

American Society of Hematology

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