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Journal Articles

In Vitro Drug Response Profiling in BCP- and T-ALL Primary Samples Adds a Robust Functional Layer Enabling Optimized Guidance of Individualized Therapy in Relapsed and Refractory Pediatric Acute Leukemia Patients

Blood (2020) 136 (Supplement 1): 15–16.

https://doi.org/10.1182/blood-2020-142314

Published: 2020

Journal Articles

Pediatric T-ALLs Developing into a Type 2 Relapse Originate from Cells That Carry the Potential of Variable Maturation into Subclones with Distinct Chromatin Landscapes

Blood (2018) 132 (Supplement 1): 1545.

https://doi.org/10.1182/blood-2018-99-118255

Published: 2018

Journal Articles

Longitudinal Multilevel Omic Analysis of Pediatric T-ALL Reveals Distinct Mechanisms for Disease Progression in Type 1 and in Type 2 Relapses

Blood (2018) 132 (Supplement 1): 2826.

https://doi.org/10.1182/blood-2018-99-117978

Published: 2018

Journal Articles

Homocygous PAX5 Sequence Mutations Define a Novel Subtype of B Cell Precursor Acute Lymphoblastic Leukemia

Blood (2017) 130 (Supplement 1): 2713.

https://doi.org/10.1182/blood.V130.Suppl_1.2713.2713

Published: 2017

Journal Articles

PDX Models Recapitulate Genetics and Epigenetics of Pediatric T-Cell Leukemia

Blood (2017) 130 (Supplement 1): 2723.

https://doi.org/10.1182/blood.V130.Suppl_1.2723.2723

Published: 2017

Journal Articles

Relapsing Pediatric T-Cell Acute Lymphoblastic Leukemia Downregulates T-Cell Properties and Upregulates Cell Adhesion

Blood (2017) 130 (Supplement 1): 2726.

https://doi.org/10.1182/blood.V130.Suppl_1.2726.2726

Published: 2017

Journal Articles

Mutational Landscape, Clonal Evolution Patterns and Role of RAS Mutations in Relapsed Acute Lymphoblastic Leukemia

Blood (2016) 128 (22): 4068.

https://doi.org/10.1182/blood.V128.22.4068.4068

Published: 2016

Journal Articles

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia Relapsing after Allogeneic Stem Cell Transplantation

Jessica I Hoell, MD, Sebastian Ginzel, MSc, Cornelia Eckert, PhD, Michael Gombert, PhD, Ute Fischer, PhD, Martin Stanulla, MD, Martin Schrappe, MD PhD, Udo zur Stadt, PhD, Peter Bader, MD, Brigitte Strahm, MD, Julia Alten, Anja Moericke, MD, Gabriele Escherich, MD, Arend Stackelberg, MD, Christina Peters, MD, Arndt Borkhardt, MD, Roland Meisel, MD

Blood (2016) 128 (22): 601.

https://doi.org/10.1182/blood.V128.22.601.601

Published: 2016

Journal Articles

Identification of an Ultra High-Risk and Targetable Molecular Signature in Relapsed Pediatric T-ALL

Paulina Richter-Pechanska, PhD, Joachim B. Kunz, MD, Jana Hof, Martin Zimmermann, PhD, Tobias Rausch, PhD, Obul Reddy Bandapalli, PhD, Elena Orlova, Greta Scapinello, Judit Sagi, Martin Stanulla, MD, Martin Schrappe, MD PhD, Renate Kirschner-Schwabe, PhD, Cornelia Eckert, PhD, Vladimir Benes, PhD, Jan O. Korbel, PhD, Martina U. Muckenthaler, PhD, Andreas E Kulozik, MD PhD

Blood (2016) 128 (22): 1084.

https://doi.org/10.1182/blood.V128.22.1084.1084

Published: 2016

Journal Articles

Multi-Genomics of Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia Reveals Three Distinct Genetic Clusters Characterized By Different Alterations

Blood (2016) 128 (22): 453.

https://doi.org/10.1182/blood.V128.22.453.453

Published: 2016

Journal Articles

Monitoring of Minimal Residual Disease before and after Allogeneic Stem Cell Transplantation Childhood ALL - a Retrospective Assessment on Behalf of the PDWP of the EBMT, the COG, PBMTC, the I-BFM and the Westhafen-Intercontinental-Group

Blood (2016) 128 (22): 985.

https://doi.org/10.1182/blood.V128.22.985.985

Published: 2016

Journal Articles

Targeted Deep Sequencing of Genetic Alterations Identified By Whole Exome Sequencing Reveals Clonal Evolution in Pediatric T-Lymphoblastic Leukemia

Blood (2014) 124 (21): 491.

https://doi.org/10.1182/blood.V124.21.491.491

Published: 2014

Journal Articles

Interventional Intensification of Chemotherapy Prior to Hematopietic Stem Cell Transplantation Reduces Residual Leukemia but Does Not Improve Survival in Children with Relapsed Acute Lymphoblastic Leukemia

Cornelia Eckert, PhD, Christiane Chen-Santel, MD, Christina Peters, MD, Thomas Klingebiel, MD, Bernd Gruhn, MD, Rupert Handgretinger, Guenter Henze, MD, Arend von Stackelberg

Blood (2014) 124 (21): 61.

https://doi.org/10.1182/blood.V124.21.61.61

Published: 2014

Journal Articles

Clinical Significance of NT5C2 Mutations in Children with First Relapse of B-Cell Precursor Acute Lymphoblastic Leukemia

Jana Hof, MSc, Annabell Szymansky, MSc, Arend von Stackelberg, MD, Cornelia Eckert, PhD, Renate Kirschner-Schwabe, PhD

Blood (2014) 124 (21): 3789.

https://doi.org/10.1182/blood.V124.21.3789.3789

Published: 2014

Journal Articles

Monitoring of Minimal Residual Disease After Allogeneic Stem Cell Transplantation In Relapsed Childhood ALL Allows The Identification Of Impending Relapse - Results Of The ALL BFM SCT 2003 Trial

Peter Bader, Hermann Kreyenberg, PhD, Arend von Stackelberg, Cornelia Eckert, PhD, Meisel Roland, MD, Pötschger Ulrike, MD, Daniel Stachel, MD, Martin Schrappe, MD, Andre Schrauder, MD, Ansgar Schulz, MD, Peter Lang, MD, Ingo Mueller, MD, Michael H. Albert, MD, Thomas Klingebiel, MD, Christina Peters, MD

Blood (2013) 122 (21): 1995.

https://doi.org/10.1182/blood.V122.21.1995.1995

Published: 2013

Journal Articles

RAS Pathway Mutations Are Highly Prevalent In Relapsed Childhood Acute Lymphoblastic Leukaemia, Are Frequently Relapse-Drivers and Confer Sensitivity To MEK Inhibition

Julie Irving, PhD, Elizabeth C. Matheson, MPhil, Lynne Minto, Helen Blair, PhD, Marian Case, MSc, Christina Halsey, MD, PhD, Isabella Swidenbank, MRes, Frida Ponthan, PhD, Renate Kirschner-Schwabe, PhD, Stefanie Groeneveld-Krentz, MSc, Jana Hof, MSc, James Allan, PhD, Christine J. Harrison, PhD, Josef Vormoor, MD, Arend Stackelberg, MD, Cornelia Eckert, PhD

Blood (2013) 122 (21): 823.

https://doi.org/10.1182/blood.V122.21.823.823

Published: 2013

Journal Articles

Novel Genomic Structural Variations in Relapsed Childhood ETV6/RUNX1 ( TEL/AML1 ) Acute Lymphoblastic Leukemias Identified by Next Generation Sequencing

Vera Okpanyi, PhD, Christoph Bartenhagen, MSc, Michael Gombert, PhD, Sebastian Ginzel, PhD, Pina Fanny Ida Krell, MSc, Peter Husemann, PhD, Cai Chen, MD, Vera Binder, MD, Jutta Bradtke, PhD, Andrea Teigler-Schlegel, PhD, Silja Roettgers, PhD, Jochen Harbott, PhD, Martin Stanulla, MD, MSc, Cornelia Eckert, PhD, Ralf Thiele, PhD, Martin Dugas, PhD, Arndt Borkhardt, MD, Ute Fischer, PhD

Blood (2012) 120 (21): 518.

https://doi.org/10.1182/blood.V120.21.518.518

Published: 2012

Journal Articles

Conventional Reinduction/Consolidation-Type Therapy Versus Short Course High Intensity Combination Chemotherapy As Post-Induction Treatment for Children with Relapsed Acute Lymphoblastic Leukemia. Early Results of Study ALL-REZ BFM 2002

Arend von Stackelberg, MD, Junko Yamanaka, MD, Gabriele Escherich, MD, Cornelia Eckert, PhD, Richard Ratei, MD, Johann K. Hitzler, MD, Georg Mann, MD, Lucie Sramkova, MD, Jean-Pierre Bourquin, MD, PhD, Martin Schrappe, MD, Günter Henze, MD

Blood (2011) 118 (21): 871.

https://doi.org/10.1182/blood.V118.21.871.871

Published: 2011

Journal Articles

Clonal Origins of 'late' Relapses in ETV6-RUNX1 Acute Lymphoblastic Leukemia..

Frederik W van Delft, Sharon W Horsley, Kristina Anderson, Caroline M Bateman, MBBS, MRCP, Susan Colman, Jan Zuna, MD, PhD, Cornelia Eckert, PhD, MSc, Helena Kempski, Vaskar Saha, PhD, FRCP, FRCPath, Lyndal Kearney, Anthony Ford, Mel Greaves

Blood (2009) 114 (22): 1583.

https://doi.org/10.1182/blood.V114.22.1583.1583

Published: 2009

Journal Articles

Childhood Acute Lymphoblastic Leukemia: High Genomic Stability from Initial Diagnosis to Early Relapse.

Barbara Meissner, MD, Cornelia Eckert, PhD, Anja Moericke, MD, Arend von Stackelberg, MD, Renate Kirschner-Schwabe, PhD, Gunnar Cario, MD, André Schrauder, MD, Martin Zimmermann, PhD, Karl Welte, MD, Martin Schrappe, MD, Martin Stanulla, MD, MSc

Blood (2008) 112 (11): 1522.

https://doi.org/10.1182/blood.V112.11.1522.1522

Published: 2008

NARROW

In Vitro Drug Response Profiling in BCP- and T-ALL Primary Samples Adds a Robust Functional Layer Enabling Optimized Guidance of Individualized Therapy in Relapsed and Refractory Pediatric Acute Leukemia Patients

Pediatric T-ALLs Developing into a Type 2 Relapse Originate from Cells That Carry the Potential of Variable Maturation into Subclones with Distinct Chromatin Landscapes

Longitudinal Multilevel Omic Analysis of Pediatric T-ALL Reveals Distinct Mechanisms for Disease Progression in Type 1 and in Type 2 Relapses

Homocygous PAX5 Sequence Mutations Define a Novel Subtype of B Cell Precursor Acute Lymphoblastic Leukemia

PDX Models Recapitulate Genetics and Epigenetics of Pediatric T-Cell Leukemia

Relapsing Pediatric T-Cell Acute Lymphoblastic Leukemia Downregulates T-Cell Properties and Upregulates Cell Adhesion

Mutational Landscape, Clonal Evolution Patterns and Role of RAS Mutations in Relapsed Acute Lymphoblastic Leukemia

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia Relapsing after Allogeneic Stem Cell Transplantation

Identification of an Ultra High-Risk and Targetable Molecular Signature in Relapsed Pediatric T-ALL

Multi-Genomics of Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia Reveals Three Distinct Genetic Clusters Characterized By Different Alterations

Monitoring of Minimal Residual Disease before and after Allogeneic Stem Cell Transplantation Childhood ALL - a Retrospective Assessment on Behalf of the PDWP of the EBMT, the COG, PBMTC, the I-BFM and the Westhafen-Intercontinental-Group

Targeted Deep Sequencing of Genetic Alterations Identified By Whole Exome Sequencing Reveals Clonal Evolution in Pediatric T-Lymphoblastic Leukemia

Interventional Intensification of Chemotherapy Prior to Hematopietic Stem Cell Transplantation Reduces Residual Leukemia but Does Not Improve Survival in Children with Relapsed Acute Lymphoblastic Leukemia

Clinical Significance of NT5C2 Mutations in Children with First Relapse of B-Cell Precursor Acute Lymphoblastic Leukemia

Monitoring of Minimal Residual Disease After Allogeneic Stem Cell Transplantation In Relapsed Childhood ALL Allows The Identification Of Impending Relapse - Results Of The ALL BFM SCT 2003 Trial

RAS Pathway Mutations Are Highly Prevalent In Relapsed Childhood Acute Lymphoblastic Leukaemia, Are Frequently Relapse-Drivers and Confer Sensitivity To MEK Inhibition

Novel Genomic Structural Variations in Relapsed Childhood ETV6/RUNX1 ( TEL/AML1 ) Acute Lymphoblastic Leukemias Identified by Next Generation Sequencing

Conventional Reinduction/Consolidation-Type Therapy Versus Short Course High Intensity Combination Chemotherapy As Post-Induction Treatment for Children with Relapsed Acute Lymphoblastic Leukemia. Early Results of Study ALL-REZ BFM 2002

Clonal Origins of 'late' Relapses in ETV6-RUNX1 Acute Lymphoblastic Leukemia..

Childhood Acute Lymphoblastic Leukemia: High Genomic Stability from Initial Diagnosis to Early Relapse.

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American Society of Hematology

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American Society of Hematology

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