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Journal Articles

Cross-Reactivity of Drug-Dependent Antibodies in Patients with Immune Thrombocytopenia Induced By Beta-Lactam Antibiotics

Matthew John Slaught, BS, Daniel W. Bougie, PhD, Richard H. Aster, MD

Blood (2019) 134 (Supplement_1): 2350.

https://doi.org/10.1182/blood-2019-131375

Published: 2019

Journal Articles

Cross-Strain Platelet Immunization in Selected Mouse Strains Recapitulates Clinical and Serologic Findings Typical of Post-Transfusion Purpura (PTP)

Daniel W. Bougie, PhD, Jessica Sutton, Richard H. Aster, MD

Blood (2019) 134 (Supplement_1): 2349.

https://doi.org/10.1182/blood-2019-126815

Published: 2019

Journal Articles

Serologic Characterization of Antibodies in Patients Experiencing Piperacillin-Induced Immune Thrombocytopenia

Mark Rasmussen, Daniel W. Bougie, PhD, Gregory H. Denomme, Richard H. Aster, MD

Blood (2019) 134 (Supplement_1): 1078.

https://doi.org/10.1182/blood-2019-130966

Published: 2019

Journal Articles

The Platelet Factor-4 (PF4)-Dependent p-Selectin Expression Assay (PEA) Is Highly Accurate for the Detection of Pathogenic HIT Antibodies: Results of a 440-Sample Prospective Blinded Study

Deepti M. Warad, MD, Bethany T Samuelson Bannow, MD, Curtis Jones, BS, Shannon Pechauer, Brian R. Curtis, PhD, Daniel W. Bougie, PhD, Parisa R Khalighi, BS, Diane E. Grill, MS, Rachel Leger, BAE, Ruchika Sharma, MD, Dong Chen, MD PhD, Richard H. Aster, MD, David A. Garcia, MD, Anand Padmanabhan, MD PhD

Blood (2018) 132 (Supplement 1): 416.

https://doi.org/10.1182/blood-2018-99-112475

Published: 2018

Journal Articles

Immunoglobulin G in Normal Plasma Inhibits HIT Antibody-Mediated Platelet Activation: Implications for Therapeutic Plasma Exchange Treatment in HIT

Curtis Jones, BS, Shannon Pechauer, Brian R. Curtis, PhDMT(ASCP), Daniel W. Bougie, PhD, Richard H. Aster, MD, Anand Padmanabhan, MD PhD

Blood (2017) 130 (Supplement 1): 2402.

https://doi.org/10.1182/blood.V130.Suppl_1.2402.2402

Published: 2017

Journal Articles

A New Assay for Platelet-Activating HIT Antibodies, the PEA, Is Specific, Reproducible and Relatively Independent of the Choice of Platelet Donor

Shannon Pechauer, Curtis Jones, BS, Daniel W. Bougie, PhD, Brian R. Curtis, PhDMT(ASCP), Richard H. Aster, MD, Anand Padmanabhan, MD PhD

Blood (2017) 130 (Supplement 1): 458.

https://doi.org/10.1182/blood.V130.Suppl_1.458.458

Published: 2017

Journal Articles

Autoimmune Thrombocytopenia in Mice Immunized with Allogeneic Platelets: A Model for Post-Transfusion Purpura (PTP)?

Daniel W. Bougie, PhD, Jessica Sutton, Richard H. Aster, MD

Blood (2016) 128 (22): 168.

https://doi.org/10.1182/blood.V128.22.168.168

Published: 2016

Journal Articles

A Novel PF4-Dependent P-Selectin Expression Assay (PEA) Facilitates Early Detection of Pathogenic HIT Antibodies: Implications for Diagnosis and Treatment of HIT

Anand Padmanabhan, MBBS, MA, PhD, Curtis G Jones, Shannon M Pechauer, Brian R Curtis, PhD D(ABMLI) MT(ASCP)SBB, Daniel W. Bougie, PhD, Mia J Sullivan, Mehraboon S. Irani, MBBChir, Binod Dhakal, MDMS, Lisa M. Baumann Kreuziger, MD MS, Brenda M. Pierce, MD, Richard H. Aster, MD

Blood (2016) 128 (22): 2599.

https://doi.org/10.1182/blood.V128.22.2599.2599

Published: 2016

Journal Articles

Intravenous Immunoglobulin (IVIg) Is a Highly Effective Treatment for HIT: Critical Role of the IgG Fc Domain in Inhibiting HIT Antibody-Mediated Platelet Activation

Anand Padmanabhan, MBBS, MA, PhD, Curtis G Jones, Shannon M Pechauer, Barbara J. Bryant, MD, Jack B. Alperin, MD, Mehraboon S. Irani, MBBChir, Binod Dhakal, MDMS, Brian R Curtis, PhD D(ABMLI) MT(ASCP)SBB, Daniel W. Bougie, PhD, Mia J Sullivan, Renren Wen, PhD, Demin Wang, PhD, Richard H. Aster, MD

Blood (2016) 128 (22): 2600.

https://doi.org/10.1182/blood.V128.22.2600.2600

Published: 2016

Journal Articles

A Novel PF4-Dependent Platelet Activation Assay Identifies Patients Likely to Have Heparin-Induced Thrombocytopenia/Thrombosis (HIT)

Anand Padmanabhan, MBBS, MA, PhD, Curtis Jones, Brian R Curtis, MS, MT(ASCP)SBB, Daniel W. Bougie, PhD, Mia Sullivan, Namrata Peswani, MD MBBS, Janice McFarland, MD, Daniel Eastwood, Demin Wang, PhD, Richard H. Aster, MD

Blood (2015) 126 (23): 764.

https://doi.org/10.1182/blood.V126.23.764.764

Published: 2015

Journal Articles

Binding of Quinine-Dependent Monoclonal Antibodies to Gpiib/Iiia Appears to Involve Drug-Induced Modulation of Antibody Affinity

Daniel W. Bougie, PhD, Julie A. Peterson, PhD, Mark Rasmussen, Richard H. Aster, MD

Blood (2015) 126 (23): 2246.

https://doi.org/10.1182/blood.V126.23.2246.2246

Published: 2015

Journal Articles

Structural Basis for Quinine-Dependent Antibody Binding to Platelet Integrin alphaIIbbeta3

Jianghai Zhu, PhD, Jieqing Zhu, PhD, Daniel W. Bougie, PhD, Richard H. Aster, MD, Timothy A. Springer, PhD

Blood (2015) 126 (23): 1063.

https://doi.org/10.1182/blood.V126.23.1063.1063

Published: 2015

Journal Articles

Quantitative Measurement of VWF Binding to the Platelet Integrin αIIbβ3 - Abnormalities Identified in Individuals with VWD

Robert R. Montgomery, MD, Veronica H Flood, MD, Jieqing Zhu, PhD, Pamela A Christopherson, Peter J. Newman, PhD, Daniel W. Bougie, PhD, Patti Morateck

Blood (2015) 126 (23): 1107.

https://doi.org/10.1182/blood.V126.23.1107.1107

Published: 2015

Journal Articles

Antibodies Specific For Human Neutrophil Antigen 3a (HNA-3a) Recognize Complex Epitopes On Choline Transporter Protein 2 (CTL2): Implications For HNA-3a Antibody Detection

Daniel W. Bougie, PhD, Julie A. Peterson, PhD, Adam Kanack, Brian R Curtis, PhD, D(ABMLI), Richard H. Aster, MD

Blood (2013) 122 (21): 3662.

https://doi.org/10.1182/blood.V122.21.3662.3662

Published: 2013

Journal Articles

A Novel Assay For The Preferential Detection Of “Pathogenic” HIT Antibodies

Anand Padmanabhan, MBBS, MA, PhD, Curtis Jones, BS, Daniel W. Bougie, PhD, Brian R Curtis, MS, MT(ASCP)SBB, Janice McFarland, MD, Richard H. Aster, MD

Blood (2013) 122 (21): 1125.

https://doi.org/10.1182/blood.V122.21.1125.1125

Published: 2013

Journal Articles

Role Of Maternal Immunization Against Low Frequency Human Platelet Antigens (LFHPA) In Neonatal Alloimmune Thrombocytopenia (NAIT)

Julie A. Peterson, PhD, Maria Gitter, Daniel W. Bougie, PhD, Shannon Pechauer, Kathleen Hopp, Brad Pietz, MS, Aniko Szabo, PhD, Brian R. Curtis, PhD, D(ABMLI), Janice McFarland, MD, Richard H. Aster, MD

Blood (2013) 122 (21): 38.

https://doi.org/10.1182/blood.V122.21.38.38

Published: 2013

Journal Articles

Drug Metabolites Formed in Vivo Promote the Clearance of Human Platelets by Metabolite-Dependent Antibodies in NOD/SCID Mice

Daniel W. Bougie, PhD, Dhirendra Nayak, Richard H. Aster, MD

Blood (2012) 120 (21): 1083.

https://doi.org/10.1182/blood.V120.21.1083.1083

Published: 2012

Journal Articles

Platelet-Targeted, Thrombin-Activatable Fibrinolytic Pro-Drugs As Novel Therapies: Application to the Prothrombotic Disorder of Heparin-Induced Thrombocytopenia (HIT)

Rudy Fuentes, PhD, Hyun Sook Ahn, Vincent M. Hayes, Valerie Tutwiler, Yuhuan Wang, PhD, Daniel W. Bougie, PhD, M. Anna Kowalska, PhD, Lubica Rauova, M.D., Ph.D., Richard H. Aster, MD, Douglas B. Cines, MD, Vladimir R Muzykantov, MD PhD, Mortimer Poncz, MD, Sergei Zaitsev, PhD

Blood (2012) 120 (21): 1171.

https://doi.org/10.1182/blood.V120.21.1171.1171

Published: 2012

Journal Articles

Prevalence and Clinical Significance of Low Avidity HPA-1a Antibodies in Women Exposed to HPA-1a During Pregnancy

Julie A. Peterson, PhD, Adam Kanack, Dhirendra Nayak, Daniel W. Bougie, PhD, Janice McFarland, MD, Brian Curtis, PhD, Richard H. Aster, MD

Blood (2012) 120 (21): 266.

https://doi.org/10.1182/blood.V120.21.266.266

Published: 2012

Journal Articles

Heparin-Induced Thrombocytopenia Antibodies Inhibit PF4-Dependent Enhancement of Activated Protein C Formation by Binding to Antigenic Complexes Formed with the Chondroitin Sulfate Side-Chain of Thrombomodulin

M. Anna Kowalska, PhD, Lubica Rauova, PhD, Vincent Hayes, BA, Douglas B. Cines, MD, Daniel W. Bougie, PhD, Richard H. Aster, MD, Sriram Krishnaswamy, PhD, Mortimer Poncz, MD

Blood (2010) 116 (21): 721.

https://doi.org/10.1182/blood.V116.21.721.721

Published: 2010

NARROW

Cross-Reactivity of Drug-Dependent Antibodies in Patients with Immune Thrombocytopenia Induced By Beta-Lactam Antibiotics

Cross-Strain Platelet Immunization in Selected Mouse Strains Recapitulates Clinical and Serologic Findings Typical of Post-Transfusion Purpura (PTP)

Serologic Characterization of Antibodies in Patients Experiencing Piperacillin-Induced Immune Thrombocytopenia

The Platelet Factor-4 (PF4)-Dependent p-Selectin Expression Assay (PEA) Is Highly Accurate for the Detection of Pathogenic HIT Antibodies: Results of a 440-Sample Prospective Blinded Study

Immunoglobulin G in Normal Plasma Inhibits HIT Antibody-Mediated Platelet Activation: Implications for Therapeutic Plasma Exchange Treatment in HIT

A New Assay for Platelet-Activating HIT Antibodies, the PEA, Is Specific, Reproducible and Relatively Independent of the Choice of Platelet Donor

Autoimmune Thrombocytopenia in Mice Immunized with Allogeneic Platelets: A Model for Post-Transfusion Purpura (PTP)?

A Novel PF4-Dependent P-Selectin Expression Assay (PEA) Facilitates Early Detection of Pathogenic HIT Antibodies: Implications for Diagnosis and Treatment of HIT

Intravenous Immunoglobulin (IVIg) Is a Highly Effective Treatment for HIT: Critical Role of the IgG Fc Domain in Inhibiting HIT Antibody-Mediated Platelet Activation

A Novel PF4-Dependent Platelet Activation Assay Identifies Patients Likely to Have Heparin-Induced Thrombocytopenia/Thrombosis (HIT)

Binding of Quinine-Dependent Monoclonal Antibodies to Gpiib/Iiia Appears to Involve Drug-Induced Modulation of Antibody Affinity

Structural Basis for Quinine-Dependent Antibody Binding to Platelet Integrin alphaIIbbeta3

Quantitative Measurement of VWF Binding to the Platelet Integrin αIIbβ3 - Abnormalities Identified in Individuals with VWD

Antibodies Specific For Human Neutrophil Antigen 3a (HNA-3a) Recognize Complex Epitopes On Choline Transporter Protein 2 (CTL2): Implications For HNA-3a Antibody Detection

A Novel Assay For The Preferential Detection Of “Pathogenic” HIT Antibodies

Role Of Maternal Immunization Against Low Frequency Human Platelet Antigens (LFHPA) In Neonatal Alloimmune Thrombocytopenia (NAIT)

Drug Metabolites Formed in Vivo Promote the Clearance of Human Platelets by Metabolite-Dependent Antibodies in NOD/SCID Mice

Platelet-Targeted, Thrombin-Activatable Fibrinolytic Pro-Drugs As Novel Therapies: Application to the Prothrombotic Disorder of Heparin-Induced Thrombocytopenia (HIT)

Prevalence and Clinical Significance of Low Avidity HPA-1a Antibodies in Women Exposed to HPA-1a During Pregnancy

Heparin-Induced Thrombocytopenia Antibodies Inhibit PF4-Dependent Enhancement of Activated Protein C Formation by Binding to Antigenic Complexes Formed with the Chondroitin Sulfate Side-Chain of Thrombomodulin

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American Society of Hematology

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American Society of Hematology

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