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Journal Articles

Discovery and Development of MEDI7247, a Novel Pyrrolobenzodiazepine (PBD)-Based Antibody Drug Conjugate Targeting ASCT2, for Treating Hematological Cancers

Nabendu Pore, Kevin P Schifferli, Noel R Monks, Ravinder Tammali, Martin Borrok, Elaine Hurt, Matt Flynn, Marlon Rebelatto, Danielle M. Townsley, MD MSc, Mary Jane Hinrichs, Rakesh Dixit, Steven Coats, Ronald Herbst, David Tice

Blood (2018) 132 (Supplement 1): 4071.

https://doi.org/10.1182/blood-2018-99-119836

Published: 2018

Journal Articles

Towards Improved Decision-Making Based on Genomics in Bone Marrow Failure

Fernanda Gutierrez-Rodrigues, PhD, Carrie Diamond, MD, Ruba Shalhoub, André Pinto, Flávia S Donaires, PhD, Diego V Clé, MD PhD, Luiz Guilherme Darrigo, PhD, Luiz Fernando Catto, MD, Xing Fan, MD, Maria del Pilar Fernandez Ibanez, Sachiko Kajigaya, PhD, Cynthia E. Dunbar, MD, Carmem M. S. Bonfim, MD, Danielle M. Townsley, MD MSc, Rodrigo T. Calado, MD PhD, Neal S. Young, MD

Blood (2018) 132 (Supplement 1): 2587.

https://doi.org/10.1182/blood-2018-99-115026

Published: 2018

Journal Articles

Somatic TERT promoter Mutations in a Broad Spectrum of Telomeropathies

Fernanda Gutierrez-Rodrigues, PhD, Flávia S Donaires, PhD, André Pinto, Alana Vicente, MD, Laura Dillon, PhD, Diego V Clé, MDPhD, Bárbara Santana, Maria del Pilar Fernandez Ibanez, Danielle M. Townsley, MD MSc, Sachiko Kajigaya, PhD, Christopher S. Hourigan, DPhil FACP FRCP, James N. Cooper, MD, Rodrigo T. Calado, MD PhD, Neal S. Young, MD

Blood (2018) 132 (Supplement 1): 539.

https://doi.org/10.1182/blood-2018-99-115430

Published: 2018

Journal Articles

Single Cell Transcriptome Analysis of GATA2 Deficiency in Hematopoiesis Modeled with Induced Pluripotent Stem Cells

Francis Guitart, BA, Moonjung Jung, MD, Stefan Cordes, MD PhD, Shiqin Yu, Jizhong Zou, So Gun Hong, PhD, Vinh Dang, Diego A Espinoza, BA, Amy Hsu, Steven M. Holland, MD, Danielle M. Townsley, MD MSc, Cynthia E. Dunbar, MD, Thomas Winkler, MD

Blood (2018) 132 (Supplement 1): 5087.

https://doi.org/10.1182/blood-2018-99-118410

Published: 2018

Journal Articles

Eltrombopag for Moderate Aplastic Anemia and Unilineage Cytopenias: Dosing, Long-Term Follow-up, Clonal Evolution and Somatic Mutation Profiling

Xing Fan, MD, Thomas Winkler, MD, Ronan Desmond, MD, Bogdan Dumitriu, MD, Danielle M. Townsley, MD MSc, Maria del Pilar Fernandez Ibanez, Fernanda Gutierrez-Rodrigues, PhD, Sophia Grasmeder, RN, Ma Evette Barranta, Diane Madey, Jennifer Lotter, Janet Valdez, Katherine R. Calvo, MD PhD, Colin Wu, PhD, Neal S. Young, MD, Cynthia E. Dunbar, MD

Blood (2018) 132 (Supplement 1): 538.

https://doi.org/10.1182/blood-2018-99-112994

Published: 2018

Journal Articles

T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

Kohei Hosokawa, MDPhD, Sachiko Kajigaya, PhD, Keyvan Keyvanfar, BS, Qiao Wangmin, BS, Yanling Xie, MS, Olga Rios, RN, Barbara Weinstein, RN, Maria del Pilar Fernandez Ibanez, BS, Danielle M. Townsley, MD, Xingmin Feng, PhD, Neal S. Young, MD

Blood (2016) 128 (22): 1042.

https://doi.org/10.1182/blood.V128.22.1042.1042

Published: 2016

Journal Articles

Heterozygous RTEL1 variants in Patients with Bone Marrow Failure Associate with Telomere Dysfunction in the Absence of Telomere Shortening

Fernanda Gutierrez-Rodrigues, MSc, PharmD, Sachiko Kajigaya, PhD, Xingmin Feng, PhD, Maria del Pilar Fernandez Ibanez, MS, Marie J. Desierto, BS, Keyvan Keyvanfar, BS, Zejuan Li, MD PhD, Soma Das, PhD, Rodrigo T. Calado, MD PhD, Danielle M. Townsley, MD, Neal S. Young

Blood (2016) 128 (22): 1044.

https://doi.org/10.1182/blood.V128.22.1044.1044

Published: 2016

Journal Articles

Single-Cell RNA-Seq Reveals the Differentiation Hierarchy of Normal Human Bone Marrow and a Distinct Transcriptome Signature of Monosomy 7 Cells

Xin Zhao, MD PhD, Shouguo Gao, PhD, Xingmin Feng, PhD, Delong Liu, PhD, Sachiko Kajigaya, PhD, Zhijie Wu, MD, Qingguo Liu, MD, Keyvan Keyvanfar, BS, Marie J. Desierto, BS, Danielle M. Townsley, MD, Xujing Wang, PhD, Neal S. Young, MD

Blood (2016) 128 (22): 574.

https://doi.org/10.1182/blood.V128.22.574.574

Published: 2016

Journal Articles

Myeloid Neoplasm Gene Somatic Mutations in Patients with Severe Aplastic Anemia Treated with Eltrombopag and Standard Immunosuppression

Danielle M. Townsley, MD, James N. Cooper, MD, Thomas Winkler, MD, Phillip Scheinberg, MD, Olga Rios, RN, Barbara Weinstein, RN, Janet Valdez, Jennifer Lotter, Marie J. Desierto, BS, Maria del Pilar Fernandez Ibanez, MS, Colin Wu, PhD, Cynthia E. Dunbar, MD, Wanlong Ma, BS, Maher Albitar, MD, Neal S. Young

Blood (2016) 128 (22): 727.

https://doi.org/10.1182/blood.V128.22.727.727

Published: 2016

Journal Articles

A Plasma microRNA Signature As a Biomarker for Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Sachiko Kajigaya, PhD, Xingmin Feng, PhD, Marie J. Desierto, BS, Maria del Pilar Fernandez Ibanez, BS, Olga Rios, RN, Barbara Weinstein, RN, Phillip Scheinberg, MD, Danielle M. Townsley, MD, Neal S. Young, MD

Blood (2016) 128 (22): 728.

https://doi.org/10.1182/blood.V128.22.728.728

Published: 2016

Journal Articles

Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia Accelerates Count Recovery and Increases Response Rates

Danielle M. Townsley, MD, Bogdan Dumitriu, MD, Phillip Scheinberg, MD, Ronan Desmond, MD, FRCPath, Xingmin Feng, PhD, Olga Rios, RN, Barbara Weinstein, RN, Janet Valdez, PA-C, Thomas Winkler, MD, Marie Desierto, BS, Harshraj Leuva, MBBS, Colin Wu, PhD, Katherine R. Calvo, MD, PhD, Andre Larochelle, MD, PhD, Cynthia E. Dunbar, MD, Neal S. Young, MD

Blood (2015) 126 (23): LBA-2.

https://doi.org/10.1182/blood.V126.23.LBA-2.LBA-2

Published: 2015

Journal Articles

Activity of the Telomerase Inhibitor GRN163L (Imetelstat) on Acute Myeloblastic Leukemia Blasts Is Enhanced By DNA Methyltransferase Inhibitors Irrespective of TERT Promoter Methylation Status

Caroline R Cantilena, BA, Xin Zhao, MD PhD, Sachiko Kajigaya, PhD, Neil Dunavin, MD, Xin Tian, PhD, Stephen A. Strickland, MD, Bipin N. Savani, MD, Sanjay R. Mohan, MD, Katayoun Rezvani, MDPhD, Xingmin Feng, PhD, Danielle M. Townsley, MD, Minoo Battiwalla, MDMS, Sawa Ito, MD, Austin John Barrett, MDFRCP,FRCPath

Blood (2015) 126 (23): 1267.

https://doi.org/10.1182/blood.V126.23.1267.1267

Published: 2015

Journal Articles

Insights into Clonal Relationships of Putative Adaptive Natural Killer Cells (NK) in Humans, Via Mapping of Somatic Piga Mutations in Patients with Paroxysmal Nocturna Hemoglobinuria (PNH)

Thomas Winkler, MD, Marcus A.F. Corat, PhD, Delong Liu, PhD, Moonjung Jung, MD, Danielle M. Townsley, MD, Chuanfeng Wu, PhD, Neal S Young, MD, Cynthia E. Dunbar, MD

Blood (2015) 126 (23): 2223.

https://doi.org/10.1182/blood.V126.23.2223.2223

Published: 2015

Journal Articles

Whole Transcriptome Sequencing Identifies Novel Pathways Associated with Paroxysmal Nocturnal Hemoglobinuria- Increased CXCR2 Expression in PNH Granulocytes

Kohei Hosokawa, MDPhD, Sachiko Kajigaya, PhD, Keyvan Keyvanfar, BS, Danielle M. Townsley, MD, Bogdan Dumitriu, MD, Marie Desierto, Olga Rios, Barbara Weinstein, Xingmin Feng, PhD, Neal S. Young, MD

Blood (2015) 126 (23): 3608.

https://doi.org/10.1182/blood.V126.23.3608.3608

Published: 2015

Journal Articles

Persistent Elevation of Plasma Thrombopoietin Levels in Severe Aplastic Anemia, Even with Hematologic Recovery

Xin Zhao, MD PhD, Xingmin Feng, PhD, Danielle M. Townsley, MD, Thomas Winkler, MD, Ronan Desmond, MD, Matthew J. Olnes, MD PhD, Harshraj Leuva, Bogdan Dumitriu, MD, Cynthia E. Dunbar, MD, Neal S. Young, MD

Blood (2015) 126 (23): 3609.

https://doi.org/10.1182/blood.V126.23.3609.3609

Published: 2015

Journal Articles

High Frequency of Circulating CD8 + Memory Stem T Cells in Acquired Aplastic Anemia

Kohei Hosokawa, MDPhD, Pawel Muranski, MD, Xingmin Feng, PhD, Danielle M. Townsley, MD, Baoying Liu, PhD, Jared Knickelbein, MD, Keyvan Keyvanfar, BS, Bogdan Dumitriu, MD, Sawa Ito, MD, Sachiko Kajigaya, PhD, James G. Taylor, MD, Mariana J. Kaplan, MD, Robert B. Nussenblatt, MD, Austin John Barrett, MDFRCP,FRCPath, John O'Shea, MD, Neal S. Young, MD

Blood (2015) 126 (23): 3613.

https://doi.org/10.1182/blood.V126.23.3613.3613

Published: 2015

Journal Articles

Development of Somatic NRAS Mutation Associated with Rapid Transition from Germline GATA2 Mutation Associated Myelodysplastic Syndrome to Acute Myeloid Leukemia

Yanqin Yang, MDMSc, Yubo Zhang, PhD, Jun Zhu, PhD, Catherine E. Lai, MD, Jingrong Tang, MD PhD, Lisa J. McReynolds, MD PhD, Amy P Hsu, Dennis D. Hickstein, MD, Danielle M. Townsley, MD, Steven M. Holland, MD, Katherine R. Calvo, MD, PhD, Christopher S. Hourigan, MDPhD

Blood (2015) 126 (23): 3616.

https://doi.org/10.1182/blood.V126.23.3616.3616

Published: 2015

Journal Articles

Altered microRNAs in T Cells from Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Pawel Muranski, MD, Xingmin Feng, PhD, Keyvan Keyvanfar, BS, Danielle M. Townsley, MD, Bogdan Dumitriu, MD, Jichun Chen, PhD, Sachiko Kajigaya, PhD, James G. Taylor, MD, Christopher S. Hourigan, MD PhD, John Barrett, MD, Neal S. Young, MD

Blood (2014) 124 (21): 2940.

https://doi.org/10.1182/blood.V124.21.2940.2940

Published: 2014

Journal Articles

Telomere Elongation and Hematologic Improvement in Humans Treated with Androgens: A Prospective Clinical Trial of Danazol in Telomeropathies

Bogdan Dumitriu, MD, Danielle M. Townsley, MD, Christina Chen, BS, Rodrigo T. Calado, MD PhD, Phillip Scheinberg, MD, Neal S. Young, MD

Blood (2014) 124 (21): 258.

https://doi.org/10.1182/blood.V124.21.258.258

Published: 2014

Journal Articles

High Resolution Mass Cytometry (CyTOF) in Aplastic Anaemia (AA) Can Identify an Aberrant Treg Subset with Pro-Inflammatory Properties, Predicting Poor Response to Immunosuppressive Therapy

Shahram Kordasti, MD PhD, Thomas Seidl, Richard J Ellis, PhD, Austin Kulasekararaj, Xingmin Feng, PhD, Danielle M. Townsley, MD MSc, Susanne Heck, PhD, Neal S. Young, MD, Judith C Marsh, MD, Ghulam J. Mufti, DM, FRCP, FRCPath

Blood (2014) 124 (21): 1600.

https://doi.org/10.1182/blood.V124.21.1600.1600

Published: 2014

NARROW

Discovery and Development of MEDI7247, a Novel Pyrrolobenzodiazepine (PBD)-Based Antibody Drug Conjugate Targeting ASCT2, for Treating Hematological Cancers

Towards Improved Decision-Making Based on Genomics in Bone Marrow Failure

Somatic TERT promoter Mutations in a Broad Spectrum of Telomeropathies

Single Cell Transcriptome Analysis of GATA2 Deficiency in Hematopoiesis Modeled with Induced Pluripotent Stem Cells

Eltrombopag for Moderate Aplastic Anemia and Unilineage Cytopenias: Dosing, Long-Term Follow-up, Clonal Evolution and Somatic Mutation Profiling

T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

Heterozygous RTEL1 variants in Patients with Bone Marrow Failure Associate with Telomere Dysfunction in the Absence of Telomere Shortening

Single-Cell RNA-Seq Reveals the Differentiation Hierarchy of Normal Human Bone Marrow and a Distinct Transcriptome Signature of Monosomy 7 Cells

Myeloid Neoplasm Gene Somatic Mutations in Patients with Severe Aplastic Anemia Treated with Eltrombopag and Standard Immunosuppression

A Plasma microRNA Signature As a Biomarker for Acquired Aplastic Anemia

Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia Accelerates Count Recovery and Increases Response Rates

Activity of the Telomerase Inhibitor GRN163L (Imetelstat) on Acute Myeloblastic Leukemia Blasts Is Enhanced By DNA Methyltransferase Inhibitors Irrespective of TERT Promoter Methylation Status

Insights into Clonal Relationships of Putative Adaptive Natural Killer Cells (NK) in Humans, Via Mapping of Somatic Piga Mutations in Patients with Paroxysmal Nocturna Hemoglobinuria (PNH)

Whole Transcriptome Sequencing Identifies Novel Pathways Associated with Paroxysmal Nocturnal Hemoglobinuria- Increased CXCR2 Expression in PNH Granulocytes

Persistent Elevation of Plasma Thrombopoietin Levels in Severe Aplastic Anemia, Even with Hematologic Recovery

High Frequency of Circulating CD8 + Memory Stem T Cells in Acquired Aplastic Anemia

Development of Somatic NRAS Mutation Associated with Rapid Transition from Germline GATA2 Mutation Associated Myelodysplastic Syndrome to Acute Myeloid Leukemia

Altered microRNAs in T Cells from Patients with Acquired Aplastic Anemia

Telomere Elongation and Hematologic Improvement in Humans Treated with Androgens: A Prospective Clinical Trial of Danazol in Telomeropathies

High Resolution Mass Cytometry (CyTOF) in Aplastic Anaemia (AA) Can Identify an Aberrant Treg Subset with Pro-Inflammatory Properties, Predicting Poor Response to Immunosuppressive Therapy

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American Society of Hematology

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American Society of Hematology

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