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Journal Articles

Emerging genetic technologies informing personalized medicine in Shwachman-Diamond syndrome and other inherited BMF disorders

Alyssa H. Cull, David G. Kent, Alan J. Warren

Blood (2024) 144 (9): 931–939.

https://doi.org/10.1182/blood.2023019986

Published: 2024

Journal Articles

Resolving the hematopoietic stem cell state by linking functional and molecular assays

Maria Jassinskaja, Monika Gonka, David G. Kent

Blood (2023) 142 (6): 543–552.

https://doi.org/10.1182/blood.2022017864

Published: 2023

Journal Articles

STAT1 is essential for HSC function and maintains MHCII hi stem cells that resist myeloablation and neoplastic expansion

Blood (2022) 140 (14): 1592–1606.

https://doi.org/10.1182/blood.2021014009

Published: 2022

Includes: Supplemental data

Journal Articles

Clonal Tracking By Whole Genome Sequencing Permits Comprehensive Mapping of the Genomic Landscape in Pre- and Post-Gene Therapy Sickle Cell Patients

Alyssa H. Cull, Michael Spencer Chapman, Marioara Ciuculescu, Emily Mitchell, Myriam Armant, Grace Boyd, Erica B. Esrick, David A. Williams, Peter J. Campbell, David G. Kent

Blood (2021) 138 (Supplement 1): 559.

https://doi.org/10.1182/blood-2021-152262

Published: 2021

Journal Articles

Clonal Dynamics of Normal Haematopoiesis with Human Ageing

Blood (2021) 138 (Supplement 1): 598.

https://doi.org/10.1182/blood-2021-150152

Published: 2021

Journal Articles

Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal

Mairi S. Shepherd, Juan Li, Nicola K. Wilson, Caroline A. Oedekoven, Jiangbing Li, Miriam Belmonte, Juergen Fink, Janine C. M. Prick, Dean C. Pask, Tina L. Hamilton, Dirk Loeffler, Anjana Rao, Timm Schröder, Berthold Göttgens, Anthony R. Green, David G. Kent

Blood (2018) 132 (8): 791–803.

https://doi.org/10.1182/blood-2017-12-821066

Published: 2018

Includes: Supplemental data

Journal Articles

A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice

Joakim S. Dahlin, Fiona K. Hamey, Blanca Pijuan-Sala, Mairi Shepherd, Winnie W. Y. Lau, Sonia Nestorowa, Caleb Weinreb, Samuel Wolock, Rebecca Hannah, Evangelia Diamanti, David G. Kent, Berthold Göttgens, Nicola K. Wilson

Blood (2018) 131 (21): e1–e11.

https://doi.org/10.1182/blood-2017-12-821413

Published: 2018

Includes: Supplemental data

Journal Articles

Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage

Juan Li, Daniel Prins, Hyun Jung Park, Jacob Grinfeld, Carlos Gonzalez-Arias, Stephen Loughran, Oliver M. Dovey, Thorsten Klampfl, Cavan Bennett, Tina L. Hamilton, Dean C. Pask, Rachel Sneade, Matthew Williams, Juliet Aungier, Cedric Ghevaert, George S. Vassiliou, David G. Kent, Anthony R. Green

Blood (2018) 131 (6): 649–661.

https://doi.org/10.1182/blood-2017-09-806356

Published: 2018

Includes: Supplemental data

Journal Articles

A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation

Sonia Nestorowa, Fiona K. Hamey, Blanca Pijuan Sala, Evangelia Diamanti, Mairi Shepherd, Elisa Laurenti, Nicola K. Wilson, David G. Kent, Berthold Göttgens

Blood (2016) 128 (8): e20–e31.

https://doi.org/10.1182/blood-2016-05-716480

Published: 2016

Includes: Supplemental data

Journal Articles

Nongenetic stochastic expansion of JAK2V617F -homozygous subclones in polycythemia vera?

Anna L. Godfrey, Jyoti Nangalia, E. Joanna Baxter, Charles E. Massie, David G. Kent, Elli Papaemmanuil, Peter J. Campbell, Anthony R. Green

Blood (2014) 124 (22): 3332–3334.

https://doi.org/10.1182/blood-2014-09-603043

Published: 2014

Includes: Supplemental data

Journal Articles

JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease

Juan Li, David G. Kent, Anna L. Godfrey, Harriet Manning, Jyoti Nangalia, Athar Aziz, Edwin Chen, Kourosh Saeb-Parsy, Juergen Fink, Rachel Sneade, Tina L. Hamilton, Dean C. Pask, Yvonne Silber, Xiaodong Zhao, Cedric Ghevaert, Pentao Liu, Anthony R. Green

Blood (2014) 123 (20): 3139–3151.

https://doi.org/10.1182/blood-2013-06-510222

Published: 2014

Includes: Supplemental data

Journal Articles

Order Matters: Sequence Of Mutation Acquisition In Myeloproliferative Neoplasms Impacts Disease Pathogenesis and Stem Cell Potency

David G. Kent, PhD, Christina Ortmann, MD, Yvonne Silber, Joanna Baxter, PhD, Beatriz Bellosillo, Konstanze Doehner, MD, Peter J. Campbell, PhD, Anthony R Green

Blood (2013) 122 (21): 2888.

https://doi.org/10.1182/blood.V122.21.2888.2888

Published: 2013

Journal Articles

The Genomic Landscape of Myeloproliferative Neoplasms: Somatic Calr Mutations in the Majority of JAK2-Wildtype Patients

Jyoti Nangalia, MBBChir FRCPath, Charles Massie, PhD, E Joanna Baxter, PhD, Francesca L Nice, MRes, Gunes Gundem, PhD, David Wedge, PhD, Edward Avezov, PhD, Juan Li, PhD, Karoline Kollmann, PhD, David G. Kent, PhD, Athar Aziz, PhD, Anna L Godfrey, BMBCh FRCPath, Jonathan Hinton, MSc, Inigo Martincorena, PhD, Peter Van Loo, PhD, Amy V Jones, PhD, Paola Guglielmelli, PhD MD, Patrick Tarpey, PhD, Heather P Harding, PhD, John D Fitzpatrick, BA, Calum T Goudie, BA, Christina A Ortmann, MD, Stephen J Loughran, PhD, Keiran Raine, MSc, David Jones, MSc, Adam Butler, MSc, Jon W Teague, MSc, Sarah O'Meara, Stuart McLaren, Michele Bianchi, Yvonne Silber, MSc, Danai Dimitropolou, BSc, David Bloxham, MSc FRCPath, Laura J Mudie, BSc, Mark Maddison, BSc, Ben Robinson, BSc, Clodagh Keohane, MD, Cathy MacLean, MSc, Kate Hill, BM BS, Kim H. Orchard, MBBS, PhD, FRCP, FRCPath, Sudhir Tauro, PhD, Ming-Qing Du, MB, PhD, Mel Greaves, PhD, FRS, David Bowen, MD, PhD, Brian Huntly, MBChB FRCPath PhD, Claire N Harrison, DM, FRCP, FRCPath, Nicholas C.P. Cross, PhD, FRCPath, David Ron, MD, Alessandro M Vannucchi, MD, Elli Papaemmanuil, PhD, Peter J. Campbell, PhD, Anthony R Green, FRCPath FMedSci

Blood (2013) 122 (21): LBA-2.

https://doi.org/10.1182/blood.V122.21.LBA-2.LBA-2

Published: 2013

Journal Articles

Early Appearance and Rapid, Selective Expansion of Lymphoid-Deficient Fetal HSCs Associated with Their Preferential Localization in the Marrow

Claudia Benz, PhD, Michael R. Copley, David G. Kent, PhD, Stefan Wohrer, MD, Connie J. Eaves, PhD

Blood (2011) 118 (21): 1271.

https://doi.org/10.1182/blood.V118.21.1271.1271

Published: 2011

Journal Articles

Inhibition of Let-7 Processing in Adult Murine Hematopoietic Stem Cells Induces a Fetal-Like High Self-Renewal Pattern in Their Progeny

Michael R. Copley, David G. Kent, PhD, Claudia Benz, PhD, Stefan Wohrer, MD, Keegan M. Rowe, Chris W. Day, Connie J. Eaves, PhD

Blood (2011) 118 (21): 45.

https://doi.org/10.1182/blood.V118.21.45.45

Published: 2011

Journal Articles

Ontogeny stage-independent and high-level clonal expansion in vitro of mouse hematopoietic stem cells stimulated by an engineered NUP98-HOX fusion transcription factor

Sanja Sekulovic, Maura Gasparetto, Véronique Lecault, Corinne A. Hoesli, David G. Kent, Patty Rosten, Adrian Wan, Christy Brookes, Carl L. Hansen, James M. Piret, Clayton Smith, Connie J. Eaves, R. Keith Humphries

Blood (2011) 118 (16): 4366–4376.

https://doi.org/10.1182/blood-2011-04-350066

Published: 2011

Includes: Supplemental data

Journal Articles

Evidence That High-Mobility Group A2 (Hmga2) Expression Contributes to the Ontogeny-Dependent Properties of Fetal Hematopoietic Stem Cells.

Michael R. Copley, BSc, David G. Kent, PhD, Claudia Benz, PhD, Keegan M. Rowe, BSc, Stefan H. Woehrer, MD, Connie J. Eaves, PhD

Blood (2010) 116 (21): 2634.

https://doi.org/10.1182/blood.V116.21.2634.2634

Published: 2010

Journal Articles

Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential

David G. Kent, Michael R. Copley, Claudia Benz, Stefan Wöhrer, Brad J. Dykstra, Elaine Ma, John Cheyne, Yongjun Zhao, Michelle B. Bowie, Yun Zhao, Maura Gasparetto, Allen Delaney, Clayton Smith, Marco Marra, Connie J. Eaves

Blood (2009) 113 (25): 6342–6350.

https://doi.org/10.1182/blood-2008-12-192054

Published: 2009

Includes: Supplemental data

Journal Articles

New Candidate Regulators of Hematopoietic Stem Cells Identified from Transcriptional Comparisons of Highly Purified Populations of Longterm Repopulating Cells with Markedly Different in Vivo Self-Renewal Activities

David G Kent, BSc, Michael R Copley, B.Sc., Claudia Benz, PhD, Brad J Dykstra, PhD, Elaine Ma, BSc, Jay Cheyne, BSc, Yongjun Zhao, MSc, Maura Gasparetto, MD, Allen Delaney, PhD, Clayton Smith, MD, FRCPC, Marco Marra, PhD, Connie J. Eaves, PhD

Blood (2008) 112 (11): 2460.

https://doi.org/10.1182/blood.V112.11.2460.2460

Published: 2008

Journal Articles

Comprehensive Profiling of Micrornas in Murine Hematopoietic Stem Cells and Lineages Using a Microfluidics Approach

Blood (2008) 112 (11): 2468.

https://doi.org/10.1182/blood.V112.11.2468.2468

Published: 2008

NARROW

Emerging genetic technologies informing personalized medicine in Shwachman-Diamond syndrome and other inherited BMF disorders

Resolving the hematopoietic stem cell state by linking functional and molecular assays

STAT1 is essential for HSC function and maintains MHCII hi stem cells that resist myeloablation and neoplastic expansion

Clonal Tracking By Whole Genome Sequencing Permits Comprehensive Mapping of the Genomic Landscape in Pre- and Post-Gene Therapy Sickle Cell Patients

Clonal Dynamics of Normal Haematopoiesis with Human Ageing

Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal

A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice

Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage

A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation

Nongenetic stochastic expansion of JAK2V617F -homozygous subclones in polycythemia vera?

JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease

Order Matters: Sequence Of Mutation Acquisition In Myeloproliferative Neoplasms Impacts Disease Pathogenesis and Stem Cell Potency

The Genomic Landscape of Myeloproliferative Neoplasms: Somatic Calr Mutations in the Majority of JAK2-Wildtype Patients

Early Appearance and Rapid, Selective Expansion of Lymphoid-Deficient Fetal HSCs Associated with Their Preferential Localization in the Marrow

Inhibition of Let-7 Processing in Adult Murine Hematopoietic Stem Cells Induces a Fetal-Like High Self-Renewal Pattern in Their Progeny

Ontogeny stage-independent and high-level clonal expansion in vitro of mouse hematopoietic stem cells stimulated by an engineered NUP98-HOX fusion transcription factor

Evidence That High-Mobility Group A2 (Hmga2) Expression Contributes to the Ontogeny-Dependent Properties of Fetal Hematopoietic Stem Cells.

Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential

New Candidate Regulators of Hematopoietic Stem Cells Identified from Transcriptional Comparisons of Highly Purified Populations of Longterm Repopulating Cells with Markedly Different in Vivo Self-Renewal Activities

Comprehensive Profiling of Micrornas in Murine Hematopoietic Stem Cells and Lineages Using a Microfluidics Approach

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American Society of Hematology

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ASH Publications

American Society of Hematology

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