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Journal Articles

CRISPR/Cas9-mediated Cxcr4 disease allele inactivation for gene therapy in a mouse model of WHIM syndrome

Ji-Liang Gao, Albert Owusu-Ansah, Alexander Yang, Erin Yim, David H. McDermott, Paejonette Jacobs, Shamik Majumdar, Uimook Choi, Colin L. Sweeney, Harry L. Malech, Philip M. Murphy

Blood (2023) 142 (1): 23–32.

https://doi.org/10.1182/blood.2022019142

Published: 2023

Journal Articles

Abnormal Cytotoxic T-Cell Expansion in the Bone Marrow of Patients with SASH3 Deficiency and Cytopenias

Saber Tadros, Shamik Majumdar, Ottavia Delmonte, Jenna Bergerson, Irene Cortese, David H. McDermott, Jaspal Khillan, Kyoungin Cho, Luigi D. Notarangelo, Philip M. Murphy, Katherine R. Calvo

Blood (2022) 140 (Supplement 1): 1650–1651.

https://doi.org/10.1182/blood-2022-167673

Published: 2022

Journal Articles

CXCR4 Drives Lympho-Myeloid Fate of Hematopoietic Progenitors Via mTOR and Mitochondrial Metabolic Pathways

Blood (2021) 138 (Supplement 1): 2150.

https://doi.org/10.1182/blood-2021-149312

Published: 2021

Journal Articles

SASH3 variants cause a novel form of X-linked combined immunodeficiency with immune dysregulation

Blood (2021) 138 (12): 1019–1033.

https://doi.org/10.1182/blood.2020008629

Published: 2021

Includes: Supplemental data

Journal Articles

Hematologic disorder–associated Cxcr4 gain-of-function mutation leads to uncontrolled extrafollicular immune response

Nagham Alouche, Amélie Bonaud, Vincent Rondeau, Rim Hussein-Agha, Julie Nguyen, Valeria Bisio, Mélanie Khamyath, Etienne Crickx, Niclas Setterblad, Nicolas Dulphy, Matthieu Mahevas, David H. McDermott, Philip M. Murphy, Karl Balabanian, Marion Espéli

Blood (2021) 137 (22): 3050–3063.

https://doi.org/10.1182/blood.2020007450

Published: 2021

Includes: Supplemental data

Journal Articles

Whim Syndrome Caused By a 5 Base Pair Deletion in the C-Terminus of Chemokine Receptor CXCR4

Qian Liu, MD, Lizbeeth Lopez, Catherina Pan, Daniel Velez, John S. Corns, Donald T. Ellenburg, Harry L. Malech, MD, Philip M. Murphy, MD, David H. McDermott, MD

Blood (2015) 126 (23): 1003.

https://doi.org/10.1182/blood.V126.23.1003.1003

Published: 2015

Journal Articles

CXCR4 Gene Dosage Is Critical for HSC Engraftment

David H. McDermott, MD, Paejonette Jacobs, PhD, Qian Liu, MD, Jiliang Gao, PhD, Philip M. Murphy, MD

Blood (2015) 126 (23): 3066.

https://doi.org/10.1182/blood.V126.23.3066.3066

Published: 2015

Journal Articles

A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor

Blood (2014) 123 (15): 2308–2316.

https://doi.org/10.1182/blood-2013-09-527226

Published: 2014

Includes: Supplemental data

Journal Articles

WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4

Qian Liu, Haoqian Chen, Teresa Ojode, Xiangxi Gao, Sandra Anaya-O'Brien, Nicholas A. Turner, Jean Ulrick, Rosamma DeCastro, Corin Kelly, Adela R. Cardones, Stuart H. Gold, Eugene I. Hwang, Daniel S. Wechsler, Harry L. Malech, Philip M. Murphy, David H. McDermott

Blood (2012) 120 (1): 181–189.

https://doi.org/10.1182/blood-2011-12-395608

Published: 2012

Includes: Supplemental data

Journal Articles

Unexpected developments in immune organs in WHIM syndrome

Philip M. Murphy, David H. McDermott

Blood (2012) 119 (24): 5610–5612.

https://doi.org/10.1182/blood-2012-04-420752

Published: 2012

Journal Articles

The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome

David H. McDermott, Qian Liu, Jean Ulrick, Nana Kwatemaa, Sandra Anaya-O'Brien, Scott R. Penzak, Joao Oliveira Filho, Debra A. Long Priel, Corin Kelly, Mary Garofalo, Patricia Littel, Martha M. Marquesen, Diane Hilligoss, Rosamma DeCastro, Thomas A. Fleisher, Douglas B. Kuhns, Harry L. Malech, Philip M. Murphy

Blood (2011) 118 (18): 4957–4962.

https://doi.org/10.1182/blood-2011-07-368084

Published: 2011

Includes: Supplemental data

Journal Articles

Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis

David H. McDermott, Suk See De Ravin, Hyun Sik Jun, Qian Liu, Debra A. Long Priel, Pierre Noel, Clifford M. Takemoto, Teresa Ojode, Scott M. Paul, Kimberly P. Dunsmore, Dianne Hilligoss, Martha Marquesen, Jean Ulrick, Douglas B. Kuhns, Janice Y. Chou, Harry L. Malech, Philip M. Murphy

Blood (2010) 116 (15): 2793–2802.

https://doi.org/10.1182/blood-2010-01-265942

Published: 2010

Journal Articles

Lack of glucose recycling between endoplasmic reticulum and cytoplasm underlies cellular dysfunction in glucose-6-phosphatase-β–deficient neutrophils in a congenital neutropenia syndrome

Hyun Sik Jun, Young Mok Lee, Yuk Yin Cheung, David H. McDermott, Philip M. Murphy, Suk See De Ravin, Brian C. Mansfield, Janice Y. Chou

Blood (2010) 116 (15): 2783–2792.

https://doi.org/10.1182/blood-2009-12-258491

Published: 2010

Journal Articles

Donor and recipient chemokine receptor CCR5 genotype is associated with survival after bone marrow transplantation

David H. McDermott, Susan E. Conway, Tao Wang, Stacy M. Ricklefs, Manza A. Agovi, Stephen F. Porcella, Huong Thi Bich Tran, Edgar Milford, Stephen Spellman, Reza Abdi

Blood (2010) 115 (11): 2311–2318.

https://doi.org/10.1182/blood-2009-08-237768

Published: 2010

Includes: Supplemental data

Journal Articles

Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease

Didier Moatti, Sophie Faure, Frédéric Fumeron, Mohamed El Walid Amara, Patrick Seknadji, David H. McDermott, Patrice Debré, Marie Claude Aumont, Philip M. Murphy, Dominique de Prost, Christophe Combadière

Blood (2001) 97 (7): 1925–1928.

https://doi.org/10.1182/blood.V97.7.1925

Published: 2001

NARROW

CRISPR/Cas9-mediated Cxcr4 disease allele inactivation for gene therapy in a mouse model of WHIM syndrome

Abnormal Cytotoxic T-Cell Expansion in the Bone Marrow of Patients with SASH3 Deficiency and Cytopenias

CXCR4 Drives Lympho-Myeloid Fate of Hematopoietic Progenitors Via mTOR and Mitochondrial Metabolic Pathways

SASH3 variants cause a novel form of X-linked combined immunodeficiency with immune dysregulation

Hematologic disorder–associated Cxcr4 gain-of-function mutation leads to uncontrolled extrafollicular immune response

Whim Syndrome Caused By a 5 Base Pair Deletion in the C-Terminus of Chemokine Receptor CXCR4

CXCR4 Gene Dosage Is Critical for HSC Engraftment

A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor

WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4

Unexpected developments in immune organs in WHIM syndrome

The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome

Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis

Lack of glucose recycling between endoplasmic reticulum and cytoplasm underlies cellular dysfunction in glucose-6-phosphatase-β–deficient neutrophils in a congenital neutropenia syndrome

Donor and recipient chemokine receptor CCR5 genotype is associated with survival after bone marrow transplantation

Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease

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American Society of Hematology

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ASH Publications

American Society of Hematology

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