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Niclas Setterblad
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Journal Articles

CXCR4 Drives Lympho-Myeloid Fate of Hematopoietic Progenitors Via mTOR and Mitochondrial Metabolic Pathways

Vincent Rondeau, Amélie Bonaud, Zeina Abou-Nader, Julia Lemos, Vanessa Gourhand, Marc Delord, Ghislain Bidaut, Adrienne Anginot, Nathalie Mazure, David H. McDermott, Véronique Parietti-Montcuquet, Niclas Setterblad, Nicolas Dulphy, Françoise Bachelerie, Daniel Stockholm, Michel Aurrand-Lions, Philip M. Murphy, Marion Espeli, Stéphane Mancini, Karl Balabanian
Journal: Blood
Blood (2021) 138 (Supplement 1): 2150.
https://doi.org/10.1182/blood-2021-149312
Published: 2021
Journal Articles

Hematologic disorder–associated Cxcr4 gain-of-function mutation leads to uncontrolled extrafollicular immune response

Nagham Alouche, Amélie Bonaud, Vincent Rondeau, Rim Hussein-Agha, Julie Nguyen, Valeria Bisio, Mélanie Khamyath, Etienne Crickx, Niclas Setterblad, Nicolas Dulphy, Matthieu Mahevas, David H. McDermott, Philip M. Murphy, Karl Balabanian, Marion Espéli
Journal: Blood
Blood (2021) 137 (22): 3050–3063.
https://doi.org/10.1182/blood.2020007450
Published: 2021
Includes: Supplemental data
Journal Articles

BCL-2 Inhibitor Venetoclax (ABT-199) and MEK Inhibitor GDC-0973 Synergise to Target AML Progenitors and Overcome Drug Resistance with the Use of PET Scanning in a Mouse Model of HR-MDS to Monitor Response to Treatment

Rose Ann Padua, PhD, Laure Sarda-Mantel, MD PhD, Mathieu Chiquet, BSc, Claire Kappel, BSc, Patricia Krief, PhD, Niclas Setterblad, PhD, Fortune Hontonnou, BSc, Benoit Hosten, PhD, Nicolas Vignal, BSc, Fabien Zassadowski, PhD, Bruno Cassinat, PharmD, PhD, Panhong Gou, BSc, Stephane Giraudier, MD PhD, Marina Y. Konopleva, MD PhD, Michael Andreeff, MD PhD, Marika PLA, PhD, Lionel Ades, MD PhD, Pierre Fenaux, MD PhD, Christine Chomienne, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5497.
https://doi.org/10.1182/blood-2018-99-114212
Published: 2018
Journal Articles

BCL-2 Inhibition with ABT-199 Shows Efficacy in AML Cell Lines with Synergistic Effects upon Addition of the MEK Inhibitor GDC-0973 and Prolongs Survival in an NAS/BCL-2-Mediated Mouse Model of AML Post-MDS

Rose Ann Padua, PhD, Mathieu Chiquet, BSc, Qi Zhang, PhD MD, Claire Kappel, Patricia Krief, PhD, Niclas Setterblad, PhD, Dr Omidvar, BSc, MSc, PhD, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD, Marika PLA, PhD, Lionel Ades, MD PhD, Pierre Fenaux, MD PhD, Christine Chomienne, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2613.
https://doi.org/10.1182/blood.V130.Suppl_1.2613.2613
Published: 2017
Journal Articles

Efficacy of ABT-737, a BCL-2 Inhibitor, in an NRAS/BCL2 Mouse Model of High Risk Myelodysplasia (HR-MDS) By Targeting Pathways Identified By Gene Expression Profiling

Rose Ann Padua, PhD, Petra Gorombei, MSc, Stéphanie Beurlet, DMV, PhD, Nader Omidvar, PhD, Satyananda Patel, PhD, Laura Guerenne, MSc, Carole Le Pogam, PhD, Niclas Setterblad, PhD, Pierre de la Grange, PhD, Fabien Guidez, PhD, Christophe Le Boeuf, PhD, Anne Janin, MD PhD, Maria-Elena Noguera, MD, Laure Sarda-Mantel, MD PhD, Pascal Merlet, MD, Robert West, PhD, Marika Pla, PhD, Pierre Fenaux, MD PhD, Patricia Krief, PhD, Christine Chomienne, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3249.
https://doi.org/10.1182/blood.V124.21.3249.3249
Published: 2014
Journal Articles

BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells

Stephanie Beurlet, Nader Omidvar, Petra Gorombei, Patricia Krief, Carole Le Pogam, Niclas Setterblad, Pierre de la Grange, Christophe Leboeuf, Anne Janin, Maria-Elena Noguera, Florence Hervatin, Laure Sarda-Mantel, Marina Konopleva, Michael Andreeff, Andrea W. Tu, Alice C. Fan, Dean W. Felsher, Anthony Whetton, Marika Pla, Robert West, Pierre Fenaux, Christine Chomienne, Rose Ann Padua
Journal: Blood
Blood (2013) 122 (16): 2864–2876.
https://doi.org/10.1182/blood-2012-07-445635
Published: 2013
Includes: Supplemental data
Journal Articles

NRAS:BCL-2 Complex Localization Determines Anti-Apoptotic Features Associated with Progressive Disease in Myelodysplastic Syndromes (MDS)

Rose Ann Padua, PhD, Carole Le Pogam, MSc, Patricia Krief, PhD, Stephanie Beurlet, DMV, PhD, Bruno Cassinat, PharmD, PhD, Hélène Cavé, PhD, Olivier Kosmider, MD, PhD, Niclas Setterblad, PhD, Christophe Leboeuf, PhD, Laure Sarda-Mantel, MD, PhD, Florence Hervatin, PhD, Pascal Merlet, MD, Maria-Elena Noguera, MD, Anne Janin, MD, PhD, Marika Pla, PhD, Michaela Fontenay, MD, PhD, Lionel Ades, MD, PhD, Pierre Fenaux, MD, PhD, Christine Chomienne, MD, PhD, Nader Omidvar, PhD
Journal: Blood
Blood (2012) 120 (21): 3835.
https://doi.org/10.1182/blood.V120.21.3835.3835
Published: 2012
Journal Articles

Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome

Youmna Kfoury, Niclas Setterblad, Marwan El-Sabban, Alessia Zamborlini, Zeina Dassouki, Hiba El Hajj, Olivier Hermine, Claudine Pique, Hugues de Thé, Ali Saïb, Ali Bazarbachi
Journal: Blood
Blood (2011) 117 (1): 190–199.
https://doi.org/10.1182/blood-2010-05-285742
Published: 2011
Includes: Supplemental data
Journal Articles

ABT-737 Targets Intrinsic Apoptosis during Cooperation of BCL-2 and Oncogenic NRAS in An in Vivo Progression Model of Myelodysplasia/Acute Myeloid Leukaemia

Nader Omidvar, Stephanie Beurlet, Carole Le Pogam, Anne Janin, Christophe Leboeuf, Annie Soulie, Niclas Setterblad, Maria-Elena Noguera, Laure Sarda-Mantel, Pascal Merlet, Marika Pla, Scott C. Kogan, MD, Irving L Weissman, Marina Konopleva, William Bormann, Michael Andreeff, Christine Chomienne, Rose Ann Padua
Journal: Blood
Blood (2008) 112 (11): 848.
https://doi.org/10.1182/blood.V112.11.848.848
Published: 2008
Journal Articles

MHC class II/CD38/CD9: a lipid-raft–dependent signaling complex in human monocytes

Marie-Thérèse Zilber, Niclas Setterblad, Thierry Vasselon, Christelle Doliger, Dominique Charron, Nuala Mooney, Catherine Gelin
Journal: Blood
Blood (2005) 106 (9): 3074–3081.
https://doi.org/10.1182/blood-2004-10-4094
Published: 2005
Journal Articles

Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria -transformed B lymphocytes

Martin Baumgartner, Pavla Angelisová, Niclas Setterblad, Nuala Mooney, Dirk Werling, Václav Horejsı́, Gordon Langsley
Journal: Blood
Blood (2003) 101 (5): 1874–1881.
https://doi.org/10.1182/blood-2002-02-0456
Published: 2003