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Dharminder Chauhan, Ph.D
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Journal Articles

Potential Therapeutic Role of the Selective Adhesion Molecule (SAM) Inhibitor Natalizumab in Multiple Myeloma.

Klaus Podar, MD, PhD, Alexander Zimmerhackl, DI, Ursula Hainz, PhD, Mariateresa Fulciniti, PhD, Sonia Vallet, MD., Dian Olsen, MSc, Yu-Tzu Tai, PhD, Teru Hideshima, MD, PhD, Dharminder Chauhan, Ph.D, Kenneth C. Anderson, MD
Journal: Blood
Blood (2009) 114 (22): 1850.
https://doi.org/10.1182/blood.V114.22.1850.1850
Published: 2009
Journal Articles

Molecular Sequaele of Activin A-Dependent Osteoblast Inhibition in Myeloma.

Sonia Vallet, MD., Siddhartha Mukherjee, M.D., Nileshwari Vaghela, Teru Hideshima, M.D., Ph.D., Mariateresa Fulciniti, PhD, Samantha Pozzi, MD, Loredana Santo, Diana Cirstea, MD, Aliyah Rahemtullah, MD, Eyal C. Attar, MD, Alexander R Guimaraes, Dharminder Chauhan, Ph.D, Wanling Xie, Chirayu Patel, Jesse Schoonmaker, Michael Churchill, Kishan Patel, Edie Weller, PhD, Nikhil C. Munshi, Jasbir Seehra, Kenneth C. Anderson, MD, David T. Scadden, MD, Noopur Raje, MD.
Journal: Blood
Blood (2009) 114 (22): 1789.
https://doi.org/10.1182/blood.V114.22.1789.1789
Published: 2009
Journal Articles

AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor Induces Antimyeloma Activity Via Potent Aurora Kinase and STAT3 Inhibition.

Loredana Santo, M.D., Teru Hideshima, MD., Ph.D., Erik A. Nelson, Ph.D, Diana Cirstea, MD, Madhavi Bandi, Ph.D, Hiroshi Ikeda, MD, PhD, Gullu Gorgun, PhD, Sonia Vallet, MD., Samantha Pozzi, MD, Giulia Perrone, MD, Kishan Patel, Yiguo Hu, Ph.D, Matthew S Squires, Murray Yule, Elisabetta Calabrese, MD., Dharminder Chauhan, Ph.D, Nikhil C. Munshi, Kenneth C. Anderson, MD, Noopur Raje, MD.
Journal: Blood
Blood (2009) 114 (22): 3833.
https://doi.org/10.1182/blood.V114.22.3833.3833
Published: 2009
Journal Articles

Deubiquitylating Enzyme USP-7, a Novel Therapeutic Target in Multiple Myeloma.

Dharminder Chauhan, Ph.D, Ze Tian, Ph.D, Benjamin Nicholson, Bin Zhou, Teru Hideshima, Nikhil Munshi, Paul Richardson, Kenneth C. Anderson
Journal: Blood
Blood (2009) 114 (22): 610.
https://doi.org/10.1182/blood.V114.22.610.610
Published: 2009
Journal Articles

PR-924, a Selective Inhibitor of the Immunoproteasome Subunit LMP-7 Blocks Multiple Myeloma Cell Growth Both in Vitro and In Vivo.

Ajita V. Singh, Madhavi Bandi, Monette Aujay, Susan Demo, PhD, Teru Hideshima, Nikhil C. Munshi, Paul G. Richardson, Dharminder Chauhan, Ph.D, Kenneth C. Anderson, MD
Journal: Blood
Blood (2009) 114 (22): 612.
https://doi.org/10.1182/blood.V114.22.612.612
Published: 2009
Journal Articles

NPI-2358, a Novel Vascular Disrupting Agent Blocks Growth and Angiogenesis in Multiple Myeloma Cells.

Dharminder Chauhan, Ph.D, Ajita V. Singh, Madhavi Bandi, Noopur Raje, M.D., Robert L Schlossman, M.D., G. Kenneth Lloyd, PhD, Paul Richardson, Michael A. Palladino, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2009) 114 (22): 3842.
https://doi.org/10.1182/blood.V114.22.3842.3842
Published: 2009
Journal Articles

Targeting MEK1/2 Signaling Cascade by AS703026, a Novel Selective MEK1/2 Inhibitor, Induces Pleiotropic Anti-Myeloma Activity in Vitro and In Vivo.

Yu-Tzu Tai, Ph.D., Kihyun Kim, M.D., Xian-Feng Li, M.S., Mariateresa Fulciniti, Ph.D., Weihua Song, M.D., Sabikun Nahar, B.S., Peter Burger, B.S., Mathew J. Rumizen, Klaus Podar, M.D., Ph.D., Dharminder Chauhan, Ph.D, Teru Hideshima, M.D., Ph.D., Robert L Schlossman, M.D., Ph.D., Nikhil C. Munshi, Paul Richardson, M.D., Ph.D., Ann Clark, Ph.D., Janet Ogden, Ph.D., Goutopoulos Andreas, Ph.D., Luca Rastelli, Ph.D., Kenneth C. Anderson, MD
Journal: Blood
Blood (2009) 114 (22): 3848.
https://doi.org/10.1182/blood.V114.22.3848.3848
Published: 2009
Journal Articles

Histone Deacetylase Inhibitors Demonstrate Significant Preclinical Activity as Single Agents, and in Combination with Bortezomib in Waldenstrom's Macroglobulinemia.

Jenny Sun, MD, Lian Xu, Hsiuyi Tseng, Bryan Ciccarelli, Mariateresa Fulciniti, Zachary Hunter, Kaveh Maghsoudi, Evdoxia Hatjiharissi, MD, Yangsheng Zhou, MD, PhD, Guang Yang, PhD, B. Zhu, Xia Liu, Ping Gong, Thea Ioakimidis, MS, Patricia Sheehy, NP, Robert Manning, Christina Hanzis, Megan Lewicki, Christopher J Patterson, Dharminder Chauhan, Ph.D, Scott J. Rodig, MD, PhD, Nikhil C. Munshi, Kenneth. C Anderson, MD, Owen O O'Connor, MD, Steven Treon, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 4785.
https://doi.org/10.1182/blood.V114.22.4785.4785
Published: 2009
Journal Articles

HDAC Inhibition by LBH589 Affects Phenotype and Function of Human Dendritic Cells.

Weihua Song, MD, Yu-Tzu Tai, Ph.D., Ze Tian, Ph.D, Teru Hideshima, M.D., Ph.D., Dharminder Chauhan, Ph.D, Puru Nanjappa, MS, Mark A. Exley, Ph.D, Kenneth C. Anderson, MD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2009) 114 (22): 1646.
https://doi.org/10.1182/blood.V114.22.1646.1646
Published: 2009
Journal Articles

Activation of B-Cell Maturation Antigen (BCMA) on Human Multiple Myeloma Cells by a Proliferation-Inducing Ligand (APRIL) Promotes Myeloma Cell Function in the Bone Marrow Microenvironment.

Merav Leiba, M.D., Jiangchun Xu, M.D., Ph.D., Weihua Song, M.D., Xian-Feng Li, M.S., Peter Burger, B.S., Jennifer Kordich, M.S., Linda Cassiano, B.A., Klaus Podar, M.D., Ph.D., Dharminder Chauhan, Ph.D., Teru Hideshima, M.D., Ph.D., Nikhil C. Munshi, M.D., Paul Richardson, M.D., Kenneth C. Anderson, M.D., Yu-Tzu Tai, PhD
Journal: Blood
Blood (2007) 110 (11): 1503.
https://doi.org/10.1182/blood.V110.11.1503.1503
Published: 2007
Journal Articles

CS1, a New Surface Target on Multiple Myeloma (MM) Cells, Protects Myeloma Cells from Apoptosis Via Regulation of ERK1/2, AKT and STAT3 Signaling Cascades.

Yu-Tzu Tai, PhD, Giovanni Tonon, M.D., Ph.D., Merav Leiba, M.D., Xian-Feng Li, M.S., Peter Burger, B.S., Weihua Song, M.D., Klaus Podar, M.D., Ph.D., Dharminder Chauhan, Ph.D., Nihkil Munshi, M.D., Kenneth C. Anderson, M.D.
Journal: Blood
Blood (2007) 110 (11): 109.
https://doi.org/10.1182/blood.V110.11.109.109
Published: 2007
Journal Articles

Nifuroxazide Inhibits STAT3 Function and Shows Potent Anti-Tumor Activity Against Multiple Myeloma.

Erik A. Nelson, PhD, Teru Hideshima, M.D. Ph.D, Laurie Gashin, Sarah R. Walker, B.S., Rebecca A. Lynch, B.S., Dharminder Chauhan, Ph.D., Kenneth C. Anderson, M.D., David A. Frank, M.D.,Ph.D.
Journal: Blood
Blood (2006) 108 (11): 3450.
https://doi.org/10.1182/blood.V108.11.3450.3450
Published: 2006
Journal Articles

BIRB796 Inhibits p38 MAPK/Hsp27 Pathway and Enhances Cytotoxicity Triggered by Bortezomib, Hsp90 Inhibitor, and Dexamethasone in Multiple Myeloma.

Hiroshi Yasui, MD, PhD, Teru Hideshima, M.D., Ph.D., Hiroshi Ikeda, M.D., Ph.D., Janice Jin, M.D., Enrique M. Ocio, D., Ph.D., Tanyel Kiziltepe, Ph.D, Yutaka Okawa, M.D., Ph.D., Sonia Vallet, M.D., Ph.D., Shweta Chhetri, Kenji Ishitsuka, M.D., Ph.D., Yu-Tzu Tai, Ph.D., Klaus Podar, M.D., Ph.D., Dharminder Chauhan, Ph.D., Chris Pargellis, Ph.D., Neil Moss, Ph.D., Noopur Raje, M.D., Ph.D., Kenneth C. Anderson, M.D.
Journal: Blood
Blood (2006) 108 (11): 3440.
https://doi.org/10.1182/blood.V108.11.3440.3440
Published: 2006
Journal Articles

p38MAPK Inhibitor LSN2322600 Modulates the Bone Marrow Microenvironment and Inhibits Osteoclastogenesis in Multiple Myeloma.

Kenji Ishitsuka, MD, PhD, Teru Hideshima, M.D., Ph.D., Paola Neri, M.D., Ph.D., Sonia Vallet, M.D., Ph.D., Norihiko Shiraishi, Ph.D., Noopur Raje, M.D., Zhenxin Shen, M.D., Ph.D., Tanyel Kiziltepe, Ph.D., Enrique M. Ocio, M.D., Ph.D., Klaus Podar, M.D., Ph.D., Dharminder Chauhan, Ph.D., Nikhil Munshi, M.D., Robert M. Campbell, Ph.D., Alfonso De Dios, Ph.D., Chuan Shih, Ph.D., James J. Starling, Ph.D., Kazuo Tamura, M.D., Ph.D., Kenneth C. Anderson, M.D.
Journal: Blood
Blood (2006) 108 (11): 5042.
https://doi.org/10.1182/blood.V108.11.5042.5042
Published: 2006
Journal Articles

Novel Etodolac Analog SDX-308 (CEP-18082) Induces Cytotoxicity in Multiple Myeloma Cells Associated with Inhibition of Wnt/β-Catenin Pathway.

Hiroshi Yasui, MD, PhD, Teru Hideshima, M.D., Ph.D., Hiroshi Ikeda, M.D., Ph.D., Enrique M. Ocio, M.D., Ph.D., Tanyel Kiziltepe, Ph.D., Sonia Vallet, M.D., Ph.D., Yutaka Okawa, M.D., Ph.D., Shweta Chhetri, Kumar Sukhdeo, Kenji Ishitsuka, M.D., Ph.D., Klaus Podar, M.D., Ph.D., Noopur Raje, M.D., Ph.D., Dharminder Chauhan, Ph.D., Daniel R. Cattasco, M.D., Ph.D., Kenneth C. Anderson, M.D.
Journal: Blood
Blood (2006) 108 (11): 5005.
https://doi.org/10.1182/blood.V108.11.5005.5005
Published: 2006
Journal Articles

A Novel Orally Available Proteasome Inhibitor NPI-0052 Induces Killing in Multiple Myeloma (MM) Cells Resistant to Conventional and Bortezomib Therapies.

Dharminder Chauhan, Ph.D, Guilan Li, M.S, Klaus Podar, Ph.D, Teru Hideshima, Ph.D, Reshma Shrigarpure, Ph.D, Laurence Catley, M.D, Constantine Mitsiades, Ph.D, Nikhil Munshi, M.D, Robert Sclossman, M.D, Rena Bahjat, Ph.D, Saskia Neuteboom, M.D., Paul Richardson, M.D, Michael Palladino, Ph.D, Kenneth C. Anderson, M.D
Journal: Blood
Blood (2004) 104 (11): 2405.
https://doi.org/10.1182/blood.V104.11.2405.2405
Published: 2004
Journal Articles

Mitochondria and Caspase-Independent Cell-Death Triggered by GCS-100, a Novel Carbohydrate-Based Therapeutic in Multiple Myeloma (MM) Cells.

Dharminder Chauhan, Ph.D, Guilan Li, M.S, Klaus Podar, Ph.D, Teru Hideshima, Ph.D, Kenji Ishitsuka, M.D, Laurence Catley, M.D, Martin Sattler, Ph.D, Yu-Tzu Tai, Ph.D, Renate Burger, Ph.D, Paul Richardson, M.D, Yan Chang, Ph.D, Joanne Schindler, M.D, Bradley Carver, M.D, Kenneth C. Anderson, M.D
Journal: Blood
Blood (2004) 104 (11): 2456.
https://doi.org/10.1182/blood.V104.11.2456.2456
Published: 2004
Journal Articles

A Novel Inosine Monophosphate Dehydrogenase Inhibitor VX-944 Overcomes Conventional Drug-Resistance in Multiple Mueloma Cells in the Bone Marrow Microenvironment.

Kenji Ishitsuka, M.D., Ph.D, Teru Hideshima, M.D., Ph.D, Makoto Hamasaki, M.D., Ph.D, Raje Noopur, M.D., Ph.D, Kumar Shaji, M.D., Ph.D, Hiroshi Yasui, M.D., Ph.D, Aldo M. Roccaro, M.D., Dharminder Chauhan, Ph.D, Klaus Podar, M.D., Ph.D, Yu-Zu Tai, Ph.D, Jugnu Jain, Ph.D, Kenneth C. Anderson, M.D., Ph.D
Journal: Blood
Blood (2004) 104 (11): 2468.
https://doi.org/10.1182/blood.V104.11.2468.2468
Published: 2004
Journal Articles

The Polycomb Group Transcriptional Repressor Bmi-1 Is Constitutively Expressed in Multiple Myeloma (MM) Cells and Modulates Proliferation through a Mechanism Independent of the Ink4a/ARF Locus.

Frank J. Desarnaud, Ph.D, Masood Shammas, Ph.D, Paola Neri, MD, Hemanta Koley, Ph.D, Rao Prabhala, Ph.D, Li Cheng, Ph.D, Suk Kim Ryung, Dharminder Chauhan, Ph.D, Pierfrancesco Tassone, MD, Jooeun Bae, Ph.D, Kenneth C. Anderson, MD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2004) 104 (11): 3346.
https://doi.org/10.1182/blood.V104.11.3346.3346
Published: 2004
Journal Articles

Targeting Mitochondrial Factor Smac/DIABLO as Therapy for Multiple Myeloma (MM).

Dharminder Chauhan, Ph.D, Guilan Li, M.S, Teru Hideshima, Ph.D, Klaus Podar, Ph.D, Pierfrancesco Tassone, M.D., Paola E. Neri, M.D., Constantine Mitsiades, Ph.D, Nicholas Mitsiades, M.D., Noopur Raje, M.D., Shaji Kumar, M.D., Robert Schlossman, M.D., Sushil Sharma, M.D., Nikhil Munshi, M.D., Leigh Zawel, Ph.D, Kenneth C. Anderson, M.D.
Journal: Blood
Blood (2004) 104 (11): 764.
https://doi.org/10.1182/blood.V104.11.764.764
Published: 2004