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Dimitri A. Breems
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Journal Articles

Outcome of Intensively Treated Elderly AML Patients Reported to the Harmony Alliance Compares Well to Outcome of Control Patients of the Prospective Randomized HOVON 103 Study in Elderly AML

Sjoerd J.F. Hermans, Jurjen Versluis, Yvette van Norden, Erik D. van Werkhoven, Jeroen J.W.M. Janssen, Gerwin A. Huls, Bob Lowenberg, Thomas Pabst, Dimitri A. Breems, Elizabeth Berkx, Avinash G. Dinmohamed, Peter C. Huijgens, Eric Sträng, Jesús María Hernández-Rivas, Hartmut Döhner, Marta Sobas, Lars Bullinger, Rosa Ayala, Joaquin Martinez-Lopez, Klaus H Metzeler, Torsten Haferlach, Christian Thiede, Carin A. Uyl-De Groot, Gert J. Ossenkoppele, Francesco Pignatti, Jan J. Cornelissen
Journal: Blood
Blood (2023) 142 (Supplement 1): 2854.
https://doi.org/10.1182/blood-2023-186277
Published: 2023
Journal Articles

Prospective validation of the prognostic relevance of CD34 + CD38 – AML stem cell frequency in the HOVON-SAKK132 trial

Clinical Trials & Observations
Lok Lam Ngai, Diana Hanekamp, Fleur Janssen, Jannemieke Carbaat-Ham, Maaike A. M. A. Hofland, Mona M. H. E Fayed, Angèle Kelder, Laura Oudshoorn-van Marsbergen, Willemijn J. Scholten, Alexander N. Snel, Costa Bachas, Jesse M. Tettero, Dimitri A. Breems, Thomas Fischer, Bjørn T. Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Arjan A. van de Loosdrecht, Johan A. Maertens, Markus G. Manz, Thomas Pabst, Jakob R. Passweg, Kimmo Porkka, Peter J. M. Valk, Patrycja Gradowska, Bob Löwenberg, David C. de Leeuw, Jeroen J. W. M. Janssen, Gert J. Ossenkoppele, Jacqueline Cloos
Journal: Blood
Blood (2023) 141 (21): 2657–2661.
https://doi.org/10.1182/blood.2022019160
Published: 2023
Includes: Supplemental data
Journal Articles

Measurable Residual Disease Guided Therapy in Intermediate-Risk AML Patients Compared to an Unguided Cohort Using Propensity Score Matching

Jesse M. Tettero, Lok Lam Ngai, Costa Bachas, Dimitri A. Breems, Thomas Fischer, Bjørn Tore Gjertsen, Patrycja Gradowska, Laimonas Griskevicius, Jeroen J.W.M. Janssen, Gunnar Juliusson, Johan A. Maertens, Markus G Manz, Thomas Pabst, Jakob Passweg, Kimmo Porkka, Peter JM Valk, Bob Lowenberg, Gert J. Ossenkoppele, Jacqueline Cloos
Journal: Blood
Blood (2022) 140 (Supplement 1): 2027–2029.
https://doi.org/10.1182/blood-2022-157009
Published: 2022
Journal Articles

Prospective Validation of CD34+CD38- Leukemic Stem Cell Frequency in the HOVON-SAKK 132 Trial: Perspectives for Future Improvements

Lok Lam Ngai, Diana Hanekamp, Fleur Janssen, Jannemieke Carbaat-Ham, Maaike A.M. Hofland, Mona M.H.E Fayed, Angèle Kelder, Laura Oudshoorn-van Marsbergen, Willemijn J. Scholten, Alexander N. Snel, Costa Bachas, Jesse M. Tettero, Dimitri A. Breems, Thomas Fischer, Bjørn Tore Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Johan A. Maertens, Markus G Manz, Thomas Pabst, Jakob R. Passweg, Kimmo Porkka, Patrycja Gradowska, Bob Lowenberg, David C. de Leeuw, Jeroen J.W.M. Janssen, Gert J. Ossenkoppele, Jacqueline Cloos
Journal: Blood
Blood (2022) 140 (Supplement 1): 9125–9127.
https://doi.org/10.1182/blood-2022-157753
Published: 2022
Journal Articles

Bayesian Inference for Optimization of Interim Analysis in Clinical Trials By Incorporation of Historical Data: Reanalysis of the HOVON AML 132 Clinical Trial

Niek Van Der Maas, Kazem Nasserinejad, Thomas Pabst, Johan A. Maertens, Dimitri A. Breems, Markus G Manz, Jacqueline Cloos, Gert J. Ossenkoppele, Yngvar Floisand, Patrycja Gradowska, Bob Lowenberg, Gerwin A. Huls, Douwe Postmus, Francesco Pignatti, Jan J. Cornelissen, Jurjen Versluis
Journal: Blood
Blood (2022) 140 (Supplement 1): 127–129.
https://doi.org/10.1182/blood-2022-158137
Published: 2022
Journal Articles

Molecular characterization of mutant TP53 acute myeloid leukemia and high-risk myelodysplastic syndrome

Tim Grob, Adil S. A. Al Hinai, Mathijs A. Sanders, François G. Kavelaars, Melissa Rijken, Patrycja L. Gradowska, Bart J. Biemond, Dimitri A. Breems, Johan Maertens, Marinus van Marwijk Kooy, Thomas Pabst, Okke de Weerdt, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht, Gerwin A. Huls, Jan J. Cornelissen, H. Berna Beverloo, Bob Löwenberg, Mojca Jongen-Lavrencic, Peter J. M. Valk
Journal: Blood
Blood (2022) 139 (15): 2347–2354.
https://doi.org/10.1182/blood.2021014472
Published: 2022
Includes: Supplemental data
Journal Articles

Therapeutic value of clofarabine in younger and middle-aged (18-65 years) adults with newly diagnosed AML

Clinical Trials & Observations
Bob Löwenberg, Thomas Pabst, Johan Maertens, Yvette van Norden, Bart J. Biemond, Harry C. Schouten, Olivier Spertini, Edo Vellenga, Carlos Graux, Violaine Havelange, Georgine E. de Greef, Okke de Weerdt, Marie-Cecile J. C. Legdeur, Juergen Kuball, Marinus van Marwijk Kooy, Bjorn T. Gjertsen, Mojca Jongen-Lavrencic, Arjan A. van de Loosdrecht, Daniëlle van Lammeren-Venema, Beata Hodossy, Dimitri A. Breems, Yves Chalandon, Jakob Passweg, Peter J. M. Valk, Markus G. Manz, Gert J. Ossenkoppele
Journal: Blood
Blood (2017) 129 (12): 1636–1645.
https://doi.org/10.1182/blood-2016-10-740613
Published: 2017
Includes: Supplemental data
Journal Articles

Early Post-Transplant Epigenetic Therapy By Panobinostat and Decitabine Followed By Donor Lymphocyte Infusion (DLI): Interim Results of the HOVON-116 Phase I/II Feasibility Study in Poor-Risk AML Recipients of Allogeneic Stem Cell Transplantation (alloHSCT)

Jan J. Cornelissen, MD PhD, Yvette van Norden, MD PhD MSc., Michel van Gelder, MD PhD, Dimitri A. Breems, MD PhD, Johan Maertens, MD PhD, Mojca Jongen-Lavrencic, MD PhD, Annoek Broers, MD PhD, Sacha S. Zeerleder, MD PhD, Lucien Noens, MD PhD, Gert Ossenkoppele, MD PhD, Ellen Meijer, MD PhD
Journal: Blood
Blood (2016) 128 (22): 832.
https://doi.org/10.1182/blood.V128.22.832.832
Published: 2016
Journal Articles

The impact of abn(17p) and monosomy −5/del(5q) on the prognostic value of the monosomal karyotype in acute myeloid leukemia

Dimitri A. Breems, Wim L. J. Van Putten, Bob Löwenberg
Journal: Blood
Blood (2013) 121 (15): 3056–3057.
https://doi.org/10.1182/blood-2013-01-475012
Published: 2013
Journal Articles

Allogeneic Hematopoietic Stem Cell Transplantation (alloHSCT) Improves Outcome As Compared to Conventional Consolidation in Patients Aged 40–60 Years with AML in CR1 with Apparent Greater Benefit for Reduced Intensity Rather Than Myeloablative Conditioning

Jan J Cornelissen, MD PhD, Alois Gratwohl, MD, Kees GM van Montfort, Thomas Pabst, MD, Johan Maertens, MD, H. Berna Beverloo, PhD, Marinus van Marwijk Kooy, P.W. Wijermans, MD, PhD, Bart J Biemond, MD, Dimitri A. Breems, MD, PhD, Edo Vellenga, PhD, Leo F Verdonck, Martin F. Fey, MD, Mojca Lavrencic, MD, PhD, Jeroen JWM Janssen, MD PhD, Gerwin Huls, Jurgen Kuball, MD, PhD, Jakob R. Passweg, MD, Carlos Graux, MD, PhD, Harry C. Schouten, MD, PhD, Gert Ossenkoppele, MD, PhD, Bob Lowenberg, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 159.
https://doi.org/10.1182/blood.V118.21.159.159
Published: 2011
Journal Articles

Clinical Useful Prognostic Index for Adult Patients with Acute Myeloid Leukemia in First Relapse.

Dimitri A. Breems, MD, PhD, Wim L.J. Van Putten, PhD, Bob Lowenberg, MD, PhD
Journal: Blood
Blood (2004) 104 (11): 2011.
https://doi.org/10.1182/blood.V104.11.2011.2011
Published: 2004
Journal Articles

Stroma-Contact Prevents Loss of Hematopoietic Stem Cell Quality During Ex Vivo Expansion of CD34 + Mobilized Peripheral Blood Stem Cells

Dimitri A. Breems, Ellen A.W. Blokland, Karen E. Siebel, Angelique E.M. Mayen, Lilian J.A. Engels, Rob E. Ploemacher
Journal: Blood
Blood (1998) 91 (1): 111–117.
https://doi.org/10.1182/blood.V91.1.111
Published: 1998
Journal Articles

Diphtheria Toxin Fused to Granulocyte-Macrophage Colony-Stimulating Factor Eliminates Acute Myeloid Leukemia Cells With the Potential to Initiate Leukemia in Immunodeficient Mice, But Spares Normal Hemopoietic Stem Cells

Wim Terpstra, Henk Rozemuller, Dimitri A. Breems, Elwin J.C. Rombouts, Arie Prins, David J.P. FitzGerald, Robert J. Kreitman, Jenne J. Wielenga, Rob E. Ploemacher, Bob Löwenberg, Anton Hagenbeek, Anton C.M. Martens
Journal: Blood
Blood (1997) 90 (9): 3735–3742.
https://doi.org/10.1182/blood.V90.9.3735
Published: 1997