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Journal Articles

Effect of the Oral LSD1 Inhibitor Ory-1001 on F-Retics in Baboons ( Papio anubis )

Vinzon Ibanez, Kestis Vaitkus, Robert Molokie, Yogenthiran Saunthararajah, Donald Lavelle

Blood (2023) 142 (Supplement 1): 1109.

https://doi.org/10.1182/blood-2023-189523

Published: 2023

Journal Articles

Prolonged Combinatorial Pharmacological Therapy Targeting the Epigenome Increases Fetal Hemoglobin to Clinically Relevant Levels in Normal, Nonanemic Baboons

Vinzon Ibanez, Kestis Vaitkus, Robert E. Molokie, Jagadeesh Ramasamy, Yogenthiran Saunthararajah, Donald Lavelle

Blood (2022) 140 (Supplement 1): 961–962.

https://doi.org/10.1182/blood-2022-155954

Published: 2022

Journal Articles

Reticulocytosis from Stress Erythropoiesis Is a Major Source of Erythrocyte Mitochondrial Retention, Oxygen Consumption and Reactive Oxygen Species in a SCD Mouse Model

Anne Gallivan, Amarachi Kanu, Mikail Alejandro, Nebeyat Zekaryas, Hart Horneman, Jagadeesh Ramasamy, Lenny Hong, Donald Lavelle, Alan Diamond, Robert E. Molokie, Elliott P. Vichinsky, Angela Rivers

Blood (2022) 140 (Supplement 1): 8239–8240.

https://doi.org/10.1182/blood-2022-160481

Published: 2022

Journal Articles

Nicotinamide Improves Anemia and Decreases Reactive Oxygen Species in Sickle Cell Disease Mice

Jagadeesh Ramasamy, Vinzon Ibanez, Vijaya Lakshmi Yalagala, Yogenthiran Saunthararajah, Robert E. Molokie, Angela Rivers, Donald Lavelle

Blood (2021) 138 (Supplement 1): 2019.

https://doi.org/10.1182/blood-2021-144956

Published: 2021

Journal Articles

Effect of the NAMPT Activator P7C3-A20 on γ-Globin Expression in Baboon CD34+ Erythroid Cell Cultures

Vinzon Ibanez, Kestis Vaitkus, Jagadeesh Ramasamy, Yogenthiran Saunthararajah, Robert E. Molokie, Donald Lavelle

Blood (2021) 138 (Supplement 1): 961.

https://doi.org/10.1182/blood-2021-145126

Published: 2021

Journal Articles

Combinatorial Administration of Pharmacological Inhibitors Targeting DNMT1 and KDM1A Produces Synergistic and Additive Increases in F Retiulocytes and γ-Globin Expression in Normal Baboons

Vinzon Ibanez, B.S., Kestis Vaitkus, Robert E. Molokie, MD, Yogenthiran Saunthararajah, MD, Donald Lavelle, PhD

Blood (2020) 136 (Supplement 1): 5.

https://doi.org/10.1182/blood-2020-136599

Published: 2020

Journal Articles

Effect of Nicotinamide, 1-Methylnicotinamide, and N'-Methylnicotinamide on Erythroid Colony Formation and γ-Globin Expression in Cultured Baboon CD34+ Cells

Donald Lavelle, PhD, Vinzon Ibanez, B.S., Kestis Vaitkus, Yogenthiran Saunthararajah, MD, Robert E. Molokie, MD

Blood (2020) 136 (Supplement 1): 4–5.

https://doi.org/10.1182/blood-2020-133974

Published: 2020

Journal Articles

Cathepsin B, a Negative Regulator of Autophagy, Identified As a Novel Therapeutic Drug Target in Sickle Cell Disease

Jagadeesh Ramasamy, PhD, Vinzon Ibanez, B.S., Kareem Al-Qadi, Helen Zhang, Jennifer Afranie-Sakyi, MD, Robert E. Molokie, MD, Donald Lavelle, PhD, Angela Rivers, MD

Blood (2020) 136 (Supplement 1): 32.

https://doi.org/10.1182/blood-2020-140119

Published: 2020

Journal Articles

The Impact of Selenium Deficiency on a Sickle Cell Disease Mouse Model

Ramasamy Jagadeeswaran, PhD, Hong Lenny, PhD, Helen Zhang, Jennifer Afranie-Sakyi, Robert E. Molokie, MD, Donald Lavelle, PhD, Alan Diamond, PhD, Angela Rivers, MD

Blood (2018) 132 (Supplement 1): 3645.

https://doi.org/10.1182/blood-2018-99-111833

Published: 2018

Journal Articles

The LSD1 Inhibitor RN-1 Increases γ-Globin Expression in Baboons By Targeting an Early Event Responsible for γ-Globin Repression

Kestis Vaitkus, Vinzon Ibanez, B.S., Maria Armila Ruiz, B.S., Ramasamy Jagadeeswaran, PhD, Yogenthiran Saunthararajah, MD, James Douglas Engel, PhD, Joseph DeSimone, PhD, Angela Rivers, MD, Donald Lavelle, PhD

Blood (2018) 132 (Supplement 1): 1054.

https://doi.org/10.1182/blood-2018-99-113539

Published: 2018

Journal Articles

Oral Administration of the LSD1 Inhibitor OG-S1335 Increases Fetal Hemoglobin in Humanized Transgenic Sickle Cell Disease Mice and in Baboons

Angela Rivers, MD PhD, Kestis Vaitkus, Ramasamy Jagadeeswaran, PhD MSc, Vinzon Ibanez, B.S., Maria Armila Ruiz, B.S., Filippo Ciceri, PhD, Fernando Cavalcanti, PhD, Robert E. Molokie, MD, Donald Lavelle, PhD

Blood (2017) 130 (Supplement 1): 356.

https://doi.org/10.1182/blood.V130.Suppl_1.356.356

Published: 2017

Journal Articles

The Abnormal Presence of Mitochondria in Circulating Red Blood Cells Cause an Increased Oxygen Consumption Rate, ROS Generation and Hemolysis in Patients with Sickle Cell Disease

Ramasamy Jagadeeswaran, PhD MSc, Hong Lenny, PhD, Benjamin Vazquez, BA, Joshua Muniz, BS, Aimee Schad, Shivi Jain, MD, Michel Gowhari, DO, Donald Lavelle, PhD, Alan Diamond, PhD, Robert E. Molokie, MD, Angela Rivers, MD PhD

Blood (2017) 130 (Supplement 1): 2237.

https://doi.org/10.1182/blood.V130.Suppl_1.2237.2237

Published: 2017

Journal Articles

Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons

Vinzon Ibanez, Kestis Vaitkus, Angela Rivers, Robert Molokie, Shuaiying Cui, James Douglas Engel, Joseph DeSimone, Donald Lavelle

Blood (2017) 129 (2): 260–263.

https://doi.org/10.1182/blood-2016-10-746727

Published: 2017

Journal Articles

Phase 1 Evaluation of Oral Tetrahydrouridine-Decitabine As Non-Cytotoxic Epigenetic Disease Modification for Sickle Cell Disease

Robert E Molokie, MD, Donald Lavelle, PhD, Michel Gowhari, DO, Michael Pacini, PharmD, Lani Krauz, Johara Hassan, MD, Vinzon Ibanez, Maria A Ruiz, Daisy Pacelli, Sherry Fada, Mitch A. Phelps, PhD, Santosh L. Saraf, MD, Lewis L. Hsu, MD PhD, Victor R. Gordeuk, MD, Joseph DeSimone, PhD, Yogenthiran Saunthararajah, MD

Blood (2016) 128 (22): 124.

https://doi.org/10.1182/blood.V128.22.124.124

Published: 2016

Journal Articles

Efficacy and Safety of Long-Term Treatment with the LSD1 Inhibitor RN-1 to Increase HbF in Normal, Non-Anemic Baboons

Kestis Vaitkus, Vinzon Ibanez, Robert E Molokie, MD, Angela Rivers, MD PhD, Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2016) 128 (22): 324.

https://doi.org/10.1182/blood.V128.22.324.324

Published: 2016

Journal Articles

Mitophagy Induction Is a Potential Therapeutic Approach for Sickle Cell Disease

Ramasamy Jagadeeswaran, PhD, Benjamin Alejandro Vazquez, BS, Vinzon Ibanez, Maria A Ruiz, Robert E Molokie, MD, Joseph DeSimone, PhD, Donald Lavelle, PhD, Angela Rivers, MD PhD

Blood (2016) 128 (22): 267.

https://doi.org/10.1182/blood.V128.22.267.267

Published: 2016

Journal Articles

Investigation of Two Combination HbF Induction Regimens, RN-1 and Hydroxyurea Versus RN-1 and Decitabine, in a Humanized Sickle Cell Mouse Model

Ramasamy Jagadeeswaran, PhD, Yash Agarwal, Vinzon Ibanez, Maria Armila Ruiz, Kestis Vaitkus, Joseph DeSimone, PhD, Donald Lavelle, PhD, Angela Rivers, MD PhD

Blood (2015) 126 (23): 3386.

https://doi.org/10.1182/blood.V126.23.3386.3386

Published: 2015

Journal Articles

The LSD1 Inhibitor RN-1 Recapitulates the Fetal Pattern of Hemoglobin Synthesis in Anemic and Normal, Non-Anemic Baboons

Angela Rivers, MD PhD, Kestis Vaitkus, Vinzon Ibanez, Maria Armila Ruiz, Ramaswamy Jagadeeswaran, PhD, Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2015) 126 (23): 642.

https://doi.org/10.1182/blood.V126.23.642.642

Published: 2015

Journal Articles

The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice

Shuaiying Cui, Kim-Chew Lim, Lihong Shi, Mary Lee, Natee Jearawiriyapaisarn, Greggory Myers, Andrew Campbell, David Harro, Shigeki Iwase, Raymond C. Trievel, Angela Rivers, Joseph DeSimone, Donald Lavelle, Yogen Saunthararajah, James Douglas Engel

Blood (2015) 126 (3): 386–396.

https://doi.org/10.1182/blood-2015-02-626259

Published: 2015

Includes: Supplemental data

Journal Articles

Cytokine-free rapid red cell regeneration

Nadim Mahmud, Donald Lavelle

Blood (2015) 125 (6): 895–896.

https://doi.org/10.1182/blood-2014-11-609024

Published: 2015

NARROW

Effect of the Oral LSD1 Inhibitor Ory-1001 on F-Retics in Baboons ( Papio anubis )

Prolonged Combinatorial Pharmacological Therapy Targeting the Epigenome Increases Fetal Hemoglobin to Clinically Relevant Levels in Normal, Nonanemic Baboons

Reticulocytosis from Stress Erythropoiesis Is a Major Source of Erythrocyte Mitochondrial Retention, Oxygen Consumption and Reactive Oxygen Species in a SCD Mouse Model

Nicotinamide Improves Anemia and Decreases Reactive Oxygen Species in Sickle Cell Disease Mice

Effect of the NAMPT Activator P7C3-A20 on γ-Globin Expression in Baboon CD34+ Erythroid Cell Cultures

Combinatorial Administration of Pharmacological Inhibitors Targeting DNMT1 and KDM1A Produces Synergistic and Additive Increases in F Retiulocytes and γ-Globin Expression in Normal Baboons

Effect of Nicotinamide, 1-Methylnicotinamide, and N'-Methylnicotinamide on Erythroid Colony Formation and γ-Globin Expression in Cultured Baboon CD34+ Cells

Cathepsin B, a Negative Regulator of Autophagy, Identified As a Novel Therapeutic Drug Target in Sickle Cell Disease

The Impact of Selenium Deficiency on a Sickle Cell Disease Mouse Model

The LSD1 Inhibitor RN-1 Increases γ-Globin Expression in Baboons By Targeting an Early Event Responsible for γ-Globin Repression

Oral Administration of the LSD1 Inhibitor OG-S1335 Increases Fetal Hemoglobin in Humanized Transgenic Sickle Cell Disease Mice and in Baboons

The Abnormal Presence of Mitochondria in Circulating Red Blood Cells Cause an Increased Oxygen Consumption Rate, ROS Generation and Hemolysis in Patients with Sickle Cell Disease

Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons

Phase 1 Evaluation of Oral Tetrahydrouridine-Decitabine As Non-Cytotoxic Epigenetic Disease Modification for Sickle Cell Disease

Efficacy and Safety of Long-Term Treatment with the LSD1 Inhibitor RN-1 to Increase HbF in Normal, Non-Anemic Baboons

Mitophagy Induction Is a Potential Therapeutic Approach for Sickle Cell Disease

Investigation of Two Combination HbF Induction Regimens, RN-1 and Hydroxyurea Versus RN-1 and Decitabine, in a Humanized Sickle Cell Mouse Model

The LSD1 Inhibitor RN-1 Recapitulates the Fetal Pattern of Hemoglobin Synthesis in Anemic and Normal, Non-Anemic Baboons

The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice

Cytokine-free rapid red cell regeneration

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American Society of Hematology

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ASH Publications

American Society of Hematology

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