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Journal Articles

Combination of Ras Modulator and Azacitidine Impacts Innate Immune Signaling Pathway in MDS-L Cell Line

Richa Rai, Foramben Patel, Jonathan Feld, Stella Melana, Shyamala C. Navada, Rosalie Odchimar-Reissig, Erin P. Demakos, E. Premkumar Reddy, Lewis R. Silverman

Blood (2021) 138 (Supplement 1): 4325.

https://doi.org/10.1182/blood-2021-152764

Published: 2021

Journal Articles

Rigosertib in Combination with Azacitidine Impacts Metabolic and Differentiation Pathways in the MDS-L Cell Line

Richa Rai, PhD, Foramben Patel, MS, Stella Melana, PhD, Jonathan Feld, MD, Shyamala C. Navada, MD, Rosalie Odchimar-Reissig, RN, Erin P. Demakos, RN, E. Premkumar Reddy, PhD, Lewis R. Silverman, MD

Blood (2020) 136 (Supplement 1): 35–36.

https://doi.org/10.1182/blood-2020-142908

Published: 2020

Journal Articles

The Sequenced Combination of Rigosertib and Azacitidine Has Modulatory Effects on CXCL8, RIG-I like Receptor (RLR) and Wnt/β-Catenin Signaling and Downstream Hematopoiesis Pathways in an in Vitro Model of the Myelodysplastic Syndrome

Richa Rai, PhD, Stella Melana, PhD, Shyamala C. Navada, MD, Rosalie Odchimar-Reissig, RN, Erin P. Demakos, RN, E. Premkumar Reddy, PhD, Lewis R. Silverman, MD

Blood (2019) 134 (Supplement_1): 4231.

https://doi.org/10.1182/blood-2019-130747

Published: 2019

Journal Articles

Sequential Treatment with Rigosertib Followed By Azacitidine Maximizes the Effects on the Interferon Signaling Pathway in Hematopoietic Cells in Myelodysplastic Syndrome (MDS)

Richa Rai, PhD, Stella Melana, PhD, Shyamala C. Navada, MD, Rosalie Odchimar-Reissig, RN, Erin P. Demakos, RN, E. Premkumar Reddy, PhD, Lewis R. Silverman, MD

Blood (2018) 132 (Supplement 1): 5500.

https://doi.org/10.1182/blood-2018-99-119266

Published: 2018

Journal Articles

Effects of Rigosertib (RIGO) Alone or in Combination with Azacitidine or Vorinostat on Epigenetic Reprogramming of CD34+ Cells in the Myelodysplastic Syndrome

Lewis R Silverman, MD, Pratima Chaurasia, PhD, Stella Melana, PhD, Rosalie Odchimar-Reissig, RN, Erin P. Demakos, BA, BSN, MSN, RN, Shyamala C. Navada, MD, E. Premkumar Reddy, PhD BSc, MSc

Blood (2017) 130 (Supplement 1): 4235.

https://doi.org/10.1182/blood.V130.Suppl_1.4235.4235

Published: 2017

Journal Articles

Rigosertib Blocks RAS Signaling By Acting As a Small Molecule RAS Mimetic That Binds to the RAS-Binding Domains of RAS Effector Proteins

E. Premkumar Reddy, PhD, Sai Krishna Divakar, PhD, Rodrigo Vasquez-Del Carpio, PhD, Kaushik Dutta, PhD, Stacey J Baker, PhD, Ramana Reddy, PhD, Aneel K Aggarwal, PhD

Blood (2014) 124 (21): 5616.

https://doi.org/10.1182/blood.V124.21.5616.5616

Published: 2014

Journal Articles

Weighted Gene Co-Expression Network Analysis (WGCNA) Identifies Highly Proliferative Myeloma Subgroup Responsive to CDK4/ARK5 Inhibition

Deepak Perumal, PhD, Violetta V. Leshchenko, PhD, Pei-Yu Kuo, MS, Zewei Jiang, MD, Ben Readhead, MBBS, Caroline Eden, BS, Sai Krishna Athaluri Divakar, PhD, Weijia Zhang, PhD, Hearn Jay Cho, MD PhD, Ajai Chari, MD, M.V.Ramana Reddy, PhD, E. Premkumar Reddy, PhD, Joel Dudley, PhD, Sundar Jagannath, MD, Samir Parekh, MD

Blood (2014) 124 (21): 3445.

https://doi.org/10.1182/blood.V124.21.3445.3445

Published: 2014

Journal Articles

Predictors Of Response To Rigosertib In Patients With a Myelodysplastic Syndrome (MDS) Or Acute Myeloid Leukemia (AML) Relapsing After Or Refractory To Hypomethylating Agents

Shyamala C. Navada, MD, Rosalie Odchimar-Reissig, RN, E. Premkumar Reddy, PhD, Erin P Demakos, RN, CCRN, James F Holland, MD, Francois Wilhelm, MD, PhD., Lewis R. Silverman, MD

Blood (2013) 122 (21): 1527.

https://doi.org/10.1182/blood.V122.21.1527.1527

Published: 2013

Journal Articles

Evaluation of Rigosertib in Patients with a Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML) Relapsed or Refractory to Hypomethylating Agents: A Phase I/II Study

Shyamala C. Navada, MD, Rosalie Odchimar-Reissig, RN, E. Premkumar Reddy, PhD, James F Holland, MD, Francois Wilhelm, MD, PhD., Lewis R. Silverman, MD

Blood (2012) 120 (21): 3794.

https://doi.org/10.1182/blood.V120.21.3794.3794

Published: 2012

Journal Articles

An In Vivo Functional Screen Identifies miRNA-150 As a Regulator of Hematopoietic Regeneration Post Chemotherapeutic Injury

Brian D. Adams, PhD, Shangqin Guo, PhD, Haitao Bai, MD, Changchun Xiao, PhD, E. Premkumar Reddy, PhD, Jun Lu, PhD

Blood (2011) 118 (21): 2333.

https://doi.org/10.1182/blood.V118.21.2333.2333

Published: 2011

Journal Articles

Synergistic Effects of a Novel Water-Soluble Small Molecule, ON 013105, and Rituximab on Mantle Cell Lymphoma In Vitro and In Vivo

Anil Prasad, Ph.D, Ashutosh Shrivastava, Ph.D, Ramana Reddy, Ph.D, Amanda M. Gillum, PhD, E. Premkumar Reddy, Ph.D., Jerome E. Groopman, MD

Blood (2010) 116 (21): 771.

https://doi.org/10.1182/blood.V116.21.771.771

Published: 2010

Journal Articles

Evaluation of ON01910.Na In Patients with a Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML) Relapsed or Refractory to Hypomethylating Agents: A Phase I Study

Lewis R Silverman, MD, Shyamala C. Navada, MD, Rosalie Odchimar-Reissig, RN, Vesna Najfeld, PhD, Takao Ohnuma, MD, Francois Wilhelm, MD, PhD., E. Premkumar Reddy, Ph.D., James F. Holland, MD

Blood (2010) 116 (21): 2944.

https://doi.org/10.1182/blood.V116.21.2944.2944

Published: 2010

Journal Articles

Single Cell Network Profiling (SCNP) to Evaluate the Mechanism of Action of ON 01910.Na, A Novel Clinical Trial Stage Compound.

David M. Soper, PhD, Ying-Wen Huang, MS, Francois Wilhelm, MD, Ph.D, S. C. Cosenza, E. Premkumar Reddy, PhD, Alessandra Cesano, MD, PhD, Peter L Greenberg, MD, Wendy J. Fantl, PhD

Blood (2009) 114 (22): 3827.

https://doi.org/10.1182/blood.V114.22.3827.3827

Published: 2009

Journal Articles

Effects of a Novel Benzyl Styryl Sulfone Derivative ON 01910.Na On the Myelodysplastic Syndrome (MDS) Derived Clone in Patients Relapsing Following Response to Azacitidine (AzaC) Therapy.

Lewis R. Silverman, MD, Rosalie Odchimar-Reissig, Shyamala C. Navada, MD, Takao Ohnuma, MD, Vesna Najfeld, Ph.D., Francois Wilhelm, MD, Ph.D, E. Premkumar Reddy, PhD, James F Holland

Blood (2009) 114 (22): 4839.

https://doi.org/10.1182/blood.V114.22.4839.4839

Published: 2009

Journal Articles

Evaluation of Novel Cell Cycle Inhibitors in Mantle Cell Lymphoma.

In-Woo Park, PhD, M.V. Ramana Reddy, Ph.D., E. Premkumar Reddy, Ph.D., Jerome E. Groopman, M.D.

Blood (2006) 108 (11): 4748.

https://doi.org/10.1182/blood.V108.11.4748.4748

Published: 2006

Journal Articles

Inhibition of tumor angiogenesis in vivo by a monoclonal antibody targeted to domain 5 of high molecular weight kininogen

James S. Song, Irma M. Sainz, Stephen C. Cosenza, Irma Isordia-Salas, Abdel Bior, Harlan N. Bradford, Yan-Lin Guo, Robin A. Pixley, E. Premkumar Reddy, Robert W. Colman

Blood (2004) 104 (7): 2065–2072.

https://doi.org/10.1182/blood-2004-02-0449

Published: 2004

Journal Articles

Mechanisms associated with IL-6–induced up-regulation of Jak3 and its role in monocytic differentiation

James K. Mangan, Sushil G. Rane, Anthony D. Kang, Arshad Amanullah, Brian C. Wong, E. Premkumar Reddy

Blood (2004) 103 (11): 4093–4101.

https://doi.org/10.1182/blood-2003-06-2165

Published: 2004

Journal Articles

Activation of the Jak3 pathway is associated with granulocytic differentiation of myeloid precursor cells

Sushil G. Rane, James K. Mangan, Arshad Amanullah, Brian C. Wong, Renu K. Vora, Dan A. Liebermann, Barbara Hoffman, Xavier Graña, E. Premkumar Reddy

Blood (2002) 100 (8): 2753–2762.

https://doi.org/10.1182/blood.V100.8.2753

Published: 2002

NARROW

Combination of Ras Modulator and Azacitidine Impacts Innate Immune Signaling Pathway in MDS-L Cell Line

Rigosertib in Combination with Azacitidine Impacts Metabolic and Differentiation Pathways in the MDS-L Cell Line

The Sequenced Combination of Rigosertib and Azacitidine Has Modulatory Effects on CXCL8, RIG-I like Receptor (RLR) and Wnt/β-Catenin Signaling and Downstream Hematopoiesis Pathways in an in Vitro Model of the Myelodysplastic Syndrome

Sequential Treatment with Rigosertib Followed By Azacitidine Maximizes the Effects on the Interferon Signaling Pathway in Hematopoietic Cells in Myelodysplastic Syndrome (MDS)

Effects of Rigosertib (RIGO) Alone or in Combination with Azacitidine or Vorinostat on Epigenetic Reprogramming of CD34+ Cells in the Myelodysplastic Syndrome

Rigosertib Blocks RAS Signaling By Acting As a Small Molecule RAS Mimetic That Binds to the RAS-Binding Domains of RAS Effector Proteins

Weighted Gene Co-Expression Network Analysis (WGCNA) Identifies Highly Proliferative Myeloma Subgroup Responsive to CDK4/ARK5 Inhibition

Predictors Of Response To Rigosertib In Patients With a Myelodysplastic Syndrome (MDS) Or Acute Myeloid Leukemia (AML) Relapsing After Or Refractory To Hypomethylating Agents

Evaluation of Rigosertib in Patients with a Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML) Relapsed or Refractory to Hypomethylating Agents: A Phase I/II Study

An In Vivo Functional Screen Identifies miRNA-150 As a Regulator of Hematopoietic Regeneration Post Chemotherapeutic Injury

Synergistic Effects of a Novel Water-Soluble Small Molecule, ON 013105, and Rituximab on Mantle Cell Lymphoma In Vitro and In Vivo

Evaluation of ON01910.Na In Patients with a Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML) Relapsed or Refractory to Hypomethylating Agents: A Phase I Study

Single Cell Network Profiling (SCNP) to Evaluate the Mechanism of Action of ON 01910.Na, A Novel Clinical Trial Stage Compound.

Effects of a Novel Benzyl Styryl Sulfone Derivative ON 01910.Na On the Myelodysplastic Syndrome (MDS) Derived Clone in Patients Relapsing Following Response to Azacitidine (AzaC) Therapy.

Evaluation of Novel Cell Cycle Inhibitors in Mantle Cell Lymphoma.

Inhibition of tumor angiogenesis in vivo by a monoclonal antibody targeted to domain 5 of high molecular weight kininogen

Mechanisms associated with IL-6–induced up-regulation of Jak3 and its role in monocytic differentiation

Activation of the Jak3 pathway is associated with granulocytic differentiation of myeloid precursor cells

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American Society of Hematology

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ASH Publications

American Society of Hematology

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