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Journal Articles

NUP98-rearranged pediatric AML is sustained by a conserved leukemia stem cell program with SPNS2/3 as a targetable vulnerability

Jihye Yoon, Elisabeth Denby, Wei Yang, Run Zhang, Masayuki Umeda, Tingting Hu, Jonny Mendoza-Castrejon, Yanan Li, Emily Casey, Riddhi Patel, J. Michael White, Jeffery Klco, Jeffrey Magee

Blood (2025) 146 (Supplement 1): 5002.

https://doi.org/10.1182/blood-2025-5002

Published: 2025

Journal Articles

MLL3 and MLL4 maintain hematopoietic stem cell multipotency by actively opposing a B-cell default state

Helen Wang, Ran Chen, Wei Yang, Tingting Hu, Riddhi Patel, Emily Casey, Elisabeth Denby, Run Zhang, Jeffrey Bednarski, Jeffrey Magee

Blood (2025) 146 (Supplement 1): 208.

https://doi.org/10.1182/blood-2025-208

Published: 2025

Journal Articles

Critical role for MLL3-phd domains in HSC self-renewal and AML suppression

Rohini Muthukumar, Helen Wang, Ran Chen, Elisabeth Denby, Riddhi Patel, Emily Casey, Jeffrey Magee

Blood (2025) 146 (Supplement 1): 4928.

https://doi.org/10.1182/blood-2025-4928

Published: 2025

Journal Articles

Fetal Differentiation Programs Afford a Protective Barrier to NUP98 Fusion-Driven AML That Dissipates Shortly after Birth

Jihye Yoon, Elisabeth Denby, Wei Yang, Emily B. Casey, Riddhi M. Patel, Yanan Li, J. Michael White, Luis Batista, Jeffrey A. Magee

Blood (2024) 144 (Supplement 1): 630.

https://doi.org/10.1182/blood-2024-194913

Published: 2024

Journal Articles

Divergent Roles of MLL3 and MLL4 in Hematopoietic Stem Cell Fate Decision

Helen C. Wang, Ran Chen, Wei Yang, Riddhi M. Patel, Emily B. Casey, Elisabeth Denby, Jeffrey Magee

Blood (2023) 142 (Supplement 1): 400.

https://doi.org/10.1182/blood-2023-178765

Published: 2023

Journal Articles

Fetal MLL-ENL Initiation Induces Developmental Stage-Specific Programs That Restrict Transformation and Depend on MLL3

Jonny Mendoza-Castrejon, Emily B. Casey, Riddhi M. Patel, Elisabeth Denby, Jeffrey Magee

Blood (2023) 142 (Supplement 1): 950.

https://doi.org/10.1182/blood-2023-178865

Published: 2023

Journal Articles

NUP98 -Rearranged Acute Myeloid Leukemia Stem Cells Superimpose Type I Interferon Signaling with Canonical Self-Renewal Programs

Yanan Li, Wei Yang, Riddhi M. Patel, Emily B. Casey, Elisabeth Denby, Jeffrey Magee

Blood (2023) 142 (Supplement 1): 4125.

https://doi.org/10.1182/blood-2023-182032

Published: 2023

Journal Articles

FLT3 ITD drives context-specific changes in cell identity and variable interferon dependence during AML initiation

Yanan Li, Wei Yang, Riddhi M. Patel, Emily B. Casey, Elisabeth Denby, Jonny Mendoza-Castrejon, Priscilla Rodriguez-Lopez, Jeffrey A. Magee

Blood (2023) 141 (12): 1442–1456.

https://doi.org/10.1182/blood.2022016889

Published: 2023

Includes: Supplemental data

Journal Articles

SKIDA1 Selectively Sustains MLL-ENL-Expressing Hematopoietic Stem and Progenitor Cells

Jonny Mendoza-Castrejon, Emily B Casey, Elisabeth Denby, Riddhi M Patel, Jeffrey A. Magee

Blood (2022) 140 (Supplement 1): 5887–5888.

https://doi.org/10.1182/blood-2022-171087

Published: 2022

Journal Articles

FLT3 -ITD Drives Context-Specific Changes in Cell Identity and Variable Interferon Dependence during AML Initiation

Yanan LI, Wei Yang, Riddhi M Patel, Emily B Casey, Elisabeth Denby, Jonny Mendoza-Castrejon, Priscilla Rodriguez-Lopez, Jeffrey A. Magee

Blood (2022) 140 (Supplement 1): 5848–5849.

https://doi.org/10.1182/blood-2022-168043

Published: 2022

Journal Articles

FLT3 ITD and NUP98 translocations Cooperate to Induce Type I Interferon Signaling That Impedes Hematopoietic Progenitor Differentiation

Yanan LI, Wei Yang, Priscilla Rodriguez-Lopez, Riddhi M Patel, Emily B Casey, Elisabeth Denby, Jeffrey A. Magee

Blood (2021) 138 (Supplement 1): 1150.

https://doi.org/10.1182/blood-2021-151702

Published: 2021

Journal Articles

Peroxisome Proliferator Activated Receptor-Delta Controls Fat Oxidation in Alloreactive T Cells

Gail Waltz, Arati Rajeevan, Andrea Dobbs, Elisabeth Denby, Craig Byersdorfer, MD

Blood (2018) 132 (Supplement 1): 476.

https://doi.org/10.1182/blood-2018-99-116727

Published: 2018

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NUP98-rearranged pediatric AML is sustained by a conserved leukemia stem cell program with SPNS2/3 as a targetable vulnerability

MLL3 and MLL4 maintain hematopoietic stem cell multipotency by actively opposing a B-cell default state

Critical role for MLL3-phd domains in HSC self-renewal and AML suppression

Fetal Differentiation Programs Afford a Protective Barrier to NUP98 Fusion-Driven AML That Dissipates Shortly after Birth

Divergent Roles of MLL3 and MLL4 in Hematopoietic Stem Cell Fate Decision

Fetal MLL-ENL Initiation Induces Developmental Stage-Specific Programs That Restrict Transformation and Depend on MLL3

NUP98 -Rearranged Acute Myeloid Leukemia Stem Cells Superimpose Type I Interferon Signaling with Canonical Self-Renewal Programs

FLT3 ITD drives context-specific changes in cell identity and variable interferon dependence during AML initiation

SKIDA1 Selectively Sustains MLL-ENL-Expressing Hematopoietic Stem and Progenitor Cells

FLT3 -ITD Drives Context-Specific Changes in Cell Identity and Variable Interferon Dependence during AML Initiation

FLT3 ITD and NUP98 translocations Cooperate to Induce Type I Interferon Signaling That Impedes Hematopoietic Progenitor Differentiation

Peroxisome Proliferator Activated Receptor-Delta Controls Fat Oxidation in Alloreactive T Cells

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