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Journal Articles

Donor-Derived CAR T Cells Engineered with Sleeping Beauty Achieve Anti-Leukemic Activity without Severe Toxicity

Blood (2020) 136 (Supplement 1): 34.

https://doi.org/10.1182/blood-2020-141236

Published: 2020

Journal Articles

Preclinical Assessment of Non-Virally Engineered CD33.CAR Cytokine-Induced Killer (CIK) Cells in Chemoresistant AML Patient-Derived Xenografts

Maria Caterina Rotiroti, PhD, Chiara Buracchi, PhD, Silvia Arcangeli, PhD, Chiara F Magnani, PhD, Claudia Cappuzzello, PhD, Zsuzsanna Izsvak, PhD, Stefania Galimberti, PhD, Maria Grazia Valsecchi, PhD, Giuseppe Dastoli, MD, Marta Serafini, PhD, Ettore Biagi, MD, Andrea Biondi, MD, Sarah Tettamanti, PhD

Blood (2019) 134 (Supplement_1): 2665.

https://doi.org/10.1182/blood-2019-130399

Published: 2019

Journal Articles

Specific Targeting of Acute Myeloid Leukemia By the Use of Non-Virally Engineered CIK (Cytokine-Induced Killer) Cells Expressing the Anti-CD33 Chimeric Antigen Receptor (CAR)

Maria Caterina Rotiroti, MSc, Silvia Arcangeli, PhD, Chiara Buracchi, PhD, Chiara Francesca Magnani, PhD, Claudia Cappuzzello, PhD, Ettore Biagi, MD, Sarah Tettamanti, PhD, Andrea Biondi, MD

Blood (2018) 132 (Supplement 1): 2201.

https://doi.org/10.1182/blood-2018-99-114572

Published: 2018

Journal Articles

Balance of Anti-CD123 Chimeric Antigen Receptor (CAR) Binding Affinity and Density for the Treatment of Acute Myeloid Leukemia

Silvia Arcangeli, PhD, Marco Bardelli, PhD, Maria Caterina Rotiroti, Luca Simonelli, PhD, Chiara F. Magnani, PhD, Luca Varani, PhD, Andrea Biondi, MD, Ettore Biagi, MD, Sarah Tettamanti, PhD

Blood (2016) 128 (22): 2163.

https://doi.org/10.1182/blood.V128.22.2163.2163

Published: 2016

Journal Articles

Final Analysis of a Multicenter Pilot Phase 2 Study of Cytokine Induced Killer (CIK) Cells for Patients with Relapse after Allogeneic Transplantation

Blood (2016) 128 (22): 1160.

https://doi.org/10.1182/blood.V128.22.1160.1160

Published: 2016

Journal Articles

Sleeping Beauty Modified CAR+ Lymphocytes Engraft and Exhibit Anti-Tumor Activity in Patient-Derived Xenograft Models of Acute Lymphoblastic Leukemia

Chiara F. Magnani, PhD, Claudia Mezzanotte, Claudia Cappuzzello, PhD, Fabrizio Benedicenti, Michela Bardini, PhD, Sarah Tettamanti, PhD, Grazia Fazio, PhD, Gianni Cazzaniga, PhD, Laurence J.N. Cooper, MD PhD, Eugenio Montini, PhD, Andrea Biondi, MD, Ettore Biagi, MD PhD

Blood (2016) 128 (22): 4022.

https://doi.org/10.1182/blood.V128.22.4022.4022

Published: 2016

Journal Articles

A Multicenter Phase II Study of Sequential Administration of Unmanipulated DLI and Donor Derived Cytokine Induced Killer (CIK) Cells in HSCT Patients, Relapsed of Disease

Martino Introna, MD, Elisa Gotti, BA, Michela Bonzi, BA, Josee Golay, PhDBA, Alessandra Algarotti, MD, Caterina Micò, MD, Anna Grassi, MD, Cristina Boschini, Maria Luisa Ferrari, BSc, Irene Cavattoni, MD, Ettore Biagi, MD, Adriana Balduzzi, Sr., MD, Attilio Rovelli, MD, Paolo Perseghin, MD, Giuseppe Gaipa, PhD, Andrea Biondi, Alessandro Rambaldi, MD

Blood (2015) 126 (23): 3160.

https://doi.org/10.1182/blood.V126.23.3160.3160

Published: 2015

Journal Articles

Unraveling the Efficacy and Safety Profiles of Anti-CD123 Chimeric Antigen Receptors (CARs) in a Model of Acute Myeloid Leukemia Immunotherapy By Investigating CAR Binding Affinity and Density Variables

Silvia Arcangeli, Marco Bardelli, Sarah Tettamanti, Maria Caterina Rotiroti, Luca Simonelli, Chiara F Magnani, Luca Varani, Andrea Biondi, Prof, MD, Ettore Biagi, MD

Blood (2015) 126 (23): 1359.

https://doi.org/10.1182/blood.V126.23.1359.1359

Published: 2015

Journal Articles

Vaccination - a Novel Strategy to Improve the Persistence of CD19CAR Transduced T-Cells in Relapsed Paediatric ALL: Preliminary Results from the CD19TPALL Study

Martin Pule, Sara Ghorashian, MD PhD FRCPath, Laura Clifton-Hadley, PhDBSc, Paul Smith, Soraya Saiagh, Paul Veys, FRCP,FRCPath, Nicholas Goulden, MD PhD, Gary Wright, Ettore Biagi, MD PhD, Bianca Altvater, PhD, Brigitte Dreno, MD, Kim Champion, PhD, Michelle Cummins, MD, Rachael Hough, MDBMBS,FRCP,FRCPath, Martin G. Sauer, MD, Claudia Rossig, MD, Persis Amrolia

Blood (2014) 124 (21): 383.

https://doi.org/10.1182/blood.V124.21.383.383

Published: 2014

Journal Articles

Low-Dose Lenalidomide Improves CAR-Based Immunotherapy In CLL By Reverting T-Cell Defects In Vivo

Maria Teresa Sabrina Bertilaccio, Sarah Tettamanti, PhD, Greta Maria Paola Giordano Attianese, PhD, Giovanni Galletti, Silvia Arcangeli, Tania Veliz Rodriguez, Chiara Francesca Magnani, PhD, Federica Barbaglio, Lydia Scarfò, MD, Maurilio Ponzoni, MD, Andrea Biondi, MD, Federico Caligaris-Cappio, MD, Ettore Biagi, MD, PhD, Paolo Ghia, MD, PhD

Blood (2013) 122 (21): 4171.

https://doi.org/10.1182/blood.V122.21.4171.4171

Published: 2013

Journal Articles

Stable Expression Of Chimeric Antigen Receptors (CARs) By Sleeping Beauty-Mediated Gene Transfer and Efficient Expansion Of Leukemia-Specific Cytokine-Induced Killer (CIK) Cells

Chiara Francesca Magnani, PhD, Nice Turazzi, Fabrizio Benedicenti, Greta Maria Paola Giordano Attianese, PhD, Sarah Tettamanti, PhD, Eugenio Montini, PhD, Laurence J N Cooper, MD, PhD, Alessandro Aiuti, MD, PhD, Andrea Biondi, MD, Ettore Biagi, MD, PhD

Blood (2013) 122 (21): 1663.

https://doi.org/10.1182/blood.V122.21.1663.1663

Published: 2013

Journal Articles

Safe and Effective Treatment of Graft Versus Host Disease with Platelet Lysate-Expanded Human Mesenchymal Stromal Cells: A Phase 1 Study On 47 Adult and Pediatric Patients

Blood (2012) 120 (21): 743.

https://doi.org/10.1182/blood.V120.21.743.743

Published: 2012

Journal Articles

Chimeric Antigen Receptor for Specific Targeting of Acute Myeloid Leukemia

Irene Pizzitola, Fernando Anjos-Afonso, Kevin Rouault-Pierre, Francois Lassailly, Sarah Tettamanti, PhD student, Andrea Biondi, Ettore Biagi, MD, PhD, Dominique Bonnet, PhD

Blood (2012) 120 (21): 4225.

https://doi.org/10.1182/blood.V120.21.4225.4225

Published: 2012

Journal Articles

Targeting of Acute Myeloid Leukemia by Cytokine-Induced Killer Cells Redirected with a Novel CD123-Specific Chimeric Antigen Receptor.

Sarah Tettamanti, PhD student, Virna Marin, PhD, Irene Pizzitola, PhD student, Chiara Francesca Magnani, PhD, Greta Maria Paola Giordano Attianese, PhD, Elisabetta Cribioli, Angel Lopez, PhD, Andrea Biondi, MD, Dominique Bonnet, PhD, Ettore Biagi, MD, PhD

Blood (2012) 120 (21): 3010.

https://doi.org/10.1182/blood.V120.21.3010.3010

Published: 2012

Journal Articles

Comparison of Dfferent Suicide Gene Strategies for the Safety Improvement of Genetically Manipulated T Cells.

Virna Marin, Post, Doc, Irene Pizzitola, PhD, student, Andrea Biondi, Professor, MD, Ettore Biagi, MD, Martin Pule

Blood (2010) 116 (21): 3753.

https://doi.org/10.1182/blood.V116.21.3753.3753

Published: 2010

Journal Articles

Understanding the Immunomodulatory Effect of Mesenchymal Stem Cell Infused In Transplanted Patients with Steroid-Refractory GvHD

Erica Dander, PhD, Giovanna Lucchini, MD, Paola Vinci, Martino Introna, MD, Sonia Bonanomi, MD, Adriana Balduzzi, MD, Giuseppe Gaipa, PhD, Paolo Perseghin, MD, Francesca Masciocchi, Chiara Capelli, PhD, Josée Golay, PhD, Alessandra Algarotti, MD, Alessandro Rambaldi, MD, Attilio Rovelli, MD, Andrea Biondi, MD, Ettore Biagi, MD, Giovanna D'Amico, PhD

Blood (2010) 116 (21): 2306.

https://doi.org/10.1182/blood.V116.21.2306.2306

Published: 2010

Journal Articles

A New Chimeric Antigen Receptor (CAR) Targeting the CD23 Antigen Expressed by Chronic Lymphocytic Leukemia (B-CLL) Cells

Greta Maria Paola Giordano Attianese, PhD, Valentina Hoyos, MD, Virna Marin, PhD, Barbara Savoldo, Irene Pizzitola, PhD, Valentina Agostoni, PhD, Matteo Parma, MD, Maria Teresa Sabrina Bertilaccio, PhD, Paolo Ghia, Andrea Biondi, MD, Gianpietro Dotti, Ettore Biagi, MD, PhD

Blood (2010) 116 (21): 2446.

https://doi.org/10.1182/blood.V116.21.2446.2446

Published: 2010

Journal Articles

Generation of a New Chimeric Antigen Receptor (CAR) to Target CD23 Expressed on Chronic Lymphocytic Leukemia (B-CLL) Cells

Greta Maria Paola Giordano Attianese, Valentina Hoyos, MD, Barbara Savoldo, MD, Virna Marin, PhD, Malika Brandi, Andrea Biondi, MD, Ettore Biagi, MD, Gianpietro Dotti, MD

Blood (2008) 112 (11): 3538.

https://doi.org/10.1182/blood.V112.11.3538.3538

Published: 2008

Journal Articles

Infusion of Donor Derived Cytokine Induced Killer Cells May Induce Clinical Remission with Limited GVHD in Patients Relapsing after Allogeneic Stem Cell Transplantation.

Martino Introna, MD, Gianmaria Borleri, Elena Conti, Anna M. Barbui, MD, Raewyn Broady, BSc, Erica Dander, BSc, Giuseppe Gaipa, BSc, Giovanna D’Amico, BSc, Ettore Biagi, MD, Matteo Parma, MD, Enrico Pogliani, MD, Orietta Spinelli, BSc, Donatella Baronciani, MD, Anna Grassi, MD, Josee Golay, PhD, Tiziano Barbui, MD, Andrea Biondi, MD, Alessandro Rambaldi, MD

Blood (2006) 108 (11): 3698.

https://doi.org/10.1182/blood.V108.11.3698.3698

Published: 2006

Journal Articles

The Migratory Activity of Anti-CD19 cTCR-Redirected CIK Cells as a Useful Property for In Vivo Targeting of B-ALL Cells.

Virna Marin, Erica Dander, Ettore Biagi, MD, Andrea Biondi, MD, Giovanna D’Amico, PhD

Blood (2005) 106 (11): 5520.

https://doi.org/10.1182/blood.V106.11.5520.5520

Published: 2005

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Donor-Derived CAR T Cells Engineered with Sleeping Beauty Achieve Anti-Leukemic Activity without Severe Toxicity

Preclinical Assessment of Non-Virally Engineered CD33.CAR Cytokine-Induced Killer (CIK) Cells in Chemoresistant AML Patient-Derived Xenografts

Specific Targeting of Acute Myeloid Leukemia By the Use of Non-Virally Engineered CIK (Cytokine-Induced Killer) Cells Expressing the Anti-CD33 Chimeric Antigen Receptor (CAR)

Balance of Anti-CD123 Chimeric Antigen Receptor (CAR) Binding Affinity and Density for the Treatment of Acute Myeloid Leukemia

Final Analysis of a Multicenter Pilot Phase 2 Study of Cytokine Induced Killer (CIK) Cells for Patients with Relapse after Allogeneic Transplantation

Sleeping Beauty Modified CAR+ Lymphocytes Engraft and Exhibit Anti-Tumor Activity in Patient-Derived Xenograft Models of Acute Lymphoblastic Leukemia

A Multicenter Phase II Study of Sequential Administration of Unmanipulated DLI and Donor Derived Cytokine Induced Killer (CIK) Cells in HSCT Patients, Relapsed of Disease

Unraveling the Efficacy and Safety Profiles of Anti-CD123 Chimeric Antigen Receptors (CARs) in a Model of Acute Myeloid Leukemia Immunotherapy By Investigating CAR Binding Affinity and Density Variables

Vaccination - a Novel Strategy to Improve the Persistence of CD19CAR Transduced T-Cells in Relapsed Paediatric ALL: Preliminary Results from the CD19TPALL Study

Low-Dose Lenalidomide Improves CAR-Based Immunotherapy In CLL By Reverting T-Cell Defects In Vivo

Stable Expression Of Chimeric Antigen Receptors (CARs) By Sleeping Beauty-Mediated Gene Transfer and Efficient Expansion Of Leukemia-Specific Cytokine-Induced Killer (CIK) Cells

Safe and Effective Treatment of Graft Versus Host Disease with Platelet Lysate-Expanded Human Mesenchymal Stromal Cells: A Phase 1 Study On 47 Adult and Pediatric Patients

Chimeric Antigen Receptor for Specific Targeting of Acute Myeloid Leukemia

Targeting of Acute Myeloid Leukemia by Cytokine-Induced Killer Cells Redirected with a Novel CD123-Specific Chimeric Antigen Receptor.

Comparison of Dfferent Suicide Gene Strategies for the Safety Improvement of Genetically Manipulated T Cells.

Understanding the Immunomodulatory Effect of Mesenchymal Stem Cell Infused In Transplanted Patients with Steroid-Refractory GvHD

A New Chimeric Antigen Receptor (CAR) Targeting the CD23 Antigen Expressed by Chronic Lymphocytic Leukemia (B-CLL) Cells

Generation of a New Chimeric Antigen Receptor (CAR) to Target CD23 Expressed on Chronic Lymphocytic Leukemia (B-CLL) Cells

Infusion of Donor Derived Cytokine Induced Killer Cells May Induce Clinical Remission with Limited GVHD in Patients Relapsing after Allogeneic Stem Cell Transplantation.

The Migratory Activity of Anti-CD19 cTCR-Redirected CIK Cells as a Useful Property for In Vivo Targeting of B-ALL Cells.

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