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Eugene Zhukovsky
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Journal Articles

Integrated Preclinical Data Analysis of ISB 2001 Enables Optimal Starting Dose Selection for a First-in-Class Trispecific T Cell Engager Phase1 Study in Multiple Myeloma

Adam Drake, Maria Pihlgren, Vinu Menon, Daniela Pais, Laura Carretero-Iglesia, Jeremy Berret, Olivia Hall, Julie Macoin, Isabelle Gruber, Elodie Stainnack, Carole Estoppey, Cyrille Dreyfus, Girish Gudi, Tomomi Matsuura, Piet H van der Graft, Michael Dyson, Cyril Konto, Lida Pacaud, Ankita Srivastava, Eugene Zhukovsky, Mario Perro
Journal: Blood
Blood (2023) 142 (Supplement 1): 6574.
https://doi.org/10.1182/blood-2023-181546
Published: 2023
Journal Articles

Initial Dose Escalation of ISB 1442, a Novel CD38 Biparatopic x CD47 Bispecific Antibody, in Patients with Relapsed / Refractory Multiple Myeloma (RRMM)

Dickran Kazandjian, Hang Quach, Hanlon Sia, Phoebe Joy Ho, Andrew Spencer, Mark A. Schroeder, Binod Dhakal, Tara Cochrane, Jeffrey A. Zonder, Nancy Yi, Dominique Duchesne, Tejas Shah, Andrew Garton, Vinu Menon, Sunitha Gn, Stefano Sammicheli, Eugene Zhukovsky, Cyril Konto, Lida Pacaud, Peter Tan
Journal: Blood
Blood (2023) 142 (Supplement 1): 4707.
https://doi.org/10.1182/blood-2023-186241
Published: 2023
Journal Articles

Dose Escalation of ISB 1342, a Novel CD38xCD3 Bispecific Antibody, in Patients with Relapsed / Refractory Multiple Myeloma (RRMM)

Prashant Kapoor, Don A. Stevens, Xavier Leleu, Karim Belhadj Merzoug, Lionel Karlin, Salomon Manier, Thomas Chalopin, Cyrille Hulin, Aurore Perrot, Jésus G Berdeja, Cristiana Costa Chase, Cyrille Touzeau, Philippe Moreau, Sanjay Mohan, Alexander Lesokhin, Carol Huff, David H. Vesole, Joshua Richter, Jeffrey Matous, Eileen Wolff, Tejas Shah, Jeppe Koch-Olsen, Andrew Garton, Vinu Menon, Sunitha Gn, Mario Perro, Eugene Zhukovsky, Cyril Konto, Lida Pacaud, Mohamad Mohty
Journal: Blood
Blood (2023) 142 (Supplement 1): 3339.
https://doi.org/10.1182/blood-2023-186664
Published: 2023
Journal Articles

A Phase 1, First-in-Human, Dose Escalation and Dose-Expansion Study of a BCMAxCD38xCD3 Targeting Trispecific Antibody ISB 2001 in Subjects with Relapsed/Refractory Multiple Myeloma

Hanlon Sia, Vinu Menon, Andrew Garton, Eileen Wolff, Tejas Shah, Colleen Charpentier, Dominique Duchesne, Maria Pihlgren, Jeppe Koch-Olsen, Adam Drake, Mario Perro, Eugene Zhukovsky, Lida Pacaud, Cyril Konto
Journal: Blood
Blood (2023) 142 (Supplement 1): 3396.
https://doi.org/10.1182/blood-2023-187106
Published: 2023
Journal Articles

Preclinical characterization of ISB 1342, a CD38 × CD3 T-cell engager for relapsed/refractory multiple myeloma

Blandine Pouleau, Carole Estoppey, Perrine Suere, Emilie Nallet, Amélie Laurendon, Thierry Monney, Daniela Pais Ferreira, Adam Drake, Laura Carretero-Iglesia, Julie Macoin, Jérémy Berret, Maria Pihlgren, Marie-Agnès Doucey, Girish S. Gudi, Vinu Menon, Venkatesha Udupa, Abhishek Maiti, Gautam Borthakur, Ankita Srivastava, Stanislas Blein, M. Lamine Mbow, Thomas Matthes, Zeynep Kaya, Claire M. Edwards, James R. Edwards, Emmanuelle Menoret, Charlotte Kervoëlen, Catherine Pellat-Deceunynck, Philippe Moreau, Eugene Zhukovsky, Mario Perro, Myriam Chimen
Journal: Blood
Blood (2023) 142 (3): 260–273.
https://doi.org/10.1182/blood.2022019451
Published: 2023
Includes: Supplemental data
Journal Articles

Preclinical Evaluation of ISB 1442, a First-in-Class CD38 and CD47 Bispecific Antibody Innate Cell Modulator for the Treatment of AML and T-ALL

Sammicheli Stefano, Camille Grandclement, Valentina Labanca, Stefania De Angelis, Carole Estoppey, Myriam Chimen, Blandine Pouleau, Perrine Suere, Emilie Nallet, Ankita Srivastava, Eric J. Feldman, Igor Proscurshim, Cyril Konto, Eugene Zhukovsky, Mario Perro
Journal: Blood
Blood (2022) 140 (Supplement 1): 6237–6238.
https://doi.org/10.1182/blood-2022-162201
Published: 2022
Journal Articles

ISB 2001, a First-in-Class Trispecific BCMA and CD38 T Cell Engager Designed to Overcome Mechanisms of Escape from Treatments for Multiple Myeloma By Targeting Two Antigens

Maria Pihlgren, Olivia Hall, Laura Carretero, Carole Estoppey, Adam Drake, Daniela Pais, Jeremy Loyau, Jeremy Berret, Isabelle Gruber, Perrine Suere, Vincent Schnorhk, Emilie Nallet, Blandine Pouleau, Myriam Chimen, Julie Macoin, Elodie Stainnack, Thierry Monney, Aurore Delachat, Cyrille Dreyfus, Thomas Matthes, Cyril Konto, Michael Dyson, Stanislas Blein, Lamine Mbow, Rebecca Wood, Ankita Srivastava, Eugene Zhukovsky, Mario Perro
Journal: Blood
Blood (2022) 140 (Supplement 1): 858–859.
https://doi.org/10.1182/blood-2022-159353
Published: 2022
Journal Articles

A Phase I Study Of An Anti-CD30 x Anti-CD16A Bispecific Tandab Antibody, AFM13, In Patients With Relapsed Or Refractory Hodgkin Lymphoma

Eugene Zhukovsky, PhD, Achim Rothe, MD, Bastian von Tresckow, MD, Max Topp, Anas Younes, MD, Dennis A. Eichenauer, MD, Horst Hummel, MD, Katrin S. Reiners, PhD, Markus Dietlein, MD, Joerg Kessler, PhD, Miroslav Ravic, MD, PhD, Christian Hucke, PhD, Elke Poggevon Strandmann, PhD, Andreas Engert, MD
Journal: Blood
Blood (2013) 122 (21): 5116.
https://doi.org/10.1182/blood.V122.21.5116.5116
Published: 2013
Journal Articles

A CD19/CD3 Bispecific Tandab, AFM11, Recruits T Cells To Potently and Safely Kill CD19 + Tumor Cells

Eugene Zhukovsky, PhD, Uwe Reusch, Carmen Burkhardt, Stefan Knackmuss, Ivica Fucek, Markus Eser, Fionnuala McAleese, Kristina Ellwanger, Melvyn Little, PhD
Journal: Blood
Blood (2013) 122 (21): 4405.
https://doi.org/10.1182/blood.V122.21.4405.4405
Published: 2013
Journal Articles

A T Cell-Engaging CD3 Recruit-Tandab Potently Kills CD19 + Tumor B Cells

Eugene Zhukovsky, PhD, Uwe Reusch, Carmen Burkhardt, Stefan Knackmuss, Ivica Fucek, Markus Eser, Fionnuala McAleese, Kristina Ellwanger
Journal: Blood
Blood (2012) 120 (21): 3721.
https://doi.org/10.1182/blood.V120.21.3721.3721
Published: 2012
Journal Articles

XmAb®5574, An Fc Engineered Humanized Anti-CD19 Monoclonal Antibody, Has Potent in Vitro and in Vivo Activities, and Has the Potential for Treating B Cell Malignancies

Chris E Lawrence, PhD, Jonathan Zalevsky, PhD, Holly Horton, PhD, Irene Leung, PhD, Seung Chu, PhD, Sher Karki, PhD, Eugene Zhukovsky, PhD, John R Desjarlais, PhD, David F Carmichael, PhD
Journal: Blood
Blood (2008) 112 (11): 2621.
https://doi.org/10.1182/blood.V112.11.2621.2621
Published: 2008
Journal Articles

XmAb™ Fc Engineered Anti-CD19 Monoclonal Antibody with Enhanced In Vitro Efficacy Against Lymphoma and Leukemia.

Eugene Zhukovsky, PhD, Seung Chu, PhD, Matthew Bernett, PhD, Sher Karki, PhD, John Richards, PhD, Erik Pong, BS, Matthias Peipp, PhD, Roland Repp, MD, John Desjarlais, PhD
Journal: Blood
Blood (2007) 110 (11): 2335.
https://doi.org/10.1182/blood.V110.11.2335.2335
Published: 2007