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Journal Articles

Whole-Genome CRISPR Screen Reveals the Mechanism of Relapse in Patient-Derived Cells Representing High-Risk Paediatric ALL

Free
Katarzyna Szoltysek, PhD, Helen Blair, Sirintra Nakjang, Ricky Tirtakusuma, Mankaran Singh, Ryan Nelson, Hesta McNeill, Catherine Dodd, Melanie Beckett, Lynsey McKenzie, Edward Law, Josef Vormoor, MD PhD, Deepali Pal, Olaf Heidenreich
Journal: Blood
Blood (2019) 134 (Supplement_1): 3952.
https://doi.org/10.1182/blood-2019-124818
Published: 2019
Journal Articles

Mutant TET2 Allele Dosage Affects Response to 5-Azacitidine in Acute Myeloid Leukemia

Free
Friedrich Stoelzel, MD, Sarah Elizabeth Fordham, PhD BSc, Wei Yu Lin, PhD, Helen Blair, PhD, Leo Ruhnke, MD, Desireé Kunadt, MD, Brigitte Mohr, PhD, Claire Elstob, PhD, Daniel Allsop, MD, Devi Nandana, BSc, Emmanouela-Niki Soura, MPhil, Catherine Park, PhD, Mohd Fadly, PhD, Thahira Rahman, PhD, Olaf Heidenreich, Heidi Altmann, PhD, Gail Jones, MD, Tobias Menne, MD PhD, Manja Wobus, PhD, Graham Jackson, MA, MB BS, FRCP, FRCPath, MD, Helen Marr, PhD, Kenan Onel, MD PhD, Manja Meggendorfer, PhD, Torsten Haferlach, MD, Martin Bornhäuser, MD, James M. Allan
Journal: Blood
Blood (2019) 134 (Supplement_1): 113.
https://doi.org/10.1182/blood-2019-123047
Published: 2019
Journal Articles

The ability to cross the blood–cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts

Free
Mark T. S. Williams, Yasar M. Yousafzai, Alex Elder, Klaus Rehe, Simon Bomken, Liron Frishman-Levy, Sigal Tavor, Paul Sinclair, Katie Dormon, Dino Masic, Tracey Perry, Victoria J. Weston, Pamela Kearns, Helen Blair, Lisa J. Russell, Olaf Heidenreich, Julie A. E. Irving, Shai Izraeli, Josef Vormoor, Gerard J. Graham, Christina Halsey
Journal: Blood
Blood (2016) 127 (16): 1998–2006.
https://doi.org/10.1182/blood-2015-08-665034
Published: 2016
Includes: Supplemental data
Journal Articles

High Abundance of Acute Lymphoblastic Leukaemia Founder Clones Does Not Translate to Functional Heterogeneity

Free
Alex Elder, PhD, Helen Blair, PhD, Katherine Dormon, Simon Bomken, PhD MBBS, Simon J Cockell, PhD, Olaf Heidenreich, PhD, Josef Vormoor, MD FRCPCH
Journal: Blood
Blood (2015) 126 (23): 844.
https://doi.org/10.1182/blood.V126.23.844.844
Published: 2015
Journal Articles

A Targeted Functional Clone Tracking Assay for the Identification of Tumour Suppressor Genes in BCP- ALL Implicates the Transcription Factors FOXO3 and PRDM1

Free
Paul Sinclair, PhD, Joanna Cheng, Prahlad Raninga, Rebecca Hanna, Shaun Hollern, Amir Enshaei, PhD, Helen Blair, PhD, Sirintra Nakjang, Sarra Ryan, PhD, Jeyanthy Eswaran, PhD, Lars Buechler, Olaf Heidenreich, PhD, Christine Harrison, PhDFRCPath FMedSci
Journal: Blood
Blood (2015) 126 (23): 2449.
https://doi.org/10.1182/blood.V126.23.2449.2449
Published: 2015
Journal Articles

A Whole Genome In Vivo Crispr Screen in Primary ALL Predicts Leukaemic Relapse

Free
Katherine Dormon, MSci, Elda S Latif, PhD, Matthew Bashton, PhD, Deepali Pal, PhD, Matthew Selby, MSci, Helen Blair, PhD, Vikki Rand, PhD, Andrew G Hall, PhD, Josef Vormoor, MD FRCPCH, Olaf Heidenreich, PhD
Journal: Blood
Blood (2015) 126 (23): 2619.
https://doi.org/10.1182/blood.V126.23.2619.2619
Published: 2015
Journal Articles

Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition

Free
Julie Irving, Elizabeth Matheson, Lynne Minto, Helen Blair, Marian Case, Christina Halsey, Isabella Swidenbank, Frida Ponthan, Renate Kirschner-Schwabe, Stefanie Groeneveld-Krentz, Jana Hof, James Allan, Christine Harrison, Josef Vormoor, Arend von Stackelberg, Cornelia Eckert
Journal: Blood
Blood (2014) 124 (23): 3420–3430.
https://doi.org/10.1182/blood-2014-04-531871
Published: 2014
Includes: Supplemental data
Journal Articles

RAS Pathway Mutations Are Highly Prevalent In Relapsed Childhood Acute Lymphoblastic Leukaemia, Are Frequently Relapse-Drivers and Confer Sensitivity To MEK Inhibition

Free
Julie Irving, PhD, Elizabeth C. Matheson, MPhil, Lynne Minto, Helen Blair, PhD, Marian Case, MSc, Christina Halsey, MD, PhD, Isabella Swidenbank, MRes, Frida Ponthan, PhD, Renate Kirschner-Schwabe, PhD, Stefanie Groeneveld-Krentz, MSc, Jana Hof, MSc, James Allan, PhD, Christine J. Harrison, PhD, Josef Vormoor, MD, Arend Stackelberg, MD, Cornelia Eckert, PhD
Journal: Blood
Blood (2013) 122 (21): 823.
https://doi.org/10.1182/blood.V122.21.823.823
Published: 2013
Journal Articles

Clonal Progression Including Evolution Of An iAMP21 Chromosome In Xenograft Models Of BCP-ALL

Free
Paul B Sinclair, PhD, Lars Buechler, PhD, Joanna Cheng, MSc, Jake Clayton, MRes, Claire Schwab, BSc, Lisa Jones, BSc, Helen Blair, PhD, Lisa J Russell, PhD, Bryan D Young, BSc, PhD, Olaf Heidenreich, PhD, Christine J Harrison, PhD
Journal: Blood
Blood (2013) 122 (21): 2485.
https://doi.org/10.1182/blood.V122.21.2485.2485
Published: 2013
Journal Articles

An Analysis Of Mechanisms Of Central Nervous System Infiltration In Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice

Free
Yasar M Yousafzai, MBBS, Mark TS Williams, PhD, Klaus Rehe, MD, Michelle Le Brocq, PhD, Simon Bomken, MBBS, PhD, Paul B Sinclair, PhD, Katie Dormon, MSc, Dino Masic, MRes, Leanne Archer, B.Sc, Jennifer Watt, BSc, Tracey A Perry, BSc, Victoria J Weston, PhD, Pamela R Kearns, MBChB, PhD, FRCPCH, Helen Blair, PhD, Russel Lisa, PhD, Olaf Heidenreich, PhD, Julie Irving, PhD, Josef Vormoor, MD, Brenda Gibson, MD, Gerard J Graham, PhD, Christina Halsey, PhD, FRCPath
Journal: Blood
Blood (2013) 122 (21): 3866.
https://doi.org/10.1182/blood.V122.21.3866.3866
Published: 2013
Journal Articles

Lentiviral Transduction of Patient Derived Leukaemic Blasts Allowing In Vivo Bioluminescent Monitoring in An NSG Model of Leukaemia Stem Cell Maintenance,

Free
Simon Bomken, MBBS, Lars Buechler, PhD, Klaus Rehe, MD, Frida Ponthan, PhD, Helen Blair, PhD, Olaf Heidenreich, PhD, Josef Vormoor, MD
Journal: Blood
Blood (2011) 118 (21): 4000.
https://doi.org/10.1182/blood.V118.21.4000.4000
Published: 2011