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Journal Articles

Dimethyl Fumarate Ameliorates Graft-Versus-Host Disease By Negatively Regulating Aerobic Glycolysis in Alloreactive T-Cells

Kiyomi Mashima, MDPhD, Kazuya Sato, MDPhD, Norihito Takayama, Junko Izawa, Takashi Ikeda, MD, Kento Umino, MD, Hirofumi Nakano, MD, Daisuke Minakata, MD, Kaoru Morita, MD PhD, Chihiro Yamamoto, MD PhD, Masahiro Ashizawa, MD, Kaoru Hatano, MD PhD, Iekuni Oh, MD PhD, Ken Ohmine, MDPhD, Shin-ichiro Fujiwara, MD PhD, Yoshinobu Kanda, MD PhD

Blood (2020) 136 (Supplement 1): 24–25.

https://doi.org/10.1182/blood-2020-136229

Published: 2020

Journal Articles

Steep Neutrophil Recovery Following Unrelated Bone Marrow Transplantation Is a Major Risk Factor for the Development of Acute Graft-Vs-Host Disease

Takashi Nagayama, MD, Shin-ichiro Fujiwara, MD PhD, Hirotomo Nakashima, MD, Shinichiro Kawaguchi, MD, Shoko Ito, MD, Kiyomi Mashima, MD, Kento Umino, MD, Daisuke Minakata, MD, Hirofumi Nakano, MD, Ryoko Yamasaki, MD, Kaoru Morita, MD PhD, Chihiro Yamamoto, MD PhD, Masahiro Ashizawa, MD, Kaoru Hatano, MD PhD, Kazuya Sato, MD PhD, Iekuni Oh, MD PhD, Ken Ohmine, MD PhD, Kazuo Muroi, MD PhD, Yoshinobu Kanda, MD PhD

Blood (2019) 134 (Supplement_1): 5686.

https://doi.org/10.1182/blood-2019-122537

Published: 2019

Journal Articles

Efficacy and Safety of Blinatumomab in Asian Adults with Relapsed/Refractory B-Precursor ALL

Yukio Kobayashi, Iekuni Oh, MD PhD, Toshihiro Miyamoto, MD PhD, Won-Sik Lee, Hiroatsu Iida, MD PhD, Hironobu Minami, MD PhD, Yoshinobu Maeda, MD PhD, Jun Ho Jang, Sung-Soo Yoon, MD PhD, Su-Peng Yeh, MD, Qui Tran, Joan Morris, Janet L. Franklin, Ka-Wing Chong, Hitoshi Kiyoi, MD PhD

Blood (2019) 134 (Supplement_1): 5069.

https://doi.org/10.1182/blood-2019-124582

Published: 2019

Journal Articles

Phase 2 Study of Blinatumomab in Japanese Adults with Relapsed/Refractory Acute Lymphoblastic Leukemia (R/R ALL)

Yukio Kobayashi, MD DSc, Zachary F. Zimmerman, Iekuni Oh, MD PhD, Yoshinobu Maeda, MD PhD, Hironobu Minami, MD PhD, Toshihiro Miyamoto, MD PhD, Toru Sakura, PhD MD, Hiroatsu Iida, MD PhD, Yuqi Chen, PhD, Hitoshi Kiyoi, MD PhD

Blood (2018) 132 (Supplement 1): 5167.

https://doi.org/10.1182/blood-2018-99-112584

Published: 2018

Journal Articles

Alloantigen-Activated Human T-Cells Increase Extracellular Fatty Acid Uptake and Intracellular Lipid Metabolism during Xenogeneic Gvhd

Hirofumi Nakano, MD, Kazuya Sato, MD PhD, Hiroko Hayakawa, PhD, Kiyomi Mashima, MD, Daisuke Minakata, MD, Kaoru Morita, MD PhD, Ryoko Yamasaki, MD, Masahiro Ashizawa, MD, Chihiro Yamamoto, MD PhD, Kaoru Hatano, MD PhD, Shin-ichiro Fujiwara, MD PhD, Iekuni Oh, MD PhD, Ken Ohmine, MD PhD, Kazuo Muroi, MD PhD, Yoshinobu Kanda, MD PhD

Blood (2018) 132 (Supplement 1): 3320.

https://doi.org/10.1182/blood-2018-99-110011

Published: 2018

Journal Articles

Comprehensive Analysis of Chemokines in Host Organs and Their Corresponding Receptors on Donor T-Cells in Xenogeneic Gvhd Model

Yasufumi Kawasaki, MD PhD, Kazuya Sato, MDPhD, Hirofumi Nakano, MD, Kiyomi Mashima, MD, Daisuke Minakata, MD, Ryoko Yamasaki, MD, Kaoru Morita, MD PhD, Masahiro Ashizawa, MD, Chihiro Yamamoto, MD PhD, Kaoru Hatano, MD PhD, Shin-ichiro Fujiwara, MD PhD, Iekuni Oh, MD PhD, Ken Ohmine, MD PhD, Kazuo Muroi, MD PhD, Yoshinobu Kanda, MD PhD

Blood (2018) 132 (Supplement 1): 5676.

https://doi.org/10.1182/blood-2018-99-111773

Published: 2018

Journal Articles

Recipient Hematopoietic, but Not Non-Hematopoietic, Antigen-Presenting Cells Are Indispensable for CD4+ T-Cell-Mediated Xenogeneic Graft-Versus-Host Disease

Yasufumi Kawasaki, Kazuya Sato, MDPhD, Hiroko Hayakawa, PhD, Norihito Takayama, PhD, Hirofumi Nakano, MD, Kiyomi Mashima, MD, Daisuke Minakata, MD, Ryoko Yamasaki, MD, Kaoru Morita, MD PhD, Masahiro Ashizawa, MD, Chihiro Yamamoto, MD PhD, Kaoru Hatano, MD PhD, Shin-ichiro Fujiwara, MD PhD, Iekuni Oh, MD PhD, Ken Ohmine, MD PhD, Kazuo Muroi, MDPhD, Yoshinobu Kanda, MD PhD

Blood (2017) 130 (Supplement 1): 4441.

https://doi.org/10.1182/blood.V130.Suppl_1.4441.4441

Published: 2017

Journal Articles

Comprehensive Analysis of Activation and Proliferation Kinetics and Effector Functions of Human Lymphocyte Subsets in Xenogeneic GvHD Model

Blood (2016) 128 (22): 3350.

https://doi.org/10.1182/blood.V128.22.3350.3350

Published: 2016

Journal Articles

CD25 Expression Is Associated with Inferior Clinical Outcomes in Elderly Patients with Acute Myeloid Leukemia

Shin-ichiro Fujiwara, Kazuo Muroi, Raine Tatara, Kiyoshi Okazuka, Sato Kazuya, Iekuni Oh, Ken Ohmine, Takahiro Suzuki, Tadashi Nagai

Blood (2014) 124 (21): 3678.

https://doi.org/10.1182/blood.V124.21.3678.3678

Published: 2014

Journal Articles

Profiles Of De Novo CD25-Positive Mature B-Cell Lymphomas

Shin-ichiro Fujiwara, Raine Tatara, Kiyoshi Okazuka, Iekuni Oh, Ken Ohmine, Takahiro Suzuki, Masaki Mori, Tadashi Nagai, Keiya Ozawa, MD, PhD, Kazuo Muroi, MD, PhD

Blood (2013) 122 (21): 4308.

https://doi.org/10.1182/blood.V122.21.4308.4308

Published: 2013

Journal Articles

Stat3 Activation in Donor CD4 T-Cells Is Critical for Acute Gvhd

Katsutoshi Ozaki, Haruko Matsu, MD, PhD, Keiko Hatanaka, Akiko Meguro, MD, PhD, Iekuni Oh, MD, PhD, Raine Tatara, MD, PhD, Takahiro Suzuki, Masaki Mori, M.D, Ph.D, Tadashi Nagai, MD, PhD, Kazuo Muroi, MD, PhD, Keiya Ozawa, M.D, Ph.D

Blood (2011) 118 (21): 1906.

https://doi.org/10.1182/blood.V118.21.1906.1906

Published: 2011

Journal Articles

Lack of IL-21 Signal Attenuates Graft-Versus-Leukemia Effect In the Absence of CD8 T-Cells.

Katsutoshi Ozaki, MD, PhD, Akiko Meguro, Keiko Hatanaka, Iekuni Oh, Haruko Matsu, Raine Tatara, Kazuya Sato, MD, Warren J Leonard, Keiya Ozawa, MD, PhD

Blood (2010) 116 (21): 3739.

https://doi.org/10.1182/blood.V116.21.3739.3739

Published: 2010

Journal Articles

Blocking of IL-21 Signal Attenuates Graft-Versus-Host Disease but Not Graft-Versus-Leukemia Effect in a Mouse Model

Akiko Meguro, Katsutoshi Ozaki, Iekuni Oh, Haruko Matsu, Keiko Hatanaka, Raine Tatara, Warren J Leonard, Kazuya Sato, Keiya Ozawa

Blood (2008) 112 (11): 1248.

https://doi.org/10.1182/blood.V112.11.1248.1248

Published: 2008

Journal Articles

Bortezomib Overcomes Cell Adhesion-Mediated Drug Resistance Via Down-Regulation of VLA-4 Expression in Multiple Myeloma.

Kaoru Hatano, Jiro Kikuchi, Masaaki Takatoku, Rumi Shimizu, Taeko Wada, Masuzu Ueda, Masaharu Nobuyoshi, Iekuni Oh, Kazuya Sato, Takahiro Suzuki, Katsutoshi Ozaki, Masaki Mori, Tadashi Nagai, Kazuo Muroi, Yasuhiko Kano, Yusuke Furukawa, Keiya Ozawa

Blood (2008) 112 (11): 1634.

https://doi.org/10.1182/blood.V112.11.1634.1634

Published: 2008

Journal Articles

Hyaluronidase and IFN-γ from Activated T-Cells Are Key Mediators To Induce Immunosuppressive Activity of Mesenchymal Stem Cells.

Kazuya Sato, MD, PhD, Ozaki Katsutoshi, MD., PhD., Iekuni Oh, MD., PhD., Haruko Matsu, MD., Raine Tatara, MD., Akiko Meguro, MD., Keiko Hatanaka, Tadashi Nagai, MD., PhD., Kazuo Muroi, MD., PhD, Keiya Ozawa, MD., PhD

Blood (2007) 110 (11): 3246.

https://doi.org/10.1182/blood.V110.11.3246.3246

Published: 2007

Journal Articles

Mesenchymal Stem Cells Produce Nitric Oxide, a Key Molecule for T Cell Suppression, upon Interaction with Activated T Cells.

Kazuya Sato, MD, Katsutoshi Ozaki, MD, PhD, Iekuni Oh, MD, PhD, Akiko Meguro, MD, Reine Tatara, MD, Keiko Hatanaka, Tadashi Nagai, MD, PhD, Kazuo Muroi, MD, PhD, Keiya Ozawa, MD, PhD

Blood (2006) 108 (11): 2556.

https://doi.org/10.1182/blood.V108.11.2556.2556

Published: 2006

Journal Articles

Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells

Kazuya Sato, Katsutoshi Ozaki, Iekuni Oh, Akiko Meguro, Keiko Hatanaka, Tadashi Nagai, Kazuo Muroi, Keiya Ozawa

Blood (2006) 109 (1): 228–234.

https://doi.org/10.1182/blood-2006-02-002246

Published: 2006

Includes: Supplemental data

Journal Articles

Mesenchymal Stem Cells (MSCs) Suppress T Cell Proliferation by a Novel NO-stat5 Dependent Mechanism.

Kazuya Sato, MD, Katsutoshi Ozaki, MD, PhD, Iekuni Oh, MD, Keiko Hatanaka, Tadashi Nagai, MD, PhD, Kazuo Muroi, MD, PhD, Keiya Ozawa, MD, PhD

Blood (2005) 106 (11): 1393.

https://doi.org/10.1182/blood.V106.11.1393.1393

Published: 2005

Journal Articles

Mesenchymal Stem Cells Self-Regulate Their Differentiation To Maintain the Bone Marrow Stromal System.

Iekuni Oh, MD, Akira Miyazato, MD PhD, Hiroyuki Mano, MD PhD, Tadashi Nagai, MD PhD, Kazuo Muroi, MD PhD, Keiya Ozawa, MD PhD

Blood (2004) 104 (11): 2335.

https://doi.org/10.1182/blood.V104.11.2335.2335

Published: 2004

NARROW

Dimethyl Fumarate Ameliorates Graft-Versus-Host Disease By Negatively Regulating Aerobic Glycolysis in Alloreactive T-Cells

Steep Neutrophil Recovery Following Unrelated Bone Marrow Transplantation Is a Major Risk Factor for the Development of Acute Graft-Vs-Host Disease

Efficacy and Safety of Blinatumomab in Asian Adults with Relapsed/Refractory B-Precursor ALL

Phase 2 Study of Blinatumomab in Japanese Adults with Relapsed/Refractory Acute Lymphoblastic Leukemia (R/R ALL)

Alloantigen-Activated Human T-Cells Increase Extracellular Fatty Acid Uptake and Intracellular Lipid Metabolism during Xenogeneic Gvhd

Comprehensive Analysis of Chemokines in Host Organs and Their Corresponding Receptors on Donor T-Cells in Xenogeneic Gvhd Model

Recipient Hematopoietic, but Not Non-Hematopoietic, Antigen-Presenting Cells Are Indispensable for CD4+ T-Cell-Mediated Xenogeneic Graft-Versus-Host Disease

Comprehensive Analysis of Activation and Proliferation Kinetics and Effector Functions of Human Lymphocyte Subsets in Xenogeneic GvHD Model

CD25 Expression Is Associated with Inferior Clinical Outcomes in Elderly Patients with Acute Myeloid Leukemia

Profiles Of De Novo CD25-Positive Mature B-Cell Lymphomas

Stat3 Activation in Donor CD4 T-Cells Is Critical for Acute Gvhd

Lack of IL-21 Signal Attenuates Graft-Versus-Leukemia Effect In the Absence of CD8 T-Cells.

Blocking of IL-21 Signal Attenuates Graft-Versus-Host Disease but Not Graft-Versus-Leukemia Effect in a Mouse Model

Bortezomib Overcomes Cell Adhesion-Mediated Drug Resistance Via Down-Regulation of VLA-4 Expression in Multiple Myeloma.

Hyaluronidase and IFN-γ from Activated T-Cells Are Key Mediators To Induce Immunosuppressive Activity of Mesenchymal Stem Cells.

Mesenchymal Stem Cells Produce Nitric Oxide, a Key Molecule for T Cell Suppression, upon Interaction with Activated T Cells.

Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells

Mesenchymal Stem Cells (MSCs) Suppress T Cell Proliferation by a Novel NO-stat5 Dependent Mechanism.

Mesenchymal Stem Cells Self-Regulate Their Differentiation To Maintain the Bone Marrow Stromal System.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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