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Journal Articles

Modulation of the Tumor Suppressor Protein PP2A Using a Small Molecule Agonist Overcomes Multi-Drug Resistance through Mitochondrial Permeability Transition Pore (MPTP) Dependent Induction of Apoptosis in Chronic Lymphocytic Leukemia

Kallesh D. Jayappa, PhD, Caroline Farrington, PhD, Vicki L. Gordon, BS, Shekhar Saha, PhD, Christopher Morris, BS, Krista M. Isaac, MD, Timothy P. Bender, PhD, Michael E. Williams, MD, Craig A. Portell, MD, Goutham Narla, MD PhD, Michael J. Weber, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 15–17.
https://doi.org/10.1182/blood-2020-138954
Published: 2020
Journal Articles

A Multi-Drug Tolerant Phenotype Is Induced By Diverse Microenvironmental Agonists in Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma

Kallesh D. Jayappa, DVM, PhD, Konrad J. Cios, BSc (2019), Vicki L. Gordon, BSc, Puja C. Arora, MD, Timothy P. Bender, PhD, Michael E. Williams, MD, Craig A. Portell, MD, Michael J. Weber, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4120.
https://doi.org/10.1182/blood-2018-99-119521
Published: 2018
Journal Articles

Drug Combinations Co-Targeting Myeloid Cell Leukemia-1 (Mcl-1) Protein Can Overcome Microenvironmentally-Induced Multi-Drug Tolerance in Non-Hodgkin Lymphomas

Kallesh D. Jayappa, DVM, PhD, Craig A. Portell, MD, Vicki L. Gordon, BSc, Goutham Narla, MD PhD, Timothy P. Bender, PhD, Michael E. Williams, MD, Michael J. Weber, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2649.
https://doi.org/10.1182/blood-2018-99-116759
Published: 2018
Journal Articles

Extrinsic Factors in the In Vivo Macroenvironment Generate Phenotypic Resistance to BTK/Bcl-2 Targeted Therapies in Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma

Kallesh D. Jayappa, DVM, PhD, Craig A. Portell, MD, Vicki L Gordon, BS, Brian J Capaldo, PhD, Stefan Bekiranov, PhD, Julia D Wulfkuhle, Rosa I Gallagher, Emanuel F. Petricoin, PhD, Timothy P. Bender, PhD, Michael E. Williams, MD, Michael J. Weber, PhD
Journal: Blood
Blood (2016) 128 (22): 754.
https://doi.org/10.1182/blood.V128.22.754.754
Published: 2016
Journal Articles

Initial Report of a Multi-Institution Phase I/Ib Study of Ibrutinib with Venetoclax in Relapsed or Refractory Mantle Cell Lymphoma

Craig A. Portell, MD, Robert W Chen, MD, Nolan Wages, PhD, Jonathon B. Cohen, MD, Michael J. Weber, PhD, Gina Petroni, PhD, Brad S. Kahl, MD, Michael E Williams, MD
Journal: Blood
Blood (2016) 128 (22): 2958.
https://doi.org/10.1182/blood.V128.22.2958.2958
Published: 2016
Journal Articles

Ligands That Mimic the Tissue Microenvironment of Replicating Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL) Protect Ex Vivo Patient Cell Samples from the Cytotoxicity of Combined Treatment with Ibrutinib and Venetoclax (ABT-199)

Kallesh D. Jayappa, PhD, Craig A. Portell, MD, Vicki Gordon, B.S., Michael E. Williams, MD, Emanuel F. Petricoin, PhD, Timothy P. Bender, PhD, Michael J. Weber, PhD
Journal: Blood
Blood (2015) 126 (23): 448.
https://doi.org/10.1182/blood.V126.23.448.448
Published: 2015
Journal Articles

Synergistic Cytotoxicity of Ibrutinib and the BCL2 Antagonist, ABT-199(GDC-0199) in Mantle Cell Lymphoma (MCL) and Chronic Lymphocytic Leukemia (CLL): Molecular Analysis Reveals Mechanisms of Target Interactions

Craig A. Portell, MD, Mark Axelrod, PhD, L. Kyle Brett, MD, Vicki L Gordon, BS, Brian Capaldo, Jeffrey C Xing, Stephan Bekiranov, PhD, Michael E. Williams, MD, Michael J. Weber, PhD
Journal: Blood
Blood (2014) 124 (21): 509.
https://doi.org/10.1182/blood.V124.21.509.509
Published: 2014
Journal Articles

Drug Screening Reveals That Ibrutinib (PCI-32765) Exhibits Synergy With BCL-2 and Proteasome Inhibitors In Models Of Mantle Cell Lymphoma (MCL) and Chronic Lymphocytic Leukemia (CLL)

L. Kyle Brett, MD, Mark Axelrod, PhD, Zhishuo Ou, MD, Liang Zhang, MD, PhD, Vicki Gordon, BS, Elyse R Lopez, Archito T. Tamayo, MS, Richard J. Ford, MD, PhD, Lan V Pham, PhD, Michael J. Weber, PhD, Michael E. Williams, MD, ScM, Michael Wang, MD
Journal: Blood
Blood (2013) 122 (21): 3080.
https://doi.org/10.1182/blood.V122.21.3080.3080
Published: 2013
Journal Articles

Gene Expression Profiling of Hematopoietic Stem and Progenitor Cells in Zebrafish.

Gerhard J. Weber, MD, Ken Chiang, Elizabeth A. Mayhall, Yi Zhou, PhD, Leonard I. Zon, MD
Journal: Blood
Blood (2005) 106 (11): 3622.
https://doi.org/10.1182/blood.V106.11.3622.3622
Published: 2005
Journal Articles

Mutant-specific gene programs in the zebrafish

Gerhard J. Weber, Sung E. Choe, Kimberly A. Dooley, Noëlle N. Paffett-Lugassy, Yi Zhou, Leonard I. Zon
Journal: Blood
Blood (2005) 106 (2): 521–530.
https://doi.org/10.1182/blood-2004-11-4541
Published: 2005
Includes: Supplemental data
Journal Articles

The beta subunit of the interleukin-2 receptor mediates interleukin-2 induction of anti-CD3 redirected cytotoxic capability in large granular lymphocytes

OR Colamonici, R Quinones, A Rosolen, JB Trepel, E Sausville, JC Phares, R Gress, D Poplack, J Weber, GP Schechter
Journal: Blood
Blood (1988) 71 (3): 825–828.
https://doi.org/10.1182/blood.V71.3.825.825
Published: 1988