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Journal Articles

The Central Role of MAPK-ERK Signaling in IL7-Dependent and IL7-Independent Steroid Resistance Reveals a Broad Application of MEK-Inhibitors Compared to JAK1/2-Inhibition in T-ALL

Jordy C.G. Van Der Zwet, MD, Jessica G.C.A.M. Buijs-Gladdines, Valentina Cordo', MSc, Donna Debets, MSc, Willem K. Smits, Zhongli Chen, MSc, Jelle Dylus, Guido Zaman, PhD, Maarten Altelaar, PhD, Koichi Oshima, MD PhD, Beat Bornhauser, Jean-Pierre Bourquin, MD PhD, Jan Cools, PhD, Adolfo A. Ferrando, MD PhD, Josef Vormoor, MD PhD, Rob Pieters, MDPhDMSc, Britta Julia Vormoor, MD, Jules P.P. Meijerink, PhD

Blood (2020) 136 (Supplement 1): 20.

https://doi.org/10.1182/blood-2020-139305

Published: 2020

Journal Articles

Opportunities of Genome Imaging for Genetic Diagnosis in Acute Lymphoblastic Leukemia

Jolien De Bie, MD PhD, Barbara Dewaele, Olga Gielen, Katrina Rack, PhD, Johan A. Maertens, MD PhD, Heidi Segers, MD PhD, Joris Vermeesch, PhD, Kim De Keersmaecker, PhD, Jan Cools, PhD, Lucienne Michaux, MD PhD

Blood (2020) 136 (Supplement 1): 10–11.

https://doi.org/10.1182/blood-2020-139541

Published: 2020

Journal Articles

Evolution of Clinically Relevant Subclones during Chemotherapy Treatment of ALL As Determined By Single-Cell DNA and RNA Sequencing

Llucia Albertí Servera, PhD, Sofie Demeyer, PhD, Inge Govaerts, MD PhD, Olga Gielen, Heidi Segers, MD PhD, Anne Uyttebroeck, MD, Nancy Boeckx, Johan A. Maertens, MD PhD, Kim De Keersmaecker, PhD, Jan Cools, PhD

Blood (2019) 134 (Supplement_1): 2749.

https://doi.org/10.1182/blood-2019-123046

Published: 2019

Journal Articles

Benzene-Induced Leukemogenesis: Irreversible Inhibition of PTPN2 and Subsequent STAT1 Signaling Alteration By the Hematotoxic Metabolite Benzoquinone

Romain Duval, Linh-Chi Bui, PhD, Cécile Mathieu, Emile Petit, Jean-Marie Dupret, PhD, Jan Cools, PhD, Fabien Guidez, PhD, Christine Chomienne, MD PhD, Fernando Rodrigues-Lima, PhD

Blood (2015) 126 (23): 3671.

https://doi.org/10.1182/blood.V126.23.3671.3671

Published: 2015

Journal Articles

ALK-Positive Anaplastic Large Cell Lymphoma with the Variant EEF1G-, RNF213- and Atic-ALK Fusions Is Featured By Copy Number Gain of the Rearranged ALK Gene

Iwona Wlodarska, Jo-Anne van der Krogt, Julio Finalet Ferreiro, Jacobs Kris, Geerdens Ellen, Anne Uyttebroeck, Peter Vandenberghe, MDPhD, Thomas Tousseyn, MDPhD, Jan Cools, PhD

Blood (2015) 126 (23): 3654.

https://doi.org/10.1182/blood.V126.23.3654.3654

Published: 2015

Journal Articles

Transcriptional Antagonism Between the Cooperative Oncogenes TLX1 and NOTCH1 in T-Cell Acute Lymphoblastic Leukemia

Kaat Durinck, Wouter Vanloocke, Joni Van der Meulen, Inge van de Walle, Pieter Rondou, PhD, Charles De Bock, Bruno Verhasselt, Bruce Graham Poppe, MD PhD, Jan Cools, PhD, Jean Soulier, MD PhD, Tom Taghon, PhD, Frank Speleman, Pieter Van Vlierberghe

Blood (2014) 124 (21): 3588.

https://doi.org/10.1182/blood.V124.21.3588.3588

Published: 2014

Journal Articles

JAK3 Mutants Transform Hematopoietic Cells through JAK1 Activation Causing T-Cell Acute Lymphoblastic Leukemia in a Bone Marrow Transplant Mouse Model

Degryse Sandrine, Charles E de Bock, PhD, Carmen Vicente, PhD, Luk Cox, PhD, Olga Gielen, Nicole Mentens, Kris Jacobs, Ellen Geerdens, Thomas Tousseyn, PhD, Jan Cools, PhD

Blood (2014) 124 (21): 361.

https://doi.org/10.1182/blood.V124.21.361.361

Published: 2014

Journal Articles

Use of Crispr/Cas Genome Editing in Ba/F3 Cells to Generate the Fip1l1-Pdgfra and Nup214-Abl1 Fusion Genes

Marlies Vanden Bempt, Msc, Charles E de Bock, PhD, Nicole Mentens, Olga Gielen, Ellen Geerdens, Sofie Demeyer, PhD, Jan Cools, PhD

Blood (2014) 124 (21): 3575.

https://doi.org/10.1182/blood.V124.21.3575.3575

Published: 2014

Journal Articles

Involvement of FER and FES in the Pathogenesis of Follicular Variant of Peripheral T-Cell Lymphoma

Iwona Wlodarska, PhD, Jo-Anne van der Krogt, Msc, Katrien Van Roosbroeck, PhD, Julio Finalet Ferreiro, Msc, Thomas Tousseyn, MD PhD, Carlos Graux, MD PhD, Daan Dierickx, MD PhD, Peter Vandenberghe, MD PhD, Jan Cools, PhD

Blood (2014) 124 (21): 5194.

https://doi.org/10.1182/blood.V124.21.5194.5194

Published: 2014

Journal Articles

The NOTCH1 Driven Long Non-Coding RNA Repertoire in T-Cell Acute Lymphoblastic Leukemia

Annelynn Wallaert, Kaat Durinck, Pieter Rondou, PhD, Inge van de Walle, Wouter Vanloocke, Pieter-Jan Volders, Suzanne Vanhauwaert, Ellen Geerdens, Maté Ongenaert, Nadine Van Roy, Bruce Graham Poppe, MD PhD, Yves Benoit, Jan Cools, PhD, Jo Vandesompele, PhD, Jean Soulier, MD PhD, Pieter Van Vlierberghe, Tom Taghon, PhD, Frank Speleman

Blood (2014) 124 (21): 900.

https://doi.org/10.1182/blood.V124.21.900.900

Published: 2014

Journal Articles

Synergism Between HOXA9 and Mutant JAK3 (M511I) Leads to Rapid Leukemia Development within an in Vivo Murine Bone Marrow Transplant Model

Charles E de Bock, PhD, Sandrine Degryse, Sofie Demeyer, PhD, Bram Sweron, Olga Gielen, Nicole Mentens, Ellen Geerdens, Jan Cools, PhD

Blood (2014) 124 (21): 1078.

https://doi.org/10.1182/blood.V124.21.1078.1078

Published: 2014

Journal Articles

Effects of Ponatinib and Other Novel TKI On Growth, Survival, and Function of Neoplastic Eosinophils Carrying FIP1L1/Pdgfra

Irina Sadovnik, M.Sc., Peter Valent, MD, Els Lierman, PhD, Harald Herrmann, M.D., Barbara Peter, D.V.M., Verena Suppan, BSc, Gabriele Stefanzl, MSc, Winfried F Pickl, MD, Jan Cools, PhD, Peter Vandenberghe, MD, PhD

Blood (2012) 120 (21): 1760.

https://doi.org/10.1182/blood.V120.21.1760.1760

Published: 2012

Journal Articles

Non- IG Aberrations of FOXP1 in B-Cell Malignancies Result in an Aberrant Expression of N-Truncated FOXP1 Isoforms.

Iwona Wlodarska, PhD, Leila Rouhi, MD, Julio Finalet Ferreiro, M Sc, Thomas Tousseyn, MD PhD, Natalie Put, MD, Eugenia Haralambieva, MD, PhD, Carlos Graux, MD, PhD, Brigitte Maes, MD, PhD, Carmen Vicente, PhD, Peter Vandenberghe, MD, PhD, Jan Cools, PhD

Blood (2012) 120 (21): 2411.

https://doi.org/10.1182/blood.V120.21.2411.2411

Published: 2012

Journal Articles

Ponatinib Is Active Against the CUX1-FGFR1 Fusion Kinase and Against Imatinib Resistance Mutations of the FIP1L1-PDGFRα Fusion Kinase and of KIT,

Els Lierman, PhD, Sanne Smits, Jan Cools, PhD, Barbara Dewaele, PhD, Maria Debiec-Rychter, MD PhD, Peter Vandenberghe, MD, PhD

Blood (2011) 118 (21): 3848.

https://doi.org/10.1182/blood.V118.21.3848.3848

Published: 2011

Journal Articles

Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project

Jinghui Zhang, PhD, Li Ding, PhD, Linda Holmfeldt, PhD, Gang Wu, PhD, Susan L. Heatley, Ph.D., Debbie Payne-Turner, John Easton, PhD, Xiang Chen, PhD, Jianmin Wang, PhD, Michael Rusch, BA, Charles Lu, PhD, Shann-Ching Chen, PhD, Racquel Collins-Underwood, PhD, Jing Ma, PhD, Kathryn G. Roberts, PhD, Stanley Pounds, PhD, Lei Wei, PhD, Anatoly Ulyanov, PhD, Jared Becksfort, Pankaj Gupta, Robert Huether, PhD, Richard Kriwacki, PhD, Daniel McGoldrick, David Zhao, Daniel Alford, Stephen Espy, Kiran Chand Bobba, Guangchun Song, Deqing Pei, MS, Cheng Cheng, PhD, Stefan Roberts, Michael Barbato, Dario Campana, MD, PhD, Elaine Coustan-Smith, MS, William E. Evans, PharmD, Sheila A Shurtleff, PhD, Maria Kleppe, Jan Cools, PhD, Kristin Shimano, Michelle L. Hermiston, MD, PhD, Sergei Doulatov, PhD, Kolja Eppert, PhD, Elisa Laurenti, PhD, Faiyaz Notta, PhD, John E Dick, PhD, Giuseppe Basso, MD PhD, Stephen P. Hunger, MD, Mignon L Loh, MD, Meenakshi Devidas, PhD, Brent L. Wood, MD, PhD, Stuart S. Winter, MD, Kimberly Dunsmore, MD, Robert S. Fulton, MS, Lucinda A. Fulton, MS, Xin Hong, PhD, Christopher C. Harris, BS, David J. Dooling, PhD, Kerri Ochoa, Kimberly J Johnson, John C Obenauer, Ching-Hon Pui, MD, Susana C. Raimondi, PhD, Clayton W Naeve, PhD, Timothy J Ley, MD, Elaine R Mardis, PhD, Richard K Wilson, PhD, James R Downing, MD, Charles G Mullighan, MBBS, MD, FRACP, FRCPA, MSc

Blood (2011) 118 (21): 68.

https://doi.org/10.1182/blood.V118.21.68.68

Published: 2011

Journal Articles

The Kinase Inhibitor TKI258 Is Active Against the Novel CUX1-FGFR1 Fusion Detected In a Patient with T-Lymphoblastic Leukemia/Lymphoma and t(7;8)(q22;p11)

Bartosz Wasag, PhD, Els Lierman, PhD, Peter Meeus, MD, Jan Cools, PhD, Peter Vandenberghe, MD, PhD

Blood (2010) 116 (21): 2715.

https://doi.org/10.1182/blood.V116.21.2715.2715

Published: 2010

Journal Articles

BMI1 , the Polycomb-Group Gene, Is Recurrently Targeted by Genomic Rearrangements in Progressive B-Cell Leukemia/Lymphoma.

Leila Rouhi, MD, Natalie Put, MD, Thomas Tousseyn, MD, PhD, Julio Finalet Ferreiro, Wim De Kelver, Hilde Demuynck, MD, Johan Verschuere, MD, Ivan Théate, MD, Carmen Vicente, Lucienne Michaux, MD, PhD, Chris De Wolf-Peeters, MD, PhD, Peter Vandenberghe, MD, PhD, Jan Cools, PhD, Iwona Wlodarska, PhD

Blood (2009) 114 (22): 1099.

https://doi.org/10.1182/blood.V114.22.1099.1099

Published: 2009

Journal Articles

JAK2 Rearrangements, Including the Novel SEC31A-JAK2 Fusion, Are Recurrent in Classical Hodgkin Lymphoma.

Katrien Van Roosbroeck, Luk Cox, PhD, Idoya Lahortiga, PhD, Olga Gielen, Thomas Tousseyn, MD, PhD, Barbara Cauwelier, PhD, Pascale De Paepe, MD, PhD, Peter Vandenberghe, MD, PhD, Peter Marynen, PhD, Chris De Wolf-Peeters, MD, PhD, Jan Cools, PhD, Iwona Wlodarska, PhD

Blood (2009) 114 (22): 140.

https://doi.org/10.1182/blood.V114.22.140.140

Published: 2009

Journal Articles

Deletion of the Protein Tyrosine Phosphatase Gene PTPN2 in T-Cell Acute Lymphoblastic Leukemia.

Maria Kleppe, Idoya Lahortiga, PhD, Tiama El Chaar, Kim De Keersmaecker, PhD, Nicole Mentens, Carlos Graux, MD, PhD, Katrien Van Roosbroeck, Adolfo A. Ferrando, MD, PhD, Anton W Langerak, PhD, Jules P.P. Meijerink, PhD, Francois Sigaux, MD, Torsten Haferlach, MD, Iwona Wlodarska, PhD, Peter Vandenberghe, MD, PhD, Jean Soulier, MD, PhD, Jan Cools, PhD

Blood (2009) 114 (22): 141.

https://doi.org/10.1182/blood.V114.22.141.141

Published: 2009

Journal Articles

Placental Growth Factor: a Novel, Stromal-Derived Target in Human CML.

Sonja Loges, M.D., Ph.D, Thomas Schmidt, M.D., Christa Maes, Ph.D., Bart Jonckx, Maria Kleppe, Kim De Keersmaecker, Ph.D., Marc Tjwa, M.D., Ph.D., Thomas Schenk, M.D., Karolien Anne Beel, Christiane DeWolf-Peeters, M.D., Geert Carmeliet, M.D., Ph.D., Jan Cools, PhD, Richard E Clark, M.D., Peter Vandenberghe, MD, PhD, Tim H Brummendorf, M.D., Tessa Holyoake, M.D., Andreas Hochhaus, MD, Peter Carmeliet, M.D., Ph.D.

Blood (2009) 114 (22): 42.

https://doi.org/10.1182/blood.V114.22.42.42

Published: 2009

NARROW

The Central Role of MAPK-ERK Signaling in IL7-Dependent and IL7-Independent Steroid Resistance Reveals a Broad Application of MEK-Inhibitors Compared to JAK1/2-Inhibition in T-ALL

Opportunities of Genome Imaging for Genetic Diagnosis in Acute Lymphoblastic Leukemia

Evolution of Clinically Relevant Subclones during Chemotherapy Treatment of ALL As Determined By Single-Cell DNA and RNA Sequencing

Benzene-Induced Leukemogenesis: Irreversible Inhibition of PTPN2 and Subsequent STAT1 Signaling Alteration By the Hematotoxic Metabolite Benzoquinone

ALK-Positive Anaplastic Large Cell Lymphoma with the Variant EEF1G-, RNF213- and Atic-ALK Fusions Is Featured By Copy Number Gain of the Rearranged ALK Gene

Transcriptional Antagonism Between the Cooperative Oncogenes TLX1 and NOTCH1 in T-Cell Acute Lymphoblastic Leukemia

JAK3 Mutants Transform Hematopoietic Cells through JAK1 Activation Causing T-Cell Acute Lymphoblastic Leukemia in a Bone Marrow Transplant Mouse Model

Use of Crispr/Cas Genome Editing in Ba/F3 Cells to Generate the Fip1l1-Pdgfra and Nup214-Abl1 Fusion Genes

Involvement of FER and FES in the Pathogenesis of Follicular Variant of Peripheral T-Cell Lymphoma

The NOTCH1 Driven Long Non-Coding RNA Repertoire in T-Cell Acute Lymphoblastic Leukemia

Synergism Between HOXA9 and Mutant JAK3 (M511I) Leads to Rapid Leukemia Development within an in Vivo Murine Bone Marrow Transplant Model

Effects of Ponatinib and Other Novel TKI On Growth, Survival, and Function of Neoplastic Eosinophils Carrying FIP1L1/Pdgfra

Non- IG Aberrations of FOXP1 in B-Cell Malignancies Result in an Aberrant Expression of N-Truncated FOXP1 Isoforms.

Ponatinib Is Active Against the CUX1-FGFR1 Fusion Kinase and Against Imatinib Resistance Mutations of the FIP1L1-PDGFRα Fusion Kinase and of KIT,

Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project

The Kinase Inhibitor TKI258 Is Active Against the Novel CUX1-FGFR1 Fusion Detected In a Patient with T-Lymphoblastic Leukemia/Lymphoma and t(7;8)(q22;p11)

BMI1 , the Polycomb-Group Gene, Is Recurrently Targeted by Genomic Rearrangements in Progressive B-Cell Leukemia/Lymphoma.

JAK2 Rearrangements, Including the Novel SEC31A-JAK2 Fusion, Are Recurrent in Classical Hodgkin Lymphoma.

Deletion of the Protein Tyrosine Phosphatase Gene PTPN2 in T-Cell Acute Lymphoblastic Leukemia.

Placental Growth Factor: a Novel, Stromal-Derived Target in Human CML.

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American Society of Hematology

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American Society of Hematology

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