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Journal Articles

Aberrant MYCN expression drives oncogenic hijacking of EZH2 as a transcriptional activator in peripheral T-cell lymphoma

Marlies Vanden Bempt, Koen Debackere, Sofie Demeyer, Quentin Van Thillo, Nienke Meeuws, Cristina Prieto, Sarah Provost, Nicole Mentens, Kris Jacobs, Olga Gielen, David Nittner, Seishi Ogawa, Keisuke Kataoka, Carlos Graux, Thomas Tousseyn, Jan Cools, Daan Dierickx

Blood (2022) 140 (23): 2463–2476.

https://doi.org/10.1182/blood.2022016428

Published: 2022

Includes: Supplemental data

Journal Articles

Single-cell DNA amplicon sequencing reveals clonal heterogeneity and evolution in T-cell acute lymphoblastic leukemia

Llucia Albertí-Servera, Sofie Demeyer, Inge Govaerts, Toon Swings, Jolien De Bie, Olga Gielen, Marco Brociner, Lucienne Michaux, Johan Maertens, Anne Uyttebroeck, Kim De Keersmaecker, Nancy Boeckx, Heidi Segers, Jan Cools

Blood (2021) 137 (6): 801–811.

https://doi.org/10.1182/blood.2020006996

Published: 2021

Includes: Supplemental data

Journal Articles

Opportunities of Genome Imaging for Genetic Diagnosis in Acute Lymphoblastic Leukemia

Jolien De Bie, MD PhD, Barbara Dewaele, Olga Gielen, Katrina Rack, PhD, Johan A. Maertens, MD PhD, Heidi Segers, MD PhD, Joris Vermeesch, PhD, Kim De Keersmaecker, PhD, Jan Cools, PhD, Lucienne Michaux, MD PhD

Blood (2020) 136 (Supplement 1): 10–11.

https://doi.org/10.1182/blood-2020-139541

Published: 2020

Journal Articles

Evolution of Clinically Relevant Subclones during Chemotherapy Treatment of ALL As Determined By Single-Cell DNA and RNA Sequencing

Llucia Albertí Servera, PhD, Sofie Demeyer, PhD, Inge Govaerts, MD PhD, Olga Gielen, Heidi Segers, MD PhD, Anne Uyttebroeck, MD, Nancy Boeckx, Johan A. Maertens, MD PhD, Kim De Keersmaecker, PhD, Jan Cools, PhD

Blood (2019) 134 (Supplement_1): 2749.

https://doi.org/10.1182/blood-2019-123046

Published: 2019

Journal Articles

Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia

Michael Broux, Cristina Prieto, Sofie Demeyer, Marlies Vanden Bempt, Llucia Alberti-Servera, Inge Lodewijckx, Roel Vandepoel, Nicole Mentens, Olga Gielen, Kris Jacobs, Ellen Geerdens, Carmen Vicente, Charles E. de Bock, Jan Cools

Blood (2019) 134 (16): 1323–1336.

https://doi.org/10.1182/blood.2019000015

Published: 2019

Includes: Supplemental data

Journal Articles

Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL

Sandrine Degryse, Simon Bornschein, Charles E. de Bock, Emilie Leroy, Marlies Vanden Bempt, Sofie Demeyer, Kris Jacobs, Ellen Geerdens, Olga Gielen, Jean Soulier, Christine J. Harrison, Stefan N. Constantinescu, Jan Cools

Blood (2018) 131 (4): 421–425.

https://doi.org/10.1182/blood-2017-07-797597

Published: 2018

Includes: Supplemental data

Journal Articles

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors

Antonis Dagklis, Sofie Demeyer, Jolien De Bie, Enrico Radaelli, Daphnie Pauwels, Sandrine Degryse, Olga Gielen, Carmen Vicente, Roel Vandepoel, Ellen Geerdens, Anne Uyttebroeck, Nancy Boeckx, Charles E. de Bock, Jan Cools

Blood (2016) 128 (23): 2642–2654.

https://doi.org/10.1182/blood-2016-03-703454

Published: 2016

Includes: Supplemental data

Journal Articles

JAK3 Mutants Transform Hematopoietic Cells through JAK1 Activation Causing T-Cell Acute Lymphoblastic Leukemia in a Bone Marrow Transplant Mouse Model

Degryse Sandrine, Charles E de Bock, PhD, Carmen Vicente, PhD, Luk Cox, PhD, Olga Gielen, Nicole Mentens, Kris Jacobs, Ellen Geerdens, Thomas Tousseyn, PhD, Jan Cools, PhD

Blood (2014) 124 (21): 361.

https://doi.org/10.1182/blood.V124.21.361.361

Published: 2014

Journal Articles

Use of Crispr/Cas Genome Editing in Ba/F3 Cells to Generate the Fip1l1-Pdgfra and Nup214-Abl1 Fusion Genes

Marlies Vanden Bempt, Msc, Charles E de Bock, PhD, Nicole Mentens, Olga Gielen, Ellen Geerdens, Sofie Demeyer, PhD, Jan Cools, PhD

Blood (2014) 124 (21): 3575.

https://doi.org/10.1182/blood.V124.21.3575.3575

Published: 2014

Journal Articles

Synergism Between HOXA9 and Mutant JAK3 (M511I) Leads to Rapid Leukemia Development within an in Vivo Murine Bone Marrow Transplant Model

Charles E de Bock, PhD, Sandrine Degryse, Sofie Demeyer, PhD, Bram Sweron, Olga Gielen, Nicole Mentens, Ellen Geerdens, Jan Cools, PhD

Blood (2014) 124 (21): 1078.

https://doi.org/10.1182/blood.V124.21.1078.1078

Published: 2014

Journal Articles

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model

Sandrine Degryse, Charles E. de Bock, Luk Cox, Sofie Demeyer, Olga Gielen, Nicole Mentens, Kris Jacobs, Ellen Geerdens, Valentina Gianfelici, Gert Hulselmans, Mark Fiers, Stein Aerts, Jules P. Meijerink, Thomas Tousseyn, Jan Cools

Blood (2014) 124 (20): 3092–3100.

https://doi.org/10.1182/blood-2014-04-566687

Published: 2014

Includes: Supplemental data

Journal Articles

JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma

Katrien Van Roosbroeck, Luk Cox, Thomas Tousseyn, Idoya Lahortiga, Olga Gielen, Barbara Cauwelier, Pascale De Paepe, Gregor Verhoef, Peter Marynen, Peter Vandenberghe, Chris De Wolf-Peeters, Jan Cools, Iwona Wlodarska

Blood (2011) 117 (15): 4056–4064.

https://doi.org/10.1182/blood-2010-06-291310

Published: 2011

Includes: Supplemental data

Journal Articles

JAK2 Rearrangements, Including the Novel SEC31A-JAK2 Fusion, Are Recurrent in Classical Hodgkin Lymphoma.

Katrien Van Roosbroeck, Luk Cox, PhD, Idoya Lahortiga, PhD, Olga Gielen, Thomas Tousseyn, MD, PhD, Barbara Cauwelier, PhD, Pascale De Paepe, MD, PhD, Peter Vandenberghe, MD, PhD, Peter Marynen, PhD, Chris De Wolf-Peeters, MD, PhD, Jan Cools, PhD, Iwona Wlodarska, PhD

Blood (2009) 114 (22): 140.

https://doi.org/10.1182/blood.V114.22.140.140

Published: 2009

NARROW

Aberrant MYCN expression drives oncogenic hijacking of EZH2 as a transcriptional activator in peripheral T-cell lymphoma

Single-cell DNA amplicon sequencing reveals clonal heterogeneity and evolution in T-cell acute lymphoblastic leukemia

Opportunities of Genome Imaging for Genetic Diagnosis in Acute Lymphoblastic Leukemia

Evolution of Clinically Relevant Subclones during Chemotherapy Treatment of ALL As Determined By Single-Cell DNA and RNA Sequencing

Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia

Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors

JAK3 Mutants Transform Hematopoietic Cells through JAK1 Activation Causing T-Cell Acute Lymphoblastic Leukemia in a Bone Marrow Transplant Mouse Model

Use of Crispr/Cas Genome Editing in Ba/F3 Cells to Generate the Fip1l1-Pdgfra and Nup214-Abl1 Fusion Genes

Synergism Between HOXA9 and Mutant JAK3 (M511I) Leads to Rapid Leukemia Development within an in Vivo Murine Bone Marrow Transplant Model

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model

JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma

JAK2 Rearrangements, Including the Novel SEC31A-JAK2 Fusion, Are Recurrent in Classical Hodgkin Lymphoma.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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