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Jennifer Brogdon, PhD
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Journal Articles

Single Chain Variable Fragment Linker Length Regulates CAR Biology and T Cell Efficacy

Nathan Singh, MD, Noelle V. Frey, MD, Boris Engels, PhD, David M. Barrett, Olga Shestova, PhD, Pranali Ravikumar, MS, Amy Shyu, Steven Highfill, PhD, Linlin Zhao, Liaomin Peng, Brian Granda, Melissa Ramones, Xeuqing Maggie Lu, David A Christian, PhD, Jessica Perazzelli, Simon F Lacey, PhD, Nathan Roy, Janis K Burkhardt, PhD, Florent Colomb, Mohamed Abdel-Mohsen, Regina M Young, PhD, Jennifer Brogdon, PhD, Stephan Grupp, MD PhD, Carl H June, MD, Shannon L. Maude, MD PhD, Saar I. Gill, MD PhD, Marco Ruella, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 247.
https://doi.org/10.1182/blood-2019-131024
Published: 2019
Journal Articles

Combination Anti-Bcma and Anti-CD19 CAR T Cells As Consolidation of Response to Prior Therapy in Multiple Myeloma

Alfred L. Garfall, MD, Adam D. Cohen, MD, Simon F Lacey, PhD, Lifeng Tian, PhD, Wei-Ting Hwang, PhD, Dan T. Vogl, MD, Adam Waxman, MD, Eric Lancaster, MD, Anne Marie Nelson, Regina Ferthio, Andrew Fesnak, MD, Anne Lamontagne, Andrea Brennan, Jamie Guilliams, Whitney Lynn Gladney, PhD, J. Joseph Melenhorst, PhD, Regina M Young, PhD, Don L. Siegel, MD PhD, Bruce L Levine, PhD, Jennifer Brogdon, PhD, Randi E. Isaacs, MD, Carl H June, MD, Michael C. Milone, Edward A. Stadtmauer, MD FACP
Journal: Blood
Blood (2019) 134 (Supplement_1): 1863.
https://doi.org/10.1182/blood-2019-131515
Published: 2019
Journal Articles

Response to Anti-Bcma CAR T Cell Therapy Correlates with T Cell Exhaustion and Activation Status in T Cells at Baseline in Myeloma

Meng Wang, BS, Iulian Pruteanu, PhD, Adam D. Cohen, MD, Alfred L. Garfall, MD, Lifeng Tian, PhD, Simon F Lacey, PhD, Joseph A Fraietta, PhD, Jennifer Brogdon, PhD, Megan Davis, PhD, Vanessa E. Gonzalez, Bruce L Levine, PhD, Don L. Siegel, MD PhD, Michael C. Milone, Edward A. Stadtmauer, MD FACP, Carl H June, MD, J. Joseph Melenhorst, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1909.
https://doi.org/10.1182/blood-2019-122396
Published: 2019
Journal Articles

Identification of Functional Determinants of Response and Resistance to CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy of Chronic Lymphocytic Leukemia

Joseph A Fraietta, PhD, Simon F Lacey, PhD BS, Elena Orlando, PhD, Julian Pruteanu, PhD, Mercy Gohil, Yan Wang, PhD, Alina Boesteanu, PhD, Roddy OConnor, PhD, David E Ambrose, BS, Wei-Ting Hwang, PhD, Nicholas Wilcox, Felipe Bedoya, PhD, Corin Dorfmeier, Fang Chen, PhD, Harit Parakandi, Minnal Gupta, Edward Pequignot, MS, F. Brad Johnson, PhD, Irina Kulikovskaya, Li Liu, Stefan M Lundh, BS, Jun Xu, PhD, Megan M Davis, PhD, Regina M Young, PhD, Bruce L Levine, PhD, Don L. Siegel, MD PhD, Alexander Huang, PhD, E. John Wherry, PhD, Jing Zhou, Patrick Paczkowski, Sean Mackay, Jennifer Brogdon, PhD, Hans Bitter, PhD, David L Porter, MD, Carl H June, MD, J. Joseph Melenhorst, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3181.
https://doi.org/10.1182/blood.V130.Suppl_1.3181.3181
Published: 2017
Journal Articles

Durable Remissions with Humanized CD19-Targeted Chimeric Antigen Receptor (CAR)-Modified T Cells in CAR-Naive and CAR-Exposed Children and Young Adults with Relapsed/Refractory Acute Lymphoblastic Leukemia

Shannon L Maude, MD PhD, George E Hucks, Colleen Callahan, Diane Baniewicz, Christina Fasano, Christine Barker, Susan R. Rheingold, MD, Richard Aplenc, MD, Amanda M. Dinofia, MD, Amanda Li, MD BSc, David T Teachey, MD, David M. Barrett, Jennifer Brogdon, PhD, Regina M Young, PhD, John Scholler, Katherine T Marcucci, PhD, Bruce L Levine, PhD, Noelle Frey, MD, David L Porter, MD, Simon F Lacey, PhD BS, J. Joseph Melenhorst, PhD, Carl H June, MD, Stephan A Grupp, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1319.
https://doi.org/10.1182/blood.V130.Suppl_1.1319.1319
Published: 2017
Journal Articles

Clinical Efficacy of Anti-CD22 Chimeric Antigen Receptor T Cells for B-Cell Acute Lymphoblastic Leukemia Is Correlated with the Length of the Scfv Linker and Can be Predicted Using Xenograft Models

Marco Ruella, MD, Shannon L Maude, MD PhD, Boris Engels, PhD, David M. Barrett, Noelle Frey, MD, Katherine T Marcucci, PhD, Olga Shestova, PhD, Nathan Singh, MD, Jessica Perazzelli, PhD, David A Christian, PhD, Dana Haagen, BS, Simon F Lacey, PhD BS, J. Joseph Melenhorst, PhD, Jennifer Brogdon, PhD, Regina M Young, PhD, David L Porter, MD, Carl H June, MD, Stephan A Grupp, MD PhD, Saar I. Gill, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 807.
https://doi.org/10.1182/blood.V130.Suppl_1.807.807
Published: 2017
Journal Articles

Efficacy and Safety of Humanized Chimeric Antigen Receptor (CAR)-Modified T Cells Targeting CD19 in Children with Relapsed/Refractory ALL

Shannon L Maude, MD PhD, David M. Barrett, MD PhD, David E Ambrose, Susan R. Rheingold, MD, Richard Aplenc, MD PhD, David T Teachey, MD, Colleen Callahan, MSN, Christine S Barker, Maya Mudambi, Pamela A Shaw, PhD, Jennifer Brogdon, PhD, Regina M Young, PhD, John Scholler, Andreas Loew, PhD, Katherine T. Marcucci, PhD, Jeffrey Finklestein, Irina Kulikovskaya, PhD, Farzana Nazimuddin, Zhaohui Zheng, MS, Bruce L. Levine, PhD, David L Porter, MD, Simon F. Lacey, PhD BS, Jan J. Melenhorst, PhD, Carl H. June, MD, Stephan A. Grupp, MD PhD
Journal: Blood
Blood (2015) 126 (23): 683.
https://doi.org/10.1182/blood.V126.23.683.683
Published: 2015