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Journal Articles

Variation in mesenchymal KITL/SCF and IGF1 expression in middle age underlies steady-state hematopoietic stem cell aging

Kira A. Young, Maria A. Telpoukhovskaia, Johanna Hofmann, Jayna J. Mistry, Konstantinos D. Kokkaliaris, Jennifer J. Trowbridge

Blood (2024) 144 (4): 378–391.

https://doi.org/10.1182/blood.2024024275

Published: 2024

Includes: Supplemental data

Journal Articles

Reduction in Lymphoid-Supporting Factors By Mesenchymal Stromal Cells Drives Myeloid-Biased Hematopoiesis at Middle Age

Kira A. Young, Maria A. Telpoukhovskaia, Johanna Hofmann, Konstantinos D. Kokkaliaris, Jayna J. Mistry, Jennifer J. Trowbridge

Blood (2023) 142 (Supplement 1): 2701.

https://doi.org/10.1182/blood-2023-181924

Published: 2023

Journal Articles

Dnmt3a -Mutant Haematopoietic Stem and Progenitor Cells Induce Mesenchymal Stromal Cell Senescence through the Production of Alarmins S100A8/A9

Jayna J. Mistry, Kira A. Young, Patricia Colom Diaz, Ines Fernandez Maestre, Ross L Levine, Jennifer J. Trowbridge

Blood (2023) 142 (Supplement 1): 1331.

https://doi.org/10.1182/blood-2023-181888

Published: 2023

Journal Articles

Elevated Functional Hematopoietic Stem and Progenitor Cells in the Peripheral Blood of G-CSF-Mobilized Dnmt3a -Mutant Mice

Kira A. Young, Griffin J. Nye, Jennifer J. Trowbridge

Blood (2023) 142 (Supplement 1): 6783.

https://doi.org/10.1182/blood-2023-181913

Published: 2023

Journal Articles

Bone Marrow Microenvironment and Hematopoietic Cell Types Are Differentially Affected By Transcriptomic Quality Control Filtering Metrics in Single Cell Data

Maria A. Telpoukhovskaia, Kira A. Young, Jayna J. Mistry, Jennifer J. Trowbridge

Blood (2023) 142 (Supplement 1): 5621.

https://doi.org/10.1182/blood-2023-181867

Published: 2023

Journal Articles

DNMT3A -Mutated Stem and Progenitor Cells Contribute to Altered T Cell Activation in Clonal Hematopoiesis

Ksenia R. Safina, Shawn David, Kyle A. Romine, Kristina D. Mujica, Daniel Ssozi, Jonathan Good, Nurefsan Sariipek, Yoke Seng Lee, Adrienne Parsons, Sarah Bibeau, Adam S. Sperling, Christopher James Gibson, Gabriel K. Griffin, Alexander G. Bick, Antonia Kreso, Jennifer J. Trowbridge, Peter van Galen

Blood (2023) 142 (Supplement 1): 1320.

https://doi.org/10.1182/blood-2023-180180

Published: 2023

Journal Articles

Oncostatin M (OSM) Regulates an Inflammatory Cytokine Network in Dnmt3a -Mutant Hematopoietic Stem Cells

Logan Sari Schwartz, Kira A. Young, Tim Stearns, Nathan Boyer, Kristina Mujica, Jennifer J. Trowbridge

Blood (2023) 142 (Supplement 1): 5603.

https://doi.org/10.1182/blood-2023-182334

Published: 2023

Journal Articles

Hematopoietic stem cell aging and leukemia transformation

Patricia A. Colom Díaz, Jayna J. Mistry, Jennifer J. Trowbridge

Blood (2023) 142 (6): 533–542.

https://doi.org/10.1182/blood.2022017933

Published: 2023

Journal Articles

Robust Mitochondrial Metabolism Provides a Fitness Advantage to Dnmt3a -Mutant Hematopoietic Stem Cells in the Context of Aging

Kira A Young, Jayna J Mistry, James Chavez, Eric Pietras, Jennifer J Trowbridge

Blood (2022) 140 (Supplement 1): 2866–2867.

https://doi.org/10.1182/blood-2022-163707

Published: 2022

Journal Articles

Metallothionein 1 (MT1) Is Selectively Required for DNMT3A;NPM1 -Mutant Acute Myeloid Leukemia Proliferation

Patricia A. Colom Diaz, Chih-Hsing Chou, Jayna J Mistry, Nathan Salomonis, Mohammad Daud Khan, H. Leighton Grimes, Jennifer J Trowbridge

Blood (2022) 140 (Supplement 1): 9103–9104.

https://doi.org/10.1182/blood-2022-163355

Published: 2022

Journal Articles

Bone Marrow Stromal Cell Senescence Induced By Dnmt3a -Mutant Hematopoietic Stem and Progenitor Cells Accelerates Clonal Hematopoiesis and Progression to Leukemia

Jayna J Mistry, Kira A Young, Jennifer J Trowbridge

Blood (2022) 140 (Supplement 1): 1265.

https://doi.org/10.1182/blood-2022-169485

Published: 2022

Journal Articles

Multi-Recombinase Mouse Models of Flt3-Driven Leukemia Identifies Distinct Trajectories of Mutational Cooperativity and Leukemic Transformation

Robert L. Bowman, Tanmay Mishra, Shira E. Eisman, Louise Cai, Wenbin Xiao, Michael R. Waarts, Pablo Sanchez Vela, Inés Fernández-Maestre, Isabelle S. Csete, Chad R. Potts, Matthew T. Jenkins, Linde A. Miles, Jennifer J. Trowbridge, Paul Brent Ferrell, Jr., Ross L. Levine

Blood (2021) 138 (Supplement 1): 2220.

https://doi.org/10.1182/blood-2021-149846

Published: 2021

Journal Articles

Intrinsic and Extrinsic Factors Driving Hematopoietic Stem Cell Aging and Bone Marrow Failure

Jennifer J. Trowbridge, PhD

Blood (2019) 134 (Supplement_1): SCI-35.

https://doi.org/10.1182/blood-2019-121044

Published: 2019

Journal Articles

Context-specific tumor suppression by PHF6

Jennifer J. Trowbridge

Blood (2019) 133 (16): 1698–1700.

https://doi.org/10.1182/blood-2019-03-900829

Published: 2019

Journal Articles

The Middle-Aged Bone Marrow Microenvironment Drives Hematopoietic Stem Cell Aging through Altered Production of Insulin-like Growth Factor-1 (IGF1)

Kira Young, PhD, Matthew Loberg, BA, Elizabeth Eudy, BS, Rebecca Bell, BA, Jennifer J. Trowbridge, PhD

Blood (2018) 132 (Supplement 1): 5091.

https://doi.org/10.1182/blood-2018-99-111055

Published: 2018

Journal Articles

Mutation in DNA Methyltransferase DNMT3A Confers Enhanced Self-Renewal Capacity Onto Multipotent Progenitor Cells and Predisposes to Acute Myeloid Leukemia (AML)

Matthew Loberg, BA, Rebecca Bell, BA, Tim Stearns, Leslie Goodwin, Kira Young, PhD, David Bergstrom, Rebekka Schneider, MD PhD, Jennifer J. Trowbridge, PhD

Blood (2018) 132 (Supplement 1): 2569.

https://doi.org/10.1182/blood-2018-99-111560

Published: 2018

Journal Articles

Decreased IGF-1 Expression in the Bone Marrow Microenvironment Drives Hematopoietic Aging

Kira Young, PhD, Matthew Loberg, BA, Rebecca Bell, BA, Jennifer J. Trowbridge, PhD

Blood (2017) 130 (Supplement 1): 2440.

https://doi.org/10.1182/blood.V130.Suppl_1.2440.2440

Published: 2017

Journal Articles

Lysine Methyltransferase Kmt5a Restricts Myeloid-Biased Output of Lymphoid-Primed Multipotent Progenitors

Sneha Borikar, Vivek Philip, PhD, Lauren Kuffler, Jennifer J. Trowbridge, PhD

Blood (2016) 128 (22): 1487.

https://doi.org/10.1182/blood.V128.22.1487.1487

Published: 2016

Journal Articles

Single-Cell Analysis of Lymphoid-Primed Multipotent Progenitors (LMPPs) Reveal Alterations in Lineage Commitment during Aging

Sneha Borikar, Vivek Philip, PhD, Jennifer J. Trowbridge, PhD

Blood (2015) 126 (23): 244.

https://doi.org/10.1182/blood.V126.23.244.244

Published: 2015

Journal Articles

Genetic or Pharmacological Reductions in DNA Methylation Selectively Inhibit Peripheral T-Cell Lymphomagenesis.

Jennifer J. Trowbridge, PhD, Mingjie Li, Charles W.M. Roberts, MD, PhD, Stuart H. Orkin, MD

Blood (2012) 120 (21): 2760.

https://doi.org/10.1182/blood.V120.21.2760.2760

Published: 2012

NARROW

Variation in mesenchymal KITL/SCF and IGF1 expression in middle age underlies steady-state hematopoietic stem cell aging

Reduction in Lymphoid-Supporting Factors By Mesenchymal Stromal Cells Drives Myeloid-Biased Hematopoiesis at Middle Age

Dnmt3a -Mutant Haematopoietic Stem and Progenitor Cells Induce Mesenchymal Stromal Cell Senescence through the Production of Alarmins S100A8/A9

Elevated Functional Hematopoietic Stem and Progenitor Cells in the Peripheral Blood of G-CSF-Mobilized Dnmt3a -Mutant Mice

Bone Marrow Microenvironment and Hematopoietic Cell Types Are Differentially Affected By Transcriptomic Quality Control Filtering Metrics in Single Cell Data

DNMT3A -Mutated Stem and Progenitor Cells Contribute to Altered T Cell Activation in Clonal Hematopoiesis

Oncostatin M (OSM) Regulates an Inflammatory Cytokine Network in Dnmt3a -Mutant Hematopoietic Stem Cells

Hematopoietic stem cell aging and leukemia transformation

Robust Mitochondrial Metabolism Provides a Fitness Advantage to Dnmt3a -Mutant Hematopoietic Stem Cells in the Context of Aging

Metallothionein 1 (MT1) Is Selectively Required for DNMT3A;NPM1 -Mutant Acute Myeloid Leukemia Proliferation

Bone Marrow Stromal Cell Senescence Induced By Dnmt3a -Mutant Hematopoietic Stem and Progenitor Cells Accelerates Clonal Hematopoiesis and Progression to Leukemia

Multi-Recombinase Mouse Models of Flt3-Driven Leukemia Identifies Distinct Trajectories of Mutational Cooperativity and Leukemic Transformation

Intrinsic and Extrinsic Factors Driving Hematopoietic Stem Cell Aging and Bone Marrow Failure

Context-specific tumor suppression by PHF6

The Middle-Aged Bone Marrow Microenvironment Drives Hematopoietic Stem Cell Aging through Altered Production of Insulin-like Growth Factor-1 (IGF1)

Mutation in DNA Methyltransferase DNMT3A Confers Enhanced Self-Renewal Capacity Onto Multipotent Progenitor Cells and Predisposes to Acute Myeloid Leukemia (AML)

Decreased IGF-1 Expression in the Bone Marrow Microenvironment Drives Hematopoietic Aging

Lysine Methyltransferase Kmt5a Restricts Myeloid-Biased Output of Lymphoid-Primed Multipotent Progenitors

Single-Cell Analysis of Lymphoid-Primed Multipotent Progenitors (LMPPs) Reveal Alterations in Lineage Commitment during Aging

Genetic or Pharmacological Reductions in DNA Methylation Selectively Inhibit Peripheral T-Cell Lymphomagenesis.

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American Society of Hematology

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American Society of Hematology

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