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Jonathan C Strefford, PhD
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Journal Articles

The Association between Deaths Due to Infection and Mutations of the BRAF, FBXW7, NRAS and XPO1 genes: A Report from the LRF CLL4 Trial

Monica Else, MA,MSc, Stuart J Blakemore, PhD, Jonathan C Strefford, PhD, Daniel Catovsky, MD FRCP
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-134544
Published: 2020
Journal Articles

High Surface IgM Levels Associate with Shorter Response Duration and Bypass of the BTK Blockade during Ibrutinib Therapy in CLL Patients

Giorgia Chiodin, David Dutton, MD, Enrica Antonia Martino, MD, Samantha Drennan, PhD, Ian Tracy, PhD, Laura Ondrisova, Isla Henderson, Annalisa D'Avola, PhD, Christina Pitsillidou, Marek Mraz, MD, Peter Johnson, MDFRCP, Andrew Duncombe, MD, Graham Packham, PhD, Andrew J Steele, PhD, Helen Parker, PhD, Silvia Bonfiglio, Lydia Scarfo, MD, Lesley-Ann Sutton, Paolo Ghia, MD PhD, Matthew John Jerome Rose-Zerilli, PhD, Jonathan C Strefford, PhD, Freda K. Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2019) 134 (Supplement_1): 1752.
https://doi.org/10.1182/blood-2019-128899
Published: 2019
Journal Articles

Clinical Importance of DNA Methylation Signatures in Chronic Lymphocytic Leukaemia Patients Treated with Chemo-Immunotherapy

Harindra Amarasinghe, PhD, Tomasz K Wojdacz, PhD MSc, Matthew John Jerome Rose-Zerilli, PhD, Alice Beattie, Jade Forster, PhD, Latha Kadalayil, Stuart Blakemore, PhD, Helen Parker, PhD, Marta Larrayoz, PhD, Ruth Clifford, Zadie Davis, Monica Else, Dena Cohen, Andrew J Steele, PhD, Richard Rosenquist, MD PhD, Andrew Collins, Andrew Pettitt, FRCPath, PhD, Peter Hillmen, MBChB, PhD, Pauline Robbe, MSc, Christopher Plass, Anna Schuh, MD PhD, Daniel Catovsky, MD FRCP, David Oscier, MD PhD, Christopher C. Oakes, PhD, Jonathan C Strefford, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 56.
https://doi.org/10.1182/blood.V130.Suppl_1.56.56
Published: 2017
Journal Articles

Influence of Baseline Disease Characteristics and Exposure to Obinutuzumab on Clinical Outcome in Patients with Previously Untreated Advanced Follicular Lymphoma Treated with Obinutuzumab-Based Immunochemotherapy in the GALLIUM Trial

Candice Jamois, Ekaterina Gibiansky, Leonid Gibiansky, Vincent Buchheit, Pauline Baumlin, Denis Sahin, Guillaume Cartron, Robert Marcus, Wolfgang Hiddemann, MD PhD, John F Seymour, MBBS, PhD, Jonathan C Strefford, PhD, Georgina Meneses-Lorente, Nicolas Frey, Günter Fingerle-Rowson
Journal: Blood
Blood (2017) 130 (Supplement 1): 3848.
https://doi.org/10.1182/blood.V130.Suppl_1.3848.3848
Published: 2017
Journal Articles

Genomic Complexity in Chronic Lymphocytic Leukemia Defined By Array-Based Analysis: Definitions, Associations with Other Biomarkers and Clinical Impact

Alexander Leeksma, MD, Panagiotis Baliakas, MD PhD, Clemens Mellink, PhD, Theodoros Moysiadis, PhD BSc, MSc, Anna Puiggros, PhD, Karla Plevova, PhD, Eva van den Berg, PhD, Eric Eldering, Aron Skaftason, Larry Mansouri, Rebeqa Gunnarsson, PhD, Paolo Ghia, MD PhD, Blanca Espinet, PhD, Sarka Pospisilova, MD PhD, Florence Nguyen-Khac, MD PhD, David Oscier, MD PhD, Kostas Stamatopoulos, Claudia Haferlach, MD, Richard Rosenquist, MD PhD, Jonathan C Strefford, PhD, Marian Stevens-Kroef, PhD, Arnon P. Kater, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4280.
https://doi.org/10.1182/blood.V130.Suppl_1.4280.4280
Published: 2017
Journal Articles

PI3Kδ/AKT Inhibition Augments 2-Phenylethynesulfonamide Induced Apoptosis Via the Unfolded Protein Response in Chronic Lymphocytic Leukemia

Matthew D Blunt, PhD, Lindsay D Smith, PhD, Adam Linley, PhD BSc, Jonathan C Strefford, PhD, Peter Johnson, Francesco Forconi, MD DM, PhD FRCPath, Freda K. Stevenson, DPhil, Graham Packham, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4290.
https://doi.org/10.1182/blood.V130.Suppl_1.4290.4290
Published: 2017
Journal Articles

Different Time-Dependent Risk for Disease Evolution in Chronic Lymphocytic Leukemia with Distinct IGHV Gene Somatic Hypermutation Status

Theodoros Moysiadis, PhD BSc, MSc, Panagiotis Baliakas, MD PhD, Davide Rossi, MD PhD, Mark Catherwood, Jonathan C Strefford, PhD, Julio Delgado, MD, Achilles Anagnostopoulos, Chrysoula Belessi, Niki Stavroyianni, Sarka Pospisilova, MD PhD, David Oscier, MD PhD, Gianluca Gaidano, MD PhD, Elias Campo, MD PhD, Richard Rosenquist, MD PhD, Paolo Ghia, Kostas Stamatopoulos
Journal: Blood
Blood (2017) 130 (Supplement 1): 3001.
https://doi.org/10.1182/blood.V130.Suppl_1.3001.3001
Published: 2017
Journal Articles

Regulation and Impact of BCR Induced Autophagy in Chronic Lymphocytic Leukemia

Lindsay D Smith, PhD, Laura I Karydis, PhD, Margaret Ashton-Key, MD, Jonathan C Strefford, PhD, Freda K. Stevenson, DPhil, Graham Packham, PhD, Mark Cragg, PhD, David A Tumbarello, PhD, Matthew D Blunt, PhD, Francesco Forconi, MD DM, PhD FRCPath, Andrew J Steele, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1717.
https://doi.org/10.1182/blood.V130.Suppl_1.1717.1717
Published: 2017
Journal Articles

The Contribution of Gene Mutations to Long-Term Clinical Outcomes: Data from the Randomised UK LRF CLL4 Trial

Stuart Blakemore, PhD, Ruth Clifford, Pavlos Antoniou, Helen Parker, PhD, Pauline Robbe, MSc, Marta Larrayoz, PhD, Zadie Davis, Latha Kadalyayil, Andrew Collins, Jade Forster, PhD, Monica Else, Andrew J Steele, PhD, Jacqueline Chan, PhD, Graham Speight, PhD, Mark Cragg, PhD, Matthew John Jerome Rose-Zerilli, PhD, Daniel Catovsky, MD FRCP, David Oscier, MD PhD, Anna Schuh, MD PhD, Jonathan C Strefford, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 259.
https://doi.org/10.1182/blood.V130.Suppl_1.259.259
Published: 2017
Journal Articles

Genomic Disruption of the Histone Methyltransferase SETD2 in Chronic Lymphocytic Leukemia

Matthew John Jerome Rose-Zerilli, PhD, Helen Parker, Marta Larrayoz, PhD, Ruth Clifford, Stuart Blakemore, Jennifer Edelmann, MD, Jane Gibson, Jun Wang, Viktor Ljungstrom, Tracy Chaplin, Ali Roghanian, Zadie Davis, Anton Parker, BSc, Eugen Tausch, MD, Stavroula Ntoufa, Sara Ramos, Pauline Robbe, MSc, Andrew J Steele, PhD, Graham Packham, PhD, Ana E. Rodriguez, Lee Brown, Feargal McNicholl, Francesco Forconi, MD DM, PhD FRCPath, Andrew R Pettitt, MRCP PhD, Peter Hillmen, Martin J.S. Dyer, Prof., Mark S Cragg, PhD, Bryan D Young, BSc, PhD, Claude Chelala, Richard Rosenquist, Kostas Stamatopoulos, MD, Stephan Stilgenbauer, Samantha Knight, Anna Schuh, MD PhD, David Oscier, Jonathan C Strefford, PhD
Journal: Blood
Blood (2015) 126 (23): 365.
https://doi.org/10.1182/blood.V126.23.365.365
Published: 2015
Journal Articles

EGR2 Mutations in Chronic Lymphocytic Leukemia: A New Bad Player

Daniel Noerenberg*, Emma Young*, Viktor Ljungström, Larry Mansouri, Karla Plevova, Panagiotis Baliakas, Stuart Blakemore, Davide Rossi, MD PhD, Ruth Clifford, Veronika Navrkalova, PhD, Lesley-Ann Sutton, Karin E Smedby, MD PhD, Gunnar Juliusson, Chrysoula Belessi, Panagiotis Panagiotidis, Nicholas Chiorazzi, MD, Frederic Davi, Anton W. Langerak, Anna Schuh, MD PhD, Gianluca Gaidano, MD PhD, Jonathan C Strefford, PhD, Paolo Ghia, Kostas Stamatopoulos, Sarka Pospisilova, Thorsten Zenz, Richard Rosenquist**, Frederik Damm**
Journal: Blood
Blood (2015) 126 (23): 4126.
https://doi.org/10.1182/blood.V126.23.4126.4126
Published: 2015
Journal Articles

Biological Significance of B Cell Receptor Mediated Regulation of Autophagy in Chronic Lymphocytic Leukemia

Lindsay Smith, PhD, Elizabeth Hogg, BSc(Hons), Angus Haynes, Jonathan C Strefford, PhD, Francesco Forconi, MD DM, PhD FRCPath, Freda K Stevenson, DPhil, Graham Packham, PhD, Mark S Cragg, PhD, David Tumbarello, Matthew D Blunt, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2015) 126 (23): 4130.
https://doi.org/10.1182/blood.V126.23.4130.4130
Published: 2015
Journal Articles

ATM Mutations in Major Stereotyped CLL Subsets: Enrichment in Subset #2 is Associated with Unfavourable Outcome

Veronika Navrkalova, PhD, Emma Young, Panagiotis Baliakas, Lenka Radova, Karla Plevova, PhD, Lesley-Ann Sutton, Larry Mansouri, Viktor Ljungstrom, Stavroula Ntoufa, Zadie Davis, Gunnar Juliusson, MD PhD, Karin E Smedby, MD PhD, Chrysoula Belessi, Panagiotis Panagiotidis, Frederic Davi, MD PhD, Anton W. Langerak, Paolo Ghia, MD PhD, Jonathan C Strefford, PhD, David G Oscier, Kostas Stamatopoulos, Sarka Pospisilova, Richard Rosenquist, Martin Trbusek, PhD
Journal: Blood
Blood (2015) 126 (23): 1712.
https://doi.org/10.1182/blood.V126.23.1712.1712
Published: 2015
Journal Articles

The Syk\Jak Inhibitor Cerdulatinib (PRT062070) Shows Promising Preclinical Activity in Chronic Lymphocytic Leukemia By Antagonising B Cell Receptor and Microenvironmental Signalling

Matthew D Blunt, PhD, Jack Parnell, BSc(hons), Marta Larrayoz, PhD, Lindsay Smith, PhD, Rachel Dobson, BSc(Hons), Jonathan C Strefford, PhD, Freda K Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath, Andrew J Davies, MRCP, Peter W Johnson, MD, Graham Packham, PhD, Greg P. Coffey, PhD, Mark S Cragg, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2015) 126 (23): 1716.
https://doi.org/10.1182/blood.V126.23.1716.1716
Published: 2015
Journal Articles

Genomic Dissection of the Fcγ Receptor Region in the Context of Monoclonal Antibody Therapy

Chantal Hargreaves, PhD, Chisako Iriyama, MD PhD, Matthew JJ Rose-Zerilli, PhD, Charlotte Lee, BSc, Kathleen Potter, PhD, Rosalind Ganderton, Khiyam Hussain, Lee Machado, PhD, Edward Hollox, Sarah E Coupland, MBBS, PhD, Michael Stackpole, Melanie Oates, PhD, Andrew R. Pettitt, PhD MRCPath, Mark Cragg, PhD, Jonathan C Strefford, PhD
Journal: Blood
Blood (2014) 124 (21): 2996.
https://doi.org/10.1182/blood.V124.21.2996.2996
Published: 2014
Journal Articles

IL-4 Exerts Opposing Effects on Surface-IgM and CXCR4 Mediated Signalling in Chronic Lymphocytic Leukaemia

Maria Montserrat Aguilar, PhD, Matthew D Blunt, PhD, Jonathan C Strefford, PhD, Francesco Forconi, MD DM, PhD FRCPath, Mark Cragg, PhD, Freda K Stevenson, DPhil, Graham Packham, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2014) 124 (21): 3299.
https://doi.org/10.1182/blood.V124.21.3299.3299
Published: 2014
Journal Articles

Splicing Inhibition By Spliceostatin_A Is a Promising Therapeutic Strategy in Chronic Lymphocytic Leukaemia

Marta Larrayoz, PhD, Stuart Blakemore, Rachel Dobson, BSc, Matthew Rose-Zerilli, PhD, Renata Walewska, Matthew Blunt, PhD, Minoru Yoshida, PhD, David G Oscier, MD, Mark Cragg, PhD, Andrew J Steele, PhD, Jonathan C Strefford, PhD
Journal: Blood
Blood (2014) 124 (21): 3301.
https://doi.org/10.1182/blood.V124.21.3301.3301
Published: 2014
Journal Articles

The Dual PI3K/mTOR Inhibitor PF-04691502 Induces Substantial Apoptosis in Chronic Lymphocytic Leukemia Cells in Vitro and Prolongs Survival in the Eµ-TCL1 Mouse Model

Matthew D Blunt, PhD, Matthew J Carter, PhD, Marta Larrayoz, PhD, Maria Montserrat Aguilar, PhD, Sarah Murphy, Mark Reynolds, Thomas Tipton, Kerry Cox, Jonathan C Strefford, PhD, Freda K Stevenson, DPhil, Francesco Forconi, Graham Packham, PhD, Mark Cragg, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2014) 124 (21): 832.
https://doi.org/10.1182/blood.V124.21.832.832
Published: 2014
Journal Articles

Deep-Sequencing Reveals the Molecular Landscape of Splenic Marginal Zone Lymphoma: Biological and Clinical Implications

Matthew JJ Rose-Zerilli, PhD, Marina Parry, Viktor Ljungstrom, Jane Gibson, Jun Wang, Renata Walewska, Helen Parker, PhD, Anton Parker, Zadie Davis, Anne Catherine Gardiner, Neil McIver-Brown, Christina H. Kalpadakis, MD, Aliki Xochelli, Achilles Anagnostopoulos, Claudia Fazi, PhD, David Gonzalez de Castro, PhD, Claire Dearden, MD, Guy Pratt, Richard Rosenquist, MD PhD, Margaret Ashton-Keys, Francesco Forconi, Andrew Collins, PhD, Paolo Ghia, MD PhD, Estella Matutes, MD PhD, Gerassimos A Pangalis, Kostas Stamatopoulos, David G Oscier, MD, Jonathan C Strefford, PhD
Journal: Blood
Blood (2014) 124 (21): 76.
https://doi.org/10.1182/blood.V124.21.76.76
Published: 2014
Journal Articles

Tracking Subclonal Mutations in IGHV-Mutated CLL with Progressive Disease

Matthew JJ Rose-Zerilli, PhD, Gibson Jane, PhD, Jun Wang, PhD, William J Tapper, PhD, Helen Parker, PhD, Anton Parker, Zadie Davis, Anne Catherine Gardiner, Jade Forster, Andrew J Steele, PhD, Renata Walewska, Helen McCarthy, Andrew Collins, PhD, David G Oscier, MD, Jonathan C Strefford, PhD
Journal: Blood
Blood (2014) 124 (21): 1962.
https://doi.org/10.1182/blood.V124.21.1962.1962
Published: 2014