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Jonathan J Keats, PhD
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Journal Articles

Chromatin Accessibility Identifies Regulatory Elements Predictive of Oncogene Expression in Multiple Myeloma

Benjamin G Barwick, PhD, Vikas A. Gupta, MD PhD, Shannon M Matulis, PhD, Jonathan C Patton, B.S., Doris R Powell, MA, Yanyan Gu, MD PhD, David L. Jaye, MD, Karen N Conneely, PhD, Yin C Lin, PhD, Craig C Hofmeister, MDMPH, Ajay Nooka, MDMPH, Jonathan J Keats, PhD, Sagar Lonial, MD FACP, Paula M Vertino, PhD, Larry H. Boise, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
https://doi.org/10.1182/blood-2020-140717
Published: 2020
Journal Articles

Unsupervised Clustering of DNA Copy Number Profiles Identifies a High-Risk Subtype of Hyperdiploid Multiple Myeloma: An Mmrf Commpass Analysis

Austin Christofferson, BSc, Sheri Skerget, PhD, Jessica Aldrich, Christophe Legendre, PhD, Sara Nasser, PhD, Jennifer Yesil, Daniel Auclair, The MMRF CoMMpass Network, Sagar Lonial, Jonathan J Keats, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1805.
https://doi.org/10.1182/blood-2019-132152
Published: 2019
Journal Articles

Molecular Characterization of Bone Marrow and Peripheral Blood Compartments from Patients with Plasma Cell Leukemia in the Mmrf Commpass Study

Sheri Skerget, PhD, Austin Christofferson, BSc, Sara Nasser, PhD, Christophe Legendre, PhD, The MMRF CoMMpass Network, Jennifer Yesil, Daniel Auclair, Sagar Lonial, Jonathan J Keats, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1782.
https://doi.org/10.1182/blood-2019-130697
Published: 2019
Journal Articles

Proteasome Inhibitors Impair the Innate Antiviral Immune Response and Potentiate Pelareorep-Based Viral Therapy in Multiple Myeloma

Ada Dona', PhD, Domenico Viola, Enrico Caserta, PhD, Francesca Besi, PhD, James F Sanchez, PhD, Guido Marcucci, MD, Jonathan J Keats, PhD, Amrita Y. Krishnan, MD, Matt Coffey, PhD, Douglas W. Sborov, MDMSc, Gerard Nuovo, MD, Craig C Hofmeister, MDMPH, Flavia Pichiorri, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1816.
https://doi.org/10.1182/blood-2019-128740
Published: 2019
Journal Articles

ADAR1 Drives Disease Progression in Multiple Myeloma By Acting Both As an RNA Editor of Specific Transcripts and As a DNA Mutator of Their Cognate Genes

Rafail Nikolaos Tasakis, MSc, BSc, Alessandro Lagana, PhD, Violetta Leshchenko, PhD, David Melnekoff, BS,MS, Itai Beno, PhD, Jonathan J Keats, PhD, Daniel Auclair, Deepu Madduri, MD, Joshua Richter, MD, Ajai Chari, MD, Hearn Jay Cho, MD PhD, Sundar Jagannath, MD, Joel Dudley, PhD, F. Nina Papavasiliou, PhD, Samir Parekh, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3092.
https://doi.org/10.1182/blood-2019-130669
Published: 2019
Journal Articles

Genomic and Immunologic Analysis of Cmaf and Hypermutated Multiple Myeloma: Implications for Immunologic Therapy

Hearn Jay Cho, MD PhD, Deepak Perumal, PhD, Adeeb H Rahman, PhD, Donald Jackson, PhD, Michael Robbins, PhD, Seunghee Kim-Schultze, PhD, Sacha Gnjatic, PhD, Samir Parekh, MD, Jonathan J Keats, PhD, Daniel Auclair
Journal: Blood
Blood (2019) 134 (Supplement_1): 3093.
https://doi.org/10.1182/blood-2019-131274
Published: 2019
Journal Articles

Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins

Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Ricardo De Matos Simoes, PhD, Geoffrey M Matthews, PhD, Dennis Buckley, Joseline Raja, Quinlan L Sievers, PhD, Olga Dashevsky, PhD, Haley Poarch, Huihui Tang, PhD, Megan Bariteau, BSc, Michal Sheffer, PhD, Sondra L. Downey-Kopyscinski, PhD, Paul Hengeveld, Brian Glassner, PhD, Eugen Dhimolea, PhD, Christopher J. Ott, PhD, Tinghu Zhang, PhD, Nicholas P Kwiatkowski, PhD, Jacob P. Laubach, MD, Robert L. Schlossman, MD, Paul G. Richardson, MD, Aedin Culhane, PhD, Richard W.J. Groen, PhD, Eric Fischer, Benjamin L. Ebert, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Joan Levy, PhD, Daniel Auclair, Jonathan D. Licht, MD, Jonathan J Keats, PhD, Lawrence H. Boise, PhD, James Bradner, MD, Nathanael Gray, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 318.
https://doi.org/10.1182/blood-2019-130549
Published: 2019
Journal Articles

Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma

Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Sondra L. Downey-Kopyscinski, PhD, Geoffrey Matthews, PhD, Hu Yiguo, PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Joshua Dempster, PhD, Robin M. Meyers, PhD, Jordan Bryan, James M. McFarland, Johanna Brueggenthies, Huihui Tang, PhD, Megan Bariteau, BSc, Minasri Borah, Quinlan L Sievers, PhD, Benjamin Ebert, MD, Brian Glassner, PhD, Christopher J. Ott, PhD, Nicholas P Kwiatkowski, PhD, John G Doench, PhD, Daniel Auclair, Joan Levy, PhD, Lawrence H. Boise, PhD, Jonathan J Keats, PhD, Jonathan D. Licht, MD, Richard Groen, Nathanael Gray, Aedin Culhane, PhD, William C. Hahn, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4407.
https://doi.org/10.1182/blood-2019-130901
Published: 2019
Journal Articles

The CCND1 870G Risk Allele Is Enriched in African Individuals with Plasma Cell Dyscrasias

Linda B Baughn, PhD, Zhou Li, MS, Kathryn E. Pearce, Celine M. Vachon, PhD, Mei-Yin Polley, PhD, Jonathan J Keats, PhD, Eran Elhaik, PhD, Michael L. Baird, PhD, Terry Therneau, PhD, James R. Cerhan, MD PhD, P. Leif Bergsagel, MD, Angela Dispenzieri, MD, S.Vincent Rajkumar, MD, Yan Asmann, PhD, Shaji K. Kumar, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4362.
https://doi.org/10.1182/blood-2019-124979
Published: 2019
Journal Articles

Multiple Myeloma Epigenetic Programming Prognostic of Outcome Converges with Loci Reprogrammed in Relapsed/Refractory Disease

Benjamin G Barwick, PhD, Sheri Skerget, PhD, Jonathan J Keats, PhD, Daniel Auclair, Sagar Lonial, Lawrence H. Boise, PhD, Paula M Vertino, PhD, Doris R Powell, MA
Journal: Blood
Blood (2019) 134 (Supplement_1): 858.
https://doi.org/10.1182/blood-2019-124422
Published: 2019
Journal Articles

Immunoglobulin Lambda Translocations Identify Poor Outcome and IMiD Resistance in Multiple Myeloma and Co-Occur with Hyperdiploidy

Benjamin G Barwick, PhD, Paola Neri, MD, Nizar Bahlis, MD, Ajay K Nooka, MDMPH, Jonathan L Kaufman, MD, Vikas A. Gupta, MD PhD, Daniel Auclair, PhD, Jonathan J Keats, PhD, Sagar Lonial, MD, Paula M Vertino, PhD, Lawrence H. Boise, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 405.
https://doi.org/10.1182/blood-2018-99-113585
Published: 2018
Journal Articles

Chromothripsis and Chromoplexy Are Associated with DNA Instability and Adverse Clinical Outcome in Multiple Myeloma

Cody Ashby, PhD, Michael A Bauer, PhD, Yan Wang, Christopher P. Wardell, PhD MSc, BSc, Ruslana G. Tytarenko, MS, Purvi Patel, Erin Flynt, Maria Ortiz, Andrew Dervan, Jake Gockley, PhD, Aneta Mikulasova, PhD, Carolina D. Schinke, MD, Sharmilan Thanendrarajan, MD, Maurizio Zangari, MD, Frits van Rhee, MD PhD, Faith E. Davies, MD, Jonathan J Keats, PhD, Daniel Auclair, PhD, Anjan Thakurta, PhD, Brian A Walker, PhD, Gareth Morgan, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 408.
https://doi.org/10.1182/blood-2018-99-117359
Published: 2018
Journal Articles

Myeloma Patient-Derived MCL1 Point Mutations Can Influence MCL1-Inhibitor Function

Brandon Chen, Wong Pamela, B.S., Daniel Auclair, PhD, Jonathan J Keats, PhD, Paul Secrist, PhD, Justin Cidado, PhD, Adriana E. Tron, PhD, Christine M Dunham, PhD, Sagar Lonial, MD, Joseph Opferman, PhD, Shannon M Matulis, PhD, Lawrence H. Boise, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 951.
https://doi.org/10.1182/blood-2018-99-113444
Published: 2018
Journal Articles

Preclinical Activity of Novel MCL1 Inhibitor AZD5991 in Multiple Myeloma

Shannon M Matulis, PhD, Vikas A. Gupta, MD PhD, Izabelle Brown, Jonathan J Keats, PhD, Paul Secrist, PhD, Justin Cidado, PhD, Adriana E. Tron, PhD, Paola Neri, MD, Nizar Bahlis, MD, Jonathan L Kaufman, MD, Leonard Heffner, MD, Sagar Lonial, MD, Ajay K Nooka, MDMPH, Lawrence H. Boise, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 952.
https://doi.org/10.1182/blood-2018-99-113504
Published: 2018
Journal Articles

MAGE-A3 Promotes Chemotherapy Resistance and Proliferation in Multiple Myeloma through Regulation of BIM and p21 Cip1

Hearn Jay Cho, MD, Anna Huo-Chang Mei, MS, Kaity Tung, BS, Jessie Han, Deepak Perumal, PhD, Jonathan J Keats, PhD, Daniel Auclair, PhD, Ajai Chari, MD, Sundar Jagannath, MD, Samir Parekh, MD, Alessandro Lagana, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4464.
https://doi.org/10.1182/blood-2018-99-118692
Published: 2018
Journal Articles

CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias

Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Dennis Buckley, Olga Dashevsky, PhD, Sondra L. Downey-Kopyscinski, PhD, Huihui Tang, PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Brian Glassner, PhD, Megan Bariteau, BSc, Jeffrey Sorrell, BA, Johanna B Bruggenthies, Quinlan Sievers, BA, Haley Poarch, Nicholas P Kwiatkowski, PhD, Tinghu Zhang, PhD, Jacob Laubach, MD, Robert L. Schlossman, MD, Paul Richardson, Aedin Culhane, PhD, Richard WJ Groen, PhD, Eric S. Fischer, PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Joan Levy, Daniel Auclair, PhD, Jonathan D. Licht, MD, Jonathan J Keats, PhD, Lawrence H. Boise, PhD, Benjamin L. Ebert, MDPhD, James Bradner, MD, Nathanae Gray, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1367.
https://doi.org/10.1182/blood-2018-99-116232
Published: 2018
Journal Articles

Analysis of Sequential Patient Samples from the Mmrf Commpass Study Identifies a High Risk Progression Phenotype

Sheri Skerget, PhD, Daniel Penaherrera, BSc, Jessica Aldrich, Sara Nasser, PhD, Austin Christofferson, BSc, Christophe Legendre, Martin Boateng, BS, Lori Cuyugan, Jonathan Adkins, Erica Tassone, Jennifer Yesil, MS, Daniel Auclair, PhD, Winnie Liang, PhD, Sagar Lonial, MD, Jonathan J Keats, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 111.
https://doi.org/10.1182/blood-2018-99-118617
Published: 2018
Journal Articles

An Integrated Genomics Analysis Identifies Recurrent Gain- and Loss-of-Function Events and in Distinct Subtypes of Multiple Myeloma

Sara Nasser, PhD, Jessica Aldrich, Daniel Penaherrera, BSc, Austin Christofferson, BSc, Christophe Legendre, Jennifer Yesil, MS, Daniel Auclair, PhD, Winnie Liang, PhD, Sagar Lonial, MD, Sheri Skerget, PhD, Jonathan J Keats, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 113.
https://doi.org/10.1182/blood-2018-99-119354
Published: 2018
Journal Articles

Increased HLA-E Expression Correlates with Early Relapse in Multiple Myeloma

Alessandro Lagana, PhD, Dan Fu Ruan, David Melnekoff, BS,MS, Violetta Leshchenko, PhD, Deepak Perumal, PhD, Adeeb Rahman, Seunghee Kim-Schultze, PhD, Ying Song, Jonathan J Keats, PhD, Jennifer Yesil, MS, Daniel Auclair, PhD, Deepu Madduri, MD, Joshua Richter, Ajai Chari, MD, Hearn Jay Cho, MD, Bart Barlogie, MD PhD, Sundar Jagannath, MD, Joel Dudley, PhD, Amir Horowitz, PhD, Samir Parekh, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 59.
https://doi.org/10.1182/blood-2018-99-116828
Published: 2018
Journal Articles

CD84: A Potential Novel Therapeutic Target in Multiple Myeloma

Emine Gulsen Gunes, PhD, Hadas Lewinsky, Domenico Viola, Enrico Caserta, Michael Rosenzweig, Myo Htut, James F Sanchez, PhD, Ralf Buettner, PhD, Guido Marcucci, Jonathan J Keats, PhD, Amrita Krishnan, MD, Steven T Rosen, Idit Shachar, Flavia Pichiorri, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1924.
https://doi.org/10.1182/blood-2018-99-119655
Published: 2018